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Volumn 124, Issue 7, 2014, Pages 2977-2987

Erratum: CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells (Journal of Clinical Investigation (2014) 124:7 (2977-2987) DOI:10.1172/JCI73174);CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; SMALL INTERFERING RNA; STAT3 PROTEIN;

EID: 84903759837     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI82555     Document Type: Erratum
Times cited : (127)

References (56)
  • 1
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012; 12(4):252-264.
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 252-264
    • Pardoll, D.M.1
  • 2
    • 84869380716 scopus 로고    scopus 로고
    • Immunology beats cancer: A blueprint for successful translation
    • Pardoll DM. Immunology beats cancer: a blueprint for successful translation. Nat Immunol. 2012; 13(12):1129-1132.
    • (2012) Nat Immunol , vol.13 , Issue.12 , pp. 1129-1132
    • Pardoll, D.M.1
  • 4
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer. 2009;9(11):798-809.
    • (2009) Nat Rev Cancer , vol.9 , Issue.11 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 5
    • 44749084859 scopus 로고    scopus 로고
    • Role of Stat3 in suppressing anti-tumor immunity
    • Kortylewski M, Yu H. Role of Stat3 in suppressing anti-tumor immunity. Curr Opin Immunol. 2008; 20(2):228-233.
    • (2008) Curr Opin Immunol , vol.20 , Issue.2 , pp. 228-233
    • Kortylewski, M.1    Yu, H.2
  • 6
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • Kortylewski M, et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med. 2005;11(12):1314- 1321.
    • (2005) Nat Med , vol.11 , Issue.12 , pp. 1314-1321
    • Kortylewski, M.1
  • 7
    • 77957327205 scopus 로고    scopus 로고
    • Targeting Stat3 in the myeloid compartment drastically improves the in vivo antitumor functions of adoptively transferred T cells
    • Herrmann A, et al. Targeting Stat3 in the myeloid compartment drastically improves the in vivo antitumor functions of adoptively transferred T cells. Cancer Res. 2010;70(19):7455-7464.
    • (2010) Cancer Res , vol.70 , Issue.19 , pp. 7455-7464
    • Herrmann, A.1
  • 8
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer-new molecular targets come of age
    • Yu H, Jove R. The STATs of cancer-new molecular targets come of age. Nat Rev Cancer. 2004;4(2):97-105.
    • (2004) Nat Rev Cancer , vol.4 , Issue.2 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 9
    • 78649916060 scopus 로고    scopus 로고
    • Targeting STAT3 in adoptively transferred T cells promotes their in vivo expansion and antitumor effects
    • Kujawski M, et al. Targeting STAT3 in adoptively transferred T cells promotes their in vivo expansion and antitumor effects. Cancer Res. 2010; 70(23):9599-9610.
    • (2010) Cancer Res , vol.70 , Issue.23 , pp. 9599-9610
    • Kujawski, M.1
  • 10
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
    • Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol. 2007;7(1):41-51.
    • (2007) Nat Rev Immunol , vol.7 , Issue.1 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 11
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 2004; 10(9):942-949.
    • (2004) Nat Med , vol.10 , Issue.9 , pp. 942-949
    • Curiel, T.J.1
  • 12
    • 0036597371 scopus 로고    scopus 로고
    • + suppressor T cells: More questions than answers
    • Shevach EM. CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol. 2002; 2(6):389-400.
    • (2002) Nat Rev Immunol , vol.2 , Issue.6 , pp. 389-400
    • Shevach, E.M.1
  • 13
    • 12244285937 scopus 로고    scopus 로고
    • Regulatory T cells suppress tumorspecific CD8 T cell cytotoxicity through TGF-β signals in vivo
    • Chen ML, et al. Regulatory T cells suppress tumorspecific CD8 T cell cytotoxicity through TGF-β signals in vivo. Proc Natl Acad Sci U S A. 2005; 102(2):419-424.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.2 , pp. 419-424
    • Chen, M.L.1
  • 14
    • 33745978399 scopus 로고    scopus 로고
    • Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
    • Mempel TR, et al. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity. 2006;25(1):129-141.
    • (2006) Immunity , vol.25 , Issue.1 , pp. 129-141
    • Mempel, T.R.1
  • 15
    • 77951692771 scopus 로고    scopus 로고
    • Plasticity in programming of effector and memory CD8 T-cell formation
    • Arens R, Schoenberger SP. Plasticity in programming of effector and memory CD8 T-cell formation. Immunol Rev. 2010;235(1):190-205.
    • (2010) Immunol Rev , vol.235 , Issue.1 , pp. 190-205
    • Arens, R.1    Schoenberger, S.P.2
  • 16
    • 38849093957 scopus 로고    scopus 로고
    • + regulatory lymphocyte generation: Implications in graft-versus-host disease and antitumor immunity
    • Pallandre JR, et al. Role of STAT3 in CD4+CD25+ FOXP3+ regulatory lymphocyte generation: implications in graft-versus-host disease and antitumor immunity. J Immunol. 2007;179(11):7593-7604.
    • (2007) J Immunol , vol.179 , Issue.11 , pp. 7593-7604
    • Pallandre, J.R.1
  • 17
    • 20944441928 scopus 로고    scopus 로고
    • Validating Stat3 in cancer therapy
    • Darnell JE. Validating Stat3 in cancer therapy. Nat Med. 2005;11(6):595-596.
    • (2005) Nat Med , vol.11 , Issue.6 , pp. 595-596
    • Darnell, J.E.1
  • 18
    • 0036782706 scopus 로고    scopus 로고
    • Transcription factors as targets for cancer therapy
    • Darnell JE Jr. Transcription factors as targets for cancer therapy. Nat Rev Cancer. 2002;2(10):740-749.
    • (2002) Nat Rev Cancer , vol.2 , Issue.10 , pp. 740-749
    • Darnell Jr., J.E.1
  • 19
    • 33747031960 scopus 로고    scopus 로고
    • Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras
    • McNamara JO 2nd, et al. Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat Biotechnol. 2006;24(8):1005-1015.
    • (2006) Nat Biotechnol , vol.24 , Issue.8 , pp. 1005-1015
    • McNamara II, J.O.1
  • 20
    • 79957905425 scopus 로고    scopus 로고
    • Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras
    • Wheeler LA, et al. Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. J Clin Invest. 2011;121(6):2401-2412.
    • (2011) J Clin Invest , vol.121 , Issue.6 , pp. 2401-2412
    • Wheeler, L.A.1
  • 21
    • 70349971417 scopus 로고    scopus 로고
    • In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses
    • Kortylewski M, et al. In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses. Nat Biotechnol. 2009;27(10):925-932.
    • (2009) Nat Biotechnol , vol.27 , Issue.10 , pp. 925-932
    • Kortylewski, M.1
  • 22
    • 84874449237 scopus 로고    scopus 로고
    • TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo
    • Zhang Q, et al. TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo. Blood. 2013;121(8):1304-1315.
    • (2013) Blood , vol.121 , Issue.8 , pp. 1304-1315
    • Zhang, Q.1
  • 23
    • 0242610799 scopus 로고    scopus 로고
    • Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity
    • Santulli-Marotto S, Nair SK, Rusconi C, Sullenger B, Gilboa E. Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity. Cancer Res. 2003;63(21):7483-7489.
    • (2003) Cancer Res , vol.63 , Issue.21 , pp. 7483-7489
    • Santulli-Marotto, S.1    Nair, S.K.2    Rusconi, C.3    Sullenger, B.4    Gilboa, E.5
  • 24
    • 53749094183 scopus 로고    scopus 로고
    • + regulatory T cell function
    • Wing K, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science. 2008;322(5899):271-275.
    • (2008) Science , vol.322 , Issue.5899 , pp. 271-275
    • Wing, K.1
  • 26
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • Peggs KS, Quezada SA, Chambers CA, Korman AJ, Allison JP. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med. 2009;206(8):1717-1725.
    • (2009) J Exp Med , vol.206 , Issue.8 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3    Korman, A.J.4    Allison, J.P.5
  • 28
    • 0028484545 scopus 로고
    • CTLA-4 can function as a negative regulator of T cell activation
    • Walunas TL, et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994; 1(5):405-413.
    • (1994) Immunity , vol.1 , Issue.5 , pp. 405-413
    • Walunas, T.L.1
  • 30
    • 35349014587 scopus 로고    scopus 로고
    • + T cell exhaustion during chronic viral infection
    • Wherry EJ, et al. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity. 2007;27(4):670-684.
    • (2007) Immunity , vol.27 , Issue.4 , pp. 670-684
    • Wherry, E.J.1
  • 31
    • 0021765921 scopus 로고
    • Synthesis and characterization of an octanucleotide containing the EcoRI recognition sequence with a phosphorothioate group at the cleavage site
    • Connolly BA, Potter BV, Eckstein F, Pingoud A, Grotjahn L. Synthesis and characterization of an octanucleotide containing the EcoRI recognition sequence with a phosphorothioate group at the cleavage site. Biochemistry. 1984;23(15):3443-3453.
    • (1984) Biochemistry , vol.23 , Issue.15 , pp. 3443-3453
    • Connolly, B.A.1    Potter, B.V.2    Eckstein, F.3    Pingoud, A.4    Grotjahn, L.5
  • 32
    • 0024202897 scopus 로고
    • Inhibition of deoxyribonucleases by phosphorothioate groups in oligodeoxyribonucleotides
    • Spitzer S, Eckstein F. Inhibition of deoxyribonucleases by phosphorothioate groups in oligodeoxyribonucleotides. Nucleic Acids Res. 1988;16(24):11691-11704.
    • (1988) Nucleic Acids Res , vol.16 , Issue.24 , pp. 11691-11704
    • Spitzer, S.1    Eckstein, F.2
  • 33
    • 84857784900 scopus 로고    scopus 로고
    • Progress toward in vivo use of siRNAs-II
    • Rettig GR, Behlke MA. Progress toward in vivo use of siRNAs-II. Mol Ther. 2011;20(3):483-512.
    • (2011) Mol Ther , vol.20 , Issue.3 , pp. 483-512
    • Rettig, G.R.1    Behlke, M.A.2
  • 34
    • 0031030349 scopus 로고    scopus 로고
    • The immunodominant antigen of an ultraviolet-induced regressor tumor is generated by a somatic point mutation in the DEAD box helicase p68
    • Dubey P, et al. The immunodominant antigen of an ultraviolet-induced regressor tumor is generated by a somatic point mutation in the DEAD box helicase p68. J Exp Med. 1997;185(4):695-705.
    • (1997) J Exp Med , vol.185 , Issue.4 , pp. 695-705
    • Dubey, P.1
  • 35
    • 1642305625 scopus 로고    scopus 로고
    • CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function
    • Pandiyan P, et al. CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function. J Exp Med. 2004;199(6):831-842.
    • (2004) J Exp Med , vol.199 , Issue.6 , pp. 831-842
    • Pandiyan, P.1
  • 36
    • 0036172220 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
    • Egen JG, Allison JP. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity. 2002;16(1):23-35.
    • (2002) Immunity , vol.16 , Issue.1 , pp. 23-35
    • Egen, J.G.1    Allison, J.P.2
  • 37
    • 0042265184 scopus 로고    scopus 로고
    • Viewpoint: Therapeutic implications of CTLA-4 compartmentalization
    • Baroja ML, Madrenas J. Viewpoint: therapeutic implications of CTLA-4 compartmentalization. Am J Transplant. 2003;3(8):919-926.
    • (2003) Am J Transplant , vol.3 , Issue.8 , pp. 919-926
    • Baroja, M.L.1    Madrenas, J.2
  • 38
    • 0346496097 scopus 로고    scopus 로고
    • CTLA-4 and tolerance: The biochemical point of view
    • Chikuma S, Bluestone JA. CTLA-4 and tolerance: the biochemical point of view. Immunol Res. 2003;28(3):241-253.
    • (2003) Immunol Res , vol.28 , Issue.3 , pp. 241-253
    • Chikuma, S.1    Bluestone, J.A.2
  • 39
    • 27144458821 scopus 로고    scopus 로고
    • CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction
    • Contardi E, et al. CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction. Int J Cancer. 2005;117(4):538-550.
    • (2005) Int J Cancer , vol.117 , Issue.4 , pp. 538-550
    • Contardi, E.1
  • 40
    • 77953708336 scopus 로고    scopus 로고
    • Enhanced CD8 T cell cross-presentation by macrophages with targeted disruption of STAT3
    • Brayer J, et al. Enhanced CD8 T cell cross-presentation by macrophages with targeted disruption of STAT3. Immunol Lett. 2010;131(2):126-130.
    • (2010) Immunol Lett , vol.131 , Issue.2 , pp. 126-130
    • Brayer, J.1
  • 41
    • 0026486220 scopus 로고
    • Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes
    • Linsley PS, et al. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J Exp Med. 1992;176(6):1595-1604.
    • (1992) J Exp Med , vol.176 , Issue.6 , pp. 1595-1604
    • Linsley, P.S.1
  • 42
    • 0026778697 scopus 로고
    • Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule
    • Linsley PS, et al. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science. 1992;257(5071):792-795.
    • (1992) Science , vol.257 , Issue.5071 , pp. 792-795
    • Linsley, P.S.1
  • 43
    • 2442552882 scopus 로고    scopus 로고
    • Conversion of CTLA-4 from inhibitor to activator of T cells with a bispecific tandem single-chain Fv ligand
    • Madrenas J, et al. Conversion of CTLA-4 from inhibitor to activator of T cells with a bispecific tandem single-chain Fv ligand. J Immunol. 2004; 172(10):5948-5956.
    • (2004) J Immunol , vol.172 , Issue.10 , pp. 5948-5956
    • Madrenas, J.1
  • 44
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatoryrole of CTLA-4
    • Tivol EA, et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatoryrole of CTLA-4. Immunity. 1995;3(5):541-547.
    • (1995) Immunity , vol.3 , Issue.5 , pp. 541-547
    • Tivol, E.A.1
  • 45
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • Waterhouse P, et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science. 1995;270(5238):985-988.
    • (1995) Science , vol.270 , Issue.5238 , pp. 985-988
    • Waterhouse, P.1
  • 46
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 1996;271(5256):1734-1736.
    • (1996) Science , vol.271 , Issue.5256 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 47
    • 33644769165 scopus 로고    scopus 로고
    • Increased expression of CTLA-4 in malignant T-cells from patients with mycosis fungoides-cutaneous T cell lymphoma
    • Wong HK, et al. Increased expression of CTLA-4 in malignant T-cells from patients with mycosis fungoides-cutaneous T cell lymphoma. J Invest Dermatol. 2006;126(1):212-219.
    • (2006) J Invest Dermatol , vol.126 , Issue.1 , pp. 212-219
    • Wong, H.K.1
  • 48
    • 0030874921 scopus 로고    scopus 로고
    • In vivo expression of the CTLA4 inhibitory receptor in malignant and reactive cells from human lymphomas
    • Xerri L, Devilard E, Hassoun J, Olive D, Birg F. In vivo expression of the CTLA4 inhibitory receptor in malignant and reactive cells from human lymphomas. J Pathol. 1997;183(2):182-187.
    • (1997) J Pathol , vol.183 , Issue.2 , pp. 182-187
    • Xerri, L.1    Devilard, E.2    Hassoun, J.3    Olive, D.4    Birg, F.5
  • 49
    • 13544259946 scopus 로고    scopus 로고
    • + cells correlates with the level of cell cycle regulators and disease progression in B-CLL patients
    • Kosmaczewska A, Ciszak L, Suwalska K, Wolowiec D, Frydecka I. CTLA-4 overexpression in CD19+/ CD5+ cells correlates with the level of cell cycle regulators and disease progression in B-CLL patients. Leukemia. 2005;19(2):301-304.
    • (2005) Leukemia , vol.19 , Issue.2 , pp. 301-304
    • Kosmaczewska, A.1    Ciszak, L.2    Suwalska, K.3    Wolowiec, D.4    Frydecka, I.5
  • 50
    • 79955485953 scopus 로고    scopus 로고
    • STAT3 inhibition is a therapeutic strategy for ABC-like diffuse large B-cell lymphoma
    • Scuto A, et al. STAT3 inhibition is a therapeutic strategy for ABC-like diffuse large B-cell lymphoma. Cancer Res. 2011;71(9):3182-3188.
    • (2011) Cancer Res , vol.71 , Issue.9 , pp. 3182-3188
    • Scuto, A.1
  • 51
    • 20844433035 scopus 로고    scopus 로고
    • STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis
    • Holtick U, et al. STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis. Leukemia. 2005;19(6):936-944.
    • (2005) Leukemia , vol.19 , Issue.6 , pp. 936-944
    • Holtick, U.1
  • 52
    • 3142735120 scopus 로고    scopus 로고
    • In vivo activation of STAT3 in cutaneous T-cell lymphoma. Evidence for an antiapoptotic function of STAT3
    • Sommer VH, et al. In vivo activation of STAT3 in cutaneous T-cell lymphoma. Evidence for an antiapoptotic function of STAT3. Leukemia. 2004; 18(7):1288-1295.
    • (2004) Leukemia , vol.18 , Issue.7 , pp. 1288-1295
    • Sommer, V.H.1
  • 53
    • 84865159639 scopus 로고    scopus 로고
    • S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma
    • Liu Y, et al. S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma. Blood. 2012;120(7):1458- 1465.
    • (2012) Blood , vol.120 , Issue.7 , pp. 1458-1465
    • Liu, Y.1
  • 54
    • 0036301503 scopus 로고    scopus 로고
    • CTLA-4: New insights into its biological function and use in tumor immunotherapy
    • Egen JG, Kuhns MS, Allison JP. CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nat Immunol. 2002;3(7):611-618.
    • (2002) Nat Immunol , vol.3 , Issue.7 , pp. 611-618
    • Egen, J.G.1    Kuhns, M.S.2    Allison, J.P.3
  • 55
    • 23244451227 scopus 로고    scopus 로고
    • Hierarchical regulation of CTLA-4 dimer-based lattice formation and its biological relevance for T cell inactivation
    • Darlington PJ, Kirchhof MG, Criado G, Sondhi J, Madrenas J. Hierarchical regulation of CTLA-4 dimer-based lattice formation and its biological relevance for T cell inactivation. J Immunol. 2005; 175(2):996-1004.
    • (2005) J Immunol , vol.175 , Issue.2 , pp. 996-1004
    • Darlington, P.J.1    Kirchhof, M.G.2    Criado, G.3    Sondhi, J.4    Madrenas, J.5
  • 56
    • 0029031518 scopus 로고
    • Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4 (CTLA-4). A disulfide-linked homodimer binds two CD86 molecules
    • Linsley PS, et al. Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4 (CTLA-4). A disulfide-linked homodimer binds two CD86 molecules. J Biol Chem. 1995;270(25):15417-15424.
    • (1995) J Biol Chem , vol.270 , Issue.25 , pp. 15417-15424
    • Linsley, P.S.1


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