-
2
-
-
0034516988
-
Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid betaprotein
-
Selkoe DJ: Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid betaprotein. Ann NY Acad Sci 2000; 924: 17-25.
-
(2000)
Ann NY Acad Sci
, vol.924
, pp. 17-25
-
-
Selkoe, D.J.1
-
3
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999; 286: 735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.C.20
Collins, F.21
Treanor, J.22
Rogers, G.23
Citron, M.24
more..
-
4
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F: Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 1998; 391: 387-390.
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
Von Figura, K.7
Van Leuven, F.8
-
5
-
-
0033616716
-
Constitutive and regulated alphasecretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
-
Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C, Fahrenholz F: Constitutive and regulated alphasecretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci USA 1999; 96: 3922-3927.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3922-3927
-
-
Lammich, S.1
Kojro, E.2
Postina, R.3
Gilbert, S.4
Pfeiffer, R.5
Jasionowski, M.6
Haass, C.7
Fahrenholz, F.8
-
6
-
-
85047690140
-
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
-
Postina R, Schroeder A, Dewachter I, Bohl J, Schmitt U, Kojro E, Prinzen C, Endres K, Hiemke C, Blessing M, Flamez P, Dequenne A, Godaux E, van Leuven F, Fahrenholz F: A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J Clin Invest 2004; 113: 1456-1464.
-
(2004)
J Clin Invest
, vol.113
, pp. 1456-1464
-
-
Postina, R.1
Schroeder, A.2
Dewachter, I.3
Bohl, J.4
Schmitt, U.5
Kojro, E.6
Prinzen, C.7
Endres, K.8
Hiemke, C.9
Blessing, M.10
Flamez, P.11
Dequenne, A.12
Godaux, E.13
Van Leuven, F.14
Fahrenholz, F.15
-
7
-
-
0035089318
-
Constitutive alphasecretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: Involvement of the pro-hormone convertase and the disintegrin metalloprotease ADAM10
-
Lopez-Perez E, Zhang Y, Frank S, Creemers J, Seidah N, Checler F: Constitutive alphasecretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase and the disintegrin metalloprotease ADAM10. J Neurochem 2001; 76: 1532-1539.
-
(2001)
J Neurochem
, vol.76
, pp. 1532-1539
-
-
Lopez-Perez, E.1
Zhang, Y.2
Frank, S.3
Creemers, J.4
Seidah, N.5
Checler, F.6
-
8
-
-
33847171931
-
Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity
-
Marcello E, Gardoni F, Mauceri D, Romorini S, Jeromin A, Epis R, Borroni B, Cattabeni F, Sala C, Padovani A, Di Luca M: Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity. J Neurosci 2007; 27: 1682-1691.
-
(2007)
J Neurosci
, vol.27
, pp. 1682-1691
-
-
Marcello, E.1
Gardoni, F.2
Mauceri, D.3
Romorini, S.4
Jeromin, A.5
Epis, R.6
Borroni, B.7
Cattabeni, F.8
Sala, C.9
Padovani, A.10
Di Luca, M.11
-
9
-
-
78649747630
-
Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage
-
Malinverno M, Carta M, Epis R, Marcello E, Verpelli C, Cattabeni F, Sala C, Mulle C, Di Luca M, Gardoni F: Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage. J Neurosci 2010; 30: 16343-16355.
-
(2010)
J Neurosci
, vol.30
, pp. 16343-16355
-
-
Malinverno, M.1
Carta, M.2
Epis, R.3
Marcello, E.4
Verpelli, C.5
Cattabeni, F.6
Sala, C.7
Mulle, C.8
Di Luca, M.9
Gardoni, F.10
-
10
-
-
84861218961
-
The neuropeptide PACAP38 induces dendritic spine remodeling through ADAM10-N-cadherin signaling pathway
-
Gardoni F, Saraceno C, Malinverno M, Marcello E, Verpelli C, Sala C, Di Luca M: The neuropeptide PACAP38 induces dendritic spine remodeling through ADAM10-N-cadherin signaling pathway. J Cell Sci 2012; 125: 1401-1406.
-
(2012)
J Cell Sci
, vol.125
, pp. 1401-1406
-
-
Gardoni, F.1
Saraceno, C.2
Malinverno, M.3
Marcello, E.4
Verpelli, C.5
Sala, C.6
Di Luca, M.7
-
11
-
-
82755162093
-
SAP97-mediated local trafficking is altered in Alzheimer disease patients' hippocampus
-
Marcello E, Epis R, Saraceno C, Gardoni F, Borroni B, Cattabeni F, Padovani A, Di Luca M: SAP97-mediated local trafficking is altered in Alzheimer disease patients' hippocampus. Neurobiol Aging 2012; 33: 422.e1-422.e10.
-
(2012)
Neurobiol Aging
, vol.33
-
-
Marcello, E.1
Epis, R.2
Saraceno, C.3
Gardoni, F.4
Borroni, B.5
Cattabeni, F.6
Padovani, A.7
Di Luca, M.8
-
12
-
-
78049476184
-
Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease
-
Epis R, Marcello E, Gardoni F, Vastagh C, Malinverno M, Balducci C, Colombo A, Borroni B, Vara H, Dell'Agli M, Cattabeni F, Giustetto M, Borsello T, Forloni G, Padovani A, Di Luca M: Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease. Brain 2010; 133: 3323-3335.
-
(2010)
Brain
, vol.133
, pp. 3323-3335
-
-
Epis, R.1
Marcello, E.2
Gardoni, F.3
Vastagh, C.4
Malinverno, M.5
Balducci, C.6
Colombo, A.7
Borroni, B.8
Vara, H.9
Dell'Agli, M.10
Cattabeni, F.11
Giustetto, M.12
Borsello, T.13
Forloni, G.14
Padovani, A.15
Di Luca, M.16
-
13
-
-
70349558522
-
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
-
Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schurmann B, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frolich L, Hampel H, Hull M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Muhleisen TW, Nothen MM, Moebus S, Jockel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O'Donovan M, Owen MJ, Williams J: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 2009; 41: 1088-1093.
-
(2009)
Nat Genet
, vol.41
, pp. 1088-1093
-
-
Harold, D.1
Abraham, R.2
Hollingworth, P.3
Sims, R.4
Gerrish, A.5
Hamshere, M.L.6
Pahwa, J.S.7
Moskvina, V.8
Dowzell, K.9
Williams, A.10
Jones, N.11
Thomas, C.12
Stretton, A.13
Morgan, A.R.14
Lovestone, S.15
Powell, J.16
Proitsi, P.17
Lupton, M.K.18
Brayne, C.19
Rubinsztein, D.C.20
Gill, M.21
Lawlor, B.22
Lynch, A.23
Morgan, K.24
Brown, K.S.25
Passmore, P.A.26
Craig, D.27
McGuinness, B.28
Todd, S.29
Holmes, C.30
Mann, D.31
Smith, A.D.32
Love, S.33
Kehoe, P.G.34
Hardy, J.35
Mead, S.36
Fox, N.37
Rossor, M.38
Collinge, J.39
Maier, W.40
Jessen, F.41
Schurmann, B.42
Van Den-Bussche, H.43
Heuser, I.44
Kornhuber, J.45
Wiltfang, J.46
Dichgans, M.47
Frolich, L.48
Hampel, H.49
Hull, M.50
Rujescu, D.51
Goate, A.M.52
Kauwe, J.S.53
Cruchaga, C.54
Nowotny, P.55
Morris, J.C.56
Mayo, K.57
Sleegers, K.58
Bettens, K.59
Engelborghs, S.60
De Deyn, P.P.61
Van Broeckhoven, C.62
Livingston, G.63
Bass, N.J.64
Gurling, H.65
McQuillin, A.66
Gwilliam, R.67
Deloukas, P.68
Al-Chalabi, A.69
Shaw, C.E.70
Tsolaki, M.71
Singleton, A.B.72
Guerreiro, R.73
Muhleisen, T.W.74
Nothen, M.M.75
Moebus, S.76
Jockel, K.H.77
Klopp, N.78
Wichmann, H.E.79
Carrasquillo, M.M.80
Pankratz, V.S.81
Younkin, S.G.82
Holmans, P.A.83
O'Donovan, M.84
Owen, M.J.85
Williams, J.86
more..
-
14
-
-
84878556106
-
Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease
-
Marcello E, Saraceno C, Musardo S, Vara H, de la Fuente AG, Pelucchi S, Di Marino D, Borroni B, Tramontano A, Perez-Otano I, Padovani A, Giustetto M, Gardoni F, Di Luca M: Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. J Clin Invest 2013; 123: 2523-2538.
-
(2013)
J Clin Invest
, vol.123
, pp. 2523-2538
-
-
Marcello, E.1
Saraceno, C.2
Musardo, S.3
Vara, H.4
De La-Fuente, A.G.5
Pelucchi, S.6
Di Marino, D.7
Borroni, B.8
Tramontano, A.9
Perez-Otano, I.10
Padovani, A.11
Giustetto, M.12
Gardoni, F.13
Di Luca, M.14
|