3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 9, 2005, Pages 2221-2224

  Lin, Ronghui ^a   Lu, Yanhua ^a   Wetter, Steven K ^a   Connolly, Peter J ^a   Turchi, Ignatius J ^a   Murray, William V ^a   Emanuel, Stuart L ^a   Gruninger, Robert H ^a   Fuentes Pesquera, Angel R ^a   Adams, Mary ^a   Pandey, Niranjan ^a   Moreno Mazza, Sandra ^a   Middleton, Steven A ^a   Jolliffe, Linda K ^a  

^a JOHNSON AND JOHNSON   (United States)

Author keywords

CDK inhibitor; Cell proliferation inhibitor; Cyclin dependent kinase inhibitor; Synthesis

Indexed keywords

7 HYDROXYSTAUROSPORINE; AMINOTHIADIAZOLE; AMINOTRIAZOLE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR; FLAVOPIRIDOL; N [5 (5 TERT BUTYL 2 OXAZOLYLMETHYLTHIO) 2 THIAZOLYL]ISONIPECOTAMIDE; PYRIDINE DERIVATIVE; ROSCOVITINE; RWJ 387252;

ARTICLE; CATALYSIS; CELL PROLIFERATION; CELL STRAIN HCT116; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; HELA CELL; HUMAN; HUMAN CELL; TUMOR CELL;

EID: 20244379731     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.03.024     Document Type: Article

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