Commentary: "There's been a flaw in our thinking"

Frontiers in Immunology

Volumn 6, Issue JUL, 2015, Pages

  Ward, E Sally ^a,b   Ober, Raimund J ^a,c  

^a TEXAS A M COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c Texas A M University   (United States)

Author keywords

FcRn; IgG; Pinocytosis; Subcellular trafficking; Transport

Indexed keywords

CELL SURFACE RECEPTOR; FC RECEPTOR; IMMUNOGLOBULIN G;

ANTIGEN PRESENTATION; BINDING AFFINITY; CELL MEMBRANE TRANSPORT; CELL MIGRATION; HUMAN; IMMUNOREGULATION; INTERNALIZATION; MOLECULAR RECOGNITION; MUCOSAL IMMUNITY; NOTE; PH; PINOCYTOSIS; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

EID: 84938493726     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00351     Document Type: Note

References (40)

1. Anderson CL. There's been a flaw in our thinking. Front Immunol (2014) 5:540. doi:10.3389/fimmu.2014.00540
2. Ghetie V, Hubbard JG, Kim JK, Tsen MF, Lee Y, Ward ES. Abnormally short serum half-lives of IgG in β2-microglobulin-deficient mice. Eur J Immunol (1996) 26(3):690-6. doi:10.1002/eji.1830260327
3. Dickinson BL, Badizadegan K, Wu Z, Ahouse JC, Zhu X, Simister NE, et al. Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line. J Clin Invest (1999) 104(7):903-11. doi:10.1172/JCI6968
4. Spiekermann GM, Finn PW, Ward ES, Dumont J, Dickinson BL, Blumberg RS, et al. Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung. J Exp Med (2002) 196(3):303-10. doi:10.1084/jem.20020400
5. McCarthy KM, Yoong Y, Simister NE. Bidirectional transcytosis of IgG by the rat neonatal Fc receptor expressed in a rat kidney cell line: a system to study protein transport across epithelia. J Cell Sci (2000) 113(Pt 7): 1277-85. http://jcs.biologists.org/content/113/7/1277.abstract
6. Brambell FWR, Hemmings WA, Morris IG. A theoretical model of γ-globulin catabolism. Nature (1964) 203:1352-5. doi:10.1038/2031352a0
7. Brambell FWR. The Transmission of Passive Immunity from Mother to Young. Amsterdam: North Holland Publ Corp (1970).
8. Rodewald R. pH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat. J Cell Biol (1976) 71(2):666-9. doi:10.1083/jcb.71.2.666
9. Simister NE, Rees AR. Isolation and characterization of an Fc receptor from neonatal rat small intestine. Eur J Immunol (1985) 15(7):733-8. doi:10.1002/eji.1830150718
10. Kim JK, Tsen MF, Ghetie V, Ward ES. Localization of the site of the murine IgG1 molecule that is involved in binding to the murine intestinal Fc receptor. Eur J Immunol (1994) 24(10):2429-34. doi:10.1002/eji.1830241025
11. Raghavan M, Chen MY, Gastinel LN, Bjorkman PJ. Investigation of the interaction between the class I MHC-related Fc receptor and its immunoglobulin G ligand. Immunity (1994) 1(4):303-15. doi:10.1016/1074-7613(94)90082-5
12. Ward ES, Ober RJ. Multitasking by exploitation of intracellular transport functions: the many faces of FcRn. Adv Immunol (2009) 103:77-115. doi:10.1016/S0065-2776(09)03004-1
13. Baker K, Rath T, Pyzik M, Blumberg RS. The role of FcRn in antigen presentation. Front Immunol (2014) 5:408. doi:10.3389/fimmu.2014.00408
14. Yoshida M, Kobayashi K, Kuo TT, Bry L, Glickman JN, Claypool SM, et al. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Invest (2006) 116(8):2142-51. doi:10.1172/JCI27821
15. Vidarsson G, Stemerding AM, Stapleton NM, Spliethoff SE, Janssen H, Rebers FE, et al. FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis. Blood (2006) 108(10):3573-9. doi:10.1182/blood-2006-05-024539
16. Ellinger I, Rothe A, Grill M, Fuchs R. Apical to basolateral transcytosis and apical recycling of immunoglobulin G in trophoblast-derived BeWo cells: effects of low temperature, nocodazole, and cytochalasin D. Exp Cell Res (2001) 269(2):322-31. doi:10.1006/excr.2001.5330
17. Kobayashi N, Suzuki Y, Tsuge T, Okumura K, Ra C, Tomino Y. FcRn-mediated transcytosis of immunoglobulin G in human renal proximal tubular epithelial cells. Am J Physiol Renal Physiol (2002) 282(2):F358-65. doi:10.1152/ajprenal.0164.2001
18. Ober RJ, Martinez C, Vaccaro C, Zhou J, Ward ES. Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn. J Immunol (2004) 172(4):2021-9. doi:10.4049/jimmunol.172.4.2021
19. Ober RJ, Martinez C, Lai X, Zhou J, Ward ES. Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level. Proc Natl Acad Sci U S A (2004) 101:11076-81. doi:10.1073/pnas.0402970101
20. Goebl NA, Babbey CM, Datta-Mannan A, Witcher DR, Wroblewski VJ, Dunn KW. Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cells. Mol Biol Cell (2008) 19(12):5490-505. doi:10.1091/mbc.E07-02-0101
21. Ward ES, Zhou J, Ghetie V, Ober RJ. Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans. Int Immunol (2003) 15(2):187-95. doi:10.1093/intimm/dxg018
22. Leitner K, Ellinger I, Grill M, Brabec M, Fuchs R. Efficient apical IgG recycling and apical-to-basolateral transcytosis in polarized BeWo cells overexpressing hFcRn. Placenta (2006) 27(8):799-811. doi:10.1016/j.placenta.2005.08.008
23. Vaccaro C, Zhou J, Ober RJ, Ward ES. Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels. Nat Biotechnol (2005) 23(10):1283-8. doi:10.1038/nbt1143
24. Vaccaro C, Bawdon R, Wanjie S, Ober RJ, Ward ES. Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies. Proc Natl Acad Sci U S A (2006) 103(49):18709-14. doi:10.1073/pnas.0606304103
25. Ram S, Prabhat P, Chao J, Ward ES, Ober RJ. High accuracy 3D quantum dot tracking with multifocal plane microscopy for the study of fast intracellular dynamics in live cells. Biophys J (2008) 95(12):6025-43. doi:10.1529/biophysj.108.140392
26. Gan Z, Ram S, Ober RJ, Ward ES. Using multifocal plane microscopy to reveal novel trafficking processes in the recycling pathway. J Cell Sci (2013) 126(Pt 5):1176-88. doi:10.1242/jcs.116327
27. Patel DA, Puig-Canto A, Challa DK, Perez Montoyo H, Ober RJ, Ward ES. Neonatal Fc receptor blockade by Fc engineering ameliorates arthritis in a murine model. J Immunol (2011) 187(2):1015-22. doi:10.4049/jimmunol.1003780
28. Swiercz R, Chiguru S, Tahmasbi A, Ramezani SM, Hao GY, Challa DK, et al. Use of Fc-engineered antibodies as clearing agents to increase contrast during PET. J Nucl Med (2014) 55(7):1204-7. doi:10.2967/jnumed.113.136481
29. Gan Z, Ram S, Vaccaro C, Ober RJ, Ward ES. Analyses of the recycling receptor, FcRn, in live cells reveal novel pathways for lysosomal delivery. Traffic (2009) 10(5):600-14. doi:10.1111/j.1600-0854.2009.00887.x
30. Hoogerwerf WA, Tsao SC, Devuyst O, Levine SA, Yun CH, Yip JW, et al. NHE2 and NHE3 are human and rabbit intestinal brush-border proteins. Am J Physiol (1996) 270(1 Pt 1):G29-41.
31. He W, Ladinsky MS, Huey-Tubman KE, Jensen GJ, McIntosh JR, Bjorkman PJ. FcRn-mediated antibody transport across epithelial cells revealed by electron tomography. Nature (2008) 455(7212):542-6. doi:10.1038/nature07255
32. Perez-Montoyo H, Vaccaro C, Hafner M, Ober RJ, Mueller W, Ward ES. Conditional deletion of the MHC Class I-related receptor, FcRn, reveals the sites of IgG homeostasis in mice. Proc Natl Acad Sci U S A (2009) 106(8):2788-93. doi:10.1073/pnas.0810796106
33. Claypool SM, Dickinson BL, Wagner JS, Johansen FE, Venu N, Borawski JA, et al. Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fc-γ receptor. Mol Biol Cell (2004) 15:1746-59. doi:10.1091/mbc.E03-11-0832
34. Tzaban S, Massol RH, Yen E, Hamman W, Frank SR, Lapierre LA, et al. The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. J Cell Biol (2009) 185(4):673-84. doi:10.1083/jcb.200809122
35. Jerdeva GV, Tesar DB, Huey-Tubman KE, Ladinsky MS, Fraser SE, Bjorkman PJ. Comparison of FcRn-and pIgR-mediated transport in MDCK cells by fluorescence confocal microscopy. Traffic (2010) 11(9):1205-20. doi:10.1111/j.1600-0854.2010.01083.x
36. Cooper PR, Kliwinski CM, Perkinson RA, Ragwan E, Mabus JR, Powers GD, et al. The contribution of cell surface FcRn in monoclonal antibody serum uptake from the intestine in suckling rat pups. Front Pharmacol (2014) 5:225. doi:10.3389/fphar.2014.00225
37. Zarate N, Mohammed SD, O'Shaughnessy E, Newell M, Yazaki E, Williams NS, et al. Accurate localization of a fall in pH within the ileocecal region: validation using a dual-scintigraphic technique. Am J Physiol Gastrointest Liver Physiol (2010) 299(6):G1276-86. doi:10.1152/ajpgi.00127.2010
38. Koziolek M, Grimm M, Becker D, Iordanov V, Zou H, Shimizu J, et al. Investigation of pH and temperature profiles in the GI tract of fasted human subjects using the intellicap system. J Pharm Sci (2014). doi:10.1002/jps.24274
39. Gharpure V, Meert KL, Sarnaik AP, Metheny NA. Indicators of postpyloric feeding tube placement in children. Crit Care Med (2000) 28(8):2962-6. doi:10.1097/00003246-200008000-00046
40. Irving SY, Lyman B, Northington L, Bartlett JA, Kemper C, Group NPW. Nasogastric tube placement and verification in children: review of the current literature. Nutr Clin Pract (2014) 29(3):267-76. doi:10.1177/0884533614531456