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Volumn 156, Issue 3, 2014, Pages 400-407

Progeria: A paradigm for translational medicine

Author keywords

[No Author keywords available]

Indexed keywords

DNA; LAMIN A; LONAFARNIB; PRAVASTATIN; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RESVERATROL; RNA; ZOLEDRONIC ACID;

EID: 84893431595     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2013.12.028     Document Type: Note
Times cited : (207)

References (74)
  • 1
    • 0019420688 scopus 로고
    • Cardiovascular abnormalities in progeria. Case report and review of the literature
    • P.B. Baker, N. Baba, and C.P. Boesel Cardiovascular abnormalities in progeria. Case report and review of the literature Arch. Pathol. Lab. Med. 105 1981 384 386
    • (1981) Arch. Pathol. Lab. Med. , vol.105 , pp. 384-386
    • Baker, P.B.1    Baba, N.2    Boesel, C.P.3
  • 2
    • 77955385716 scopus 로고    scopus 로고
    • Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence
    • E.K. Benson, S.W. Lee, and S.A. Aaronson Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence J. Cell Sci. 123 2010 2605 2612
    • (2010) J. Cell Sci. , vol.123 , pp. 2605-2612
    • Benson, E.K.1    Lee, S.W.2    Aaronson, S.A.3
  • 3
    • 84871501642 scopus 로고    scopus 로고
    • The nuclear lamins: Flexibility in function
    • B. Burke, and C.L. Stewart The nuclear lamins: flexibility in function Nat. Rev. Mol. Cell Biol. 14 2013 13 24
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 13-24
    • Burke, B.1    Stewart, C.L.2
  • 4
    • 77954950116 scopus 로고    scopus 로고
    • Progeria syndromes and ageing: What is the connection?
    • C.R. Burtner, and B.K. Kennedy Progeria syndromes and ageing: what is the connection? Nat. Rev. Mol. Cell Biol. 11 2010 567 578
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 567-578
    • Burtner, C.R.1    Kennedy, B.K.2
  • 6
    • 79959776029 scopus 로고    scopus 로고
    • Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells
    • K. Cao, J.J. Graziotto, C.D. Blair, J.R. Mazzulli, M.R. Erdos, D. Krainc, and F.S. Collins Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells Sci. Transl. Med. 3 2011 89ra58
    • (2011) Sci. Transl. Med. , vol.3
    • Cao, K.1    Graziotto, J.J.2    Blair, C.D.3    Mazzulli, J.R.4    Erdos, M.R.5    Krainc, D.6    Collins, F.S.7
  • 10
    • 84864524683 scopus 로고    scopus 로고
    • Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation
    • J.C. Choi, A. Muchir, W. Wu, S. Iwata, S. Homma, J.P. Morrow, and H.J. Worman Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation Sci. Transl. Med. 4 2012 144ra102
    • (2012) Sci. Transl. Med. , vol.4
    • Choi, J.C.1    Muchir, A.2    Wu, W.3    Iwata, S.4    Homma, S.5    Morrow, J.P.6    Worman, H.J.7
  • 12
    • 77950273954 scopus 로고    scopus 로고
    • Mechanobiology and the microcirculation: Cellular, nuclear and fluid mechanics
    • K.N. Dahl, A. Kalinowski, and K. Pekkan Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics Microcirculation 17 2010 179 191
    • (2010) Microcirculation , vol.17 , pp. 179-191
    • Dahl, K.N.1    Kalinowski, A.2    Pekkan, K.3
  • 17
    • 33645060977 scopus 로고    scopus 로고
    • A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria
    • L.G. Fong, D. Frost, M. Meta, X. Qiao, S.H. Yang, C. Coffinier, and S.G. Young A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria Science 311 2006 1621 1623
    • (2006) Science , vol.311 , pp. 1621-1623
    • Fong, L.G.1    Frost, D.2    Meta, M.3    Qiao, X.4    Yang, S.H.5    Coffinier, C.6    Young, S.G.7
  • 19
    • 0001254975 scopus 로고
    • Progeria: A form of senilism
    • H. Gilford Progeria: A form of senilism Practitioner 73 1904 188 217
    • (1904) Practitioner , vol.73 , pp. 188-217
    • Gilford, H.1
  • 20
    • 27544498316 scopus 로고    scopus 로고
    • Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition
    • M.W. Glynn, and T.W. Glover Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition Hum. Mol. Genet. 14 2005 2959 2969
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 2959-2969
    • Glynn, M.W.1    Glover, T.W.2
  • 22
    • 84893488285 scopus 로고    scopus 로고
    • PRF By The Numbers (The Progeria Research Foundation)
    • Gordon, L.B. (2013). PRF By The Numbers (The Progeria Research Foundation). http://www.progeriaresearch.org/prf-by-the-numbers.html.
    • (2013)
    • Gordon, L.B.1
  • 23
    • 14844304398 scopus 로고    scopus 로고
    • Reduced adiponectin and HDL cholesterol without elevated C-reactive protein: Clues to the biology of premature atherosclerosis in Hutchinson-Gilford Progeria Syndrome
    • L.B. Gordon, I.A. Harten, M.E. Patti, and A.H. Lichtenstein Reduced adiponectin and HDL cholesterol without elevated C-reactive protein: clues to the biology of premature atherosclerosis in Hutchinson-Gilford Progeria Syndrome J. Pediatr. 146 2005 336 341
    • (2005) J. Pediatr. , vol.146 , pp. 336-341
    • Gordon, L.B.1    Harten, I.A.2    Patti, M.E.3    Lichtenstein, A.H.4
  • 26
    • 34047113394 scopus 로고    scopus 로고
    • Progeria of stem cells: Stem cell exhaustion in Hutchinson-Gilford progeria syndrome
    • J. Halaschek-Wiener, and A. Brooks-Wilson Progeria of stem cells: stem cell exhaustion in Hutchinson-Gilford progeria syndrome J. Gerontol. A Biol. Sci. Med. Sci. 62 2007 3 8
    • (2007) J. Gerontol. A Biol. Sci. Med. Sci. , vol.62 , pp. 3-8
    • Halaschek-Wiener, J.1    Brooks-Wilson, A.2
  • 27
    • 79959954439 scopus 로고    scopus 로고
    • The vascular adventitia: Its role in the arterial injury response
    • G.E. Havelka, and M.R. Kibbe The vascular adventitia: its role in the arterial injury response Vasc. Endovascular Surg. 45 2011 381 390
    • (2011) Vasc. Endovascular Surg. , vol.45 , pp. 381-390
    • Havelka, G.E.1    Kibbe, M.R.2
  • 29
    • 30744473703 scopus 로고    scopus 로고
    • Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference
    • S. Huang, L. Chen, N. Libina, J. Janes, G.M. Martin, J. Campisi, and J. Oshima Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference Hum. Genet. 118 2005 444 450
    • (2005) Hum. Genet. , vol.118 , pp. 444-450
    • Huang, S.1    Chen, L.2    Libina, N.3    Janes, J.4    Martin, G.M.5    Campisi, J.6    Oshima, J.7
  • 30
    • 0001546586 scopus 로고
    • Congenital absence of hair and mammary glands with atrophic condition of the skin and its appendages
    • J. Hutchinson Congenital absence of hair and mammary glands with atrophic condition of the skin and its appendages Med. Chir. Trans. 69 1886 473 477
    • (1886) Med. Chir. Trans. , vol.69 , pp. 473-477
    • Hutchinson, J.1
  • 31
    • 84878940945 scopus 로고    scopus 로고
    • Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria
    • M.X. Ibrahim, V.I. Sayin, M.K. Akula, M. Liu, L.G. Fong, S.G. Young, and M.O. Bergo Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria Science 340 2013 1330 1333
    • (2013) Science , vol.340 , pp. 1330-1333
    • Ibrahim, M.X.1    Sayin, V.I.2    Akula, M.K.3    Liu, M.4    Fong, L.G.5    Young, S.G.6    Bergo, M.O.7
  • 34
    • 84881268900 scopus 로고    scopus 로고
    • Moving from gene discovery to clinical trials in Hutchinson-Gilford progeria syndrome
    • A.A. King, and G.L. Heyer Moving from gene discovery to clinical trials in Hutchinson-Gilford progeria syndrome Neurology 81 2013 408 409
    • (2013) Neurology , vol.81 , pp. 408-409
    • King, A.A.1    Heyer, G.L.2
  • 35
    • 84856431819 scopus 로고    scopus 로고
    • RNA therapeutics: Beyond RNA interference and antisense oligonucleotides
    • R. Kole, A.R. Krainer, and S. Altman RNA therapeutics: beyond RNA interference and antisense oligonucleotides Nat. Rev. Drug Discov. 11 2012 125 140
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 125-140
    • Kole, R.1    Krainer, A.R.2    Altman, S.3
  • 36
    • 59449095581 scopus 로고    scopus 로고
    • Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53
    • B.A. Kudlow, M.N. Stanfel, C.R. Burtner, E.D. Johnston, and B.K. Kennedy Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53 Mol. Biol. Cell 19 2008 5238 5248
    • (2008) Mol. Biol. Cell , vol.19 , pp. 5238-5248
    • Kudlow, B.A.1    Stanfel, M.N.2    Burtner, C.R.3    Johnston, E.D.4    Kennedy, B.K.5
  • 37
    • 33845699084 scopus 로고    scopus 로고
    • DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A
    • Y. Liu, A. Rusinol, M. Sinensky, Y. Wang, and Y. Zou DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A J. Cell Sci. 119 2006 4644 4649
    • (2006) J. Cell Sci. , vol.119 , pp. 4644-4649
    • Liu, Y.1    Rusinol, A.2    Sinensky, M.3    Wang, Y.4    Zou, Y.5
  • 39
    • 84870506099 scopus 로고    scopus 로고
    • Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria
    • B. Liu, S. Ghosh, X. Yang, H. Zheng, X. Liu, Z. Wang, G. Jin, B. Zheng, B.K. Kennedy, and Y. Suh et al. Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria Cell Metab. 16 2012 738 750
    • (2012) Cell Metab. , vol.16 , pp. 738-750
    • Liu, B.1    Ghosh, S.2    Yang, X.3    Zheng, H.4    Liu, X.5    Wang, Z.6    Jin, G.7    Zheng, B.8    Kennedy, B.K.9    Suh, Y.10
  • 40
    • 84879808450 scopus 로고    scopus 로고
    • Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells
    • Y. Liu, I. Drozdov, R. Shroff, L.E. Beltran, and C.M. Shanahan Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells Circ. Res. 112 2013 e99 e109
    • (2013) Circ. Res. , vol.112
    • Liu, Y.1    Drozdov, I.2    Shroff, R.3    Beltran, L.E.4    Shanahan, C.M.5
  • 42
    • 79954992400 scopus 로고    scopus 로고
    • The role of cellular senescence during vascular calcification: A key paradigm in aging research
    • N.C. Mackenzie, and V.E. MacRae The role of cellular senescence during vascular calcification: a key paradigm in aging research Curr. Aging Sci. 4 2011 128 136
    • (2011) Curr. Aging Sci. , vol.4 , pp. 128-136
    • Mackenzie, N.C.1    Macrae, V.E.2
  • 43
    • 26444463068 scopus 로고    scopus 로고
    • Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome
    • M.P. Mallampalli, G. Huyer, P. Bendale, M.H. Gelb, and S. Michaelis Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome Proc. Natl. Acad. Sci. USA 102 2005 14416 14421
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 14416-14421
    • Mallampalli, M.P.1    Huyer, G.2    Bendale, P.3    Gelb, M.H.4    Michaelis, S.5
  • 45
    • 77957981121 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function
    • G. Mariño, A.P. Ugalde, A.F. Fernández, F.G. Osorio, A. Fueyo, J.M. Freije, and C. López-Otín Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function Proc. Natl. Acad. Sci. USA 107 2010 16268 16273
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 16268-16273
    • Mariño, G.1    Ugalde, A.P.2    Fernández, A.F.3    Osorio, F.G.4    Fueyo, A.5    Freije, J.M.6    López-Otín, C.7
  • 46
    • 41649101975 scopus 로고    scopus 로고
    • The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin
    • D. McClintock, D. Ratner, M. Lokuge, D.M. Owens, L.B. Gordon, F.S. Collins, and K. Djabali The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin PLoS ONE 2 2007 e1269
    • (2007) PLoS ONE , vol.2 , pp. 1269
    • McClintock, D.1    Ratner, D.2    Lokuge, M.3    Owens, D.M.4    Gordon, L.B.5    Collins, F.S.6    Djabali, K.7
  • 47
    • 84873349707 scopus 로고    scopus 로고
    • Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome
    • R.P. McCord, A. Nazario-Toole, H. Zhang, P.S. Chines, Y. Zhan, M.R. Erdos, F.S. Collins, J. Dekker, and K. Cao Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome Genome Res. 23 2013 260 269
    • (2013) Genome Res. , vol.23 , pp. 260-269
    • McCord, R.P.1    Nazario-Toole, A.2    Zhang, H.3    Chines, P.S.4    Zhan, Y.5    Erdos, M.R.6    Collins, F.S.7    Dekker, J.8    Cao, K.9
  • 49
    • 69949144385 scopus 로고    scopus 로고
    • Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A
    • P.R. Musich, and Y. Zou Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A Aging (Albany, N.Y. Online) 1 2009 28 37
    • (2009) Aging (Albany, N.Y. Online) , vol.1 , pp. 28-37
    • Musich, P.R.1    Zou, Y.2
  • 58
    • 67649188781 scopus 로고    scopus 로고
    • Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging
    • S. Rodriguez, F. Coppedè, H. Sagelius, and M. Eriksson Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging Eur. J. Hum. Genet. 17 2009 928 937
    • (2009) Eur. J. Hum. Genet. , vol.17 , pp. 928-937
    • Rodriguez, S.1    Coppedè, F.2    Sagelius, H.3    Eriksson, M.4
  • 59
    • 81155125086 scopus 로고    scopus 로고
    • Stem cell depletion in Hutchinson-Gilford progeria syndrome
    • Y. Rosengardten, T. McKenna, D. Grochová, and M. Eriksson Stem cell depletion in Hutchinson-Gilford progeria syndrome Aging Cell 10 2011 1011 1020
    • (2011) Aging Cell , vol.10 , pp. 1011-1020
    • Rosengardten, Y.1    McKenna, T.2    Grochová, D.3    Eriksson, M.4
  • 60
    • 17644373758 scopus 로고    scopus 로고
    • Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome
    • P. Scaffidi, and T. Misteli Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome Nat. Med. 11 2005 440 445
    • (2005) Nat. Med. , vol.11 , pp. 440-445
    • Scaffidi, P.1    Misteli, T.2
  • 61
    • 33646745137 scopus 로고    scopus 로고
    • Lamin A-dependent nuclear defects in human aging
    • P. Scaffidi, and T. Misteli Lamin A-dependent nuclear defects in human aging Science 312 2006 1059 1063
    • (2006) Science , vol.312 , pp. 1059-1063
    • Scaffidi, P.1    Misteli, T.2
  • 62
    • 43149124203 scopus 로고    scopus 로고
    • Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
    • P. Scaffidi, and T. Misteli Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing Nat. Cell Biol. 10 2008 452 459
    • (2008) Nat. Cell Biol. , vol.10 , pp. 452-459
    • Scaffidi, P.1    Misteli, T.2
  • 70
    • 84964846245 scopus 로고    scopus 로고
    • Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo
    • V. Wenzel, D. Roedl, D. Gabriel, L.B. Gordon, M. Herlyn, R. Schneider, J. Ring, and K. Djabali Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo Biol. Open 1 2012 516 526
    • (2012) Biol. Open , vol.1 , pp. 516-526
    • Wenzel, V.1    Roedl, D.2    Gabriel, D.3    Gordon, L.B.4    Herlyn, M.5    Schneider, R.6    Ring, J.7    Djabali, K.8
  • 71
    • 34249788998 scopus 로고    scopus 로고
    • "Laminopathies": A wide spectrum of human diseases
    • H.J. Worman, and G. Bonne "Laminopathies": a wide spectrum of human diseases Exp. Cell Res. 313 2007 2121 2133
    • (2007) Exp. Cell Res. , vol.313 , pp. 2121-2133
    • Worman, H.J.1    Bonne, G.2
  • 73
    • 39049111972 scopus 로고    scopus 로고
    • Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation
    • S.H. Yang, X. Qiao, L.G. Fong, and S.G. Young Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation Biochim. Biophys. Acta 1781 2008 36 39
    • (2008) Biochim. Biophys. Acta , vol.1781 , pp. 36-39
    • Yang, S.H.1    Qiao, X.2    Fong, L.G.3    Young, S.G.4


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