메뉴 건너뛰기




Volumn 6, Issue 9, 2011, Pages 1605-1620

Improving delivery and efficacy of nanomedicines in solid tumors: Role of tumor priming

Author keywords

apoptosis; extracellular matrix; interstitial fluid pressure; nanomedicine; nanotechnology; paclitaxel; RNAi; tumor priming; tumor penetrating microparticles; vasculature normalization

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; CARBOPLATIN; CISPLATIN; DOCETAXEL; DOXORUBICIN; GLYCERYL TRINITRATE; MONOCLONAL ANTIBODY DC101; NANOCARRIER; NAVELBINE; PACLITAXEL; PAZOPANIB; RAZOXANE; TRASTUZUMAB;

EID: 81255143243     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.11.141     Document Type: Review
Times cited : (73)

References (98)
  • 2
    • 14644396096 scopus 로고    scopus 로고
    • Nanomedicine: Current status and future prospects
    • Moghimi SM, Hunter AC, Murray JC. Nanomedicine: current status and future prospects. FASEB J. 19(3), 311-330 (2005).
    • (2005) Faseb J. , vol.19 , Issue.3 , pp. 311-330
    • Moghimi, S.M.1    Hunter, A.C.2    Murray, J.C.3
  • 3
    • 14644439267 scopus 로고    scopus 로고
    • Cancer nanotechnology: Opportunities and challenges
    • Ferrari M. Cancer nanotechnology: opportunities and challenges. Nat. Rev. Cancer 5(3), 161-171 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , Issue.3 , pp. 161-171
    • Ferrari, M.1
  • 4
    • 0036096946 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of ABI-007 a cremophor-free protein-stabilized nanoparticle formulation of paclitaxel
    • Ibrahim NK, Desai N, Legha S et al. Phase I and pharmacokinetic study of ABI-007, a Cremophor-free, protein-stabilized, nanoparticle formulation of paclitaxel. Clin. Cancer Res. 8(5), 1038-1044 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , Issue.5 , pp. 1038-1044
    • Ibrahim, N.K.1    Desai, N.2    Legha, S.3
  • 5
    • 0346392116 scopus 로고    scopus 로고
    • Development and characterization of a novel liposome-based formulation of SN-38
    • Zhang JA, Xuan T, Parmar M et al. Development and characterization of a novel liposome-based formulation of SN-38. Int. J. Pharm. 270(1-2), 93-107 (2004).
    • (2004) Int. J. Pharm. , vol.270 , Issue.1-2 , pp. 93-107
    • Zhang, J.A.1    Xuan, T.2    Parmar, M.3
  • 6
    • 40649100957 scopus 로고    scopus 로고
    • Antitumor efficacy of cisplatin-loaded glycol chitosan nanoparticles in tumor-bearing mice
    • Kim JH, Kim YS, Park K et al. Antitumor efficacy of cisplatin-loaded glycol chitosan nanoparticles in tumor-bearing mice. J. Control. Release 127(1), 41-49 (2008).
    • (2008) J. Control. Release , vol.127 , Issue.1 , pp. 41-49
    • Kim, J.H.1    Kim, Y.S.2    Park, K.3
  • 7
    • 77952365921 scopus 로고    scopus 로고
    • Efficacy biodistribution and pharmacokinetics of CD22-targeted PEGylated liposomal doxorubicin in a β-cell non-Hodgkins lymphoma xenograft mouse model
    • Tuscano JM, Martin SM, Ma Y, Zamboni W, O'Donnell RT. Efficacy, biodistribution, and pharmacokinetics of CD22-targeted PEGylated liposomal doxorubicin in a β-cell non- Hodgkin's lymphoma xenograft mouse model. Clin. Cancer Res. 16(10), 2760-2768 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , Issue.10 , pp. 2760-2768
    • Tuscano, J.M.1    Martin, S.M.2    Ma, Y.3    Zamboni, W.4    O'Donnell, R.T.5
  • 9
    • 65949122823 scopus 로고    scopus 로고
    • Development of idarubicin and doxorubicin solid lipid nanoparticles to overcome Pgp-mediated multiple drug resistance in leukemia
    • Ma P, Dong X, Swadley CL et al. Development of idarubicin and doxorubicin solid lipid nanoparticles to overcome Pgp-mediated multiple drug resistance in leukemia. J. Biomed. Nanotechnol. 5(2), 151-161 (2009).
    • (2009) J. Biomed. Nanotechnol. , vol.5 , Issue.2 , pp. 151-161
    • Ma, P.1    Dong, X.2    Swadley, C.L.3
  • 10
    • 78649659237 scopus 로고    scopus 로고
    • Delivery of siRNA therapeutics: Barriers and carriers
    • Wang J, Lu Z, Wientjes MG, Au JL. Delivery of siRNA therapeutics: barriers and carriers. AAPS J. 12(4), 492-503 (2010).
    • (2010) AAPS J. , vol.12 , Issue.4 , pp. 492-503
    • Wang, J.1    Lu, Z.2    Wientjes, M.G.3    Au, J.L.4
  • 11
    • 77953412389 scopus 로고    scopus 로고
    • Understanding and overcoming major barriers in cancer nanomedicine
    • Lond
    • Nie S. Understanding and overcoming major barriers in cancer nanomedicine. Nanomedicine (Lond.) 5(4), 523-528 (2010).
    • (2010) Nanomedicine , vol.5 , Issue.4 , pp. 523-528
    • Nie, S.1
  • 12
    • 51049090204 scopus 로고    scopus 로고
    • Nanoparticle therapeutics: An emerging treatment modality for cancer
    • Davis ME, Chen ZG, Shin DM. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat. Rev. Drug Discov. 7(9), 771-782 (2008).
    • (2008) Nat. Rev. Drug Discov. , vol.7 , Issue.9 , pp. 771-782
    • Davis, M.E.1    Chen, Z.G.2    Shin, D.M.3
  • 14
    • 0141790758 scopus 로고    scopus 로고
    • Drug delivery and transport to solid tumors
    • Jang SH, Wientjes MG, Lu D, Au JL. Drug delivery and transport to solid tumors. Pharm. Res. 20(9), 1337-1350 (2003).
    • (2003) Pharm. Res. , vol.20 , Issue.9 , pp. 1337-1350
    • Jang, S.H.1    Wientjes, M.G.2    Lu, D.3    Au, J.L.4
  • 15
    • 33645123894 scopus 로고    scopus 로고
    • Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment
    • Cairns R, Papandreou I, Denko N. Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment. Mol. Cancer Res. 4(2), 61-70 (2006).
    • (2006) Mol. Cancer Res. , vol.4 , Issue.2 , pp. 61-70
    • Cairns, R.1    Papandreou, I.2    Denko, N.3
  • 16
    • 51049092308 scopus 로고    scopus 로고
    • Factors affecting the clearance and biodistribution of polymeric nanoparticles
    • Alexis F, Pridgen E, Molnar LK, Farokhzad OC. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol. Pharm. 5(4), 505-515 (2008).
    • (2008) Mol. Pharm. , vol.5 , Issue.4 , pp. 505-515
    • Alexis, F.1    Pridgen, E.2    Molnar, L.K.3    Farokhzad, O.C.4
  • 17
    • 34250765337 scopus 로고    scopus 로고
    • Tumor priming enhances delivery and efficacy of nanomedicines
    • Lu D, Wientjes MG, Lu Z, Au JL. Tumor priming enhances delivery and efficacy of nanomedicines. J. Pharmacol. Exp. Ther. 322(1), 80-88 (2007).
    • (2007) J. Pharmacol. Exp. Ther. , vol.322 , Issue.1 , pp. 80-88
    • Lu, D.1    Wientjes, M.G.2    Lu, Z.3    Au, J.L.4
  • 18
    • 0019478990 scopus 로고
    • A new approach to cancer chemotherapy: Selective enhancement of tumor blood flow with angiotensin II
    • Suzuki M, Hori K, Abe I, Saito S, Sato H. A new approach to cancer chemotherapy: selective enhancement of tumor blood flow with angiotensin II. J. Natl Cancer Inst. 67, 663-669 (1981).
    • (1981) J. Natl Cancer Inst. , vol.67 , pp. 663-669
    • Suzuki, M.1    Hori, K.2    Abe, I.3    Saito, S.4    Sato, H.5
  • 19
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res. 64(11), 3731-3736 (2004).
    • (2004) Cancer Res. , vol.64 , Issue.11 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 20
    • 70449374917 scopus 로고    scopus 로고
    • Elevating blood pressure as a strategy to increase tumor-targeted delivery of macromolecular drug SMANCS: Cases of advanced solid tumors
    • Nagamitsu A, Greish K, Maeda H. Elevating blood pressure as a strategy to increase tumor-targeted delivery of macromolecular drug SMANCS: cases of advanced solid tumors. Jpn J. Clin. Oncol. 39(11), 756-766 (2009).
    • (2009) Jpn J. Clin. Oncol. , vol.39 , Issue.11 , pp. 756-766
    • Nagamitsu, A.1    Greish, K.2    Maeda, H.3
  • 21
    • 18444367428 scopus 로고    scopus 로고
    • Targeting vaccinia to solid tumors with local hyperthermia
    • Chang E, Chalikonda S, Friedl J et al. Targeting vaccinia to solid tumors with local hyperthermia. Hum.Gene Ther. 16(4), 435-444 (2005).
    • (2005) Hum.Gene Ther. , vol.16 , Issue.4 , pp. 435-444
    • Chang, E.1    Chalikonda, S.2    Friedl, J.3
  • 22
    • 0034662609 scopus 로고    scopus 로고
    • Hyperthermia enables tumor-specific nanoparticle delivery: Effect of particle size
    • Kong G, Braun RD, Dewhirst MW. Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size. Cancer Res. 60, 4440-4445 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 4440-4445
    • Kong, G.1    Braun, R.D.2    Dewhirst, M.W.3
  • 23
    • 0015493534 scopus 로고
    • Metastases and the normalization of tumour blood vessels by ICRF 159: A new type of drug action
    • Le Serve AW, Hellmann K. Metastases and the normalization of tumour blood vessels by ICRF 159: a new type of drug action. Br. Med. J. 1(5800), 597-601 (1972).
    • (1972) Br. Med. J. , vol.1 , Issue.5800 , pp. 597-601
    • Le Serve, A.W.1    Hellmann, K.2
  • 24
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307(5706), 58-62 (2005).
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 25
    • 77953419154 scopus 로고    scopus 로고
    • Effect of pazopanib on tumor microenvironment and liposome delivery
    • Tailor TD, Hanna G, Yarmolenko PS et al. Effect of pazopanib on tumor microenvironment and liposome delivery. Mol. Cancer Ther. 9(6), 1798-1808 (2010).
    • (2010) Mol. Cancer Ther. , vol.9 , Issue.6 , pp. 1798-1808
    • Tailor, T.D.1    Hanna, G.2    Yarmolenko, P.S.3
  • 26
    • 10944242667 scopus 로고    scopus 로고
    • Antiangiogenic therapy: Creating a unique window of opportunity
    • Lin MI, Sessa WC. Antiangiogenic therapy: creating a unique "window" of opportunity. Cancer Cell 6(6), 529-531 (2004).
    • (2004) Cancer Cell , vol.6 , Issue.6 , pp. 529-531
    • Lin, M.I.1    Sessa, W.C.2
  • 27
    • 19944422751 scopus 로고    scopus 로고
    • Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation angiopoietin-1 and matrix metalloproteinases
    • Winkler F, Kozin SV, Tong RT et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 6(6), 553-563 (2004).
    • (2004) Cancer Cell , vol.6 , Issue.6 , pp. 553-563
    • Winkler, F.1    Kozin, S.V.2    Tong, R.T.3
  • 28
    • 34447121919 scopus 로고    scopus 로고
    • Bevacizumaβ-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy
    • Dickson PV, Hamner JB, Sims TL et al. Bevacizumaβ-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy. Clin. Cancer Res. 13(13), 3942-3950 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , Issue.13 , pp. 3942-3950
    • Dickson, P.V.1    Hamner, J.B.2    Sims, T.L.3
  • 29
    • 0028227005 scopus 로고
    • Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor
    • Maeda H, Noguchi Y, Sato K, Akaike T. Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor. Jpn. J. Cancer Res. 85(4), 331-334 (1994).
    • (1994) Jpn. J. Cancer Res. , vol.85 , Issue.4 , pp. 331-334
    • Maeda, H.1    Noguchi, Y.2    Sato, K.3    Akaike, T.4
  • 30
    • 70649088695 scopus 로고    scopus 로고
    • Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application
    • Seki T, Fang J, Maeda H. Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application. Cancer Sci. 100(12), 2426-2430 (2009).
    • (2009) Cancer Sci. , vol.100 , Issue.12 , pp. 2426-2430
    • Seki, T.1    Fang, J.2    Maeda, H.3
  • 31
    • 33845303951 scopus 로고    scopus 로고
    • Nitroglycerin treatment may enhance chemosensitivity to docetaxel and carboplatin in patients with lung adenocarcinoma
    • Yasuda H, Nakayama K, Watanabe M et al. Nitroglycerin treatment may enhance chemosensitivity to docetaxel and carboplatin in patients with lung adenocarcinoma. Clin. Cancer Res. 12(22), 6748-6757 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , Issue.22 , pp. 6748-6757
    • Yasuda, H.1    Nakayama, K.2    Watanabe, M.3
  • 32
    • 33644838950 scopus 로고    scopus 로고
    • Randomized phase II trial comparing nitroglycerin plus vinorelbine and cisplatin with vinorelbine and cisplatin alone in previously untreated stage IIIB/IV non-small-cell lung cancer
    • Yasuda H, Yamaya M, Nakayama K et al. Randomized phase II trial comparing nitroglycerin plus vinorelbine and cisplatin with vinorelbine and cisplatin alone in previously untreated stage IIIB/IV non-small-cell lung cancer. J. Clin. Oncol. 24(4), 688-694 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.4 , pp. 688-694
    • Yasuda, H.1    Yamaya, M.2    Nakayama, K.3
  • 33
    • 77950635816 scopus 로고    scopus 로고
    • Pancreatic cancer: Pathobiology treatment options and drug delivery
    • Li J, Wientjes MG, Au JL. Pancreatic cancer: pathobiology, treatment options, and drug delivery. AAPS J. 12(2), 223-232 (2010).
    • (2010) AAPS J. , vol.12 , Issue.2 , pp. 223-232
    • Li, J.1    Wientjes, M.G.2    Au, J.L.3
  • 34
    • 67149134933 scopus 로고    scopus 로고
    • Cancer breaching the cancer fortress
    • Olson P, Hanahan D. Cancer. Breaching the cancer fortress. Science 324(5933), 1400-1401 (2009).
    • (2009) Science , vol.324 , Issue.5933 , pp. 1400-1401
    • Olson, P.1    Hanahan, D.2
  • 35
    • 0034193258 scopus 로고    scopus 로고
    • Role of extracellular matrix assembly in interstitial transport in solid tumors
    • Netti PA, Berk DA, Swartz MA, Grodzinsky AJ, Jain RK. Role of extracellular matrix assembly in interstitial transport in solid tumors. Cancer Res. 60(9), 2497-2503 (2000).
    • (2000) Cancer Res. , vol.60 , Issue.9 , pp. 2497-2503
    • Netti, P.A.1    Berk, D.A.2    Swartz, M.A.3    Grodzinsky, A.J.4    Jain, R.K.5
  • 36
    • 33645693408 scopus 로고    scopus 로고
    • Intraperitoneal immunotherapy for metastatic ovarian carcinoma: Resistance of intratumoral collagen to antibody penetration
    • Choi J, Credit K, Henderson K et al. Intraperitoneal immunotherapy for metastatic ovarian carcinoma: resistance of intratumoral collagen to antibody penetration. Clin. Cancer Res. 12(6), 1906-1912 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , Issue.6 , pp. 1906-1912
    • Choi, J.1    Credit, K.2    Henderson, K.3
  • 37
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP, Jacobetz MA, Davidson CJ et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324(5933), 1457-1461 (2009).
    • (2009) Science , vol.324 , Issue.5933 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3
  • 38
    • 63149124772 scopus 로고    scopus 로고
    • Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
    • USA
    • Tian H, Callahan CA, DuPree KJ et al. Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad. Sci. USA 106(11), 4254-4259 (2009).
    • (2009) Proc. Natl. Acad. Sci. , vol.106 , Issue.11 , pp. 4254-4259
    • Tian, H.1    Callahan, C.A.2    DuPree, K.J.3
  • 39
    • 0038578294 scopus 로고    scopus 로고
    • Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation
    • Brown E, McKee T, diTomaso E et al. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nat. Med. 9(6), 796-800 (2003).
    • (2003) Nat. Med. , vol.9 , Issue.6 , pp. 796-800
    • Brown, E.1    McKee, T.2    Di Tomaso, E.3
  • 40
    • 33645066093 scopus 로고    scopus 로고
    • Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector
    • McKee TD, Grandi P, Mok W et al. Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector. Cancer Res. 66(5), 2509-2513 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.5 , pp. 2509-2513
    • McKee, T.D.1    Grandi, P.2    Mok, W.3
  • 41
    • 3142660422 scopus 로고    scopus 로고
    • Collagenase increases the transcapillary pressure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts
    • Eikenes L, Bruland OS, Brekken C, Davies CL. Collagenase increases the transcapillary pressure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts. Cancer Res. 64(14), 4768-4773 (2004).
    • (2004) Cancer Res. , vol.64 , Issue.14 , pp. 4768-4773
    • Eikenes, L.1    Bruland, O.S.2    Brekken, C.3    Davies, C.L.4
  • 42
    • 23144448579 scopus 로고    scopus 로고
    • Hyaluronidase induces a transcapillary pressure gradient and improves the distribution and uptake of liposomal doxorubicin caelyx in human osteosarcoma xenografts
    • Eikenes L, Tari M, Tufto I, Bruland OS, de Lange DC. Hyaluronidase induces a transcapillary pressure gradient and improves the distribution and uptake of liposomal doxorubicin (Caelyx) in human osteosarcoma xenografts. Br. J. Cancer 93(1), 81-88 (2005).
    • (2005) Br. J. Cancer , vol.93 , Issue.1 , pp. 81-88
    • Eikenes, L.1    Tari, M.2    Tufto, I.3    Bruland, O.S.4    De Lange, D.C.5
  • 43
    • 0030136756 scopus 로고    scopus 로고
    • Dynamics of matrix turnover during pathologic remodeling of the extracellular matrix
    • Stetler-Stevenson WG. Dynamics of matrix turnover during pathologic remodeling of the extracellular matrix. Am J. Pathol. 148(5), 1345-1350 (1996).
    • (1996) Am J. Pathol. , vol.148 , Issue.5 , pp. 1345-1350
    • Stetler-Stevenson, W.G.1
  • 44
    • 38049156416 scopus 로고    scopus 로고
    • Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin
    • Magzoub M, Jin S, Verkman AS. Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin. FASEB J. 22(1), 276-284 (2008).
    • (2008) Faseb J. , vol.22 , Issue.1 , pp. 276-284
    • Magzoub, M.1    Jin, S.2    Verkman, A.S.3
  • 45
    • 36348930079 scopus 로고    scopus 로고
    • Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus
    • Mok W, Boucher Y, Jain RK. Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus. Cancer Res. 67(22), 10664-10668 (2007).
    • (2007) Cancer Res. , vol.67 , Issue.22 , pp. 10664-10668
    • Mok, W.1    Boucher, Y.2    Jain, R.K.3
  • 46
    • 42249095831 scopus 로고    scopus 로고
    • Increased nanoparticle penetration in collagenase-treated multicellular spheroids
    • Goodman TT, Olive PL, Pun SH. Increased nanoparticle penetration in collagenase-treated multicellular spheroids. Int. J. Nanomed. 2(2), 265-274 (2007).
    • (2007) Int. J. Nanomed. , vol.2 , Issue.2 , pp. 265-274
    • Goodman, T.T.1    Olive, P.L.2    Pun, S.H.3
  • 47
    • 0034082134 scopus 로고    scopus 로고
    • Systemic therapy emergencies
    • Albanell J, Baselga J. Systemic therapy emergencies. Semin. Oncol 27(3), 347-361 (2000).
    • (2000) Semin. Oncol , vol.27 , Issue.3 , pp. 347-361
    • Albanell, J.1    Baselga, J.2
  • 48
    • 0024512041 scopus 로고
    • Metaphylactic effect of mitomycin C with and without hyaluronidase after transurethral resection of bladder cancer: Randomized trial
    • Maier U, Baumgartner G. Metaphylactic effect of mitomycin C with and without hyaluronidase after transurethral resection of bladder cancer: randomized trial. J. Urol. 141(3), 529-530 (1989).
    • (1989) J. Urol. , vol.141 , Issue.3 , pp. 529-530
    • Maier, U.1    Baumgartner, G.2
  • 49
    • 0031048011 scopus 로고    scopus 로고
    • Hyaluronidase enhances the therapeutic effect of vinblastine in intralesional treatment of Kaposis sarcoma
    • Military Medical Consortium for the Advancement of Retroviral Research MMCARR 2 Pt 1
    • Smith KJ, Skelton HG, Turiansky G, Wagner KF. Hyaluronidase enhances the therapeutic effect of vinblastine in intralesional treatment of Kaposi's sarcoma. Military Medical Consortium for the Advancement of Retroviral Research (MMCARR).J. Am Acad. Dermatol. 36(2 Pt 1), 239-242 (1997).
    • (1997) J. Am Acad. Dermatol. , vol.36 , pp. 239-242
    • Smith, K.J.1    Skelton, H.G.2    Turiansky, G.3    Wagner, K.F.4
  • 50
    • 0034488852 scopus 로고    scopus 로고
    • Interstitial collagenases as markers of tumor progression
    • Brinckerhoff CE, Rutter JL, Benbow U. Interstitial collagenases as markers of tumor progression. Clin. Cancer Res. 6(12), 4823-4830 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , Issue.12 , pp. 4823-4830
    • Brinckerhoff, C.E.1    Rutter, J.L.2    Benbow, U.3
  • 51
    • 70449732503 scopus 로고    scopus 로고
    • Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer
    • Roy R, Yang J, Moses MA. Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer. J. Clin. Oncol. 27(31), 5287-5297 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.31 , pp. 5287-5297
    • Roy, R.1    Yang, J.2    Moses, M.A.3
  • 52
    • 33845877573 scopus 로고    scopus 로고
    • Hyaluronidase expression induces prostate tumor metastasis in an orthotopic mouse model
    • Kovar JL, Johnson MA, Volcheck WM, Chen J, Simpson MA. Hyaluronidase expression induces prostate tumor metastasis in an orthotopic mouse model. Am. J. Pathol. 169(4), 1415-1426 (2006).
    • (2006) Am. J. Pathol. , vol.169 , Issue.4 , pp. 1415-1426
    • Kovar, J.L.1    Johnson, M.A.2    Volcheck, W.M.3    Chen, J.4    Simpson, M.A.5
  • 53
    • 0024379967 scopus 로고
    • Acid pH in tumors and its potential for therapeutic exploitation
    • Tannock IF, Rotin D. Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res. 49(16), 4373-4384 (1989).
    • (1989) Cancer Res. , vol.49 , Issue.16 , pp. 4373-4384
    • Tannock, I.F.1    Rotin, D.2
  • 54
    • 45549094086 scopus 로고    scopus 로고
    • Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors
    • Nagano S, Perentes JY, Jain RK, Boucher Y. Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors. Cancer Res. 68(10), 3795-3802 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.10 , pp. 3795-3802
    • Nagano, S.1    Perentes, J.Y.2    Jain, R.K.3    Boucher, Y.4
  • 55
    • 77449084996 scopus 로고    scopus 로고
    • Dynamics of different-sized solid-state nanocrystals as tracers for a drug-delivery system in the interstitium of a human tumor xenograft
    • Kawai M, Higuchi H, Takeda M, Kobayashi Y, Ohuchi N. Dynamics of different-sized solid-state nanocrystals as tracers for a drug-delivery system in the interstitium of a human tumor xenograft. Breast Cancer Res. 11(4), R43 (2009).
    • (2009) Breast Cancer Res. , vol.11 , Issue.4
    • Kawai, M.1    Higuchi, H.2    Takeda, M.3    Kobayashi, Y.4    Ohuchi, N.5
  • 56
    • 33644753906 scopus 로고    scopus 로고
    • Increased antitumor activity intratumor paclitaxel concentrations and endothelial cell transport of cremophor-free albumin-bound paclitaxel ABI-007 compared with cremophor-based paclitaxel
    • Desai N, Trieu V, Yao Z et al. Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel. Clin. Cancer Res. 12(4), 1317-1324 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , Issue.4 , pp. 1317-1324
    • Desai, N.1    Trieu, V.2    Yao, Z.3
  • 57
    • 70350134980 scopus 로고    scopus 로고
    • SPARC expression correlates with tumor response to albumin-bound paclitaxel in head and neck cancer patients
    • Desai N, Trieu V, Damascelli B, Soon-Shiong P. SPARC expression correlates with tumor response to albumin-bound paclitaxel in head and neck cancer patients. Transl. Oncol. 2(2), 59-64 (2009).
    • (2009) Transl. Oncol. , vol.2 , Issue.2 , pp. 59-64
    • Desai, N.1    Trieu, V.2    Damascelli, B.3    Soon-Shiong, P.4
  • 58
    • 68649119049 scopus 로고    scopus 로고
    • SPARC correlation with response to gemcitabine G plus naβ-paclitaxel naβ-P in patients with advanced metastatic pancreatic cancer: A Phase I/II study
    • Meeting Abstracts
    • Von Hoff DD, Ramanathan R, Borad M et al. SPARC correlation with response to gemcitabine (G) plus naβ-paclitaxel (naβ-P) in patients with advanced metastatic pancreatic cancer: a Phase I/II study. J. Clin. Oncol. (Meeting Abstracts) 27(15S), 4525 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.15 S , pp. 4525
    • Von Hoff, D.D.1    Ramanathan, R.2    Borad, M.3
  • 59
    • 84862000368 scopus 로고    scopus 로고
    • Use of SPARC EGFR and VEGFR expression to predict response to naβ-paclitaxel nabP/carboplatin C/bevacizumab B chemotherapy in triple-negative metastatic breast cancer TNMBC
    • Meeting Abstracts
    • Hamilton EP, Kimmick GG, Desai N et al. Use of SPARC, EGFR, and VEGFR expression to predict response to naβ-paclitaxel (nabP)/carboplatin (C)/ bevacizumab (B) chemotherapy in triple-negative metastatic breast cancer (TNMBC).J. Clin. Oncol. (Meeting Abstracts) 28(15S), 1109 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.15 S , pp. 1109
    • Hamilton, E.P.1    Kimmick, G.G.2    Desai, N.3
  • 60
    • 70749103751 scopus 로고    scopus 로고
    • Tissue-penetrating delivery of compounds and nanoparticles into tumors
    • Sugahara KN, Teesalu T, Karmali PP et al. Tissue-penetrating delivery of compounds and nanoparticles into tumors. Cancer Cell 16(6), 510-520 (2009).
    • (2009) Cancer Cell , vol.16 , Issue.6 , pp. 510-520
    • Sugahara, K.N.1    Teesalu, T.2    Karmali, P.P.3
  • 61
    • 77952901022 scopus 로고    scopus 로고
    • Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs
    • Sugahara KN, Teesalu T, Karmali PP et al. Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Science 328(5981), 1031-1035 (2010).
    • (2010) Science , vol.328 , Issue.5981 , pp. 1031-1035
    • Sugahara, K.N.1    Teesalu, T.2    Karmali, P.P.3
  • 62
    • 72949119124 scopus 로고    scopus 로고
    • Integrins in cancer: Biological implications and therapeutic opportunities
    • Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat. Rev. Cancer 10(1), 9-22 (2010).
    • (2010) Nat. Rev. Cancer , vol.10 , Issue.1 , pp. 9-22
    • Desgrosellier, J.S.1    Cheresh, D.A.2
  • 63
    • 70349482671 scopus 로고    scopus 로고
    • C-end rule peptides mediate neuropilin-1-dependent cell vascular and tissue penetration
    • USA
    • Teesalu T, Sugahara KN, Kotamraju VR, Ruoslahti E. C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration. Proc Natl Acad. Sci. USA 106(38), 16157-16162 (2009).
    • (2009) Proc. Natl. Acad. Sci. , vol.106 , Issue.38 , pp. 16157-16162
    • Teesalu, T.1    Sugahara, K.N.2    Kotamraju, V.R.3    Ruoslahti, E.4
  • 64
    • 0035816178 scopus 로고    scopus 로고
    • Determinants of drug delivery and transport to solid tumors
    • Au JLS, Jang SH, Zheng J et al. Determinants of drug delivery and transport to solid tumors. J. Control. Release 74(1-3), 31-46 (2001).
    • (2001) J. Control. Release , vol.74 , Issue.1-3 , pp. 31-46
    • Au, J.L.S.1    Jang, S.H.2    Zheng, J.3
  • 65
    • 0035126527 scopus 로고    scopus 로고
    • Enhancement of paclitaxel delivery to solid tumors by apoptosis-inducing pretreatment: Effect of treatment schedule
    • Jang SH, Wientjes MG, Au JL. Enhancement of paclitaxel delivery to solid tumors by apoptosis-inducing pretreatment: effect of treatment schedule. J. Pharmacol. Exp. Ther. 296(3), 1035-1042 (2001).
    • (2001) J. Pharmacol. Exp. Ther. , vol.296 , Issue.3 , pp. 1035-1042
    • Jang, S.H.1    Wientjes, M.G.2    Au, J.L.3
  • 66
    • 0035023997 scopus 로고    scopus 로고
    • Determinants of paclitaxel uptake accumulation and retention in solid tumors
    • Jang SH, Wientjes MG, Au JL. Determinants of paclitaxel uptake, accumulation and retention in solid tumors. Invest. New Drugs 19(2), 113-123 (2001).
    • (2001) Invest. New Drugs , vol.19 , Issue.2 , pp. 113-123
    • Jang, S.H.1    Wientjes, M.G.2    Au, J.L.3
  • 67
  • 68
    • 0035783157 scopus 로고    scopus 로고
    • Time-and concentration-dependent penetration of doxorubicin in prostate tumors
    • Zheng JH, Chen CT, Au JL, Wientjes MG. Time- and concentration-dependent penetration of doxorubicin in prostate tumors. AAPS Pharm. Sci. 3(2), E15 (2001).
    • (2001) AAPS Pharm. Sci. , vol.3 , Issue.2
    • Zheng, J.H.1    Chen, C.T.2    Au, J.L.3    Wientjes, M.G.4
  • 69
    • 0343526851 scopus 로고    scopus 로고
    • Computational model of intracellular pharmacokinetics of paclitaxel
    • Kuh HJ, Jang SH, Wientjes MG, Au JL. Computational model of intracellular pharmacokinetics of paclitaxel. J. Pharmacol. Exp. Ther. 293(3), 761-770 (2000).
    • (2000) J. Pharmacol. Exp. Ther. , vol.293 , Issue.3 , pp. 761-770
    • Kuh, H.J.1    Jang, S.H.2    Wientjes, M.G.3    Au, J.L.4
  • 70
    • 0017809904 scopus 로고
    • Permeability of interstitial space of muscle rat diaphragm to solutes of different molecular weights
    • Schultz JS, Armstrong W. Permeability of interstitial space of muscle (rat diaphragm) to solutes of different molecular weights. J. Pharm. Sci. 67(5), 696-700 (1978).
    • (1978) J. Pharm. Sci. , vol.67 , Issue.5 , pp. 696-700
    • Schultz, J.S.1    Armstrong, W.2
  • 71
    • 14444280360 scopus 로고    scopus 로고
    • Pharmacodynamics of immediate and delayed effects of paclitaxel: Role of slow apoptosis and intracellular drug retention
    • Au JLS, Li D, Gan Y et al. Pharmacodynamics of immediate and delayed effects of paclitaxel: role of slow apoptosis and intracellular drug retention. Cancer Res. 58, 2141-2148 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 2141-2148
    • Au, J.L.S.1    Li, D.2    Gan, Y.3
  • 72
    • 33947098532 scopus 로고    scopus 로고
    • Kinetics of hallmark biochemical changes in paclitaxel-induced apoptosis
    • Au JLS, Kumar RR, Li D, Wientjes MG. Kinetics of hallmark biochemical changes in paclitaxel-induced apoptosis. AAPS Pharm. Sci. 1(3), E8 (1999).
    • (1999) AAPS Pharm. Sci. , vol.1 , Issue.3
    • Au, J.L.S.1    Kumar, R.R.2    Li, D.3    Wientjes, M.G.4
  • 73
    • 0031913993 scopus 로고    scopus 로고
    • Pharmacodynamics of doxorubicin in human prostate tumors
    • Chen CT, Au JL, Wientjes MG. Pharmacodynamics of doxorubicin in human prostate tumors. Clin. Cancer Res. 4(2), 277-282 (1998).
    • (1998) Clin. Cancer Res. , vol.4 , Issue.2 , pp. 277-282
    • Chen, C.T.1    Au, J.L.2    Wientjes, M.G.3
  • 74
    • 0000881538 scopus 로고
    • Characterisations of taxolinduced apoptosis and altered gene expression in human breast cancer cells
    • Cheng L, Zheng S, Raghunathan K et al. Characterisations of taxolinduced apoptosis and altered gene expression in human breast cancer cells. Cell. Pharmacol. 2, 249-257 (1995).
    • (1995) Cell. Pharmacol. , vol.2 , pp. 249-257
    • Cheng, L.1    Zheng, S.2    Raghunathan, K.3
  • 75
    • 0029877212 scopus 로고    scopus 로고
    • Pharmacodynamics of taxol in human head and neck tumors
    • Gan Y, Wientjes MG, Schuller DE, Au JLS. Pharmacodynamics of taxol in human head and neck tumors. Cancer Res. 56, 2086-2093 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 2086-2093
    • Gan, Y.1    Wientjes, M.G.2    Schuller, D.E.3    Au, J.L.S.4
  • 76
    • 0028906559 scopus 로고
    • Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with taxol
    • Milas L, Hunter NR, Kurdoglu B et al. Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with taxol. Cancer Chemother. Pharmacol. 35, 297-303 (1995).
    • (1995) Cancer Chemother. Pharmacol. , vol.35 , pp. 297-303
    • Milas, L.1    Hunter, N.R.2    Kurdoglu, B.3
  • 78
    • 0033178578 scopus 로고    scopus 로고
    • Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: Clinical implications
    • Griffon-Etienne G, Boucher Y, Brekken C, Suit Hd, Jain RK. Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications. Cancer Res. 59, 3776-3782 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 3776-3782
    • Griffon-Etienne, G.1    Boucher, Y.2    Brekken, C.3    Suit, H.D.4    Jain, R.K.5
  • 81
    • 77954616958 scopus 로고    scopus 로고
    • Docetaxel increases antitumor efficacy of oncolytic prostate-restricted replicative adenovirus by enhancing cell killing and virus distribution
    • Li X, Liu Y, Tang Y, Roger P, Jeng MH, Kao C. Docetaxel increases antitumor efficacy of oncolytic prostate-restricted replicative adenovirus by enhancing cell killing and virus distribution. J. Gene Med. 12(6), 516-527 (2010).
    • (2010) J. Gene Med. , vol.12 , Issue.6 , pp. 516-527
    • Li, X.1    Liu, Y.2    Tang, Y.3    Roger, P.4    Jeng, M.H.5    Kao, C.6
  • 82
    • 0034814352 scopus 로고    scopus 로고
    • Augmentation of antitumor activity of an antibody-interleukin 2 immunocytokine with chemotherapeutic agents
    • Holden SA, Lan Y, Pardo AM, Wesolowski JS, Gillies SD. Augmentation of antitumor activity of an antibody-interleukin 2 immunocytokine with chemotherapeutic agents. Clin. Cancer Res. 7(9), 2862-2869 (2001).
    • (2001) Clin. Cancer Res. , vol.7 , Issue.9 , pp. 2862-2869
    • Holden, S.A.1    Lan, Y.2    Pardo, A.M.3    Wesolowski, J.S.4    Gillies, S.D.5
  • 83
    • 0027968083 scopus 로고
    • Paclitaxel a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer
    • Spencer CM, Faulds D. Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer. Drugs 48(5), 794-847 (1994).
    • (1994) Drugs , vol.48 , Issue.5 , pp. 794-847
    • Spencer, C.M.1    Faulds, D.2
  • 84
    • 0031935690 scopus 로고    scopus 로고
    • Cytostatic and apoptotic effects of paclitaxel in human ovarian tumors
    • Millenbaugh NJ, Gan Y, Au JLS. Cytostatic and apoptotic effects of paclitaxel in human ovarian tumors. Pharm. Res. 15, 122-127 (1998).
    • (1998) Pharm. Res. , vol.15 , pp. 122-127
    • Millenbaugh, N.J.1    Gan, Y.2    Au, J.L.S.3
  • 85
    • 0031849621 scopus 로고    scopus 로고
    • Cytostatic and apoptotic effects of paclitaxel in human breast tumors
    • Gan Y, Wientjes MG, Lu J, Au JL. Cytostatic and apoptotic effects of paclitaxel in human breast tumors. Cancer Chemother. Pharmacol. 42(3), 177-182 (1998).
    • (1998) Cancer Chemother. Pharmacol. , vol.42 , Issue.3 , pp. 177-182
    • Gan, Y.1    Wientjes, M.G.2    Lu, J.3    Au, J.L.4
  • 86
    • 0032127380 scopus 로고    scopus 로고
    • Androgen-dependent and-independent human prostate xenograft tumors as models for drug activity evaluation
    • Chen CT, Gan Y, Au JL, Wientjes MG. Androgen-dependent and -independent human prostate xenograft tumors as models for drug activity evaluation. Cancer Res. 58(13), 2777-2783 (1998).
    • (1998) Cancer Res. , vol.58 , Issue.13 , pp. 2777-2783
    • Chen, C.T.1    Gan, Y.2    Au, J.L.3    Wientjes, M.G.4
  • 88
    • 14444280360 scopus 로고    scopus 로고
    • Pharmacodynamics of immediate and delayed effects of paclitaxel: Role of slow apoptosis and intracellular drug retention
    • Au JL, Li D, Gan Y et al. Pharmacodynamics of immediate and delayed effects of paclitaxel: role of slow apoptosis and intracellular drug retention. Cancer Res. 58(10), 2141-2148 (1998).
    • (1998) Cancer Res. , vol.58 , Issue.10 , pp. 2141-2148
    • Au, J.L.1    Li, D.2    Gan, Y.3
  • 89
    • 0029150245 scopus 로고
    • Vascular permeability in a human tumor xenograft: Molecular size dependence and cutoff size
    • Yuan F, Dellian M, Fukumura D et al. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res. 55(17), 3752-3756 (1995).
    • (1995) Cancer Res. , vol.55 , Issue.17 , pp. 3752-3756
    • Yuan, F.1    Dellian, M.2    Fukumura, D.3
  • 90
    • 0026089377 scopus 로고
    • Microvascular architecture in a mammary carcinoma: Branching patterns and vessel dimensions
    • Less JR, Skalak TC, Sevick EM, Jain RK. Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions. Cancer Res. 51, 265-273 (1991).
    • (1991) Cancer Res. , vol.51 , pp. 265-273
    • Less, J.R.1    Skalak, T.C.2    Sevick, E.M.3    Jain, R.K.4
  • 91
    • 57349141530 scopus 로고    scopus 로고
    • Tumor-penetrating microparticles for intraperitoneal therapy of ovarian cancer
    • Lu Z, Tsai M, Lu D, Wang J, Wientjes MG, Au JL. Tumor-penetrating microparticles for intraperitoneal therapy of ovarian cancer. J. Pharmacol. Exp. Ther. 327(3), 673-682 (2008).
    • (2008) J. Pharmacol. Exp. Ther. , vol.327 , Issue.3 , pp. 673-682
    • Lu, Z.1    Tsai, M.2    Lu, D.3    Wang, J.4    Wientjes, M.G.5    Au, J.L.6
  • 92
    • 78149457486 scopus 로고    scopus 로고
    • Intraperitoneal therapy for peritoneal cancer
    • Lu Z, Wang J, Wientjes MG, Au JL. Intraperitoneal therapy for peritoneal cancer. Future. Oncol. 6(10), 1625-1641 (2010).
    • (2010) Future. Oncol. , vol.6 , Issue.10 , pp. 1625-1641
    • Lu, Z.1    Wang, J.2    Wientjes, M.G.3    Au, J.L.4
  • 93
    • 34547639533 scopus 로고    scopus 로고
    • Effects of carrier on disposition and antitumor activity of intraperitoneal Paclitaxel
    • Tsai M, Lu Z, Wang J, Yeh TK, Wientjes MG, Au JL. Effects of carrier on disposition and antitumor activity of intraperitoneal Paclitaxel. Pharm. Res 24(9), 1691-1701 (2007).
    • (2007) Pharm. Res. , vol.24 , Issue.9 , pp. 1691-1701
    • Tsai, M.1    Lu, Z.2    Wang, J.3    Yeh, T.K.4    Wientjes, M.G.5    Au, J.L.6
  • 94
    • 79956066632 scopus 로고    scopus 로고
    • Paclitaxel tumor-priming enhances siRNA delivery and transfection in 3-dimensional tumor cultures
    • Wong HL, Shen Z, Lu Z, Wientjes MG, Au J. Paclitaxel tumor-priming enhances siRNA delivery and transfection in 3-dimensional tumor cultures. Mol. Pharm. 8(3), 833-840 (2011)
    • (2011) Mol. Pharm. , vol.8 , Issue.3 , pp. 833-840
    • Wong, H.L.1    Shen, Z.2    Lu, Z.3    Wientjes, M.G.4    Au, J.5
  • 95
    • 33746883220 scopus 로고    scopus 로고
    • A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium
    • Santel A, Aleku M, Keil O et al. A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium. Gene Ther. 13(16), 1222-1234 (2006).
    • (2006) Gene Ther. , vol.13 , Issue.16 , pp. 1222-1234
    • Santel, A.1    Aleku, M.2    Keil, O.3
  • 96
    • 51049092308 scopus 로고    scopus 로고
    • Factors affecting the clearance and biodistribution of polymeric nanoparticles
    • Alexis F, Pridgen E, Molnar LK, Farokhzad OC. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol. Pharm. 5(4), 505-515 (2008).
    • (2008) Mol. Pharm. , vol.5 , Issue.4 , pp. 505-515
    • Alexis, F.1    Pridgen, E.2    Molnar, L.K.3    Farokhzad, O.C.4
  • 97
    • 51049104302 scopus 로고    scopus 로고
    • Pharmacokinetics and biodistribution of nanoparticles
    • Li SD, Huang L. Pharmacokinetics and biodistribution of nanoparticles. Mol. Pharm. 5(4), 496-504 (2008).
    • (2008) Mol. Pharm. , vol.5 , Issue.4 , pp. 496-504
    • Li, S.D.1    Huang, L.2
  • 98
    • 0023684046 scopus 로고
    • Increased intratumor concentration of fluorescein-isothiocyanatelabeled neocarzinostatin in rats under angiotensin-induced hypertension
    • Abe I, Hori K, Saito S, Tanda S, Li YL, Suzuki M. Increased intratumor concentration of fluorescein-isothiocyanatelabeled neocarzinostatin in rats under angiotensin-induced hypertension. Jpn J. Cancer Res. 79, 874-879 (1988).
    • (1988) Jpn J. Cancer Res. , vol.79 , pp. 874-879
    • Abe, I.1    Hori, K.2    Saito, S.3    Tanda, S.4    Li, Y.L.5    Suzuki, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.