Accurate localization of a fall in pH within the ileocecal region: Validation using a dual-scintigraphic technique

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 299, Issue 6, 2010, Pages

  Zarate, Natalia ^a   Mohammed, Sahar D ^a   O'Shaughnessy, Emma ^b   Newell, Margaret ^b   Yazaki, Etsuro ^a   Williams, Norman S ^a   Lunniss, Peter J ^a   Semler, Jack R ^c   Scott, S Mark ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b ROYAL LONDON HOSPITAL   (United Kingdom)

^c Smart Pill Corporation   (United States)

Author keywords

pH profile; Wireless (telemetric) capsule

Indexed keywords

EDETATE CHROMIUM CR 51; PENTETATE INDIUM IN 111;

ADULT; ANALYTICAL EQUIPMENT; ARTICLE; ASCENDING COLON; CECUM; FEMALE; GASTROINTESTINAL TRACT; HUMAN; HUMAN EXPERIMENT; ILEOCECAL VALVE; ILEUM; INGESTION; ISOTOPE LABELING; MALE; NASOTRACHEAL INTUBATION; NORMAL HUMAN; PH; PH MEASUREMENT; PRIORITY JOURNAL; SCINTIGRAPHY; SCINTILLATION CAMERA;

ADULT; CECUM; FEMALE; GASTROINTESTINAL TRANSIT; HUMANS; HYDROGEN-ION CONCENTRATION; ILEOCECAL VALVE; ILEUM; MALE; MIDDLE AGED; RADIONUCLIDE IMAGING; TELEMETRY;

EID: 78649730177     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00127.2010     Document Type: Article

References (47)

1. Basit AW. Advances in colonic drug delivery. Drugs 65: 1991-2007, 2005.
2. Bharucha AE. Constipation. Baillieres Best Pract Res Clin Gastroenterol 21: 709-731, 2007.
3. Bonapace ES, Maurer AH, Davidoff S, Krevsky B, Fisher RS, Parkman HP. Whole gut transit scintigraphy in the clinical evaluation of patients with upper and lower gastrointestinal symptoms. Am J Gastroenterol 95: 2838-2847, 2000.
4. Bown RL, Gibson JA, Sladen GE, Hicks B, Dawson AM. Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device. Gut 15: 999-1004, 1974.
5. Brinkworth GD, Noakes M, Clifton PM, Bird AR. Comparative effects of very low-carbohydrate, high-fat and high-carbohydrate, low-fat weight-loss diets on bowel habit and faecal short-chain fatty acids and bacterial populations. Br J Nutr 101: 1493-1502, 2009.
6. Camilleri M, Bharucha AE, di Lorenzo C, Hasler WL, Prather CM, Rao SS, Wald A. American Neurogastroenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice. Neurogastroenterol Motil 20: 1269-1282, 2008.
7. Chang L. Review article: epidemiology and quality of life in functional gastrointestinal disorders. Aliment Pharmacol Ther 20, Suppl 7: 31-39, 2004.
8. Charles F, Camilleri M, Phillips SF, Thomforde GM, Forstrom LA. Scintigraphy of the whole gut: clinical evaluation of transit disorders. Mayo Clin Proc 70: 113-118, 1995.
9. Chiarioni G, Salandini L, Whitehead WE. Biofeedback benefits only patients with outlet dysfunction, not patients with isolated slow transit constipation. Gastroenterology 129: 86-97, 2005.
10. Chiarioni G, Whitehead WE, Pezza V, Morelli A, Bassotti G. Biofeedback is superior to laxatives for normal transit constipation due to pelvic floor dyssynergia. Gastroenterology 130: 657-664, 2006.
11. Chourasia MK, Jain SK. Pharmaceutical approaches to colon targeted drug delivery systems. J Pharm Pharm Sci 6: 33-66, 2003.
12. Connell AM, McCall J, Misiewicz JJ, Rowlands EN. Observations on the clinical use of radio pills. Br Med J 2: 771-774, 1963.
13. Cook IJ, Talley NJ, Benninga MA, Rao SS, Scott SM. Chronic constipation: overview and challenges. Neurogastroenterol Motil 21, Suppl 2: 1-8, 2009.
14. Corazziari E. Definition and epidemiology of functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol 18: 613-631, 2004.
15. Cummings JH, Macfarlane GT. The control and consequences of bacterial fermentation in the human colon. J Appl Bacteriol 70: 443-459, 1991.
16. Dinning PG, Bampton PA, Andre J, Kennedy ML, Lubowski DZ, King DW, Cook IJ. Abnormal predefecatory colonic motor patterns define constipation in obstructed defecation. Gastroenterology 127: 49-56, 2004.
17. Dinning PG, Smith TK, Scott SM. Pathophysiology of colonic causes of chronic constipation. Neurogastroenterol Motil 21, Suppl 2: 20-30, 2009.
18. Duncan SH, Louis P, Thomson JM, Flint HJ. The role of pH in determining the species composition of the human colonic microbiota. Environ Microbiol 11: 2112-2122, 2009.
19. Evans DF, Pye G, Bramley R, Clark AG, Dyson TJ, Hardcastle JD. Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut 29: 1035-1041, 1988.
20. Everhart JE, Ruhl CE. Burden of digestive diseases in the United States part II: lower gastrointestinal diseases. Gastroenterology 136: 741-754, 2009.
21. Ewe K, Schwartz S, Petersen S, Press AG. Inflammation does not decrease intraluminal pH in chronic inflammatory bowel disease. Dig Dis Sci 44: 1434-1439, 1999.
22. Fallingborg J, Christensen LA, Ingeman-Nielsen M, Jacobsen BA, Abildgaard K, Rasmussen HH. pH-profile and regional transit times of the normal gut measured by a radiotelemetry device. Aliment Pharmacol Ther 3: 605-613, 1989.
23. Fell JT. Targeting of drugs and delivery systems to specific sites in the gastrointestinal tract. J Anat 189: 517-519, 1996.
24. Holdstock DJ, Misiewicz JJ, Smith T, Rowlands EW. Propulsion (mass movements) in the human colon and its relationship to meals and somatic activity. Gut 11: 91-99, 1970.
25. Hughes JS, Watson SJ, Jones AL, Oatway WB. Review of the radiation exposure of the UK population. J Radiol Prot 25: 493-496, 2005.
26. Knowles CH, Scott M, Lunniss PJ. Outcome of colectomy for slow transit constipation. Ann Surg 230: 627-638, 1999.
27. Kuo B, McCallum RW, Koch KL, Sitrin MD, Wo JM, Chey WD, Hasler WL, Lackner JM, Katz LA, Semler JR, Wilding GE, Parkman HP. Comparison of gastric emptying of a nondigestible capsule to a radio-labeled meal in healthy and gastroparetic subjects. Aliment Pharmacol Ther 27: 186-196, 2008.
28. Kumar D, Phillips SF. The contribution of external ligamentous attachments to function of the ileocecal junction. Dis Colon Rectum 30: 410-416, 1987.
29. Lembo A, Camilleri M. Chronic constipation. N Engl J Med 349: 1360-1368, 2003.
30. Lin HC, Prather C, Fisher RS, Meyer JH, Summers RW, Pimentel M, McCallum RW, Akkermans LM, Loening-Baucke V; AMS Task Force Committee on Gastrointestinal Transit. Measurement of gastrointestinal transit. Dig Dis Sci 50: 989-1004, 2005.
31. Macfarlane GT, Gibson GR, Cummings JH. Comparison of fermentation reactions in different regions of the human colon. J Appl Bacteriol 72: 57-64, 1992.
32. Maqbool S, Parkman HP, Friedenberg FK. Wireless capsule motility: comparison of the SmartPill GI monitoring system with scintigraphy for measuring whole gut transit. Dig Dis Sci 54: 2167-2174, 2009.
33. McOrist AL, Abell GC, Cooke C, Nyland K. Bacterial population dynamics and faecal short-chain fatty acid (SCFA) concentrations in healthy humans. Br J Nutr 100: 138-146, 2008.
34. Nugent SG, Kumar D, Rampton DS, Evans DF. Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs. Gut 48: 571-577, 2001.
35. Nyam DC, Pemberton JH, Ilstrup DM, Rath DM. Long-term results of surgery for chronic constipation. Dis Colon Rectum 40: 273-279, 1997.
36. Press AG, Hauptmann IA, Hauptmann L, Fuchs B, Fuchs M, Ewe K, Ramadori G. Gastrointestinal pH profiles in patients with inflammatory bowel disease. Aliment Pharmacol Ther 12: 673-678, 1998.
37. Rao SS, Welcher KD, Pelsang RE. Effects of biofeedback therapy on anorectal function in obstructive defecation. Dig Dis Sci 42: 2197-2205, 1997.
38. Rao SS, Ozturk R, Laine L. Clinical utility of diagnostic tests for constipation in adults: a systematic review. Am J Gastroenterol 100: 1605-1615, 2005.
39. Rao SS, Kuo B, McCallum RW, Chey WD, Dibaise JK, Hasler WL, Koch KL, Lackner JM, Miller C, Saad R, Semler JR, Sitrin MD, Wilding GE, Parkman HP. Investigation of colonic and whole-gut transit with wireless motility capsule and radioopaque markers in constipation. Clin Gastroenterol Hepatol 7: 537-544, 2009.
40. Redmond JM, Smith GW, Barofsky I, Ratych RE, Goldsborough DC, Schuster MM. Physiological tests to predict long-term outcome of total abdominal colectomy for intractable constipation. Am J Gastroenterol 90: 748-753, 1995.
41. Reynolds JR, Evans DF, Clarke AG, Hardcastle JD. Use of a portable radiotelemetry system to study the effect of mebeverine, ispaghula husk and combination therapy on colonic motor activity in healthy men. J Amb Monitoring 1: 223-232, 1988.
42. Scott SM, Picon L, Knowles CH, Fourquet F, Yazaki E, Williams NS, Lunniss PJ, Wingate DL. Automated quantitative analysis of nocturnal jejunal motor activity identifies abnormalities in individuals and subgroups of patients with slow transit constipation. Am J Gastroenterol 98: 1123-1134, 2003.
43. Stewart WF, Liberman JN, Sandler RS, Woods MS, Stemhagen A, Chee E, Lipton RB, Farup CE. Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features. Am J Gastroenterol 94: 3530-3540, 1999.
44. Thorburn HA, Carter KB, Goldberg JA, Finlay IG. Does ispaghula husk stimulate the entire colon in diverticular disease? Gut 33: 352-356, 1992.
45. Waller SL. Differential measurement of small and large bowel transit times in constipation and diarrhoea: a new approach. Gut 16: 372-378, 1975.
46. Watson BW, Meldrum SJ, Riddle HC, Brown RL, Sladen GE. pH profile of gut as measured by radiotelemetry capsule. Br Med J 2: 104-106, 1972.
47. Zarate N, Knowles CH, Yazaki E, Lunniss PJ, Scott SM. Clinical presentation and patterns of slow transit constipation do not predict coexistent upper gut dysmotility. Dig Dis Sci 54: 122-131, 2009.