Emulsions made of oils from seeds of GM flax protect V79 cells against oxidative stress

Oxidative Medicine and Cellular Longevity

Volumn 2016, Issue , 2016, Pages

  Skorkowska Telichowska, Katarzyna ^a   Hasiewicz Derkacz, Karolina ^b   Gębarowski, Tomasz ^c   Kulma, Anna ^b   Moreira, Helena ^c   Kostyn, Kamil ^b   Gębczak, Katarzyna ^c   Szyjka, Anna ^c   Wojtasik, Wioleta ^b   Gąsiorowski, Kazimierz ^c  

^a MILITARY HOSPITAL   (Poland)

^b UNIVERSITY OF WROC AW   (Poland)

^c WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CELLS; CYTOLOGY; EMULSIFICATION; EMULSIONS; FATTY ACIDS; FIBROBLASTS; FLAX; GENE EXPRESSION; GENES; LINEN; POLYUNSATURATED FATTY ACIDS; YARN;

ANTI-INFLAMMATORIES; APOPTOTIC CELL DEATH; BENEFICIAL EFFECTS; BIOMEDICAL PRODUCTS; EXPRESSION ANALYSIS; LOW CONCENTRATIONS; PHENOLIC COMPOUNDS; REACTIVE OXYGEN SPECIES;

OILSEEDS;

GENOMIC DNA; HISTONE; HISTONE DEACETYLASE; LINSEED OIL; POLYUNSATURATED FATTY ACID; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; STEROL; ANTIOXIDANT; DNA; EMULSION; VEGETABLE OIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; EMULSION; FATTY ACID ANALYSIS; FIBROBLAST; GAS CHROMATOGRAPHY; GENE EXPRESSION; GENE EXPRESSION REGULATION; LINSEED; MASS SPECTROMETRY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPREGULATION; V79 CELL LINE; ANIMAL; CELL LINE; CELL PROTECTION; CHEMISTRY; DRUG EFFECTS; FLAX; GENOME; HAMSTER; METABOLISM; NONPARAMETRIC TEST; PLANT SEED; TRANSGENIC PLANT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL LINE; CELL PROLIFERATION; CRICETINAE; CYTOPROTECTION; DNA; EMULSIONS; FLAX; GENE EXPRESSION REGULATION; GENOME; OXIDATIVE STRESS; PLANT OILS; PLANTS, GENETICALLY MODIFIED; REACTIVE OXYGEN SPECIES; SEEDS; STATISTICS, NONPARAMETRIC;

EID: 84953285171     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2016/7510759     Document Type: Article

References (56)

1. M. Valko, D. Leibfritz, J. Moncol, M. T. D. Cronin, M. Mazur, and J. Telser, Free radicals and antioxidants in normal physiological functions and human disease, International Journal of Biochemistry and Cell Biology, vol. 39, no. 1, pp. 44-84, 2007.
2. K. R. Martin and J. C. Barrett, Reactive oxygen species as double-edged swords in cellular processes: low-dose cell signaling versus high-dose toxicity, Human and Experimental Toxicology, vol. 21, no. 2, pp. 71-75, 2002.
3. J.-H. Chen, C. N. Hales, and S. E. Ozanne, DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Research, vol. 35, no. 22, pp. 7417-7428, 2007.
4. S. Ding, C. Li, N. Cheng, X. Cui, X. Xu, and G. Zhou, Redox regulation in cancer stem cells, OxidativeMedicine and Cellular Longevity, vol. 2015, Article ID 750798, 11 pages, 2015.
5. J. Hu, Q. Yu, F. Zhao et al., Protection of Quercetin against Triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells, Chemico-Biological Interactions, vol. 240, pp. 38-46, 2015.
6. G. Valacchi, C. Sticozzi, G. Belmonte et al., Vitamin C compound mixtures prevent ozone-induced oxidative damage in human keratinocytes as initial assessment of pollution protection, PLoS ONE, vol. 10, no. 8, Article IDe0131097, 2015.
7. M. Czemplik, A. Boba, K. Kostyn et al., Flax engineering for biomedical application, in Biomedical Engineering, Trends, Research and Technologies, M. A. Komorowska and S. Olsztynska-Janus, Eds., chapter 17, InTech, Rijeka, Croatia, 2011.
8. M. D. Alister and W. D. Neil, Eds., Flax: The Genus Linum, Medicinal andAromatic Plants-Industrial Profiles, CRCPress, 1st edition, 2003.
9. M. Styrczewska, A. Kulma, K. Kostyn, K. Hasiewicz-Derkacz, and J. Szopa, Flax terpenoid pathway as a source of health promoting compounds, Mini-Reviews in Medicinal Chemistry, vol. 13, no. 3, pp. 353-364, 2013.
10. M. Fujisawa, M. Watanabe, S.-K. Choi, M. Teramoto, K. Ohyama, and N. Misawa, Enrichment of carotenoids in flaxseed (Linum usitatissimum) by metabolic engineering with introduction of bacterial phytoene synthase gene crtB, Journal of Bioscience and Bioengineering, vol. 105, no. 6, pp. 636-641, 2008.
11. J. Gruszka and J. Kruk, RP-LC for determination of plastochromanol, tocotrienols and tocopherols in plant oils, Chromatographia, vol. 66, no. 11-12, pp. 909-913, 2007.
12. L. Velasco and F. D. Goffman, Tocopherol, plastochromanol and fatty acid patterns in the genusLinum, Plant Systematics and Evolution, vol. 221, no. 1-2, pp. 77-88, 2000.
13. A.-N. Li, S. Li, Y.-J. Zhang, X.-R. Xu, Y.-M. Chen, and H.-B. Li, Resources and biological activities of natural polyphenols, Nutrients, vol. 6, no. 12, pp. 6020-6047, 2014.
14. M. Zuk, A. Prescha, M. Stryczewska, and J. Szopa, Engineering flax plants to increase their antioxidant capacity and improve oil composition and stability, Journal of Agricultural and Food Chemistry, vol. 60, no. 19, pp. 5003-5012, 2012.
15. K. Lorenc-Kukula, R. Amarowicz, J. Oszmianski et al., Pleiotropic effect of phenolic compounds content increases in transgenic flax plant, Journal of Agricultural and Food Chemistry, vol. 53, no. 9, pp. 3685-3692, 2005.
16. K. Lorenc-Kukula, M. Zuk, A. Kulma et al., Engineering flax with the GT family 1 Solanum sogarandinum glycosyltransferase SsGT1 confers increased resistance to fusarium infection, Journal of Agricultural and Food Chemistry, vol. 57, no. 15, pp. 6698-6705, 2009.
17. K. Hasiewicz-Derkacz, K. Kostyn, A. Kulma, T. Gebarowski, K. Gasiorowski, and J. Szopa, The properties of emulsion based on the ideal oil obtained from seed of transgenic flax plants overproducing phenylpropanoid compounds, FEBS Journal, vol. 280, pp. 518-519, 2013.
18. M. Czemplik, A. Kulma, K. Bazela, and J. Szopa, The biomedical potential of genetically modified flax seeds overexpressing the glucosyltransferase gene, BMC Complementary and Alternative Medicine, vol. 12, article 251, 2012.
19. K. Skorkowska-Telichowska, M. Zuk, A. Kulma et al., New dressing materials derived fromtransgenic flax products to treat long-standing venous ulcers-a pilot study, Wound Repair and Regeneration, vol. 18, no. 2, pp. 168-179, 2010.
20. K. Hasiewicz-Derkacz, A. Kulma, T. Czuj et al., Natural phenolics greatly increase flax (Linum usitatissimum) oil stability, BMC Biotechnology, vol. 15, no. 1, article 62, 2015.
21. M. Lukaszewicz, I. Matysiak-Kata, J. Skala, I. Fecka, W. Cisowski, and J. Szopa, Antioxidant capacity manipulation in transgenic potato tuber by changes in phenolic compounds content, Journal of Agricultural and Food Chemistry, vol. 52, no. 6, pp. 1526-1533, 2004.
22. A. Prescha, A. Swiedrych, J. Biernat, and J. Szopa, Increase in lipid content in potato tubers modified by 14-3-3 gene overexpression, Journal of Agricultural and Food Chemistry, vol. 49, no. 8, pp. 3638-3643, 2001.
23. A. Prescha, M. Grajzer, M. Dedyk, and H. Grajeta, The antioxidant activity and oxidative stability of cold-pressed oils, Journal of the American Oil Chemists Society, vol. 91, no. 8, pp. 1291-1301, 2014.
24. V. K. S. Shukla, P. C. Dutta, and W. E. Artz, Camelina oil and its unusual cholesterol content, Journal of the American Oil Chemists Society, vol. 79, no. 10, pp. 965-969, 2002.
25. A. Jaromin, R. Zarnowski, and A. Kozubek, Emulsions of oil fromAdenanthera pavonina L. seeds and their protective effect, Cellular and Molecular Biology Letters, vol. 11, no. 3, pp. 438-448, 2006.
26. Y. Li, Z. Cao, and H. Zhu, Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress, Pharmacological Research, vol. 53, no. 1, pp. 6-15, 2006.
27. V. Vichai and K. Kirtikara, Sulforhodamine B colorimetric assay for cytotoxicity screening, Nature Protocols, vol. 1, no. 3, pp. 1112-1116, 2006.
28. E. Eruslanov and S. Kusmartsev, Identification of ROS using oxidized DCFDA and flow-cytometry, Methods in Molecular Biology, vol. 594, pp. 57-72, 2010.
29. S. Roy, S. Khanna, K. Nallu, T. K. Hunt, and C. K. Sen, Dermal wound healing is subject to redox control, Molecular Therapy, vol. 13, no. 1, pp. 211-220, 2006.
30. A. E. K. Loo and B. Halliwell, Effects of hydrogen peroxide in a keratinocyte-fibroblast co-culture model of wound healing, Biochemical and Biophysical Research Communications, vol. 423, no. 2, pp. 253-258, 2012.
31. A. R. Collins, The comet assay for DNA damage and repair: principles, applications, and limitations, Applied Biochemistry and Biotechnology, vol. 26, no. 3, pp. 249-261, 2004.
32. K. Gasiorowski, B. Brokos, A. Kulma, A. Ogorzalek, and K. Skorkowska, Impact of four antimutagens on apoptosis in genotoxically damaged lymphocytes in vitro, Cellular and Molecular Biology Letters, vol. 6, no. 3, pp. 649-675, 2001.
33. V. Sapountzi and J. Cote, MYST-family histone acetyltransferases: beyond chromatin, Cellular andMolecular Life Sciences, vol. 68, no. 7, pp. 1147-1156, 2011.
34. I. B. Wall, R. Moseley, D. M. Baird et al., Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers, Journal of Investigative Dermatology, vol. 128, no. 10, pp. 2526-2540, 2008.
35. D. M. Kasote, Flaxseed phenolics as natural antioxidants, International Food Research Journal, vol. 20, no. 1, pp. 27-34, 2013.
36. V. Lattanzio, V. M. T. Lattanzio, and A. Cardinali, Role of phenolics in the resistance mechanisms of plants against fungal pathogens and insects, in Phytochemistry: Advances in Research, F. Imperato, Ed., pp. 23-67, Research Signpost, 2006.
37. S. M. Mandal, D. Chakraborty, and S. Dey, Phenolic acids act as signaling molecules in plant-microbe symbioses, Plant Signaling and Behavior, vol. 5, no. 4, pp. 359-368, 2010.
38. F. Afaq, D. N. Syed, A. Malik et al., Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human HaCaT keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosis, Journal of Investigative Dermatology, vol. 127, no. 1, pp. 222-232, 2007.
39. J. Neradil, R. Veselska, and J. Slanina, UVC-protective effect of caffeic acid on normal and transformed human skin cells in vitro, Folia Biologica, vol. 49, no. 5, pp. 197-202, 2003.
40. A. L. Ronco and E. De Stefani, Squalene: a multi-task link in the crossroads of cancer and aging, Functional Foods in Health and Disease, vol. 3, no. 12, p. 462, 2013.
41. B. J. Grattan Jr., Plant sterols as anticancer nutrients: evidence for their role in breast cancer, Nutrients, vol. 5, no. 2, pp. 359-387, 2013.
42. J. K. Winkler and K. Warner, The effect of phytosterol concentration on oxidative stability and thermal polymerization of heated oils, European Journal of Lipid Science and Technology, vol. 110, no. 5, pp. 455-464, 2008.
43. A. Singh, Sitosterol as an antioxidant in frying oils, Food Chemistry, vol. 137, no. 1-4, pp. 62-67, 2013.
44. D. J. Ruthig and K. A. Meckling-Gill, Both (n -3) and (n -6) fatty acids stimulate wound healing in the rat intestinal epithelial cell line, IEC-6,The Journal of Nutrition, vol. 129, no. 10, pp. 1791-1798, 1999.
45. B. Lipinski, Hydroxyl radical and its scavengers in health and disease, Oxidative Medicine and Cellular Longevity, vol. 2011, Article ID 809696, 9 pages, 2011.
46. M. Darvin, L. Zastrow, W. Sterry, and J. Lademann, Effect of supplemented and topically applied antioxidant substances on human tissue, Skin Pharmacology and Physiology, vol. 19, no. 5, pp. 238-247, 2006.
47. J. D. Lambert, J. Hong, G. Y. Yang, J. Liao, and C. S. Yang, Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations, The American Journal of Clinical Nutrition, vol. 81, no. 1, supplement, pp. 284S-291S, 2005.
48. T. M. Lima, C. C. Kanunfre, C. Pompeia, R. Verlengia, and R. Curi, Ranking the toxicity of fatty acids on Jurkat and Raji cells by flow cytometric analysis, Toxicology in Vitro, vol. 16, no. 6, pp. 741-747, 2002.
49. A. Vecchini, V. Ceccarelli, F. Susta et al., Dietary alphalinolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells, Journal of Lipid Research, vol. 45, no. 2, pp. 308-316, 2004.
50. S. Serini, E. Piccioni, N. Merendino, and G. Calviello, Dietary polyunsaturated fatty acids as inducers of apoptosis: implications for cancer, Apoptosis, vol. 14, no. 2, pp. 135-152, 2009.
51. Novartis, Ed., MF59 Adjuvant Fact Sheet, Novartis, 2009.
52. F. Mosca, E. Tritto, A. Muzzi et al., Molecular and cellular signatures of human vaccine adjuvants, Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 30, pp. 10501-10506, 2008.
53. L. Kalvodova, Squalene-based oil-in-water emulsion adjuvants perturb metabolism of neutral lipids and enhance lipid droplet formation, Biochemical and Biophysical Research Communications, vol. 393, no. 3, pp. 350-355, 2010.
54. A. Azzi, K. J. A. Davies, and F. Kelly, Free radical biology-terminology and critical thinking, FEBS Letters, vol. 558, no. 1-3, pp. 3-6, 2004.
55. A. Scalbert, I. T. Johnson, and M. Saltmarsh, Polyphenols: antioxidants and beyond, The American Journal of Clinical Nutrition, vol. 81, no. 1, supplement, pp. 215S-217S, 2005.
56. H. Sies, Polyphenols and health: update and perspectives, Archives of Biochemistry and Biophysics, vol. 501, no. 1, pp. 2-5, 2010.