Neuroprotective profile of pyridothiazepines with blocking activity of the mitochondrial Na+/Ca2+ exchanger

European Journal of Medicinal Chemistry

Volumn 109, Issue , 2016, Pages 114-123

  Martínez Sanz, Francisco J ^a,b   Lajarín Cuesta, Rocío ^a,b   González Lafuente, Laura ^b   Moreno Ortega, Ana J ^a,b   Punzón, Eva ^a   Cano Abad, María F ^a,b   De Los Ríos, Cristóbal ^a,b  

^a INSTITUTO TEÓFILO HERNANDO   (Spain)

^b HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

Author keywords

CGP37157; Mitochondria; Mitochondrial Na Ca2 exchanger; Neurodegeneration; Neuroprotection; Pyridothiazepines

Indexed keywords

(2 AMINO 5 CHLOROPYRIDIN 3 YL) (2' BROMOPHENYL)METHANOL; (2 AMINO 5 CHLOROPYRIDIN 3 YL) (2' CHLOROPHENYL)METHANOL; (2 AMINO 5 CHLOROPYRIDIN 3 YL) (2' ETHOXYPHENYL)METHANOL; (2 AMINO 5 CHLOROPYRIDIN 3 YL) (2' ISOPROPYL)METHANOL; (2 AMINO 5 CHLOROPYRIDIN 3 YL) (2' METHOXYPHENYL)METHANOL; (2 AMINO 5 CHLOROPYRIDIN 3 YL) (2' TRIFLUOROMETHYLPHENYL)METHANOL; (2 AMINO 5 CHLOROPYRIDIN 3 YL) (4' FLUOROPHENYL)METHANOL; (2 AMINO 5 CHLOROPYRIDIN 3 YL) (4' METHOXYPHENYL)METHANOL; (2 AMINO 5 CHLOROPYRIDIN 3 YL) (O TOLUYL)METHANOL; (2 AMINO 5 CHLOROPYRIDIN 3 YL) (PHENYL)METHANOL; 7 CHLORO 5 (2 CHLOROPHENYL) 1,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2(3H) ONE; METHYL 2 [(2 AMINO 5 CHLOROPYRIDIN 3 YL) (2' ISO PROPYLPHENYL)METHYLTHIO]ACETATE; METHYL 2 [(2 AMINO 5 CHLOROPYRIDIN 3 YL) (2' METHOXYPHENYL)METHYLTHIO]ACETATE; METHYL 2 [(2 AMINO 5 CHLOROPYRIDIN 3 YL) (2' TRI FLUOROMETHYLPHENYL)METHYLTHIO]ACETATE; METHYL 2 [(2 AMINO 5 CHLOROPYRIDIN 3 YL) (4' METHOXYPHENYL)METHYLTHIO]ACETATE; METHYL 2 [(2 AMINO 5 CHLOROPYRIDIN 3 YL) (O TOLUYL)METHYLTHIO]ACETATE; METHYL 2 [(2 AMINO 5 CHLOROPYRIDIN 3 YL) (PHENYL)METHYLTHIO]ACETATE; N [5 CHLORO 3 [HYDROXY(2' BROMOPHENYL)METHYL]PYRIDIN 2 YL] PIVALAMIDE; N [5 CHLORO 3 [HYDROXY(2' CHLOROPHENYL)METHYL]PYRIDIN 2 YL] PIVALAMIDE; N [5 CHLORO 3 [HYDROXY(2' ETHOXYPHENYL)METHYL]PYRIDIN 2 YL] PIVALAMIDE; N [5 CHLORO 3 [HYDROXY(2' ISOPROPYLPHENYL)METHYL]PYRIDIN 2 YL] PIVALAMIDE; N [5 CHLORO 3 [HYDROXY(2' METHOXYPHENYL)METHYL]PYRIDIN 2 YL] PIVALAMIDE; N [5 CHLORO 3 [HYDROXY(2' TRIFLUOROMETHYLPHENYL)METHYL]PYRIDIN 2 YL] PIVALAMIDE; N [5 CHLORO 3 [HYDROXY(4' FLUOROPHENYL)METHYL]PYRIDIN 2 YL] PIVALAMIDE; N [5 CHLORO 3 [HYDROXY(4' METHOXYPHENYL)METHYL]PYRIDIN 2 YL] PIVALAMIDE; N [5 CHLORO 3 [HYDROXY(O TOLUYL)METHYL]PYRIDIN 2 YL]PIVALAMIDE; N-[5 CHLORO 3 [HYDROXY(PHENYL)METHYL]PYRIDIN 2 YL]PIVALAMIDE; NEUROPROTECTIVE AGENT; THIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG; 7-CHLORO-5-(2-ISOPROPYLPHENYL)-3,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2-(1H)-ONE; CALCIUM; PYRIDINE DERIVATIVE; SODIUM CALCIUM EXCHANGE PROTEIN;

APOPTOSIS; ARTICLE; DRUG CLEARANCE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG SYNTHESIS; LIPOPHILICITY; MITOCHONDRIAL MEMBRANE; NEUROPROTECTION; SODIUM CALCIUM EXCHANGE; ANIMAL; ANTAGONISTS AND INHIBITORS; BOVINE; CELL LINE; CHEMISTRY; DRUG EFFECTS; HELA CELL LINE; HIPPOCAMPUS; HUMAN; METABOLISM; MITOCHONDRION; RAT; SOLUBILITY; TUMOR CELL LINE;

ANIMALS; CALCIUM; CATTLE; CELL LINE; CELL LINE, TUMOR; HELA CELLS; HIPPOCAMPUS; HUMANS; MITOCHONDRIA; NEUROPROTECTIVE AGENTS; PYRIDINES; RATS; SODIUM-CALCIUM EXCHANGER; SOLUBILITY; THIAZEPINES;

EID: 84954188637     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.12.043     Document Type: Article

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