Combining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon-α induced early antiviral signalling

FEBS Journal

Volumn 277, Issue 22, 2010, Pages 4741-4754

  Maiwald, Tim ^a   Schneider, Annette ^b   Busch, Hauke ^c   Sahle, Sven ^a   Gretz, Norbert ^a   Weiss, Thomas S ^d   Kummer, Ursula ^a   Klingmüller, Ursula ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

Antiviral signalling; Interferon ; IRF9; Kinetic model; Signal transduction

Indexed keywords

ALPHA INTERFERON; INTERFERON REGULATORY FACTOR 9; JANUS KINASE; STAT PROTEIN;

ARTICLE; CONTROLLED STUDY; HUMAN; INTRACELLULAR SIGNALING; KINETICS; MATHEMATICAL MODEL; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SIMULATION;

ANIMALS; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; INTERFERON-ALPHA; INTERFERON-STIMULATED GENE FACTOR 3, GAMMA SUBUNIT; MODELS, THEORETICAL; SIGNAL TRANSDUCTION; STAT2 TRANSCRIPTION FACTOR; VIRUSES;

EID: 78049247990     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07880.x     Document Type: Article

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