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ChemMedChem

Volumn 11, Issue 1, 2016, Pages 22-30

Designing Irreversible Inhibitors - Worth the Effort?

(1) González Bello, Concepciõn a

a Universidade de Santiago de Compostela ^* (Spain)

Author keywords

covalent catalysis; efficiency; irreversible inhibition; selectivity; toxicity

Indexed keywords

ENZYME INHIBITOR; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; OXACILLINASE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG; 3-DEHYDROQUINATE DEHYDRATASE; BETA LACTAMASE; HYDROLYASE; MOLECULAR LIBRARY; OXACILLINASE;

CATALYSIS; CHEMICAL MODIFICATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; PRIORITY JOURNAL; REVIEW; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CONFORMATION; HUMAN; METABOLISM; MOLECULAR LIBRARY; MOLECULAR MODEL; PHARMACOLOGY; SYNTHESIS;

BETA-LACTAMASES; DRUG DESIGN; ENZYME INHIBITORS; H(+)-K(+)-EXCHANGING ATPASE; HUMANS; HYDRO-LYASES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; SMALL MOLECULE LIBRARIES;

EID: 84954025935 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201500469 Document Type: Review

Times cited : (58)

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