-
1
-
-
0000293742
-
Über eine eigenartige Erkrankung der Hirnrinde [About a peculiar disease of the cerebral cortex]
-
Alzheimer A,. Über eine eigenartige Erkrankung der Hirnrinde [About a peculiar disease of the cerebral cortex]. Allgemeine Z Psychiatrie Psychisch-Gerichtliche Med, 1907; 64: 146-148.
-
(1907)
Allgemeine Z Psychiatrie Psychisch-Gerichtliche Med
, vol.64
, pp. 146-148
-
-
Alzheimer, A.1
-
2
-
-
84875354777
-
2013 Alzheimer's disease facts and figures
-
Thies W, Bleiler L,. 2013 Alzheimer's disease facts and figures. Alzheimers Dement, 2013; 9: 208-245.
-
(2013)
Alzheimers Dement
, vol.9
, pp. 208-245
-
-
Thies, W.1
Bleiler, L.2
-
3
-
-
0035987489
-
Potential novel targets for Alzheimer pharmacotherapy: I secretases
-
Maiorini AF, Gaunt MJ, Jacobsen TM, McKay AE, Waldman LD, Raffa RB,. Potential novel targets for Alzheimer pharmacotherapy: I secretases. J Clin Pharm Ther, 2002; 27: 169-183.
-
(2002)
J Clin Pharm Ther
, vol.27
, pp. 169-183
-
-
Maiorini, A.F.1
Gaunt, M.J.2
Jacobsen, T.M.3
McKay, A.E.4
Waldman, L.D.5
Raffa, R.B.6
-
4
-
-
84867463345
-
Alzheimer's drugs take a new tack
-
Callaway E,. Alzheimer's drugs take a new tack. Nature, 2012; 489: 13-14.
-
(2012)
Nature
, vol.489
, pp. 13-14
-
-
Callaway, E.1
-
5
-
-
84864471159
-
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
-
Jonsson T, Atwal JK, Steinberg S, et al,. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature, 2012; 488: 96-99.
-
(2012)
Nature
, vol.488
, pp. 96-99
-
-
Jonsson, T.1
Atwal, J.K.2
Steinberg, S.3
-
6
-
-
0035116273
-
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
-
Luo Y, Bolon B, Kahn S, et al,. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci, 2001; 4: 231-232.
-
(2001)
Nat Neurosci
, vol.4
, pp. 231-232
-
-
Luo, Y.1
Bolon, B.2
Kahn, S.3
-
7
-
-
0028169925
-
Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43)
-
Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y,. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron, 1994; 13: 45-53.
-
(1994)
Neuron
, vol.13
, pp. 45-53
-
-
Iwatsubo, T.1
Odaka, A.2
Suzuki, N.3
Mizusawa, H.4
Nukina, N.5
Ihara, Y.6
-
8
-
-
33645280382
-
Gamma-secretase as a therapeutic target for treatment of Alzheimer's disease
-
Tomita T, Iwatsubo T,. gamma-secretase as a therapeutic target for treatment of Alzheimer's disease. Curr Pharm Des, 2006; 12: 661-670.
-
(2006)
Curr Pharm des
, vol.12
, pp. 661-670
-
-
Tomita, T.1
Iwatsubo, T.2
-
9
-
-
18344384560
-
The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample
-
Dermaut B, Theuns J, Sleegers K, et al,. The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample. Am J Hum Genet, 2002; 70: 1568-1574.
-
(2002)
Am J Hum Genet
, vol.70
, pp. 1568-1574
-
-
Dermaut, B.1
Theuns, J.2
Sleegers, K.3
-
10
-
-
33646369950
-
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity
-
Chen F, Hasegawa H, Schmitt-Ulms G, et al,. TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature, 2006; 440: 1208-1212.
-
(2006)
Nature
, vol.440
, pp. 1208-1212
-
-
Chen, F.1
Hasegawa, H.2
Schmitt-Ulms, G.3
-
11
-
-
33645234720
-
Gamma-secretase inhibitors for Alzheimer's disease: Balancing efficacy and toxicity
-
Barten DM, Meredith JE Jr, Zaczek R, Houston JG, Albright CF,. Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity. Drugs R D, 2006; 7: 87-97.
-
(2006)
Drugs R D
, vol.7
, pp. 87-97
-
-
Barten, D.M.1
Meredith, Jr.J.E.2
Zaczek, R.3
Houston, J.G.4
Albright, C.F.5
-
12
-
-
84866122213
-
Sting of Alzheimer's failures offset by upcoming prevention trials
-
Mullard A,. Sting of Alzheimer's failures offset by upcoming prevention trials. Nat Rev Drug Discov, 2012; 11: 657-660.
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 657-660
-
-
Mullard, A.1
-
14
-
-
56849085242
-
Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor
-
Wang L, Rahn JJ, Lun X, et al,. Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor. PLoS Biol, 2008; 6: e289.
-
(2008)
PLoS Biol
, vol.6
-
-
Wang, L.1
Rahn, J.J.2
Lun, X.3
-
27
-
-
84856593265
-
-
NCT00574132 Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Non-Carrier) accessed 28 October 2013
-
NCT00574132. Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Non-Carrier)-Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Non-Carrier). Available at: http://clinicaltrials. gov/show/NCT00574132 (accessed 28 October 2013).
-
Bapineuzumab in Patients with Mild to Moderate Alzheimer's Disease (ApoE4 Non-Carrier)
-
-
-
29
-
-
84891828590
-
-
NCT01760005 A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. (DIAN TU) (accessed 28 October 2013)
-
NCT01760005. Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. (DIAN TU). Available at: http://clinicaltrials.gov/show/ NCT01760005 (accessed 28 October 2013).
-
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia
-
-
-
36
-
-
84865309350
-
Clinical utility of neuroprotective agents in neurodegenerative diseases: Current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis
-
Dunkel P, Chai CL, Sperlagh B, Huleatt PB, Matyus P,. Clinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis. Expert Opin Investig Drugs, 2012; 21: 1267-1308.
-
(2012)
Expert Opin Investig Drugs
, vol.21
, pp. 1267-1308
-
-
Dunkel, P.1
Chai, C.L.2
Sperlagh, B.3
Huleatt, P.B.4
Matyus, P.5
-
37
-
-
81255143061
-
Robust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor
-
May PC, Dean RA, Lowe SL, et al,. Robust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor. J Neurosci, 2011; 31: 16507-16516.
-
(2011)
J Neurosci
, vol.31
, pp. 16507-16516
-
-
May, P.C.1
Dean, R.A.2
Lowe, S.L.3
-
41
-
-
84891827428
-
-
Anonymous. (accessed 28 October 2013)
-
Anonymous. (2013) http://www.ttpharma.com/TherapeuticAreas/ AlzheimersDisease/HPP854/tabid/125/Default.aspx. (accessed 28 October 2013).
-
(2013)
-
-
-
42
-
-
84874289532
-
-
PhRMA accessed 28 October 2013
-
PhRMA. (2012) Medicines in development: Alzheimer's disease. Available at: http://phrma.org/sites/default/files/pdf/alzheimers2012.pdf. (accessed 28 October 2013).
-
(2012)
Medicines in Development: Alzheimer's Disease
-
-
-
43
-
-
84867583311
-
Identification of BACE2 as an avid ss-amyloid-degrading protease
-
Abdul-Hay SO, Sahara T, McBride M, Kang D, Leissring MA,. Identification of BACE2 as an avid ss-amyloid-degrading protease. Mol Neurodegener, 2012; 7: 46.
-
(2012)
Mol Neurodegener
, vol.7
, pp. 46
-
-
Abdul-Hay, S.O.1
Sahara, T.2
McBride, M.3
Kang, D.4
Leissring, M.A.5
-
44
-
-
84868516038
-
Safety and tolerability of the gamma-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease
-
Coric V, van Dyck CH, Salloway S, et al,. Safety and tolerability of the gamma-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease. Arch Neurol, 2012; 69: 1430-1440.
-
(2012)
Arch Neurol
, vol.69
, pp. 1430-1440
-
-
Coric, V.1
Van Dyck, C.H.2
Salloway, S.3
-
45
-
-
67650407720
-
Development of semagacestat (LY450139), a functional gamma-secretase inhibitor, for the treatment of Alzheimer's disease
-
Henley DB, May PC, Dean RA, Siemers ER,. Development of semagacestat (LY450139), a functional gamma-secretase inhibitor, for the treatment of Alzheimer's disease. Expert Opin Pharmacother, 2009; 10: 1657-1664.
-
(2009)
Expert Opin Pharmacother
, vol.10
, pp. 1657-1664
-
-
Henley, D.B.1
May, P.C.2
Dean, R.A.3
Siemers, E.R.4
-
47
-
-
84891837358
-
-
PharmaTimes Online accessed 28 October 2013
-
McKee S, (2010) Lilly Hit by Spectacular Failure of Phase III Alzheimer's Candidate. PharmaTimes Online. Available at: http://www.pharmatimes.com/ article/10-08-18/Lilly-hit-by-spectacular-failure-of-Phase-III-Alzheimer-s- candidate.aspx (accessed 28 October 2013).
-
(2010)
Lilly Hit by Spectacular Failure of Phase III Alzheimer's Candidate
-
-
McKee, S.1
-
48
-
-
84891831362
-
-
Anonymous accessed 28 October 2013
-
Anonymous. (2012) 2012: A Pivotal Year for Alzheimer's Disease Drug Development. Available at: http://www.minyanville.com/sectors/biotech-pharma/ articles/alzheimers-disease-alzheimers-alzheimer-disease-eli/4/10/2012/id/40336 (accessed 28 October 2013).
-
(2012)
2012: A Pivotal Year for Alzheimer's Disease Drug Development
-
-
-
49
-
-
84864286560
-
Structural basis of C-terminal beta-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer's disease
-
La Porte SL, Bollini SS, Lanz TA, et al,. Structural basis of C-terminal beta-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer's disease. J Mol Biol, 2012; 421: 525-536.
-
(2012)
J Mol Biol
, vol.421
, pp. 525-536
-
-
La Porte, S.L.1
Bollini, S.S.2
Lanz, T.A.3
-
50
-
-
84891835024
-
-
n T.Pfizer Halts Development of Aβ Antibody. (accessed 28 October 2013)
-
n T. (2011) Pfizer Halts Development of Aβ Antibody. Available at: http://www.alzforum.org/new/detail.asp?id=2950. (accessed 28 October 2013).
-
(2011)
-
-
-
51
-
-
5144234938
-
Immunotherapy for Alzheimer's disease
-
Gelinas DS, DaSilva K, Fenili D, St George-Hyslop P, McLaurin J,. Immunotherapy for Alzheimer's disease. Proc Natl Acad Sci USA, 2004; 101 (Suppl 2): 14657-14662.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.SUPPL. 2
, pp. 14657-14662
-
-
Gelinas, D.S.1
Dasilva, K.2
Fenili, D.3
St George-Hyslop, P.4
McLaurin, J.5
-
54
-
-
0037638809
-
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: A randomized controlled trial
-
Aisen PS, Schafer KA, Grundman M, et al,. Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. JAMA, 2003; 289: 2819-2826.
-
(2003)
JAMA
, vol.289
, pp. 2819-2826
-
-
Aisen, P.S.1
Schafer, K.A.2
Grundman, M.3
-
56
-
-
84891830122
-
-
Alzheimer Research Forum accessed 28 October 2013
-
Alzheimer Research Forum. Drugs In Clinical Trials. Available at: http://www.alzforum.org/dis/tre/drc/ (accessed 28 October 2013).
-
Drugs in Clinical Trials
-
-
-
57
-
-
84891830856
-
-
Alzheimer Research Forum accessed 28 October 2013
-
Alzheimer Research Forum. Will Tau Drug Show Its True Colors in Phase 3 Trials? Available at: http://www.alzforum.org/new/detail.asp?id=3283 (accessed 28 October 2013).
-
Will Tau Drug Show Its True Colors in Phase 3 Trials?
-
-
-
60
-
-
84891829670
-
-
NCT00965588 Study to Evaluate Safety, Tolerability and Immunogenicity of Vaccine (UB 311) in Subjects With Alzheimer's Disease. Available at: http://clinicaltrials.gov/show/NCT00965588 (accessed 28 October 2013).
-
NCT00965588. http://clinicaltrials.gov/show/NCT00965588. Study to Evaluate Safety, Tolerability and Immunogenicity of Vaccine (UB 311) in Subjects With Alzheimer's Disease. Available at: http://clinicaltrials.gov/show/ NCT00965588 (accessed 28 October 2013).
-
-
-
-
62
-
-
84891827874
-
-
accessed 28 October 2013
-
Kolata G, (2012) Three Drugs to Be Tested to Stave Off Alzheimer's. Available at: http://www.nytimes.com/2012/10/11/health/alzheimers-prevention- studies-to-test-three-drugs.html (accessed 28 October 2013).
-
(2012)
Three Drugs to Be Tested to Stave off Alzheimer's
-
-
Kolata, G.1
-
64
-
-
0034680078
-
Patterns of brain activation in people at risk for Alzheimer's disease
-
Bookheimer SY, Strojwas MH, Cohen MS, et al,. Patterns of brain activation in people at risk for Alzheimer's disease. N Engl J Med, 2000; 343: 450-456.
-
(2000)
N Engl J Med
, vol.343
, pp. 450-456
-
-
Bookheimer, S.Y.1
Strojwas, M.H.2
Cohen, M.S.3
-
65
-
-
84877074899
-
Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease
-
Teipel SJ, Grothe M, Lista S, Toschi N, Garaci FG, Hampel H,. Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease. Med Clin North Am, 2013; 97: 399-424.
-
(2013)
Med Clin North Am
, vol.97
, pp. 399-424
-
-
Teipel, S.J.1
Grothe, M.2
Lista, S.3
Toschi, N.4
Garaci, F.G.5
Hampel, H.6
-
66
-
-
79956098248
-
Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the national institute on aging-Alzheimer's association workgroups on diagnostic guidelines for Alzheimer's disease
-
Sperling RA, Aisen PS, Beckett LA, et al,. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the national institute on aging-Alzheimer's association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement, 2011; 7: 280-292.
-
(2011)
Alzheimers Dement
, vol.7
, pp. 280-292
-
-
Sperling, R.A.1
Aisen, P.S.2
Beckett, L.A.3
-
71
-
-
79959987552
-
Combination therapy for Alzheimer's disease
-
Patel L, Grossberg GT,. Combination therapy for Alzheimer's disease. Drugs Aging, 2011; 28: 539-546.
-
(2011)
Drugs Aging
, vol.28
, pp. 539-546
-
-
Patel, L.1
Grossberg, G.T.2
-
72
-
-
84856293013
-
Clinical and research diagnostic criteria for Alzheimer's disease
-
viii.
-
Sarazin M, de SL, Lehericy S, Dubois B, Clinical and research diagnostic criteria for Alzheimer's disease. Neuroimaging Clin N Am, 2012; 22: 23-32,viii.
-
(2012)
Neuroimaging Clin N Am
, vol.22
, pp. 23-32
-
-
Sarazin, M.1
De, S.L.2
Lehericy, S.3
Dubois, B.4
-
73
-
-
66249119999
-
Application of pet imaging to diagnosis of Alzheimer's disease and mild cognitive impairment
-
Noble JM, Scarmeas N,. Application of pet imaging to diagnosis of Alzheimer's disease and mild cognitive impairment. Int Rev Neurobiol, 2009; 84: 133-149.
-
(2009)
Int Rev Neurobiol
, vol.84
, pp. 133-149
-
-
Noble, J.M.1
Scarmeas, N.2
-
74
-
-
84863005761
-
Contribution of single photon emission computed tomography to the differential diagnosis of dementia in a memory clinic
-
Rollin-Sillaire A, Bombois S, Deramecourt V, et al,. Contribution of single photon emission computed tomography to the differential diagnosis of dementia in a memory clinic. J Alzheimer's Dis, 2012; 30: 833-845.
-
(2012)
J Alzheimer's Dis
, vol.30
, pp. 833-845
-
-
Rollin-Sillaire, A.1
Bombois, S.2
Deramecourt, V.3
-
75
-
-
84863800460
-
Plasma amyloid-beta as a predictor of dementia and cognitive decline: A systematic review and meta-analysis
-
Koyama A, Okereke OI, Yang T, Blacker D, Selkoe DJ, Grodstein F,. Plasma amyloid-beta as a predictor of dementia and cognitive decline: a systematic review and meta-analysis. Arch Neurol, 2012; 69: 824-831.
-
(2012)
Arch Neurol
, vol.69
, pp. 824-831
-
-
Koyama, A.1
Okereke, O.I.2
Yang, T.3
Blacker, D.4
Selkoe, D.J.5
Grodstein, F.6
-
76
-
-
84863598082
-
CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings
-
Seppälä TT, Nerg O, Koivisto AM, et al,. CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings. Neurology, 2012; 78: 1568-1575.
-
(2012)
Neurology
, vol.78
, pp. 1568-1575
-
-
Seppälä, T.T.1
Nerg, O.2
Koivisto, A.M.3
-
77
-
-
68249141258
-
Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease
-
Nelissen N, Van Laere K, Thurfjell L, et al,. Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease. J Nucl Med, 2009; 50: 1251-1259.
-
(2009)
J Nucl Med
, vol.50
, pp. 1251-1259
-
-
Nelissen, N.1
Van Laere, K.2
Thurfjell, L.3
|