-
1
-
-
0019420688
-
Cardiovascular abnormalities in progeria. Case report and review of the literature
-
P.B. Baker, N. Baba, and C.P. Boesel Cardiovascular abnormalities in progeria. Case report and review of the literature Arch. Pathol. Lab. Med. 105 1981 384 386
-
(1981)
Arch. Pathol. Lab. Med.
, vol.105
, pp. 384-386
-
-
Baker, P.B.1
Baba, N.2
Boesel, C.P.3
-
2
-
-
77955385716
-
Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence
-
E.K. Benson, S.W. Lee, and S.A. Aaronson Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence J. Cell Sci. 123 2010 2605 2612
-
(2010)
J. Cell Sci.
, vol.123
, pp. 2605-2612
-
-
Benson, E.K.1
Lee, S.W.2
Aaronson, S.A.3
-
3
-
-
84871501642
-
The nuclear lamins: Flexibility in function
-
B. Burke, and C.L. Stewart The nuclear lamins: flexibility in function Nat. Rev. Mol. Cell Biol. 14 2013 13 24
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 13-24
-
-
Burke, B.1
Stewart, C.L.2
-
4
-
-
77954950116
-
Progeria syndromes and ageing: What is the connection?
-
C.R. Burtner, and B.K. Kennedy Progeria syndromes and ageing: what is the connection? Nat. Rev. Mol. Cell Biol. 11 2010 567 578
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 567-578
-
-
Burtner, C.R.1
Kennedy, B.K.2
-
5
-
-
79959928025
-
Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts
-
K. Cao, C.D. Blair, D.A. Faddah, J.E. Kieckhaefer, M. Olive, M.R. Erdos, E.G. Nabel, and F.S. Collins Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts J. Clin. Invest. 121 2011 2833 2844
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 2833-2844
-
-
Cao, K.1
Blair, C.D.2
Faddah, D.A.3
Kieckhaefer, J.E.4
Olive, M.5
Erdos, M.R.6
Nabel, E.G.7
Collins, F.S.8
-
6
-
-
79959776029
-
Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells
-
K. Cao, J.J. Graziotto, C.D. Blair, J.R. Mazzulli, M.R. Erdos, D. Krainc, and F.S. Collins Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells Sci. Transl. Med. 3 2011 89ra58
-
(2011)
Sci. Transl. Med.
, vol.3
-
-
Cao, K.1
Graziotto, J.J.2
Blair, C.D.3
Mazzulli, J.R.4
Erdos, M.R.5
Krainc, D.6
Collins, F.S.7
-
7
-
-
24644520772
-
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome
-
B.C. Capell, M.R. Erdos, J.P. Madigan, J.J. Fiordalisi, R. Varga, K.N. Conneely, L.B. Gordon, C.J. Der, A.D. Cox, and F.S. Collins Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome Proc. Natl. Acad. Sci. USA 102 2005 12879 12884
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 12879-12884
-
-
Capell, B.C.1
Erdos, M.R.2
Madigan, J.P.3
Fiordalisi, J.J.4
Varga, R.5
Conneely, K.N.6
Gordon, L.B.7
Der, C.J.8
Cox, A.D.9
Collins, F.S.10
-
8
-
-
57349159315
-
A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model
-
B.C. Capell, M. Olive, M.R. Erdos, K. Cao, D.A. Faddah, U.L. Tavarez, K.N. Conneely, X. Qu, H. San, and S.K. Ganesh et al. A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model Proc. Natl. Acad. Sci. USA 105 2008 15902 15907
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 15902-15907
-
-
Capell, B.C.1
Olive, M.2
Erdos, M.R.3
Cao, K.4
Faddah, D.A.5
Tavarez, U.L.6
Conneely, K.N.7
Qu, X.8
San, H.9
Ganesh, S.K.10
-
9
-
-
80054746923
-
Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria
-
V. Cenni, C. Capanni, M. Columbaro, M. Ortolani, M.R. D'Apice, G. Novelli, M. Fini, S. Marmiroli, E. Scarano, and N.M. Maraldi et al. Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria Eur. J. Histochem. 55 2011 e36
-
(2011)
Eur. J. Histochem.
, vol.55
, pp. 36
-
-
Cenni, V.1
Capanni, C.2
Columbaro, M.3
Ortolani, M.4
D'Apice, M.R.5
Novelli, G.6
Fini, M.7
Marmiroli, S.8
Scarano, E.9
Maraldi, N.M.10
-
10
-
-
84864524683
-
Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation
-
J.C. Choi, A. Muchir, W. Wu, S. Iwata, S. Homma, J.P. Morrow, and H.J. Worman Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation Sci. Transl. Med. 4 2012 144ra102
-
(2012)
Sci. Transl. Med.
, vol.4
-
-
Choi, J.C.1
Muchir, A.2
Wu, W.3
Iwata, S.4
Homma, S.5
Morrow, J.P.6
Worman, H.J.7
-
11
-
-
84866729769
-
A prospective study of radiographic manifestations in Hutchinson-Gilford progeria syndrome
-
R.H. Cleveland, L.B. Gordon, M.E. Kleinman, D.T. Miller, C.M. Gordon, B.D. Snyder, A. Nazarian, A. Giobbie-Hurder, D. Neuberg, and M.W. Kieran A prospective study of radiographic manifestations in Hutchinson-Gilford progeria syndrome Pediatr. Radiol. 42 2012 1089 1098
-
(2012)
Pediatr. Radiol.
, vol.42
, pp. 1089-1098
-
-
Cleveland, R.H.1
Gordon, L.B.2
Kleinman, M.E.3
Miller, D.T.4
Gordon, C.M.5
Snyder, B.D.6
Nazarian, A.7
Giobbie-Hurder, A.8
Neuberg, D.9
Kieran, M.W.10
-
12
-
-
77950273954
-
Mechanobiology and the microcirculation: Cellular, nuclear and fluid mechanics
-
K.N. Dahl, A. Kalinowski, and K. Pekkan Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics Microcirculation 17 2010 179 191
-
(2010)
Microcirculation
, vol.17
, pp. 179-191
-
-
Dahl, K.N.1
Kalinowski, A.2
Pekkan, K.3
-
13
-
-
84882312902
-
Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion
-
J. de la Rosa, J.M. Freije, R. Cabanillas, F.G. Osorio, M.F. Fraga, M.S. Fernandez-Garcia, R. Rad, V. Fanjul, A.P. Ugalde, and Q. Liang et al. Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion Nat. Commun. 4 2013 2268
-
(2013)
Nat. Commun.
, vol.4
, pp. 2268
-
-
De La Rosa, J.1
Freije, J.M.2
Cabanillas, R.3
Osorio, F.G.4
Fraga, M.F.5
Fernandez-Garcia, M.S.6
Rad, R.7
Fanjul, V.8
Ugalde, A.P.9
Liang, Q.10
-
14
-
-
10744229294
-
Lamin a truncation in Hutchinson-Gilford progeria
-
A. De Sandre-Giovannoli, R. Bernard, P. Cau, C. Navarro, J. Amiel, I. Boccaccio, S. Lyonnet, C.L. Stewart, A. Munnich, M. Le Merrer, and N. Lévy Lamin a truncation in Hutchinson-Gilford progeria Science 300 2003 2055
-
(2003)
Science
, vol.300
, pp. 2055
-
-
De Sandre-Giovannoli, A.1
Bernard, R.2
Cau, P.3
Navarro, C.4
Amiel, J.5
Boccaccio, I.6
Lyonnet, S.7
Stewart, C.L.8
Munnich, A.9
Le Merrer, M.10
Lévy, N.11
-
15
-
-
0037673950
-
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome
-
M. Eriksson, W.T. Brown, L.B. Gordon, M.W. Glynn, J. Singer, L. Scott, M.R. Erdos, C.M. Robbins, T.Y. Moses, and P. Berglund et al. Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome Nature 423 2003 293 298
-
(2003)
Nature
, vol.423
, pp. 293-298
-
-
Eriksson, M.1
Brown, W.T.2
Gordon, L.B.3
Glynn, M.W.4
Singer, J.5
Scott, L.6
Erdos, M.R.7
Robbins, C.M.8
Moses, T.Y.9
Berglund, P.10
-
16
-
-
42049117585
-
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice
-
J. Espada, I. Varela, I. Flores, A.P. Ugalde, J. Cadiñanos, A.M. Pendás, C.L. Stewart, K. Tryggvason, M.A. Blasco, J.M. Freije, and C. López-Otín Nuclear envelope defects cause stem cell dysfunction in premature-aging mice J. Cell Biol. 181 2008 27 35
-
(2008)
J. Cell Biol.
, vol.181
, pp. 27-35
-
-
Espada, J.1
Varela, I.2
Flores, I.3
Ugalde, A.P.4
Cadiñanos, J.5
Pendás, A.M.6
Stewart, C.L.7
Tryggvason, K.8
Blasco, M.A.9
Freije, J.M.10
López-Otín, C.11
-
17
-
-
33645060977
-
A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria
-
L.G. Fong, D. Frost, M. Meta, X. Qiao, S.H. Yang, C. Coffinier, and S.G. Young A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria Science 311 2006 1621 1623
-
(2006)
Science
, vol.311
, pp. 1621-1623
-
-
Fong, L.G.1
Frost, D.2
Meta, M.3
Qiao, X.4
Yang, S.H.5
Coffinier, C.6
Young, S.G.7
-
18
-
-
83655167073
-
Mechanisms of premature vascular aging in children with Hutchinson-Gilford progeria syndrome
-
M. Gerhard-Herman, L.B. Smoot, N. Wake, M.W. Kieran, M.E. Kleinman, D.T. Miller, A. Schwartzman, A. Giobbie-Hurder, D. Neuberg, and L.B. Gordon Mechanisms of premature vascular aging in children with Hutchinson-Gilford progeria syndrome Hypertension 59 2012 92 97
-
(2012)
Hypertension
, vol.59
, pp. 92-97
-
-
Gerhard-Herman, M.1
Smoot, L.B.2
Wake, N.3
Kieran, M.W.4
Kleinman, M.E.5
Miller, D.T.6
Schwartzman, A.7
Giobbie-Hurder, A.8
Neuberg, D.9
Gordon, L.B.10
-
19
-
-
0001254975
-
Progeria: A form of senilism
-
H. Gilford Progeria: A form of senilism Practitioner 73 1904 188 217
-
(1904)
Practitioner
, vol.73
, pp. 188-217
-
-
Gilford, H.1
-
20
-
-
27544498316
-
Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition
-
M.W. Glynn, and T.W. Glover Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition Hum. Mol. Genet. 14 2005 2959 2969
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 2959-2969
-
-
Glynn, M.W.1
Glover, T.W.2
-
21
-
-
2942643923
-
Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome
-
R.D. Goldman, D.K. Shumaker, M.R. Erdos, M. Eriksson, A.E. Goldman, L.B. Gordon, Y. Gruenbaum, S. Khuon, M. Mendez, R. Varga, and F.S. Collins Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome Proc. Natl. Acad. Sci. USA 101 2004 8963 8968
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 8963-8968
-
-
Goldman, R.D.1
Shumaker, D.K.2
Erdos, M.R.3
Eriksson, M.4
Goldman, A.E.5
Gordon, L.B.6
Gruenbaum, Y.7
Khuon, S.8
Mendez, M.9
Varga, R.10
Collins, F.S.11
-
22
-
-
84893488285
-
-
PRF By The Numbers (The Progeria Research Foundation)
-
Gordon, L.B. (2013). PRF By The Numbers (The Progeria Research Foundation). http://www.progeriaresearch.org/prf-by-the-numbers.html.
-
(2013)
-
-
Gordon, L.B.1
-
23
-
-
14844304398
-
Reduced adiponectin and HDL cholesterol without elevated C-reactive protein: Clues to the biology of premature atherosclerosis in Hutchinson-Gilford Progeria Syndrome
-
L.B. Gordon, I.A. Harten, M.E. Patti, and A.H. Lichtenstein Reduced adiponectin and HDL cholesterol without elevated C-reactive protein: clues to the biology of premature atherosclerosis in Hutchinson-Gilford Progeria Syndrome J. Pediatr. 146 2005 336 341
-
(2005)
J. Pediatr.
, vol.146
, pp. 336-341
-
-
Gordon, L.B.1
Harten, I.A.2
Patti, M.E.3
Lichtenstein, A.H.4
-
24
-
-
79959494879
-
Hutchinson-Gilford progeria is a skeletal dysplasia
-
C.M. Gordon, L.B. Gordon, B.D. Snyder, A. Nazarian, N. Quinn, S. Huh, A. Giobbie-Hurder, D. Neuberg, R. Cleveland, and M. Kleinman et al. Hutchinson-Gilford progeria is a skeletal dysplasia J. Bone Miner. Res. 26 2011 1670 1679
-
(2011)
J. Bone Miner. Res.
, vol.26
, pp. 1670-1679
-
-
Gordon, C.M.1
Gordon, L.B.2
Snyder, B.D.3
Nazarian, A.4
Quinn, N.5
Huh, S.6
Giobbie-Hurder, A.7
Neuberg, D.8
Cleveland, R.9
Kleinman, M.10
-
25
-
-
84867380060
-
Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome
-
L.B. Gordon, M.E. Kleinman, D.T. Miller, D.S. Neuberg, A. Giobbie-Hurder, M. Gerhard-Herman, L.B. Smoot, C.M. Gordon, R. Cleveland, and B.D. Snyder et al. Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome Proc. Natl. Acad. Sci. USA 109 2012 16666 16671
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 16666-16671
-
-
Gordon, L.B.1
Kleinman, M.E.2
Miller, D.T.3
Neuberg, D.S.4
Giobbie-Hurder, A.5
Gerhard-Herman, M.6
Smoot, L.B.7
Gordon, C.M.8
Cleveland, R.9
Snyder, B.D.10
-
26
-
-
34047113394
-
Progeria of stem cells: Stem cell exhaustion in Hutchinson-Gilford progeria syndrome
-
J. Halaschek-Wiener, and A. Brooks-Wilson Progeria of stem cells: stem cell exhaustion in Hutchinson-Gilford progeria syndrome J. Gerontol. A Biol. Sci. Med. Sci. 62 2007 3 8
-
(2007)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.62
, pp. 3-8
-
-
Halaschek-Wiener, J.1
Brooks-Wilson, A.2
-
27
-
-
79959954439
-
The vascular adventitia: Its role in the arterial injury response
-
G.E. Havelka, and M.R. Kibbe The vascular adventitia: its role in the arterial injury response Vasc. Endovascular Surg. 45 2011 381 390
-
(2011)
Vasc. Endovascular Surg.
, vol.45
, pp. 381-390
-
-
Havelka, G.E.1
Kibbe, M.R.2
-
28
-
-
81955161812
-
Coronary artery disease in a Werner syndrome-like form of progeria characterized by low levels of progerin, a splice variant of lamin A
-
F.M. Hisama, D. Lessel, D. Leistritz, K. Friedrich, K.L. McBride, M.T. Pastore, G.S. Gottesman, B. Saha, G.M. Martin, C. Kubisch, and J. Oshima Coronary artery disease in a Werner syndrome-like form of progeria characterized by low levels of progerin, a splice variant of lamin A Am. J. Med. Genet. A. 155A 2011 3002 3006
-
(2011)
Am. J. Med. Genet. A.
, vol.155 A
, pp. 3002-3006
-
-
Hisama, F.M.1
Lessel, D.2
Leistritz, D.3
Friedrich, K.4
McBride, K.L.5
Pastore, M.T.6
Gottesman, G.S.7
Saha, B.8
Martin, G.M.9
Kubisch, C.10
Oshima, J.11
-
29
-
-
30744473703
-
Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference
-
S. Huang, L. Chen, N. Libina, J. Janes, G.M. Martin, J. Campisi, and J. Oshima Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference Hum. Genet. 118 2005 444 450
-
(2005)
Hum. Genet.
, vol.118
, pp. 444-450
-
-
Huang, S.1
Chen, L.2
Libina, N.3
Janes, J.4
Martin, G.M.5
Campisi, J.6
Oshima, J.7
-
30
-
-
0001546586
-
Congenital absence of hair and mammary glands with atrophic condition of the skin and its appendages
-
J. Hutchinson Congenital absence of hair and mammary glands with atrophic condition of the skin and its appendages Med. Chir. Trans. 69 1886 473 477
-
(1886)
Med. Chir. Trans.
, vol.69
, pp. 473-477
-
-
Hutchinson, J.1
-
31
-
-
84878940945
-
Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria
-
M.X. Ibrahim, V.I. Sayin, M.K. Akula, M. Liu, L.G. Fong, S.G. Young, and M.O. Bergo Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria Science 340 2013 1330 1333
-
(2013)
Science
, vol.340
, pp. 1330-1333
-
-
Ibrahim, M.X.1
Sayin, V.I.2
Akula, M.K.3
Liu, M.4
Fong, L.G.5
Young, S.G.6
Bergo, M.O.7
-
32
-
-
84863115487
-
Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA
-
H.J. Jung, C. Coffinier, Y. Choe, A.P. Beigneux, B.S. Davies, S.H. Yang, R.H. Barnes 2nd, J. Hong, T. Sun, and S.J. Pleasure et al. Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA Proc. Natl. Acad. Sci. USA 109 2012 E423 E431
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
-
-
Jung, H.J.1
Coffinier, C.2
Choe, Y.3
Beigneux, A.P.4
Davies, B.S.5
Yang, S.H.6
Barnes II, R.H.7
Hong, J.8
Sun, T.9
Pleasure, S.J.10
-
34
-
-
84881268900
-
Moving from gene discovery to clinical trials in Hutchinson-Gilford progeria syndrome
-
A.A. King, and G.L. Heyer Moving from gene discovery to clinical trials in Hutchinson-Gilford progeria syndrome Neurology 81 2013 408 409
-
(2013)
Neurology
, vol.81
, pp. 408-409
-
-
King, A.A.1
Heyer, G.L.2
-
35
-
-
84856431819
-
RNA therapeutics: Beyond RNA interference and antisense oligonucleotides
-
R. Kole, A.R. Krainer, and S. Altman RNA therapeutics: beyond RNA interference and antisense oligonucleotides Nat. Rev. Drug Discov. 11 2012 125 140
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 125-140
-
-
Kole, R.1
Krainer, A.R.2
Altman, S.3
-
36
-
-
59449095581
-
Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53
-
B.A. Kudlow, M.N. Stanfel, C.R. Burtner, E.D. Johnston, and B.K. Kennedy Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53 Mol. Biol. Cell 19 2008 5238 5248
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 5238-5248
-
-
Kudlow, B.A.1
Stanfel, M.N.2
Burtner, C.R.3
Johnston, E.D.4
Kennedy, B.K.5
-
37
-
-
33845699084
-
DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A
-
Y. Liu, A. Rusinol, M. Sinensky, Y. Wang, and Y. Zou DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A J. Cell Sci. 119 2006 4644 4649
-
(2006)
J. Cell Sci.
, vol.119
, pp. 4644-4649
-
-
Liu, Y.1
Rusinol, A.2
Sinensky, M.3
Wang, Y.4
Zou, Y.5
-
38
-
-
79957866291
-
Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs
-
G.H. Liu, K. Suzuki, J. Qu, I. Sancho-Martinez, F. Yi, M. Li, S. Kumar, E. Nivet, J. Kim, and R.D. Soligalla et al. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs Cell Stem Cell 8 2011 688 694
-
(2011)
Cell Stem Cell
, vol.8
, pp. 688-694
-
-
Liu, G.H.1
Suzuki, K.2
Qu, J.3
Sancho-Martinez, I.4
Yi, F.5
Li, M.6
Kumar, S.7
Nivet, E.8
Kim, J.9
Soligalla, R.D.10
-
39
-
-
84870506099
-
Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria
-
B. Liu, S. Ghosh, X. Yang, H. Zheng, X. Liu, Z. Wang, G. Jin, B. Zheng, B.K. Kennedy, and Y. Suh et al. Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria Cell Metab. 16 2012 738 750
-
(2012)
Cell Metab.
, vol.16
, pp. 738-750
-
-
Liu, B.1
Ghosh, S.2
Yang, X.3
Zheng, H.4
Liu, X.5
Wang, Z.6
Jin, G.7
Zheng, B.8
Kennedy, B.K.9
Suh, Y.10
-
40
-
-
84879808450
-
Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells
-
Y. Liu, I. Drozdov, R. Shroff, L.E. Beltran, and C.M. Shanahan Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells Circ. Res. 112 2013 e99 e109
-
(2013)
Circ. Res.
, vol.112
-
-
Liu, Y.1
Drozdov, I.2
Shroff, R.3
Beltran, L.E.4
Shanahan, C.M.5
-
41
-
-
84878864199
-
The hallmarks of aging
-
C. López-Otín, M.A. Blasco, L. Partridge, M. Serrano, and G. Kroemer The hallmarks of aging Cell 153 2013 1194 1217
-
(2013)
Cell
, vol.153
, pp. 1194-1217
-
-
López-Otín, C.1
Blasco, M.A.2
Partridge, L.3
Serrano, M.4
Kroemer, G.5
-
42
-
-
79954992400
-
The role of cellular senescence during vascular calcification: A key paradigm in aging research
-
N.C. Mackenzie, and V.E. MacRae The role of cellular senescence during vascular calcification: a key paradigm in aging research Curr. Aging Sci. 4 2011 128 136
-
(2011)
Curr. Aging Sci.
, vol.4
, pp. 128-136
-
-
Mackenzie, N.C.1
Macrae, V.E.2
-
43
-
-
26444463068
-
Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome
-
M.P. Mallampalli, G. Huyer, P. Bendale, M.H. Gelb, and S. Michaelis Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome Proc. Natl. Acad. Sci. USA 102 2005 14416 14421
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 14416-14421
-
-
Mallampalli, M.P.1
Huyer, G.2
Bendale, P.3
Gelb, M.H.4
Michaelis, S.5
-
44
-
-
46249086799
-
Premature aging in mice activates a systemic metabolic response involving autophagy induction
-
G. Mariño, A.P. Ugalde, N. Salvador-Montoliu, I. Varela, P.M. Quirós, J. Cadiñanos, I. van der Pluijm, J.M. Freije, and C. López-Otín Premature aging in mice activates a systemic metabolic response involving autophagy induction Hum. Mol. Genet. 17 2008 2196 2211
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 2196-2211
-
-
Mariño, G.1
Ugalde, A.P.2
Salvador-Montoliu, N.3
Varela, I.4
Quirós, P.M.5
Cadiñanos, J.6
Van Der Pluijm, I.7
Freije, J.M.8
López-Otín, C.9
-
45
-
-
77957981121
-
Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function
-
G. Mariño, A.P. Ugalde, A.F. Fernández, F.G. Osorio, A. Fueyo, J.M. Freije, and C. López-Otín Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function Proc. Natl. Acad. Sci. USA 107 2010 16268 16273
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 16268-16273
-
-
Mariño, G.1
Ugalde, A.P.2
Fernández, A.F.3
Osorio, F.G.4
Fueyo, A.5
Freije, J.M.6
López-Otín, C.7
-
46
-
-
41649101975
-
The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin
-
D. McClintock, D. Ratner, M. Lokuge, D.M. Owens, L.B. Gordon, F.S. Collins, and K. Djabali The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin PLoS ONE 2 2007 e1269
-
(2007)
PLoS ONE
, vol.2
, pp. 1269
-
-
McClintock, D.1
Ratner, D.2
Lokuge, M.3
Owens, D.M.4
Gordon, L.B.5
Collins, F.S.6
Djabali, K.7
-
47
-
-
84873349707
-
Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome
-
R.P. McCord, A. Nazario-Toole, H. Zhang, P.S. Chines, Y. Zhan, M.R. Erdos, F.S. Collins, J. Dekker, and K. Cao Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome Genome Res. 23 2013 260 269
-
(2013)
Genome Res.
, vol.23
, pp. 260-269
-
-
McCord, R.P.1
Nazario-Toole, A.2
Zhang, H.3
Chines, P.S.4
Zhan, Y.5
Erdos, M.R.6
Collins, F.S.7
Dekker, J.8
Cao, K.9
-
48
-
-
38949105879
-
Phenotype and course of Hutchinson-Gilford progeria syndrome
-
M.A. Merideth, L.B. Gordon, S. Clauss, V. Sachdev, A.C. Smith, M.B. Perry, C.C. Brewer, C. Zalewski, H.J. Kim, and B. Solomon et al. Phenotype and course of Hutchinson-Gilford progeria syndrome N. Engl. J. Med. 358 2008 592 604
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 592-604
-
-
Merideth, M.A.1
Gordon, L.B.2
Clauss, S.3
Sachdev, V.4
Smith, A.C.5
Perry, M.B.6
Brewer, C.C.7
Zalewski, C.8
Kim, H.J.9
Solomon, B.10
-
49
-
-
69949144385
-
Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A
-
P.R. Musich, and Y. Zou Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A Aging (Albany, N.Y. Online) 1 2009 28 37
-
(2009)
Aging (Albany, N.Y. Online)
, vol.1
, pp. 28-37
-
-
Musich, P.R.1
Zou, Y.2
-
50
-
-
84864317150
-
Unique preservation of neural cells in Hutchinson- Gilford progeria syndrome is due to the expression of the neural-specific miR-9 microRNA
-
X. Nissan, S. Blondel, C. Navarro, Y. Maury, C. Denis, M. Girard, C. Martinat, A. De Sandre-Giovannoli, N. Levy, and M. Peschanski Unique preservation of neural cells in Hutchinson- Gilford progeria syndrome is due to the expression of the neural-specific miR-9 microRNA Cell Rep. 2 2012 1 9
-
(2012)
Cell Rep.
, vol.2
, pp. 1-9
-
-
Nissan, X.1
Blondel, S.2
Navarro, C.3
Maury, Y.4
Denis, C.5
Girard, M.6
Martinat, C.7
De Sandre-Giovannoli, A.8
Levy, N.9
Peschanski, M.10
-
51
-
-
78149283243
-
Cardiovascular pathology in Hutchinson-Gilford progeria: Correlation with the vascular pathology of aging
-
M. Olive, I. Harten, R. Mitchell, J.K. Beers, K. Djabali, K. Cao, M.R. Erdos, C. Blair, B. Funke, and L. Smoot et al. Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging Arterioscler. Thromb. Vasc. Biol. 30 2010 2301 2309
-
(2010)
Arterioscler. Thromb. Vasc. Biol.
, vol.30
, pp. 2301-2309
-
-
Olive, M.1
Harten, I.2
Mitchell, R.3
Beers, J.K.4
Djabali, K.5
Cao, K.6
Erdos, M.R.7
Blair, C.8
Funke, B.9
Smoot, L.10
-
52
-
-
80054886882
-
Splicing-directed therapy in a new mouse model of human accelerated aging
-
F.G. Osorio, C.L. Navarro, J. Cadinanos, I.C. Lopez-Mejia, P.M. Quiros, C. Bartoli, J. Rivera, J. Tazi, G. Guzman, and I. Varela et al. Splicing-directed therapy in a new mouse model of human accelerated aging Sci. Transl. Med. 3 2011 106ra107
-
(2011)
Sci. Transl. Med.
, vol.3
-
-
Osorio, F.G.1
Navarro, C.L.2
Cadinanos, J.3
Lopez-Mejia, I.C.4
Quiros, P.M.5
Bartoli, C.6
Rivera, J.7
Tazi, J.8
Guzman, G.9
Varela, I.10
-
53
-
-
84867736667
-
Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response
-
F.G. Osorio, C. Bárcena, C. Soria-Valles, A.J. Ramsay, F. de Carlos, J. Cobo, A. Fueyo, J.M. Freije, and C. López-Otín Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response Genes Dev. 26 2012 2311 2324
-
(2012)
Genes Dev.
, vol.26
, pp. 2311-2324
-
-
Osorio, F.G.1
Bárcena, C.2
Soria-Valles, C.3
Ramsay, A.J.4
De Carlos, F.5
Cobo, J.6
Fueyo, A.7
Freije, J.M.8
López-Otín, C.9
-
54
-
-
70349645266
-
Ageing-related chromatin defects through loss of the NURD complex
-
G. Pegoraro, N. Kubben, U. Wickert, H. Göhler, K. Hoffmann, and T. Misteli Ageing-related chromatin defects through loss of the NURD complex Nat. Cell Biol. 11 2009 1261 1267
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1261-1267
-
-
Pegoraro, G.1
Kubben, N.2
Wickert, U.3
Göhler, H.4
Hoffmann, K.5
Misteli, T.6
-
55
-
-
80052191669
-
Challenging issues in pediatric oncology
-
C.H. Pui, A.J. Gajjar, J.R. Kane, I.A. Qaddoumi, and A.S. Pappo Challenging issues in pediatric oncology Nat. Rev. Clin. Oncol. 8 2011 540 549
-
(2011)
Nat. Rev. Clin. Oncol.
, vol.8
, pp. 540-549
-
-
Pui, C.H.1
Gajjar, A.J.2
Kane, J.R.3
Qaddoumi, I.A.4
Pappo, A.S.5
-
56
-
-
77953023624
-
Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging
-
C.D. Ragnauth, D.T. Warren, Y. Liu, R. McNair, T. Tajsic, N. Figg, R. Shroff, J. Skepper, and C.M. Shanahan Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging Circulation 121 2010 2200 2210
-
(2010)
Circulation
, vol.121
, pp. 2200-2210
-
-
Ragnauth, C.D.1
Warren, D.T.2
Liu, Y.3
McNair, R.4
Tajsic, T.5
Figg, N.6
Shroff, R.7
Skepper, J.8
Shanahan, C.M.9
-
57
-
-
84864523531
-
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival
-
F.J. Ramos, S.C. Chen, M.G. Garelick, D.F. Dai, C.Y. Liao, K.H. Schreiber, V.L. MacKay, E.H. An, R. Strong, and W.C. Ladiges et al. Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival Sci. Transl. Med. 4 2012 144ra103
-
(2012)
Sci. Transl. Med.
, vol.4
-
-
Ramos, F.J.1
Chen, S.C.2
Garelick, M.G.3
Dai, D.F.4
Liao, C.Y.5
Schreiber, K.H.6
Mackay, V.L.7
An, E.H.8
Strong, R.9
Ladiges, W.C.10
-
58
-
-
67649188781
-
Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging
-
S. Rodriguez, F. Coppedè, H. Sagelius, and M. Eriksson Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging Eur. J. Hum. Genet. 17 2009 928 937
-
(2009)
Eur. J. Hum. Genet.
, vol.17
, pp. 928-937
-
-
Rodriguez, S.1
Coppedè, F.2
Sagelius, H.3
Eriksson, M.4
-
60
-
-
17644373758
-
Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome
-
P. Scaffidi, and T. Misteli Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome Nat. Med. 11 2005 440 445
-
(2005)
Nat. Med.
, vol.11
, pp. 440-445
-
-
Scaffidi, P.1
Misteli, T.2
-
61
-
-
33646745137
-
Lamin A-dependent nuclear defects in human aging
-
P. Scaffidi, and T. Misteli Lamin A-dependent nuclear defects in human aging Science 312 2006 1059 1063
-
(2006)
Science
, vol.312
, pp. 1059-1063
-
-
Scaffidi, P.1
Misteli, T.2
-
62
-
-
43149124203
-
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
-
P. Scaffidi, and T. Misteli Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing Nat. Cell Biol. 10 2008 452 459
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 452-459
-
-
Scaffidi, P.1
Misteli, T.2
-
63
-
-
84878488910
-
Imaging characteristics of cerebrovascular arteriopathy and stroke in Hutchinson-Gilford progeria syndrome
-
V.M. Silvera, L.B. Gordon, D.B. Orbach, S.E. Campbell, J.T. Machan, and N.J. Ullrich Imaging characteristics of cerebrovascular arteriopathy and stroke in Hutchinson-Gilford progeria syndrome AJNR Am. J. Neuroradiol. 34 2013 1091 1097
-
(2013)
AJNR Am. J. Neuroradiol.
, vol.34
, pp. 1091-1097
-
-
Silvera, V.M.1
Gordon, L.B.2
Orbach, D.B.3
Campbell, S.E.4
Machan, J.T.5
Ullrich, N.J.6
-
64
-
-
0028118904
-
The processing pathway of prelamin A
-
M. Sinensky, K. Fantle, M. Trujillo, T. McLain, A. Kupfer, and M. Dalton The processing pathway of prelamin A J. Cell Sci. 107 1994 61 67
-
(1994)
J. Cell Sci.
, vol.107
, pp. 61-67
-
-
Sinensky, M.1
Fantle, K.2
Trujillo, M.3
McLain, T.4
Kupfer, A.5
Dalton, M.6
-
65
-
-
24644459728
-
Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes
-
J.I. Toth, S.H. Yang, X. Qiao, A.P. Beigneux, M.H. Gelb, C.L. Moulson, J.H. Miner, S.G. Young, and L.G. Fong Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes Proc. Natl. Acad. Sci. USA 102 2005 12873 12878
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 12873-12878
-
-
Toth, J.I.1
Yang, S.H.2
Qiao, X.3
Beigneux, A.P.4
Gelb, M.H.5
Moulson, C.L.6
Miner, J.H.7
Young, S.G.8
Fong, L.G.9
-
66
-
-
79957900395
-
Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53
-
A.P. Ugalde, A.J. Ramsay, J. de la Rosa, I. Varela, G. Mariño, J. Cadiñanos, J. Lu, J.M. Freije, and C. López-Otín Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53 EMBO J. 30 2011 2219 2232
-
(2011)
EMBO J.
, vol.30
, pp. 2219-2232
-
-
Ugalde, A.P.1
Ramsay, A.J.2
De La Rosa, J.3
Varela, I.4
Mariño, G.5
Cadiñanos, J.6
Lu, J.7
Freije, J.M.8
López-Otín, C.9
-
67
-
-
84881307604
-
Neurologic features of Hutchinson-Gilford progeria syndrome after lonafarnib treatment
-
N.J. Ullrich, M.W. Kieran, D.T. Miller, L.B. Gordon, Y.J. Cho, V.M. Silvera, A. Giobbie-Hurder, D. Neuberg, and M.E. Kleinman Neurologic features of Hutchinson-Gilford progeria syndrome after lonafarnib treatment Neurology 81 2013 427 430
-
(2013)
Neurology
, vol.81
, pp. 427-430
-
-
Ullrich, N.J.1
Kieran, M.W.2
Miller, D.T.3
Gordon, L.B.4
Cho, Y.J.5
Silvera, V.M.6
Giobbie-Hurder, A.7
Neuberg, D.8
Kleinman, M.E.9
-
68
-
-
25644440744
-
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
-
I. Varela, J. Cadiñanos, A.M. Pendás, A. Gutiérrez-Fernández, A.R. Folgueras, L.M. Sánchez, Z. Zhou, F.J. Rodríguez, C.L. Stewart, and J.A. Vega et al. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation Nature 437 2005 564 568
-
(2005)
Nature
, vol.437
, pp. 564-568
-
-
Varela, I.1
Cadiñanos, J.2
Pendás, A.M.3
Gutiérrez- Fernández, A.4
Folgueras, A.R.5
Sánchez, L.M.6
Zhou, Z.7
Rodríguez, F.J.8
Stewart, C.L.9
Vega, J.A.10
-
69
-
-
46849106102
-
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging
-
I. Varela, S. Pereira, A.P. Ugalde, C.L. Navarro, M.F. Suárez, P. Cau, J. Cadiñanos, F.G. Osorio, N. Foray, and J. Cobo et al. Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging Nat. Med. 14 2008 767 772
-
(2008)
Nat. Med.
, vol.14
, pp. 767-772
-
-
Varela, I.1
Pereira, S.2
Ugalde, A.P.3
Navarro, C.L.4
Suárez, M.F.5
Cau, P.6
Cadiñanos, J.7
Osorio, F.G.8
Foray, N.9
Cobo, J.10
-
70
-
-
84964846245
-
Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo
-
V. Wenzel, D. Roedl, D. Gabriel, L.B. Gordon, M. Herlyn, R. Schneider, J. Ring, and K. Djabali Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo Biol. Open 1 2012 516 526
-
(2012)
Biol. Open
, vol.1
, pp. 516-526
-
-
Wenzel, V.1
Roedl, D.2
Gabriel, D.3
Gordon, L.B.4
Herlyn, M.5
Schneider, R.6
Ring, J.7
Djabali, K.8
-
71
-
-
34249788998
-
"Laminopathies": A wide spectrum of human diseases
-
H.J. Worman, and G. Bonne "Laminopathies": a wide spectrum of human diseases Exp. Cell Res. 313 2007 2121 2133
-
(2007)
Exp. Cell Res.
, vol.313
, pp. 2121-2133
-
-
Worman, H.J.1
Bonne, G.2
-
72
-
-
22544440839
-
Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation
-
S.H. Yang, M.O. Bergo, J.I. Toth, X. Qiao, Y. Hu, S. Sandoval, M. Meta, P. Bendale, M.H. Gelb, S.G. Young, and L.G. Fong Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation Proc. Natl. Acad. Sci. USA 102 2005 10291 10296
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 10291-10296
-
-
Yang, S.H.1
Bergo, M.O.2
Toth, J.I.3
Qiao, X.4
Hu, Y.5
Sandoval, S.6
Meta, M.7
Bendale, P.8
Gelb, M.H.9
Young, S.G.10
Fong, L.G.11
-
73
-
-
39049111972
-
Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation
-
S.H. Yang, X. Qiao, L.G. Fong, and S.G. Young Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation Biochim. Biophys. Acta 1781 2008 36 39
-
(2008)
Biochim. Biophys. Acta
, vol.1781
, pp. 36-39
-
-
Yang, S.H.1
Qiao, X.2
Fong, L.G.3
Young, S.G.4
-
74
-
-
78650995671
-
A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects
-
J. Zhang, Q. Lian, G. Zhu, F. Zhou, L. Sui, C. Tan, R.A. Mutalif, R. Navasankari, Y. Zhang, and H.F. Tse et al. A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects Cell Stem Cell 8 2011 31 45
-
(2011)
Cell Stem Cell
, vol.8
, pp. 31-45
-
-
Zhang, J.1
Lian, Q.2
Zhu, G.3
Zhou, F.4
Sui, L.5
Tan, C.6
Mutalif, R.A.7
Navasankari, R.8
Zhang, Y.9
Tse, H.F.10
|