Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration

ACS Chemical Neuroscience

Volumn 6, Issue 9, 2015, Pages 1626-1636

  Martínez Sanz, Francisco J ^a,b   Lajarín Cuesta, Rocío ^a   Moreno Ortega, Ana J ^a,b   González Lafuente, Laura ^a,b   Fernández Morales, Jose C ^a,c   López Arribas, Raquel ^a   Cano Abad, María F ^a,b   De Los Ríos, Cristóbal ^a,b  

^a INSTITUTO TEÓFILO HERNANDO   (Spain)

^b HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^c Medical University of South Carolina and Clemson University   (United States)

Author keywords

Benzothiazepines; mitochondria; mNCX; NCLX; neurodegeneration; neuroprotection

Indexed keywords

7 CHLORO 5 (2 CHLOROPHENYL) 1,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2(3H) ONE; 7 CHLORO 5 (2' BROMOPHENYL) 3,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2 (1H)ONE; 7 CHLORO 5 (2' ETHOXYPHENYL) 3,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2 (1H)ONE; 7 CHLORO 5 (2' FLUOROPHENYL) 3,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2 (1H)ONE; 7 CHLORO 5 (2' ISOPROPYLPHENYL) 3,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2 (1H)ONE; 7 CHLORO 5 (2' METHOXYPHENYL) 3,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2 (1H)ONE; 7 CHLORO 5 (2' TRIFLUOROMETHYLPHENYL) 3,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2 (1H)ONE; 7 CHLORO 5 (2',6' DICHLOROPHENYL) 3,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2 (1H)ONE; 7 CHLORO 5 (O TOLUYL) 3,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2 (1H)ONE; 7 CHLORO 5 PHENYL 3,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2 (1H)ONE; BENZOTHIAZEPINE DERIVATIVE; CYTOPROTECTIVE AGENT; HYDROGEN; MEMANTINE; MITOCHONDRIAL PROTEIN; NEUROPROTECTIVE AGENT; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG; 7-CHLORO-5-(2'-ISOPROPYLPHENYL)-3,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2-(1H)-ONE; CALCIUM; SODIUM; THIAZEPINE DERIVATIVE;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN MITOCHONDRION; CELL PROTECTION; CONTROLLED STUDY; CYTOPROTECTIVE EFFECT; DRUG ACTIVITY; DRUG CLEARANCE; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; EC50; FEMALE; HELA CELL LINE; HIPPOCAMPAL SLICE; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; NERVE DEGENERATION; NEUROPROTECTION; NEUROPROTECTIVE ACTIVITY; NONHUMAN; POSITION; PRIORITY JOURNAL; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BOVINE; CELL DEATH; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CHROMAFFIN CELL; DRUG EFFECTS; MEMBRANE POTENTIAL; METABOLISM; MITOCHONDRION; NEURODEGENERATIVE DISEASES; PHYSIOLOGY; PRECLINICAL STUDY; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; CALCIUM; CATTLE; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CHROMAFFIN CELLS; CYTOPROTECTION; DRUG EVALUATION, PRECLINICAL; HELA CELLS; HUMANS; MEMBRANE POTENTIALS; MITOCHONDRIA; MOLECULAR STRUCTURE; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; SODIUM; SODIUM-CALCIUM EXCHANGER; THIAZEPINES;

EID: 84942059998     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.5b00161     Document Type: Article

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