β-Lactamase inhibition by 7-alkylidenecephalosporin sulfones: Allylic transposition and formation of an unprecedented stabilized acyl-enzyme

Journal of the American Chemical Society

Volumn 135, Issue 49, 2013, Pages 18358-18369

  Rodkey, Elizabeth A ^a   McLeod, David C ^b   Bethel, Christopher R ^c,d   Smith, Kerri M ^e   Xu, Yan ^e   Chai, Weirui ^b   Che, Tao ^a   Carey, Paul R ^a   Bonomo, Robert A ^c   Van Den Akker, Focco ^a   Buynak, John D ^b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SOUTHERN METHODIST UNIVERSITY   (United States)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

^e CLEVELAND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE RESIDUES; ALLYLIC TRANSPOSITION; CARBONYL OXYGEN; ENZYME COMPLEXES; INHIBITOR DESIGN; MECHANISTIC SCHEME; RESONANCE STABILIZATION; X RAY CRYSTAL STRUCTURES;

AMINO ACIDS; STABILIZATION;

ENZYME INHIBITION;

BETA LACTAMASE; CARBONYL DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CEPHALOSPORIN DERIVATIVE; CLAVULANIC ACID; OXYGEN; SERINE; SULFONE DERIVATIVE; TAZOBACTAM; THIAZINE DERIVATIVE;

ACYLATION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; CRYSTALLOGRAPHY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STABILITY; MASS SPECTROMETRY; NUCLEOPHILICITY; PROTEIN INTERACTION; SPECTROSCOPY; X RAY;

BASE SEQUENCE; BETA-LACTAMASES; CEPHALOSPORINS; CRYSTALLOGRAPHY, X-RAY; DNA PRIMERS; MODELS, MOLECULAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFONES;

EID: 84890491172     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja403598g     Document Type: Article

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