Efficient syntheses of benzothiazepines as antagonists for the mitochondrial sodium-calcium exchanger: Potential therapeutics for type II diabetes

Journal of Organic Chemistry

Volumn 68, Issue 1, 2003, Pages 92-103

  Pei, Yazhong ^a   Lilly, Michael J ^b   Owen, David J ^b   D'Souza, Lawrence J ^a   Tang, Xiao Qing ^a   Yu, Jinghua ^a   Nazarbaghi, Ramina ^a   Hunter, Andrew ^b   Anderson, Christen M ^a   Glasco, Susan ^a   Ede, Nicholas J ^b   James, Ian W ^b   Maitra, Uday ^c   Chandrasekaran, S ^c   Moos, Walter H ^a   Ghosh, Soumitra S ^a  

^a Migenix Inc   (United States)

^b Mimotopes Pty Ltd   (Australia)

^c INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

DIABETES;

BLOOD; CARDIOVASCULAR SYSTEM; CELL MEMBRANES; DISEASES; ENZYME INHIBITION; GLUCOSE; INSULIN; ION EXCHANGERS; METABOLISM; NEUROLOGY; ORGANIC COMPOUNDS; SYNTHESIS (CHEMICAL);

DRUG THERAPY;

ANTIDIABETIC AGENT; BENZOTHIAZEPINE DERIVATIVE; CLONAZEPAM; DILTIAZEM; SODIUM CALCIUM EXCHANGE PROTEIN;

AEROBIC METABOLISM; ALKYLATION; ARTICLE; CALCIUM TRANSPORT; CARDIOVASCULAR DISEASE; DRUG EFFICACY; DRUG SYNTHESIS; GASTROINTESTINAL SYMPTOM; GLUCOSE BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INSULIN RELEASE; KIDNEY DISEASE; METABOLIC DISORDER; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MONOTHERAPY; NEUROLOGIC DISEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; RETINA DISEASE; STRUCTURE ACTIVITY RELATION; WEIGHT GAIN;

ANIMALS; BENZODIAZEPINES; CALCIUM; CATALYSIS; CELLS, CULTURED; COMBINATORIAL CHEMISTRY TECHNIQUES; DIABETES MELLITUS, TYPE 2; INSULIN; MAGNETIC RESONANCE SPECTROSCOPY; MITOCHONDRIA; MOLECULAR STRUCTURE; RATS; SODIUM-CALCIUM EXCHANGER; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 12244256774     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo020446t     Document Type: Article

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