The origin of aging: Imperfectness-driven non-random damage defines the aging process and control of lifespan

Trends in Genetics

Volumn 29, Issue 9, 2013, Pages 506-512

  Gladyshev, Vadim N ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; BIOLOGICAL FUNCTIONS; DNA DAMAGE; GENOME; LIFESPAN; PHYSICAL CHEMISTRY; PHYSICOCHEMICAL MODEL; PRIORITY JOURNAL; REVIEW;

EID: 84882603593     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tig.2013.05.004     Document Type: Review

References (34)

1. Kirkwood T.B., Austad S.N. Why do we age?. Nature 2000, 408:233-238.
2. Vijg J., Campisi J. Puzzles, promises and a cure for ageing. Nature 2008, 454:1065-1071.
3. Orgel L.E. Ageing of clones of mammalian cells. Nature 1973, 243:441-445.
4. Blagosklonny M.V. Aging: ROS or TOR. Cell Cycle 2008, 7:3344-3354.
5. Tawfik D.S. Messy biology and the origins of evolutionary innovations. Nat. Chem. Biol. 2010, 6:692-696.
6. Weng J.K., Noel J.P. The remarkable pliability and promiscuity of specialized metabolism. Cold Spring Harb. Symp. Quant. Biol. 2013, 10.1101/sqb.2012.77.014787.
7. Gladyshev V.N. On the cause of aging and control of lifespan: heterogeneity leads to inevitable damage accumulation, causing aging; control of damage composition and rate of accumulation define lifespan. Bioessays 2012, 34:925-929.
8. Crick F.H. The origin of the genetic code. J. Mol. Biol. 1968, 38:367-379.
9. Kirkwood T.B., Cremer T. Cytogerontology since 1881: a reappraisal of August Weismann and a review of modern progress. Hum. Genet. 1982, 60:101-121.
10. Longo V.D., et al. Programmed and altruistic ageing. Nat. Rev. Genet. 2005, 6:866-872.
11. Ackerman D., Gems D. The mystery of C. elegans aging: An emerging role for fat: Distant parallels between C. elegans aging and metabolic syndrome?. Bioessays 2012, 34:466-471.
12. Gems D.H., de la Guardia Y.I. Alternative perspectives on aging in C. elegans: reactive oxygen species or hyperfunction?. Antioxid. Redox Signal. 2013, 10.1089/ars.2012.4840.
13. de Magalhaes J.P. Programmatic features of aging originating in development: aging mechanisms beyond molecular damage?. FASEB J. 2012, 26:4821-4826.
14. Blagosklonny M.V. Rapamycin and quasi-programmed aging: four years later. Cell Cycle 2010, 9:1859-1862.
15. Medawar P.B. An Unsolved Problem of Biology 1952, H. K. Lewis.
16. Williams G.C. Pleiotropy, natural selection, and the evolution of senescence. Evolution 1957, 11:398-411.
17. Hamilton W.D. The moulding of senescence by natural selection. J. Theor. Biol. 1966, 12:12-45.
18. Kirkwood T.B. Evolution of ageing. Nature 1977, 270:301-304.
19. Reznick D.N., et al. Effect of extrinsic mortality on the evolution of senescence in guppies. Nature 2004, 431:1095-1099.
20. Grandison R.C., et al. Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature 2009, 462:1061-1064.
21. Kirkwood T.B. A systematic look at an old problem. Nature 2008, 451:644-647.
22. Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 1956, 11:298-300.
23. Koc A., et al. Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:7999-8004.
24. Failla G. The aging process and cancerogenesis. Ann. N. Y. Acad. Sci. 1958, 71:1124-1140.
25. Vijg J. Aging of the genome. The Dual Role of DNA in Life and Death 2007, Oxford University Press.
26. Kennedy B.K., et al. Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span. J. Cell Biol. 1994, 127:1985-1993.
27. de Magalhães J.P., et al. An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts. J. Gerontol. A: Biol. Sci. Med. Sci. 2007, 62:149-160.
28. Lin S.J., et al. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 2002, 418:344-348.
29. Harrison D.E., et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009, 460:392-395.
30. Carey J.R., et al. Slowing of mortality rates at older ages in large medfly cohorts. Science 1992, 258:457-461.
31. Ackermann M., et al. Senescence in a bacterium with asymmetric division. Science 2003, 300:1920.
32. Finkel T., et al. The common biology of cancer and ageing. Nature 2007, 448:767-774.
33. Muller F.L., et al. Passenger deletions generate therapeutic vulnerabilities in cancer. Nature 2012, 488:337-342.
34. Nijhawan D., et al. Cancer vulnerabilities unveiled by genomic loss. Cell 2012, 150:842-854.