Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2’-O-Methylation Mutant

PLoS Pathogens

Volumn 11, Issue 12, 2015, Pages

  Schmid, Bianca ^a   Rinas, Melanie ^a,b   Ruggieri, Alessia ^a   Acosta, Eliana Gisela ^a   Bartenschlager, Marie ^a   Reuter, Antje ^a   Fischl, Wolfgang ^a,c   Harder, Nathalie ^a   Bergeest, Jan Philip ^a   Flossdorf, Michael ^a,b   Rohr, Karl ^a   Höfer, Thomas ^a,b   Bartenschlager, Ralf ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c Haplogen GmbH   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

NONSTRUCTURAL PROTEIN 5; DENGUE VACCINE; INTERFERON; VIRUS RNA;

ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CONTENT VALIDITY; CONTROLLED STUDY; DENGUE VIRUS 2; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; IMAGE ANALYSIS; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; INTERFERON PRODUCTION; MATHEMATICAL MODEL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN METHYLATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; SINGLE CELL ANALYSIS; VALIDATION PROCESS; VIRUS PURIFICATION; VIRUS REPLICATION; WESTERN BLOTTING; CELL LINE; CELL SURVIVAL; DENGUE; DENGUE VIRUS; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HUMAN; IMMUNOLOGY; METHYLATION; REAL TIME POLYMERASE CHAIN REACTION; THEORETICAL MODEL;

CELL LINE; CELL SURVIVAL; DENGUE; DENGUE VACCINES; DENGUE VIRUS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOBLOTTING; INTERFERONS; METHYLATION; MODELS, THEORETICAL; REAL-TIME POLYMERASE CHAIN REACTION; RNA, VIRAL;

EID: 84953215262     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005345     Document Type: Article

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