Mutated ATP synthase induces oxidative stress and impaired insulin secretion in β-cells of female BHE/cdb rats

Diabetes/Metabolism Research and Reviews

Volumn 24, Issue 5, 2008, Pages 392-403

  Saleh, Monique C ^a   Fatehi Hassanabad, Zahra ^a   Wang, Rennian ^b   Nino Fong, Rodolpho ^a   Wadowska, Dorota W ^a   Wright, Glenda M ^a   Harper, Mary Ellen ^c   Chan, Catherine B ^a,d  

^a UNIVERSITY OF PRINCE EDWARD ISLAND   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

^d UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cell mass; ATP synthase; BHE cdb rat; Insulin secretion; Reactive oxygen species; Type 2 diabetes

Indexed keywords

3 NITROTYROSINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUCOSE; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; MANGANESE SUPEROXIDE DISMUTASE; OXYGEN RADICAL; PROINSULIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL GRANULE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION; HYPERTROPHY; IMPAIRED GLUCOSE TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; INSULIN SENSITIVITY; ISOLATED PANCREAS ISLET; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; ORAL GLUCOSE TOLERANCE TEST; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; RAT STRAIN; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; FEMALE; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; OXIDATIVE STRESS; PHENOTYPE; PHOSPHOTRANSFERASES (PHOSPHATE GROUP ACCEPTOR); PROINSULIN; PROTON-TRANSLOCATING ATPASES; RATS;

EID: 49449113869     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.819     Document Type: Article

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