Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies

Journal of Biological Chemistry

Volumn 289, Issue 24, 2014, Pages 17228-17239

  Sand, Kine Marita Knudsen ^a,b   Dalhus, Bjørn ^b   Christianson, Gregory J ^c   Bern, Malin ^a,b   Foss, Stian ^a,b   Cameron, Jason ^d   Sleep, Darrell ^d   Bjørås, Magnar ^b   Roopenian, Derry C ^c   Sandlie, Inger ^a,b   Andersen, Jan Terje ^b  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c JACKSON LABORATORY   (United States)

^d Novozymes Biopharma DK A S   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; BINDING SITES; ENZYME ACTIVITY; METABOLITES; MONOCLONAL ANTIBODIES; PHYSIOLOGY; PROTEINS;

INTERACTION INTERFACE; INTRACELLULAR DEGRADATION; NEONATAL FC RECEPTORS; PROTEIN THERAPEUTICS; SITE DIRECTED MUTAGENESIS; STRUCTURAL DIFFERENCES; STRUCTURAL MODELING; TRYPTOPHAN RESIDUES;

DISSECTION;

ALBUMIN ANTIBODY; FC RECEPTOR; FC RECEPTOR ANTIBODY; HUMAN SERUM ALBUMIN; MONOCLONAL ANTIBODY; PROTEIN VARIANT; RECEPTOR ANTIBODY; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; HOMEOSTASIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BLOCKING; SITE DIRECTED MUTAGENESIS; SPECIES DIVERSITY; STRUCTURE ANALYSIS;

ALBUMIN; ANTIBODY; BIODEGRADATION; BIOENGINEERING; FC RECEPTOR; FCRN; HALF-LIFE; HYDROPHOBIC; PH REGULATION;

ALBUMINS; AMINO ACID SEQUENCE; ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; BINDING SITES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; RECEPTORS, FC;

EID: 84902449067     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.522565     Document Type: Article

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