Role of E166 in the imine to enamine tautomerization of the clinical β-lactamase inhibitor sulbactam

Biochemistry

Volumn 48, Issue 43, 2009, Pages 10196-10198

  Kalp, Matthew ^a   Buynak, John D ^b   Carey, Paul R ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SOUTHERN METHODIST UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CHEMICAL TRANSFORMATIONS; CLASS A; COMPLEX SERIES; ENAMINES; ENZYME ACTIVE SITES; EXPERIMENTAL DATA; GENERAL BASE; LACTAMASES; TAUTOMERIZATIONS;

ENZYMES; GRAFTING (CHEMICAL); NITROGEN COMPOUNDS; SYNTHESIS (CHEMICAL);

ENZYME INHIBITION;

ENAMINE; IMINE; SERINE DERIVATIVE; SULBACTAM;

ANTIBACTERIAL ACTIVITY; ARTICLE; CATALYST; CHEMICAL REACTION; DRUG INHIBITION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; HYDROLYSIS; PRIORITY JOURNAL;

BETA-LACTAMASES; BIPHENYL COMPOUNDS; CATALYTIC DOMAIN; ENZYME INHIBITORS; IMIDAZOLES; IMINES; MODELS, MOLECULAR; SPECTRUM ANALYSIS, RAMAN; STRUCTURE-ACTIVITY RELATIONSHIP; SULBACTAM;

EID: 70350516697     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901416t     Document Type: Article

References (9)

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