Enhanced FcRn-dependent transepithelial delivery of IgG by Fc-engineering and polymerization

Journal of Controlled Release

Volumn 223, Issue , 2016, Pages 42-52

  Foss, Stian ^a   Grevys, Algirdas ^a   Sand, Kine Marita Knudsen ^a   Bern, Malin ^a   Blundell, Pat ^d   Michaelsen, Terje E ^b,c   Pleass, Richard J ^d   Sandlie, Inger ^a   Andersen, Jan Terje ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

Epithelial; Fc fusion; FcRn; IgG; Mucosal barrier; pH dependent binding; Transcytosis

Indexed keywords

CELL CULTURE; CELLS; CONTROLLED DRUG DELIVERY; POLYMERIZATION; PROTEINS; TARGETED DRUG DELIVERY;

EPITHELIAL; FCRN; MUCOSAL BARRIERS; PH-DEPENDENT; TRANSCYTOSIS;

CELL ENGINEERING;

FC RECEPTOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; FC RECEPTOR, NEONATAL; HLA ANTIGEN CLASS 1; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; MONOCLONAL ANTIBODY;

ARTICLE; ASSAY; CELL TRANSPORT; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; ENGINEERING; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PH; POLYMERIZATION; PRIORITY JOURNAL; GENETICS; METABOLISM; PROTEIN ENGINEERING; TUMOR CELL LINE;

ANTIBODIES, MONOCLONAL; CELL LINE, TUMOR; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; POLYMERIZATION; PROTEIN ENGINEERING; RECEPTORS, FC; RECOMBINANT FUSION PROTEINS;

EID: 84952361181     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.12.033     Document Type: Article

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