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Angewandte Chemie - International Edition

Volumn 54, Issue 35, 2015, Pages 10313-10316

Covalent-Allosteric Kinase Inhibitors

(15) Weisner, Jörn a Gontla, Rajesh a Van der westhuizen, Leandi b Oeck, Sebastian c Ketzer, Julia d,e Janning, Petra f Richters, André a Mühlenberg, Thomas d,e Fang, Zhizhou a Taher, Abu b Jendrossek, Verena c Pelly, Stephen C b Bauer, Sebastian d,e Van otterlo, Willem A L b Rauh, Daniel a

a TU DORTMUND UNIVERSITY (Germany)

b STELLENBOSCH UNIVERSITY (South Africa)

c UNIVERSITY OF DUISBURG ESSEN (Germany)

d UNIVERSITY HOSPITAL ESSEN (Germany)

e GERMAN CANCER RESEARCH CENTER DKFZ (Germany)

f MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY (Germany)

Author keywords

cancer; drug design; inter domain interactions; medicinal chemistry; tumor thermapeutics

Indexed keywords

AMINO ACIDS; ENZYMES;

ALLOSTERIC INHIBITOR; CANCER; DRUG DESIGN; INNOVATIVE APPROACHES; INTER-DOMAIN INTERACTIONS; MEDICINAL CHEMISTRY; PLECKSTRIN HOMOLOGY DOMAINS; STRUCTURE-BASED DESIGNS;

CONFORMATIONS;

ADENOSINE TRIPHOSPHATE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR;

ALLOSTERISM; ANTAGONISTS AND INHIBITORS; BINDING COMPETITION; CHEMICAL STRUCTURE; DRUG EFFECTS; HUMAN; METABOLISM; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; BINDING, COMPETITIVE; HUMANS; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84939567831 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201502142 Document Type: Article

Times cited : (82)

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