Histamine and neuroinflammation: Insights from murine experimental autoimmune encephalomyelitis

Frontiers in Systems Neuroscience

Volumn , Issue MAY 2012, 2012, Pages

  Passani, Maria B ^a   Ballerini, Clara ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Autoimmune diseases; EAE; H 1 receptor; H 2 receptor; H 4 receptor; Multiple sclerosis

Indexed keywords

1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE; G PROTEIN COUPLED RECEPTOR; HISTAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H1 RECEPTOR ANTAGONIST; HISTAMINE H2 RECEPTOR; HISTAMINE H3 RECEPTOR; HISTAMINE H4 RECEPTOR; HISTAMINE H4 RECEPTOR ANTAGONIST;

ALLERGIC ENCEPHALOMYELITIS; ASTHMA; AUTOIMMUNE DISEASE; DENDRITIC CELL; DISEASE COURSE; DISEASE MODEL; DISEASE PREDISPOSITION; MAST CELL; MICROARRAY ANALYSIS; MOUSE; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PRURITUS; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 84865035215     PISSN: 16625137     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnsys.2012.00032     Document Type: Review

References (58)

1. Alonso, A., Jick, S. S., and Hernán, M. A. (2006). Allergy, histamine 1 receptor blockers, and the risk of multiple sclerosis. Neurology 66, 572-575.
2. Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., Giudici, F., Romagnani, P., Parronchi, P., Tonelli, F., Maggi, E., and Romagnani, S. (2007). Phenotypic and functional features of human Th17 cells. J. Exp. Med. 204, 1849-1861.
3. Arrang, J. M., Garbarg, M., and Schwartz, J. C. (1983). Autoinhibition of brain histamine release mediated by a novel class (H3) of histamine receptors. Nature 302, 832-837.
4. Bakker, R. A., Timmerman, H., and Leurs, R. (2002). Histamine receptors: specific ligands, receptor biochemistry, and signal transduction. Clin. Allergy Immunol. 17, 27-64.
5. Ballerini, C., Guerini, F. R., Rombolà, G., Rosati, E., Massacesi, L., Ferrante, P., Caputo, D., Talamanca, L. F., Naldi, P., Liguori, M., Alizadeh, M., Momigliano-Richiardi, P., and D'Alfonso, S. (2004). HLA-multiple sclerosis association in continental Italy and correlation with disease prevalence in Europe. J. Neuroimmunol. 150, 178-185.
6. Barnard, R., Barnard, A., Salmon, G., Liu, W., and Sreckovic, S. (2008). Histamine-induced actin polymerization in human eosinophils: an imaging approach for histamine H4 receptor. Cytometry 73, 299-304.
7. Bhatt, H. G., Agrawal, Y. K., Raval, H. G., Manna, K., and Desai, P. R. (2010). Histamine H4 receptor: a novel therapeutic target for immune and allergic responses. Mini Rev. Med. Chem. 10, 1293-1308.
8. Blankenhorn, E. P., Butterfield, R., Case, L. K., Wall, E. H., Rio, R. D., Diehl, S. A., Krementsov, D. N., Saligrama, N., and Teuscher, C. (2011). Genetics of experimental allergic encephalomyelitis supports the role of T helper cells in multiple sclerosis pathogenesis. Ann. Neurol. 70, 887-896.
9. Bongers, G., Sallmen, T., Passani, M. B., Mariottini, C., Wendelin, D., Lozada, A., Marle, A. V., Navis, M., Blandina, P., Bakker, R. A., Panula, P., and Leurs, R. (2007). Akt/GSK- 3b axis as a new signaling pathway of the histamine H3 receptor. J. Neurochem. 103, 248-258.
10. Buckland, K. F., Austin, N., Jackson, A., and Inder, T. (2003). Histamine induces cytoskeletal changes in human eosinophils via the histamine H4 receptor. Br. J. Pharmacol. 140, 1117-1126.
11. Connelly, W. M., Shenton, F. C., Lethbridge, N., Leurs, R., Waldvogel, H. J., Faull, R. L. M., Lees, G., and Chazot, P. L. (2009). The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. Br. J. Pharmacol. 1 57, 55-63.
12. Correale, J., Ysrraelit, M. C., and Mi, M. I. G. (2009). Immunomodulatory effects of Vitamin D in multiple sclerosis. Brain 132, 1146-1160.
13. del Rio, R., Noubade, R., Saligrama, N., Wall, E. H., Krementsov, D. N., Poynter, M. E., Zachary, J. F., Thurmond, R. L., and Teuscher, C. (2012). Histamine H4 receptor optimizes T tegulatory cell frequency and facilitates antiinflammatory responses within the central nervous system. J. Immunol. 188, 541-547.
14. Dijkstra, D., Leurs, R., Chazot, P. L., Shenton, F. C., Stark, H., Werfel, T., and Gutzmer, R. (2007). Histamine downregulates monocyte CCL2 production through the histamine H4 receptor. J. Allergy Clin. Immunol. 120, 300-307.
15. El Behi, M., Zéphir, H., Lefranc, D., Dutoit, V., Dussart, P., Devos, P., Dessaint, J. P., Vermersch, P., and Prin, L. (2007). Changes in self-reactive IgG antibody repertoire after treatment of experimental autoimmune encephalomyelitis with antiallergic drugs. J. Neuroimmunol. 182, 80-88.
16. Emerson, M. R., Orentas, D. M., Lynch, S. G., and LeVine, S. M. (2002). Activation of histamine H2 receptors ameliorates experimental allergic encephalomyelitis. Neuroreport 13, 1407-1410.
17. Gourraud, P. A., Mcelroy, J. P., Caillier, S. J., Johnson, B. A., Santaniello, A., Hauser, S. L., and Oksenberg, J. R. (2011). Aggregation of multiple sclerosis genetic risk variants in multiple and single case families. Ann. Neurol. 69, 65-74.
18. Gschwandtner, R., Schäkel, K., Werfel, T., and Gutzmer, R. (2011). Histamine H(4) receptor activation on human slan-dendritic cells downregulates their pro-inflammatory capacity. Immunology 132, 49-56.
19. Gutcher, I., and Becher, B. (2007). APC- derived cytokines and T cell polarization in autoimmune inflammation. J. Clin. Invest. 117, 1119-1127.
20. Gutzmer, R., Diestel, C., Mommert, S., Köther, B., Stark, H., Wittmann, M., and Werfel, T. (2005). Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocytederived dendritic cells. J. Immunol. 174, 5224-5232.
21. Haas, H. L., Sergeeva, O. A., and Selbach, O. (2008). Histamine in the nervous system. Physiol. Rev. 88, 1183-1241.
22. Jadidi-Niaragh, F., and Mirshafiey, A. (2010). Histamine and histamine receptors in pathogenesis and treatment of multiple sclerosis. Neuropharmacology 59, 180-189.
23. Jutel, M., Watanabe, T., Klunker, S., Akdis, M., Thomet, O. A., Malolepszy, J., Zak-Nejmark, T., Koga, R., Kobayashi, T., Blaser, K., and Akdis, C. A. (2001). Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors. Nature 413, 420-425.
24. Kipp, M., Clarner, T., Dang, J., Copray, S., and Beyer, C. (2009). The cuprizone animal model: new insights into an old story. Acta Neuropathol. 118, 723-736.
25. Lapilla, M., Gallo, B., Martinello, M., Procaccini, C., Costanza, M., Musio, S., Rossi, B., Angiari, S., Farina, C., Steinman, L., Matarese, G., Constantin, G., and Pedotti, R. (2011). Histamine regulates autoreactive T cell activation and adhesiveness in inflamed brain microcirculation. J. Leukoc. Biol. 89, 259-267.
26. Liu, C., Ma, X-J., Wilson, S., Hofstra, C., Blevitt, J., Pyati, J., Li, X., Chai, W., Carruthers, N., and Lovenberg, T. (2001). Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow. Mol. Pharmacol. 59, 420-426.
27. Lock, C., Hermans, G., Pedotti, R., Brendolan, A., Schadt, E., Garren, H., Langer-Gould, A., Strober, S., Cannella, B., Allard, J., Klonowski, P., Austin, A., Lad, N., Kaminski, N., Galli, S. J., Oksenberg, J. R., Raine, C. S., Heller, R., and Steinman, L. (2002). Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 8, 500-508.
28. Logothetis, L., Mylonas, I. A., Baloyannis, S., Pashalidou, M., Orologas, A., Zafeiropoulos, A., Kosta, V., and Theoharides, T. C. (2005). A pilot, open label, clinical trial using hydroxyzine in multiple sclerosis. Int. J. Immunopathol. Pharmacol. 18, 771-778.
29. Lu, C., Diehl, S. A., Noubade, R., Ledoux, J., Nelson, M. T., Spach, K., Zachary, J. F., Blankenhorn, E. P., and Teuscher, C. (2010). Endothelial histamine H1 receptor signaling reduces blood-brain barrier permeability and susceptibility to autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. U.S.A. 107, 18967-18972.
30. Ma, R. Z., Gao, J., Meeker, N. D., Fillmore, P. D., Tung, K. S., Watanabe, T., Zachary, J. F., Offner, H., Blankenhorn, E. P., and Teuscher, C. (2002). Identification of Bphs, an autoimmune disease locus, as histamine receptor H1. Science 297, 620-623.
31. Mariottini, C., Scartabelli, T., Bongers, G., Attucci, S., Nosi, D., Leurs, R., Chiarugi, A., Blandina, P., PellegriniGiampietro, D. E., and Passani, M. B. (2009). Activation of the hista- minergic H3 receptor phosphory- lates the Akt/GSK-3beta pathway incultured cortical neurons and protects against neurotoxic insults. J. Neurochem. 110, 1469-1478.
32. Mommert, S., Gschwandtner, M., Koether, B., Gutzmer, R., and Werfel, T. (2012). Human memory Th17 cells express a functional histamine H4 receptor. Am. J. Pathol. 180, 177-185.
33. Morgan, R. K., Mcallister, B., Cross, L., Green, D. S., Kornfeld, H., Center, D. M., and Cruikshank, W. W. (2007). Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. J. Immunol. 178, 8081-8089.
34. Mukasa, R., Balasubramani, A., Lee, Y. K., Whitley, S. K., Weaver, B. T., Shibata, Y., Crawford, G. E., Hatton, R. D., and Weaver, C. T. (2010). Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. Immunity 32, 616-627.
35. Musio, S., Gallo, B., Scabeni, S., Lapilla, M., Poliani, P. L., Matarese, G., Ohtsu, H., Galli, S. J., Mantegazza, R., Steinman, L., and Pedotti, R. (2006). A key regulatory role for histamine in experimental autoimmune encephalomyelitis: disease exacerbation in histidine decarboxylase-deficient mice. J. Immunol. 176, 17-26.
36. Noubade, R., Milligan, G., Zachary, J. F., Blankenhorn, E. P., Rio, R. D., Rincon, M., and Teuscher, C. (2007). Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN- gamma production in mice. J. Clin. Invest. 117, 3507-3518.
37. Olson, J. K., Croxford, J. L., Calenoff, M. A., Canto, M. C. D., and Miller, S. D. (2001). A virus-induced molecular mimicry model of multiple sclerosis. J. Clin. Invest. 108, 311-318.
38. Owen, D. A., Poy, E., Woodward, D. F., and Daniel, D. (1980). Evaluation of the role of Histamine H1- and H2-receptors in cutaneous inflammation in the guinea-pig produced by histamine and mast cell degranulation. Br. J. Pharmacol. 69, 615-623.
39. Passani, M. B., Aldinucci, A., Masini, E., Blandina, P., Bani, D., Chazot, P. L., and Ballerini, C. (2011a). "Antagonism of the histaminergic H4 receptor exacerbates clinical and pathological signs of EAE," 256.12/AA14 42nd Meeting of the Society for Neuroscience, Washington, DC, USA.
40. Passani, M. B., Blandina, P., and Torrealba, F. (2011b). The histamine H3 receptor and eating behavior. J. Pharmacol. Exp. Ther. 336, 24-29.
41. Passani, M. B., and Blandina, P. (2011). Histamine receptors in the CNS as targets for therapeutic intervention. Trends Pharmacol. Sci. 32, 242-249.
42. Pedotti, R., Devoss, J. J., Youssef, S., Mitchell, D., Wedemeyer, J., Madanat, R., Garren, H., Fontoura, P., Tsai, M., Galli, S. J., Sobel, R. A., and Steinman, L. (2003). Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination. Proc. Natl. Acad. Sci. U.S.A. 100, 1867-1872.
43. Petit-Bertron, A. F., Machavoine, F., Defresne, M. P., Gillard, M., Chatelain, P., Mistry, P., Schneider, E., and Dy, M. (2009). H4 histamine receptors mediate cell cycle arrest in growth factor-induced murine and human hematopoietic progenitor cells. PLoS One 4:e6504. doi: 10.1371/journal.pone.0006504
44. Rosethorne, E. M., and Charlton, S. J. (2011). Agonist-biased signaling at the histamine H4 receptor: JNJ7777120 recruits β-arrestin without activating G proteins. Mol. Pharmacol. 79, 749-757.
45. Rozniecki, J. J., Hauser, S. L., Stein, M., Lincoln, R., and Theoharides, T. C. (1995). Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients. Ann. Neurol. 37, 63-66.
46. Sayed, B. A., Walker, M. E., and Brown, M. A. (2011). Cutting edge: mast cells regulate disease severity in a relapsing-remitting model of multiple sclerosis. J. Immunol. 186, 3294-3298.
47. Schneider, E., Bertron, A. F., and Dy, M. (2011). Modulation of hematopoiesis through histamine receptor signaling. Front. Biosci. 3, 467-473.
48. Schneider, E., Leite-De-Moraes, M., and Dy, M. (2010). Histamine, immune cells and autoimmunity. Adv. Exp. Med. Biol. 709, 81-94.
49. Schreiner, B., Heppner, F. L., and Becher, B. (2009). Modeling multiple sclerosis in laboratory animals. Semin. Immunopathol. 31, 479-495.
50. Secor, V. H., Secor, W. E., Gutekunst, C. A., and Brown, M. A. (2000). Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis. J. Exp. Med. 191, 813-822.
51. Strakhova, M. I., Nikkel, A. L., Manelli, A. M., Hsieh, G. C., Esbenshade, T. A., Brioni, J. D., and Bitner, R. S. (2009). Localization of histamine H4 receptors in the central nervous system of human and rat. Brain Res. 1250, 41-48.
52. Teuscher, C., Poynter, M. E., Offner, H., Zamora, A., Watanabe, T., Fillmore, P. D., Zachary, J. F., and Blankenhorn, E. P. (2004). Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigenpresenting cells. Am. J. Pathol. 164, 883-892.
53. Teuscher, C., Subramanian, M., Noubade, R., Gao, J. F., Offner, H., Zachary, J. F., and Blankenhorn, E. P. (2007). Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS. Proc. Natl. Acad. Sci. U.S.A. 104, 10146-10151.
54. Thurmond, R. L., Gelfand, E. W., and Dunford, P. J. (2008). The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat. Rev. Drug Discov. 7, 41-53.
55. Tuomisto, L., Kilpeläinen, H., and Riekkinen, P. (1983). Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis. Agents Actions 13, 255-257.
56. Volterra, A., and Meldolesi, J. (2005). Astrocytes, from brain glue to communication elements: the revolution continues. Nat. Rev. Neurosci. 6, 626-640.
57. Woodruff, R. H., and Franklin, R. J. (1999). Demyelination and remyelination of the caudal cerebellar peduncle of adult rats following stereotaxic injections of lysolecithin, ethidium bromide, and complement/antigalactocerebroside: a comparative study. Glia 25, 216-228.
58. Zampeli, E., and Tiligada, E. (2009). The role of histamine H4 receptor in immune and inflammatory disorders. Br. J. Pharmacol. 157, 24-33.