Epigenetic rejuvenation of mesenchymal stromal cells derived from induced pluripotent stem cells

Stem Cell Reports

Volumn 3, Issue 3, 2014, Pages 414-422

  Frobel, Joana ^a   Hemeda, Hatim ^a   Lenz, Michael ^a   Abagnale, Giulio ^a   Joussen, Sylvia ^a   Denecke, Bernd ^b   Šarić, Tomo ^c   Zenke, Martin ^a,b   Wagner, Wolfgang ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5' NUCLEOTIDASE; BETA1 INTEGRIN; CD14 ANTIGEN; CD31 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; CD56 ANTIGEN; ENDOGLIN; HERMES ANTIGEN; MICROSOMAL AMINOPEPTIDASE; OCTAMER TRANSCRIPTION FACTOR 4; ORGANIC CATION TRANSPORTER 3; THY 1 ANTIGEN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTOME;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CPG ISLAND; CULTURE MEDIUM; DNA METHYLATION; EPIGENETICS; FEMUR HEAD; GENE EXPRESSION; HUMAN; HUMAN CELL; ILIAC CREST; IMMUNE RESPONSE; IMMUNOPHENOTYPING; MESENCHYMAL STROMA CELL; NUCLEOTIDE SEQUENCE; PLURIPOTENT STEM CELL; REJUVENATION; SENESCENCE; T LYMPHOCYTE ACTIVATION; UPREGULATION; CYTOLOGY; GENETIC EPIGENESIS; METABOLISM;

CELL DIFFERENTIATION; CELLS, CULTURED; DNA METHYLATION; EPIGENESIS, GENETIC; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MESENCHYMAL STROMAL CELLS; TRANSCRIPTOME;

EID: 84914113138     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2014.07.003     Document Type: Article

References (23)

1. T. Barberi, L.M. Willis, N.D. Socci, and L. Studer Derivation of multipotent mesenchymal precursors from human embryonic stem cells PLoS Med. 2 2005 e161
2. N.L. Boyd, K.R. Robbins, S.K. Dhara, F.D. West, and S.L. Stice Human embryonic stem cell-derived mesoderm-like epithelium transitions to mesenchymal progenitor cells Tissue Eng. Part A 15 2009 1897 1907
3. Y.S. Chen, R.A. Pelekanos, R.L. Ellis, R. Horne, E.J. Wolvetang, and N.M. Fisk Small molecule mesengenic induction of human induced pluripotent stem cells to generate mesenchymal stem/stromal cells Stem Cells Transl. Med. 1 2012 83 95
4. G.M. de Peppo, S. Svensson, M. Lennerås, J. Synnergren, J. Stenberg, R. Strehl, J. Hyllner, P. Thomsen, and C. Karlsson Human embryonic mesodermal progenitors highly resemble human mesenchymal stem cells and display high potential for tissue engineering applications Tissue Eng. Part A 16 2010 2161 2182
5. S. Diederichs, and R.S. Tuan Functional Comparison of Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Cells and Bone Marrow-Derived Mesenchymal Stromal Cells from the Same Donor Stem Cells Dev. 23 2014 1594 1610
6. M. Dominici, K. Le Blanc, I. Mueller, I. Slaper-Cortenbach, F. Marini, D. Krause, R. Deans, A. Keating, Dj. Prockop, and E. Horwitz Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement Cytotherapy 8 2006 315 317
7. Q.L. Fu, Y.Y. Chow, S.J. Sun, Q.X. Zeng, H.B. Li, J.B. Shi, Y.Q. Sun, W. Wen, H.F. Tse, Q. Lian, and G. Xu Mesenchymal stem cells derived from human induced pluripotent stem cells modulate T-cell phenotypes in allergic rhinitis Allergy 67 2012 1215 1222
8. J.A. Hackett, S. Dietmann, K. Murakami, T.A. Down, H.G. Leitch, and M.A. Surani Synergistic Mechanisms of DNA Demethylation during Transition to Ground-State Pluripotency Stem Cell Rep. 1 2013 518 531
9. S. Horvath DNA methylation age of human tissues and cell types Genome Biol. 14 2013 R115
10. K. Huang, Y. Shen, Z. Xue, M. Bibikova, C. April, Z. Liu, L. Cheng, A. Nagy, M. Pellegrini, J.B. Fan, and G. Fan A panel of CpG methylation sites distinguishes human embryonic stem cells and induced pluripotent stem cells Stem Cell Rep. 2 2014 36 43
11. E.A. Kimbrel, N.A. Kouris, G.J. Yavanian, J. Chu, Y. Qin, A. Chan, R.P. Singh, D. McCurdy, L. Gordon, R.D. Levinson, and R. Lanza Mesenchymal Stem Cell Population Derived from Human Pluripotent Stem Cells Displays Potent Immunomodulatory and Therapeutic Properties Stem Cells Dev. 23 2014 1611 1624
12. C.M. Koch, S. Joussen, A. Schellenberg, Q. Lin, M. Zenke, and W. Wagner Monitoring of cellular senescence by DNA-methylation at specific CpG sites Aging Cell 11 2012 366 369
13. C.M. Koch, K. Reck, K. Shao, Q. Lin, S. Joussen, P. Ziegler, G. Walenda, W. Drescher, B. Opalka, and T. May Pluripotent stem cells escape from senescence-associated DNA methylation changes Genome Res. 23 2013 248 259
14. M. Lenz, B.M. Schuldt, F.J. Müller, and A. Schuppert PhysioSpace: relating gene expression experiments from heterogeneous sources using shared physiological processes PLoS ONE 8 2013 e77627
15. Y. Liu, A.J. Goldberg, J.E. Dennis, G.A. Gronowicz, and L.T. Kuhn One-step derivation of mesenchymal stem cell (MSC)-like cells from human pluripotent stem cells on a fibrillar collagen coating PLoS ONE 7 2012 e33225
16. F.J. Müller, B.M. Schuldt, R. Williams, D. Mason, G. Altun, E.P. Papapetrou, S. Danner, J.E. Goldmann, A. Herbst, and N.O. Schmidt A bioinformatic assay for pluripotency in human cells Nat. Methods 8 2011 315 317
17. A. Schellenberg, Q. Lin, H. Schüler, C.M. Koch, S. Joussen, B. Denecke, G. Walenda, N. Pallua, C.V. Suschek, M. Zenke, and W. Wagner Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks Aging (Albany, N.Y. Online) 3 2011 873 888
18. A. Schellenberg, T. Stiehl, P. Horn, S. Joussen, N. Pallua, A.D. Ho, and W. Wagner Population dynamics of mesenchymal stromal cells during culture expansion Cytotherapy 14 2012 401 411
19. K. Shao, C. Koch, M.K. Gupta, Q. Lin, M. Lenz, S. Laufs, B. Denecke, M. Schmidt, M. Linke, and H.C. Hennies Induced pluripotent mesenchymal stromal cell clones retain donor-derived differences in DNA methylation profiles Mol. Ther. 21 2013 240 250
20. W. Wagner, and A.D. Ho Mesenchymal stem cell preparations - comparing apples and oranges Stem Cell Rev. 3 2007 239 248
21. J.R. Wagner, S. Busche, B. Ge, T. Kwan, T. Pastinen, and M. Blanchette The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts Genome Biol. 15 2014 R37
22. C.I. Weidner, Q. Lin, C.M. Koch, L. Eisele, F. Beier, P. Ziegler, D.O. Bauerschlag, K.H. Jöckel, R. Erbel, and T.W. Mühleisen Aging of blood can be tracked by DNA methylation changes at just three CpG sites Genome Biol. 15 2014 R24
23. J. Zhang, Q. Lian, G. Zhu, F. Zhou, L. Sui, C. Tan, R.A. Mutalif, R. Navasankari, Y. Zhang, and H.F. Tse A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects Cell Stem Cell 8 2011 31 45