-
1
-
-
84930388499
-
Harnessing RNAi nanomedicine for precision therapy
-
Peer D. Harnessing RNAi nanomedicine for precision therapy. Mol Cell Therap 2014, 2:5.
-
(2014)
Mol Cell Therap
, vol.2
, pp. 5
-
-
Peer, D.1
-
2
-
-
84908564426
-
Current issues of RNAi therapeutics delivery and development
-
Haussecker D. Current issues of RNAi therapeutics delivery and development. J Control Release 2014, 195:49-54.
-
(2014)
J Control Release
, vol.195
, pp. 49-54
-
-
Haussecker, D.1
-
4
-
-
84867642276
-
RNAi-based nanomedicines for targeted personalized therapy
-
Daka A., Peer D. RNAi-based nanomedicines for targeted personalized therapy. Adv Drug Deliv Rev 2012, 64:1508-1521.
-
(2012)
Adv Drug Deliv Rev
, vol.64
, pp. 1508-1521
-
-
Daka, A.1
Peer, D.2
-
5
-
-
78650624101
-
RNA interference in the clinic: challenges and future directions
-
Pecot C.V., Calin G.A., Coleman R.L., Lopez-Berestein G., Sood A.K. RNA interference in the clinic: challenges and future directions. Nat Rev Cancer 2011, 11:59-67.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 59-67
-
-
Pecot, C.V.1
Calin, G.A.2
Coleman, R.L.3
Lopez-Berestein, G.4
Sood, A.K.5
-
6
-
-
84920918393
-
Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications
-
Meade B.R., Gogoi K., Hamil A.S., Palm-Apergi C., van den Berg A., Hagopian J.C., Springer A.D., Eguchi A., Kacsinta A.D., Dowdy C.F., Presente A., Lonn P., Kaulich M., Yoshioka N., Gros E., Cui X.S., Dowdy S.F. Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications. Nat Biotechnol 2014, 32:1256-1261.
-
(2014)
Nat Biotechnol
, vol.32
, pp. 1256-1261
-
-
Meade, B.R.1
Gogoi, K.2
Hamil, A.S.3
Palm-Apergi, C.4
van den Berg, A.5
Hagopian, J.C.6
Springer, A.D.7
Eguchi, A.8
Kacsinta, A.D.9
Dowdy, C.F.10
Presente, A.11
Lonn, P.12
Kaulich, M.13
Yoshioka, N.14
Gros, E.15
Cui, X.S.16
Dowdy, S.F.17
-
7
-
-
84896259886
-
2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity
-
Wu S.Y., Yang X., Gharpure K.M., Hatakeyama H., Egli M., McGuire M.H., Nagaraja A.S., Miyake T.M., Rupaimoole R., Pecot C.V., Taylor M., Pradeep S., Sierant M., Rodriguez-Aguayo C., Choi H.J., Previs R.A., Armaiz-Pena G.N., Huang L., Martinez C., Hassell T., Ivan C., Sehgal V., Singhania R., Han H.D., Su C., Kim J.H., Dalton H.J., Kovvali C., Keyomarsi K., McMillan N.A., Overwijk W.W., Liu J., Lee J.S., Baggerly K.A., Lopez-Berestein G., Ram P.T., Nawrot B., Sood A.K. 2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity. Nat Commun 2014, 5:3459.
-
(2014)
Nat Commun
, vol.5
, pp. 3459
-
-
Wu, S.Y.1
Yang, X.2
Gharpure, K.M.3
Hatakeyama, H.4
Egli, M.5
McGuire, M.H.6
Nagaraja, A.S.7
Miyake, T.M.8
Rupaimoole, R.9
Pecot, C.V.10
Taylor, M.11
Pradeep, S.12
Sierant, M.13
Rodriguez-Aguayo, C.14
Choi, H.J.15
Previs, R.A.16
Armaiz-Pena, G.N.17
Huang, L.18
Martinez, C.19
Hassell, T.20
Ivan, C.21
Sehgal, V.22
Singhania, R.23
Han, H.D.24
Su, C.25
Kim, J.H.26
Dalton, H.J.27
Kovvali, C.28
Keyomarsi, K.29
McMillan, N.A.30
Overwijk, W.W.31
Liu, J.32
Lee, J.S.33
Baggerly, K.A.34
Lopez-Berestein, G.35
Ram, P.T.36
Nawrot, B.37
Sood, A.K.38
more..
-
8
-
-
36849067019
-
Nanocarriers as an emerging platform for cancer therapy
-
Peer D., Karp J.M., Hong S., Farokhzad O.C., Margalit R., Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2007, 2:751-760.
-
(2007)
Nat Nanotechnol
, vol.2
, pp. 751-760
-
-
Peer, D.1
Karp, J.M.2
Hong, S.3
Farokhzad, O.C.4
Margalit, R.5
Langer, R.6
-
9
-
-
84905718745
-
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
-
Dahlman J.E., Barnes C., Khan O.F., Thiriot A., Jhunjunwala S., Shaw T.E., Xing Y., Sager H.B., Sahay G., Speciner L., Bader A., Bogorad R.L., Yin H., Racie T., Dong Y., Jiang S., Seedorf D., Dave A., Singh Sandhu K., Webber M.J., Novobrantseva T., Ruda V.M., Lytton-Jean A.K., Levins C.G., Kalish B., Mudge D.K., Perez M., Abezgauz L., Dutta P., Smith L., Charisse K., Kieran M.W., Fitzgerald K., Nahrendorf M., Danino D., Tuder R.M., von Andrian U.H., Akinc A., Panigrahy D., Schroeder A., Koteliansky V., Langer R., Anderson D.G. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nat Nanotechnol 2014, 9:648-655.
-
(2014)
Nat Nanotechnol
, vol.9
, pp. 648-655
-
-
Dahlman, J.E.1
Barnes, C.2
Khan, O.F.3
Thiriot, A.4
Jhunjunwala, S.5
Shaw, T.E.6
Xing, Y.7
Sager, H.B.8
Sahay, G.9
Speciner, L.10
Bader, A.11
Bogorad, R.L.12
Yin, H.13
Racie, T.14
Dong, Y.15
Jiang, S.16
Seedorf, D.17
Dave, A.18
Singh Sandhu, K.19
Webber, M.J.20
Novobrantseva, T.21
Ruda, V.M.22
Lytton-Jean, A.K.23
Levins, C.G.24
Kalish, B.25
Mudge, D.K.26
Perez, M.27
Abezgauz, L.28
Dutta, P.29
Smith, L.30
Charisse, K.31
Kieran, M.W.32
Fitzgerald, K.33
Nahrendorf, M.34
Danino, D.35
Tuder, R.M.36
von Andrian, U.H.37
Akinc, A.38
Panigrahy, D.39
Schroeder, A.40
Koteliansky, V.41
Langer, R.42
Anderson, D.G.43
more..
-
10
-
-
84938747156
-
Targeted therapy for breast cancer stem cells by liposomal delivery of siRNA against fibronectin EDB
-
Sun Y., Kim H.S., Saw P.E., Jon S., Moon W.K. Targeted therapy for breast cancer stem cells by liposomal delivery of siRNA against fibronectin EDB. Adv Healthc Mater 2015, 4:1675-1680.
-
(2015)
Adv Healthc Mater
, vol.4
, pp. 1675-1680
-
-
Sun, Y.1
Kim, H.S.2
Saw, P.E.3
Jon, S.4
Moon, W.K.5
-
11
-
-
0022858683
-
A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
-
Matsumura Y., Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986, 46:6387-6392.
-
(1986)
Cancer Res
, vol.46
, pp. 6387-6392
-
-
Matsumura, Y.1
Maeda, H.2
-
12
-
-
84897003921
-
Modulation of drug resistance in ovarian adenocarcinoma using chemotherapy entrapped in hyaluronan-grafted nanoparticle clusters
-
Cohen K., Emmanuel R., Kisin-Finfer E., Shabat D., Peer D. Modulation of drug resistance in ovarian adenocarcinoma using chemotherapy entrapped in hyaluronan-grafted nanoparticle clusters. ACS Nano 2014, 8:2183-2195.
-
(2014)
ACS Nano
, vol.8
, pp. 2183-2195
-
-
Cohen, K.1
Emmanuel, R.2
Kisin-Finfer, E.3
Shabat, D.4
Peer, D.5
-
13
-
-
84924411834
-
Aptamers: active targeting ligands for cancer diagnosis and therapy
-
Wu X., Chen J., Wu M., Zhao J.X. Aptamers: active targeting ligands for cancer diagnosis and therapy. Theranostics 2015, 5:322-344.
-
(2015)
Theranostics
, vol.5
, pp. 322-344
-
-
Wu, X.1
Chen, J.2
Wu, M.3
Zhao, J.X.4
-
14
-
-
84870570270
-
Co-injection of a targeted, reversibly masked endosomolytic polymer dramatically improves the efficacy of cholesterol-conjugated small interfering RNAs in vivo
-
Wong S.C., Klein J.J., Hamilton H.L., Chu Q.L., Frey C.L., Trubetskoy V.S., Hegge J., Wakefield D., Rozema D.B., Lewis D.L. Co-injection of a targeted, reversibly masked endosomolytic polymer dramatically improves the efficacy of cholesterol-conjugated small interfering RNAs in vivo. Nucleic Acid Therap 2012, 22:380-390.
-
(2012)
Nucleic Acid Therap
, vol.22
, pp. 380-390
-
-
Wong, S.C.1
Klein, J.J.2
Hamilton, H.L.3
Chu, Q.L.4
Frey, C.L.5
Trubetskoy, V.S.6
Hegge, J.7
Wakefield, D.8
Rozema, D.B.9
Lewis, D.L.10
-
15
-
-
84938423574
-
Nanomedicine as an emerging platform for metastatic lung cancer therapy
-
Landesman-Milo D., Ramishetti S., Peer D. Nanomedicine as an emerging platform for metastatic lung cancer therapy. Cancer Metastasis Rev 2015, 34:291-301.
-
(2015)
Cancer Metastasis Rev
, vol.34
, pp. 291-301
-
-
Landesman-Milo, D.1
Ramishetti, S.2
Peer, D.3
-
16
-
-
84923459414
-
Localized RNAi therapeutics of chemoresistant grade IV glioma using hyaluronan-grafted lipid-based nanoparticles
-
Cohen Z.R., Ramishetti S., Peshes-Yaloz N., Goldsmith M., Wohl A., Zibly Z., Peer D. Localized RNAi therapeutics of chemoresistant grade IV glioma using hyaluronan-grafted lipid-based nanoparticles. ACS Nano 2015, 9:1581-1591.
-
(2015)
ACS Nano
, vol.9
, pp. 1581-1591
-
-
Cohen, Z.R.1
Ramishetti, S.2
Peshes-Yaloz, N.3
Goldsmith, M.4
Wohl, A.5
Zibly, Z.6
Peer, D.7
-
17
-
-
84938152114
-
Systemic gene silencing in primary T lymphocytes using targeted lipid nanoparticles
-
Ramishetti S., Kedmi R., Goldsmith M., Leonard F., Sprague A.G., Godin B., Gozin M., Cullis P.R., Dykxhoorn D.M., Peer D. Systemic gene silencing in primary T lymphocytes using targeted lipid nanoparticles. ACS Nano 2015.
-
(2015)
ACS Nano
-
-
Ramishetti, S.1
Kedmi, R.2
Goldsmith, M.3
Leonard, F.4
Sprague, A.G.5
Godin, B.6
Gozin, M.7
Cullis, P.R.8
Dykxhoorn, D.M.9
Peer, D.10
-
18
-
-
77954385672
-
The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation
-
Kedmi R., Ben-Arie N., Peer D. The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation. Biomaterials 2010, 31:6867-6875.
-
(2010)
Biomaterials
, vol.31
, pp. 6867-6875
-
-
Kedmi, R.1
Ben-Arie, N.2
Peer, D.3
-
19
-
-
84893531193
-
Toxicity profiling of several common RNAi-based nanomedicines: a comparative study
-
Landesman-Milo D., Peer D. Toxicity profiling of several common RNAi-based nanomedicines: a comparative study. Drug Deliv Transl Res 2014, 4:96-103.
-
(2014)
Drug Deliv Transl Res
, vol.4
, pp. 96-103
-
-
Landesman-Milo, D.1
Peer, D.2
-
20
-
-
84896344539
-
Tumor targeting profiling of hyaluronan-coated lipid based-nanoparticles
-
Mizrahy S., Goldsmith M., Leviatan-Ben-Arye S., Kisin-Finfer E., Redy O., Srinivasan S., Shabat D., Godin B., Peer D. Tumor targeting profiling of hyaluronan-coated lipid based-nanoparticles. Nanoscale 2014, 6:3742-3752.
-
(2014)
Nanoscale
, vol.6
, pp. 3742-3752
-
-
Mizrahy, S.1
Goldsmith, M.2
Leviatan-Ben-Arye, S.3
Kisin-Finfer, E.4
Redy, O.5
Srinivasan, S.6
Shabat, D.7
Godin, B.8
Peer, D.9
-
22
-
-
0029160083
-
A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine
-
Boussif O., Lezoualc'h F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., Behr J.P. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A 1995, 92:7297-7301.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 7297-7301
-
-
Boussif, O.1
Lezoualc'h, F.2
Zanta, M.A.3
Mergny, M.D.4
Scherman, D.5
Demeneix, B.6
Behr, J.P.7
-
23
-
-
84880274434
-
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling
-
Sahay G., Querbes W., Alabi C., Eltoukhy A., Sarkar S., Zurenko C., Karagiannis E., Love K., Chen D., Zoncu R., Buganim Y., Schroeder A., Langer R., Anderson D.G. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling. Nat Biotechnol 2013, 31:653-658.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 653-658
-
-
Sahay, G.1
Querbes, W.2
Alabi, C.3
Eltoukhy, A.4
Sarkar, S.5
Zurenko, C.6
Karagiannis, E.7
Love, K.8
Chen, D.9
Zoncu, R.10
Buganim, Y.11
Schroeder, A.12
Langer, R.13
Anderson, D.G.14
-
24
-
-
67149115119
-
Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs
-
Khan A.A., Betel D., Miller M.L., Sander C., Leslie C.S., Marks D.S. Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs. Nat Biotechnol 2009, 27:549-555.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 549-555
-
-
Khan, A.A.1
Betel, D.2
Miller, M.L.3
Sander, C.4
Leslie, C.S.5
Marks, D.S.6
-
25
-
-
84891340265
-
Stable RNA interference rules for silencing
-
Fellmann C., Lowe S.W. Stable RNA interference rules for silencing. Nat Cell Biol 2014, 16:10-18.
-
(2014)
Nat Cell Biol
, vol.16
, pp. 10-18
-
-
Fellmann, C.1
Lowe, S.W.2
-
26
-
-
79251538918
-
Modeling RNA interference in mammalian cells
-
Cuccato G., Polynikis A., Siciliano V., Graziano M., di Bernardo M., di Bernardo D. Modeling RNA interference in mammalian cells. BMC Syst Biol 2011, 5:19.
-
(2011)
BMC Syst Biol
, vol.5
, pp. 19
-
-
Cuccato, G.1
Polynikis, A.2
Siciliano, V.3
Graziano, M.4
di Bernardo, M.5
di Bernardo, D.6
-
27
-
-
84896697586
-
Image-based analysis of the size- and time-dependent penetration of polymeric micelles in multicellular tumor spheroids and tumor xenografts
-
Mikhail A.S., Eetezadi S., Ekdawi S.N., Stewart J., Allen C. Image-based analysis of the size- and time-dependent penetration of polymeric micelles in multicellular tumor spheroids and tumor xenografts. Int J Pharm 2014, 464:168-177.
-
(2014)
Int J Pharm
, vol.464
, pp. 168-177
-
-
Mikhail, A.S.1
Eetezadi, S.2
Ekdawi, S.N.3
Stewart, J.4
Allen, C.5
-
31
-
-
81255143243
-
Improving delivery and efficacy of nanomedicines in solid tumors: role of tumor priming
-
Wang J., Lu Z., Gao Y., Wientjes M.G., Au J.L. Improving delivery and efficacy of nanomedicines in solid tumors: role of tumor priming. Nanomedicine (Lond) 2011, 6:1605-1620.
-
(2011)
Nanomedicine (Lond)
, vol.6
, pp. 1605-1620
-
-
Wang, J.1
Lu, Z.2
Gao, Y.3
Wientjes, M.G.4
Au, J.L.5
-
32
-
-
84872838282
-
Markedly enhanced permeability and retention effects induced by photo-immunotherapy of tumors
-
Sano K., Nakajima T., Choyke P.L., Kobayashi H. Markedly enhanced permeability and retention effects induced by photo-immunotherapy of tumors. ACS Nano 2013, 7:717-724.
-
(2013)
ACS Nano
, vol.7
, pp. 717-724
-
-
Sano, K.1
Nakajima, T.2
Choyke, P.L.3
Kobayashi, H.4
-
33
-
-
34250765337
-
Tumor priming enhances delivery and efficacy of nanomedicines
-
Lu D., Wientjes M.G., Lu Z., Au J.L. Tumor priming enhances delivery and efficacy of nanomedicines. J Pharmacol Exp Therap 2007, 322:80-88.
-
(2007)
J Pharmacol Exp Therap
, vol.322
, pp. 80-88
-
-
Lu, D.1
Wientjes, M.G.2
Lu, Z.3
Au, J.L.4
-
34
-
-
84921711123
-
Improving drug delivery to solid tumors: priming the tumor microenvironment
-
Khawar I.A., Kim J.H., Kuh H.J. Improving drug delivery to solid tumors: priming the tumor microenvironment. J Control Release 2015, 201:78-89.
-
(2015)
J Control Release
, vol.201
, pp. 78-89
-
-
Khawar, I.A.1
Kim, J.H.2
Kuh, H.J.3
-
35
-
-
84881539307
-
HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression
-
Philip B., Ito K., Moreno-Sanchez R., Ralph S.J. HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression. Carcinogenesis 2013, 34:1699-1707.
-
(2013)
Carcinogenesis
, vol.34
, pp. 1699-1707
-
-
Philip, B.1
Ito, K.2
Moreno-Sanchez, R.3
Ralph, S.J.4
-
36
-
-
84943363654
-
Cancer stem cells and the tumor microenvironment: interplay in tumor heterogeneity
-
Albini A., Bruno A., Gallo C., Pajardi G., Noonan D.M., Dallaglio K. Cancer stem cells and the tumor microenvironment: interplay in tumor heterogeneity. Connect Tissue Res 2015, 1-12.
-
(2015)
Connect Tissue Res
, pp. 1-12
-
-
Albini, A.1
Bruno, A.2
Gallo, C.3
Pajardi, G.4
Noonan, D.M.5
Dallaglio, K.6
-
37
-
-
84893769522
-
Cancer-associated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-beta signalling
-
Yu Y., Xiao C.H., Tan L.D., Wang Q.S., Li X.Q., Feng Y.M. Cancer-associated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-beta signalling. Br J Cancer 2014, 110:724-732.
-
(2014)
Br J Cancer
, vol.110
, pp. 724-732
-
-
Yu, Y.1
Xiao, C.H.2
Tan, L.D.3
Wang, Q.S.4
Li, X.Q.5
Feng, Y.M.6
-
38
-
-
84877724314
-
Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis
-
Jung Y., Kim J.K., Shiozawa Y., Wang J., Mishra A., Joseph J., Berry J.E., McGee S., Lee E., Sun H., Wang J., Jin T., Zhang H., Dai J., Krebsbach P.H., Keller E.T., Pienta K.J., Taichman R.S. Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis. Nat Commun 2013, 4:1795.
-
(2013)
Nat Commun
, vol.4
, pp. 1795
-
-
Jung, Y.1
Kim, J.K.2
Shiozawa, Y.3
Wang, J.4
Mishra, A.5
Joseph, J.6
Berry, J.E.7
McGee, S.8
Lee, E.9
Sun, H.10
Wang, J.11
Jin, T.12
Zhang, H.13
Dai, J.14
Krebsbach, P.H.15
Keller, E.T.16
Pienta, K.J.17
Taichman, R.S.18
-
39
-
-
84924249260
-
The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?
-
Plaks V., Kong N., Werb Z. The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?. Cell Stem Cell 2015, 16:225-238.
-
(2015)
Cell Stem Cell
, vol.16
, pp. 225-238
-
-
Plaks, V.1
Kong, N.2
Werb, Z.3
-
40
-
-
84888639681
-
The roles of TGFbeta in the tumour microenvironment
-
Pickup M., Novitskiy S., Moses H.L. The roles of TGFbeta in the tumour microenvironment. Nat Rev Cancer 2013, 13:788-799.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 788-799
-
-
Pickup, M.1
Novitskiy, S.2
Moses, H.L.3
-
41
-
-
84937970942
-
Tumorigenesis: it takes a village
-
Tabassum D.P., Polyak K. Tumorigenesis: it takes a village. Nat Rev Cancer 2015, 15:473-483.
-
(2015)
Nat Rev Cancer
, vol.15
, pp. 473-483
-
-
Tabassum, D.P.1
Polyak, K.2
-
42
-
-
84955387882
-
Modulating the tumor microenvironment with RNA interference as a cancer treatment strategy
-
Zins K., Sioud M., Aharinejad S., Lucas T., Abraham D. Modulating the tumor microenvironment with RNA interference as a cancer treatment strategy. Methods Mol Biol 2015, 1218:143-161.
-
(2015)
Methods Mol Biol
, vol.1218
, pp. 143-161
-
-
Zins, K.1
Sioud, M.2
Aharinejad, S.3
Lucas, T.4
Abraham, D.5
-
43
-
-
84887444879
-
Microenvironmental regulation of tumor progression and metastasis
-
Quail D.F., Joyce J.A. Microenvironmental regulation of tumor progression and metastasis. Nat Med 2013, 19:1423-1437.
-
(2013)
Nat Med
, vol.19
, pp. 1423-1437
-
-
Quail, D.F.1
Joyce, J.A.2
-
44
-
-
84880626610
-
Short hairpin RNA targeting of fibroblast activation protein inhibits tumor growth and improves the tumor microenvironment in a mouse model
-
Cai F., Li Z., Wang C., Xian S., Xu G., Peng F., Wei Y., Lu Y. Short hairpin RNA targeting of fibroblast activation protein inhibits tumor growth and improves the tumor microenvironment in a mouse model. BMB Rep 2013, 46:252-257.
-
(2013)
BMB Rep
, vol.46
, pp. 252-257
-
-
Cai, F.1
Li, Z.2
Wang, C.3
Xian, S.4
Xu, G.5
Peng, F.6
Wei, Y.7
Lu, Y.8
-
45
-
-
84948568477
-
Dual targeted immunotherapy via in vivo delivery of biohybrid RNAi-peptide nanoparticles to tumor-associated macrophages and cancer cells
-
Conde J., Bao C.C., Tan Y.Q., Cui D.X., Edelman E.R., Azevedo H.S., Byrne H.J., Artzi N., Tian F.R. Dual targeted immunotherapy via in vivo delivery of biohybrid RNAi-peptide nanoparticles to tumor-associated macrophages and cancer cells. Adv Funct Mater 2015, 25:4183-4194.
-
(2015)
Adv Funct Mater
, vol.25
, pp. 4183-4194
-
-
Conde, J.1
Bao, C.C.2
Tan, Y.Q.3
Cui, D.X.4
Edelman, E.R.5
Azevedo, H.S.6
Byrne, H.J.7
Artzi, N.8
Tian, F.R.9
-
46
-
-
84899457547
-
Nanoparticle-delivered transforming growth factor-beta siRNA enhances vaccination against advanced melanoma by modifying tumor microenvironment
-
Xu Z., Wang Y., Zhang L., Huang L. Nanoparticle-delivered transforming growth factor-beta siRNA enhances vaccination against advanced melanoma by modifying tumor microenvironment. ACS Nano 2014, 8:3636-3645.
-
(2014)
ACS Nano
, vol.8
, pp. 3636-3645
-
-
Xu, Z.1
Wang, Y.2
Zhang, L.3
Huang, L.4
-
47
-
-
84924424616
-
MicroRNA silencing for cancer therapy targeted to the tumour microenvironment
-
Cheng C.J., Bahal R., Babar I.A., Pincus Z., Barrera F., Liu C., Svoronos A., Braddock D.T., Glazer P.M., Engelman D.M., Saltzman W.M., Slack F.J. MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature 2015, 518:107-110.
-
(2015)
Nature
, vol.518
, pp. 107-110
-
-
Cheng, C.J.1
Bahal, R.2
Babar, I.A.3
Pincus, Z.4
Barrera, F.5
Liu, C.6
Svoronos, A.7
Braddock, D.T.8
Glazer, P.M.9
Engelman, D.M.10
Saltzman, W.M.11
Slack, F.J.12
-
48
-
-
84948718039
-
Delivery of siRNA using CXCR4-targeted nanoparticles modulates tumor microenvironment and achieves a potent anti-tumor response in liver cancer
-
Liu J.Y., Chiang T., Liu C.H., Chern G.G., Lin T.T., Gao D.Y., Chen Y. Delivery of siRNA using CXCR4-targeted nanoparticles modulates tumor microenvironment and achieves a potent anti-tumor response in liver cancer. Mol Therap 2015.
-
(2015)
Mol Therap
-
-
Liu, J.Y.1
Chiang, T.2
Liu, C.H.3
Chern, G.G.4
Lin, T.T.5
Gao, D.Y.6
Chen, Y.7
-
49
-
-
84938523103
-
Silencing beta3 integrin by targeted ECO/siRNA nanoparticles inhibits EMT and metastasis of triple-negative breast cancer
-
Parvani J.G., Gujrati M.D., Mack M.A., Schiemann W.P., Lu Z.R. Silencing beta3 integrin by targeted ECO/siRNA nanoparticles inhibits EMT and metastasis of triple-negative breast cancer. Cancer Res 2015, 75:2316-2325.
-
(2015)
Cancer Res
, vol.75
, pp. 2316-2325
-
-
Parvani, J.G.1
Gujrati, M.D.2
Mack, M.A.3
Schiemann, W.P.4
Lu, Z.R.5
-
50
-
-
84857407549
-
Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
-
Conley S.J., Gheordunescu E., Kakarala P., Newman B., Korkaya H., Heath A.N., Clouthier S.G., Wicha M.S. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc Natl Acad Sci U S A 2012, 109:2784-2789.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 2784-2789
-
-
Conley, S.J.1
Gheordunescu, E.2
Kakarala, P.3
Newman, B.4
Korkaya, H.5
Heath, A.N.6
Clouthier, S.G.7
Wicha, M.S.8
-
51
-
-
43249095919
-
Tumor angiogenesis
-
Kerbel R.S. Tumor angiogenesis. N Engl J Med 2008, 358:2039-2049.
-
(2008)
N Engl J Med
, vol.358
, pp. 2039-2049
-
-
Kerbel, R.S.1
-
52
-
-
84912079521
-
Nanovaccine loaded with poly I:C and STAT3 siRNA robustly elicits anti-tumor immune responses through modulating tumor-associated dendritic cells in vivo
-
Luo Z., Wang C., Yi H., Li P., Pan H., Liu L., Cai L., Ma Y. Nanovaccine loaded with poly I:C and STAT3 siRNA robustly elicits anti-tumor immune responses through modulating tumor-associated dendritic cells in vivo. Biomaterials 2015, 38:50-60.
-
(2015)
Biomaterials
, vol.38
, pp. 50-60
-
-
Luo, Z.1
Wang, C.2
Yi, H.3
Li, P.4
Pan, H.5
Liu, L.6
Cai, L.7
Ma, Y.8
-
53
-
-
84903759837
-
CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells
-
Herrmann A., Priceman S.J., Swiderski P., Kujawski M., Xin H., Cherryholmes G.A., Zhang W., Zhang C., Lahtz C., Kowolik C., Forman S.J., Kortylewski M., Yu H. CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells. J Clin Invest 2014, 124:2977-2987.
-
(2014)
J Clin Invest
, vol.124
, pp. 2977-2987
-
-
Herrmann, A.1
Priceman, S.J.2
Swiderski, P.3
Kujawski, M.4
Xin, H.5
Cherryholmes, G.A.6
Zhang, W.7
Zhang, C.8
Lahtz, C.9
Kowolik, C.10
Forman, S.J.11
Kortylewski, M.12
Yu, H.13
-
54
-
-
84867120348
-
Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression
-
Bobrie A., Krumeich S., Reyal F., Recchi C., Moita L.F., Seabra M.C., Ostrowski M., Thery C. Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer Res 2012, 72:4920-4930.
-
(2012)
Cancer Res
, vol.72
, pp. 4920-4930
-
-
Bobrie, A.1
Krumeich, S.2
Reyal, F.3
Recchi, C.4
Moita, L.F.5
Seabra, M.C.6
Ostrowski, M.7
Thery, C.8
-
55
-
-
38849166053
-
Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target
-
Peer D., Park E.J., Morishita Y., Carman C.V., Shimaoka M. Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science 2008, 319:627-630.
-
(2008)
Science
, vol.319
, pp. 627-630
-
-
Peer, D.1
Park, E.J.2
Morishita, Y.3
Carman, C.V.4
Shimaoka, M.5
-
56
-
-
34247255870
-
Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1
-
Peer D., Zhu P., Carman C.V., Lieberman J., Shimaoka M. Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1. Proc Natl Acad Sci U S A 2007, 104:4095-4100.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 4095-4100
-
-
Peer, D.1
Zhu, P.2
Carman, C.V.3
Lieberman, J.4
Shimaoka, M.5
-
57
-
-
84934307590
-
Knocking down disease: a progress report on siRNA therapeutics
-
Wittrup A., Lieberman J. Knocking down disease: a progress report on siRNA therapeutics. Nat Rev Genet 2015, 16:543-552.
-
(2015)
Nat Rev Genet
, vol.16
, pp. 543-552
-
-
Wittrup, A.1
Lieberman, J.2
-
58
-
-
84924625044
-
Are RNAi and miRNA therapeutics truly dead?
-
Conde J., Artzi N. Are RNAi and miRNA therapeutics truly dead?. Trends Biotechnol 2015, 33:141-144.
-
(2015)
Trends Biotechnol
, vol.33
, pp. 141-144
-
-
Conde, J.1
Artzi, N.2
-
59
-
-
84877258007
-
Treatment of HCV infection by targeting microRNA
-
Janssen H.L., Reesink H.W., Lawitz E.J., Zeuzem S., Rodriguez-Torres M., Patel K., van der Meer A.J., Patick A.K., Chen A., Zhou Y., Persson R., King B.D., Kauppinen S., Levin A.A., Hodges M.R. Treatment of HCV infection by targeting microRNA. N Engl J Med 2013, 368:1685-1694.
-
(2013)
N Engl J Med
, vol.368
, pp. 1685-1694
-
-
Janssen, H.L.1
Reesink, H.W.2
Lawitz, E.J.3
Zeuzem, S.4
Rodriguez-Torres, M.5
Patel, K.6
van der Meer, A.J.7
Patick, A.K.8
Chen, A.9
Zhou, Y.10
Persson, R.11
King, B.D.12
Kauppinen, S.13
Levin, A.A.14
Hodges, M.R.15
-
60
-
-
84883118140
-
Safety and efficacy of RNAi therapy for transthyretin amyloidosis
-
Coelho T., Adams D., Silva A., Lozeron P., Hawkins P.N., Mant T., Perez J., Chiesa J., Warrington S., Tranter E., Munisamy M., Falzone R., Harrop J., Cehelsky J., Bettencourt B.R., Geissler M., Butler J.S., Sehgal A., Meyers R.E., Chen Q., Borland T., Hutabarat R.M., Clausen V.A., Alvarez R., Fitzgerald K., Gamba-Vitalo C., Nochur S.V., Vaishnaw A.K., Sah D.W., Gollob J.A., Suhr O.B. Safety and efficacy of RNAi therapy for transthyretin amyloidosis. N Engl J Med 2013, 369:819-829.
-
(2013)
N Engl J Med
, vol.369
, pp. 819-829
-
-
Coelho, T.1
Adams, D.2
Silva, A.3
Lozeron, P.4
Hawkins, P.N.5
Mant, T.6
Perez, J.7
Chiesa, J.8
Warrington, S.9
Tranter, E.10
Munisamy, M.11
Falzone, R.12
Harrop, J.13
Cehelsky, J.14
Bettencourt, B.R.15
Geissler, M.16
Butler, J.S.17
Sehgal, A.18
Meyers, R.E.19
Chen, Q.20
Borland, T.21
Hutabarat, R.M.22
Clausen, V.A.23
Alvarez, R.24
Fitzgerald, K.25
Gamba-Vitalo, C.26
Nochur, S.V.27
Vaishnaw, A.K.28
Sah, D.W.29
Gollob, J.A.30
Suhr, O.B.31
more..
-
61
-
-
84891831985
-
In vitro and in vivo efficacy of SYL040012, a novel siRNA compound for treatment of glaucoma
-
Martinez T., Gonzalez M.V., Roehl I., Wright N., Paneda C., Jimenez A.I. In vitro and in vivo efficacy of SYL040012, a novel siRNA compound for treatment of glaucoma. Mol Therap 2014, 22:81-91.
-
(2014)
Mol Therap
, vol.22
, pp. 81-91
-
-
Martinez, T.1
Gonzalez, M.V.2
Roehl, I.3
Wright, N.4
Paneda, C.5
Jimenez, A.I.6
|