-
1
-
-
54249124057
-
Why do so many drugs for Alzheimer's disease fail in development? Time for new methods and new practices?
-
Becker RE, Greig NH, Giacobini E Why do so many drugs for Alzheimer's disease fail in development? Time for new methods and new practices?. J Alzheimers Dis 2008, 15:303-325.
-
(2008)
J Alzheimers Dis
, vol.15
, pp. 303-325
-
-
Becker, R.E.1
Greig, N.H.2
Giacobini, E.3
-
2
-
-
84907995546
-
6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): a randomised, double-blind, placebo-controlled phase 2 trial
-
published online Oct 6.
-
6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Neurol 2014, published online Oct 6. http://dx.doi.org/10.1016/S1474-4422(14)70198-X.
-
(2014)
Lancet Neurol
-
-
Wilkinson, D.1
Windfeld, K.2
Colding-Jørgensen, E.3
-
3
-
-
46749118971
-
6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease
-
6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease. Neurotherapeutics 2008, 5:458-469.
-
(2008)
Neurotherapeutics
, vol.5
, pp. 458-469
-
-
Upton, N.1
Chuang, T.2
Hunter, A.3
Virley, D.4
-
4
-
-
0034098959
-
6 antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5-HT, glutamate and aspartate
-
6 antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5-HT, glutamate and aspartate. Br J Pharmacol 2000, 130:23-26.
-
(2000)
Br J Pharmacol
, vol.130
, pp. 23-26
-
-
Dawson, L.A.1
Nguyen, H.Q.2
Li, P.3
-
5
-
-
0034782825
-
6 receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus
-
6 receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus. Neuropsychopharmacology 2001, 25:662-668.
-
(2001)
Neuropsychopharmacology
, vol.25
, pp. 662-668
-
-
Dawson, L.A.1
Nguyen, H.Q.2
Li, P.3
-
6
-
-
77957240422
-
6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats
-
6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats. Int J Neuropsychopharmacol 2010, 13:1021-1033.
-
(2010)
Int J Neuropsychopharmacol
, vol.13
, pp. 1021-1033
-
-
Arnt, J.1
Bang-Andersen, B.2
Grayson, B.3
-
7
-
-
79960840347
-
Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats
-
de Bruin NMWJ, Prickaerts J, van Loevezijn A, et al. Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats. Neurobiol Learn Mem 2011, 96:392-402.
-
(2011)
Neurobiol Learn Mem
, vol.96
, pp. 392-402
-
-
de Bruin, N.M.W.J.1
Prickaerts, J.2
van Loevezijn, A.3
-
8
-
-
77957240989
-
6 receptor antagonist, SB-742457, in Alzheimers disease
-
6 receptor antagonist, SB-742457, in Alzheimers disease. Curr Alzheimer Res 2010, 7:374-385.
-
(2010)
Curr Alzheimer Res
, vol.7
, pp. 374-385
-
-
Maher-Edwards, G.1
Zvartau-Hind, M.2
Hunter, A.J.3
-
9
-
-
79953235869
-
SB-742457 and donepezil in Alzheimer disease: a randomized, placebo-controlled study
-
Maher-Edwards G, Dixon R, Hunter J, et al. SB-742457 and donepezil in Alzheimer disease: a randomized, placebo-controlled study. Int J Geriatr Psychiatry 2011, 26:536-544.
-
(2011)
Int J Geriatr Psychiatry
, vol.26
, pp. 536-544
-
-
Maher-Edwards, G.1
Dixon, R.2
Hunter, J.3
-
10
-
-
69349100072
-
Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities
-
Schaffhauser H, Mathiasen JR, DiCamillo A, et al. Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities. Biochem Pharmacol 2009, 78:1035-1042.
-
(2009)
Biochem Pharmacol
, vol.78
, pp. 1035-1042
-
-
Schaffhauser, H.1
Mathiasen, J.R.2
DiCamillo, A.3
-
11
-
-
77956666900
-
Dimebon disappointment
-
Jones R Dimebon disappointment. Alzheimers Res Ther 2010, 2:25.
-
(2010)
Alzheimers Res Ther
, vol.2
, pp. 25
-
-
Jones, R.1
-
12
-
-
78651295101
-
Treatment with cholinesterase inhibitors and memantine of patients in the Alzheimer's Disease Neuroimaging Initiative
-
Alzheimer's Disease Neuroimaging Initiative
-
Schneider LS, Insel PS, Weiner MW Treatment with cholinesterase inhibitors and memantine of patients in the Alzheimer's Disease Neuroimaging Initiative. Arch Neurol 2011, 68:58-66. for the Alzheimer's Disease Neuroimaging Initiative.
-
(2011)
Arch Neurol
, vol.68
, pp. 58-66
-
-
Schneider, L.S.1
Insel, P.S.2
Weiner, M.W.3
|