Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

Nature Medicine

Volumn 20, Issue 8, 2014, Pages 954-960

  Mei, Feng ^a   Fancy, Stephen P J ^a,b   Shen, Yun An A ^a   Niu, Jianqin ^c   Zhao, Chao ^d   Presley, Bryan ^e   Miao, Edna ^a   Lee, Seonok ^a   Mayoral, Sonia R ^a   Redmond, Stephanie A ^a   Etxeberria, Ainhoa ^a   Xiao, Lan ^c   Franklin, Robin J M ^d   Green, Ari ^a   Hauser, Stephen L ^a   Chan, Jonah R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c THIRD MILITARY MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e Trianja Technologies ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZATROPINE; CLEMASTINE; IPRATROPIUM BROMIDE; OXYBUTYNIN; QUETIAPINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINARY INDICANT FOR MYELINATION USING MICROPILLAR ARRAY; CELL DIFFERENTIATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; OLIGODENDROCYTE PRECURSOR CELL; OLIGODENDROGLIA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REMYELINIZATION; SEMICONDUCTOR;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CLEMASTINE; DRUG EVALUATION, PRECLINICAL; FEMALE; HIGH-THROUGHPUT SCREENING ASSAYS; HISTAMINE H1 ANTAGONISTS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MULTIPLE SCLEROSIS; MUSCARINIC ANTAGONISTS; NANOSTRUCTURES; NERVE FIBERS, MYELINATED; OLIGODENDROGLIA; RATS; RATS, SPRAGUE-DAWLEY; REGENERATION;

EID: 84906851190     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3618     Document Type: Article

References (27)

1. Franklin, R.J.M. Why does remyelination fail in multiple sclerosis? Nat. Rev. Neurosci. 3, 705-714 (2002). (Pubitemid 135706676)
2. Keirstead, H.S. & Blakemore, W. Identification of post-mitotic oligodendrocytes incapable of remyelination within the demyelinated adult spinal cord. J. Neuropathol. Exp. Neurol. 56, 1191-1201 (1997). (Pubitemid 27492775)
3. Keirstead, H.S., Levine, J.M. & Blakemore, W.F. Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord. Glia 22, 161-170 (1998). (Pubitemid 28084388)
4. Scolding, N. et al. Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis. Brain 121, 2221-2228 (1998). (Pubitemid 28552461)
5. Wolswijk, G. Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells. J. Neurosci. 18, 601-609 (1998). (Pubitemid 28041896)
6. Chang, A., Nishiyama, A., Peterson, J., Prineas, J. & Trapp, B.D. NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. J. Neurosci. 20, 6404-6412 (2000).
7. Shi, J., Marinovich, A. & Barres, B.A. Purification and characterization of adult oligodendrocyte precursor cells from the rat optic nerve. J. Neurosci. 18, 4627-4636 (1998). (Pubitemid 28280171)
8. Tang, D.G., Tokumoto, Y.M. & Raff, M.C. Long-term culture of purified postnatal oligodendrocyte precursor cells. Evidence for an intrinsic maturation program that plays out over months. J. Cell Biol. 148, 971-984 (2000).
9. Zawadzka, M. et al. CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination. Cell Stem Cell 6, 578-590 (2010).
10. Wolswijk, G. & Noble, M. Cooperation between PDGF and FGF converts slowly dividing O-2Aadult progenitor cells to rapidly dividing cells with characteristics of O-2Aperinatal progenitor cells. J. Cell Biol. 118, 889-900 (1992).
11. Woodruff, R.H., Fruttiger, M., Richardson, W.D. & Franklin, R.J.M. Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination. Mol. Cell. Neurosci. 25, 252-262 (2004). (Pubitemid 38344108)
12. Colello, R.J. & Pott, U. Signals that initiate myelination in the developing mammalian nervous system. Mol. Neurobiol. 15, 83-100 (1997). (Pubitemid 127719574)
13. Friede, R.L. Control of myelin formation by axon caliber (with a model of the control mechanism). J. Comp. Neurol. 144, 233-252 (1972).
14. Voyvodic, J.T. Target size regulates calibre and myelination of sympathetic axons. Nature 342, 430-433 (1989). (Pubitemid 19277517)
15. Michailov, G.V. et al. Axonal neuregulin-1 regulates myelin sheath thickness. Science 304, 700-703 (2004). (Pubitemid 38560869)
16. Taveggia, C. et al. Neuregulin-1 type III determines the ensheathment fate of axons. Neuron 47, 681-694 (2005). (Pubitemid 41208007)
17. Rosenberg, S.S., Kelland, E.E., Tokar, E., De la Torre, A.R. & Chan, J.R. The geometric and spatial constraints of the microenvironment induce oligodendrocyte differentiation. Proc. Natl. Acad. Sci. USA 105, 14662-14667 (2008).
18. Lee, S. et al. A culture system to study oligodendrocyte myelination processes using engineered nanofibers. Nat. Methods 9, 917-922 (2012).
19. Lee, S., Chong, S.Y.C., Tuck, S.J., Corey, J.M. & Chan, J.R. A rapid and reproducible assay for modeling myelination by oligodendrocytes using engineered nanofibers. Nat. Protoc. 8, 771-782 (2013).
20. Fancy, S.P.J. et al. Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nat. Neurosci. 14, 1009-1016 (2011).
21. Chan, J.R. et al. NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes. Neuron 43, 183-191 (2004). (Pubitemid 38942959)
22. Fancy, S.P.J. et al. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev. 23, 1571-1585 (2009).
23. Chong, S.Y.C. et al. Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination. Proc. Natl. Acad. Sci. USA 109, 1299-1304 (2012).
24. Etxeberria, A., Mangin, J.M., Aguirre, A. & Gallo, V. Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum. Nat. Neurosci. 13, 287-289 (2010).
25. Buckley, C.E., Goldsmith, P. & Franklin, R.J.M. Zebrafish myelination: A transparent model for remyelination? Dis. Model. Mech. 1, 221-228 (2008).
26. Buckley, C.E. et al. Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects. Neuropharmacology 59, 149-159 (2010).
27. De Angelis, F., Bernardo, A., Magnaghi, V., Minghetti, L. & Tata, A.M. Muscarinic receptor subtypes as potential targets to modulate oligodendrocyte progenitor survival, proliferation, and differentiation. Dev. Neurobiol. 72, 713-728 (2012).