메뉴 건너뛰기




Volumn 8, Issue 1, 2015, Pages

Diverse mechanisms of Sp1-Dependent transcriptional regulation potentially involved in the adaptive response of cancer cells to oxygen-deficient conditions

Author keywords

Cancer; Hypoxia; Sp1; Transcriptional regulation

Indexed keywords

BLOOD CLOTTING FACTOR 7; CARBONATE DEHYDRATASE IX; CD147 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; ENDOSIALIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INTERLEUKIN 8; ISOCITRATE DEHYDROGENASE 2; KRUPPEL LIKE FACTOR 6; LEPTIN; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER 8; MONOCYTE CHEMOTACTIC PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 1; PRION PROTEIN; PROTEIN MSH2; PROTEIN MSH6; SIRTUIN 1; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TRANSCRIPTION FACTOR SP1; UROKINASE RECEPTOR; VASCULOTROPIN; XERODERMA PIGMENTOSUM GROUP D PROTEIN;

EID: 84951959021     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers8010002     Document Type: Review
Times cited : (28)

References (75)
  • 2
    • 34247527730 scopus 로고    scopus 로고
    • Hypoxia inducible factors, Stem cells, and Cancer
    • [CrossRef] [PubMed]
    • Keith, B.; Simon, MC. Hypoxia inducible factors, Stem cells, and Cancer. Cell 2007, 129, 465-472. [CrossRef] [PubMed]
    • (2007) Cell , vol.129 , pp. 465-472
    • Keith, B.1    Simon, M.C.2
  • 3
    • 84655161946 scopus 로고    scopus 로고
    • HIF1α and HIF2α: Sibling rivalry in hypoxic tumor growth and progression
    • [CrossRef] [PubMed]
    • Keith, B.; Johnson, R.S.; Simon, M.C. HIF1α and HIF2α: Sibling rivalry in hypoxic tumor growth and progression. Nat. Rev. Cancer 2012, 12, 9-22. [CrossRef] [PubMed]
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 9-22
    • Keith, B.1    Johnson, R.S.2    Simon, M.C.3
  • 4
    • 84893077858 scopus 로고    scopus 로고
    • Transcriptional regulation by hypoxia inducible factors
    • [CrossRef] [PubMed]
    • Dengler, V.L.; Galbraith, M.; Espinosa, J.M. Transcriptional regulation by hypoxia inducible factors. Crit. Rev. Biochem. Mol. Biol. 2014, 49, 1-15. [CrossRef] [PubMed]
    • (2014) Crit. Rev. Biochem. Mol. Biol. , vol.49 , pp. 1-15
    • Dengler, V.L.1    Galbraith, M.2    Espinosa, J.M.3
  • 5
    • 44349157832 scopus 로고    scopus 로고
    • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    • [CrossRef] [PubMed]
    • Dewhirst, M.W.; Cao, Y.; Moeller, B. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat. Rev. Cancer 2008, 8, 425-437. [CrossRef] [PubMed]
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 425-437
    • Dewhirst, M.W.1    Cao, Y.2    Moeller, B.3
  • 6
    • 84897990135 scopus 로고    scopus 로고
    • Tumor stroma: A complexity dictated by the hypoxic tumor microenvironment
    • [CrossRef] [PubMed]
    • Casazza, A.; di Conza, G.; Wenes, M.; Finisguerra, V.; Deschomaeker, S.; Mazzone, M. Tumor stroma: A complexity dictated by the hypoxic tumor microenvironment. Oncogene 2014, 33, 1743-1754. [CrossRef] [PubMed]
    • (2014) Oncogene , vol.33 , pp. 1743-1754
    • Casazza, A.1    di Conza, G.2    Wenes, M.3    Finisguerra, V.4    Deschomaeker, S.5    Mazzone, M.6
  • 7
    • 54549089738 scopus 로고    scopus 로고
    • Hypoxia signaling through mTOR and the unfolded protein response in cancer
    • [CrossRef] [PubMed]
    • Wouters, B.G.; Koritzinsky, M. Hypoxia signaling through mTOR and the unfolded protein response in cancer. Nat. Rev. Cancer 2008, 8, 851-864. [CrossRef] [PubMed]
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 851-864
    • Wouters, B.G.1    Koritzinsky, M.2
  • 8
    • 44749090905 scopus 로고    scopus 로고
    • Sp1: Emerging roles-beyond constitutive activation of TATA-less housekeeping genes
    • [CrossRef] [PubMed]
    • Wierstra, I. Sp1: Emerging roles-beyond constitutive activation of TATA-less housekeeping genes. Biochem. Biophys. Res. Commun. 2008, 372, 1-13. [CrossRef] [PubMed]
    • (2008) Biochem. Biophys. Res. Commun. , vol.372 , pp. 1-13
    • Wierstra, I.1
  • 9
    • 84926081071 scopus 로고    scopus 로고
    • Sp1 and the "hallmarks of cancer"
    • [CrossRef] [PubMed]
    • Beishline, K.; Azizkhan-Clifford, J. Sp1 and the "hallmarks of cancer". FEBS J. 2015, 282, 224-258. [CrossRef] [PubMed]
    • (2015) FEBS J. , vol.282 , pp. 224-258
    • Beishline, K.1    Azizkhan-Clifford, J.2
  • 10
    • 0037096732 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene
    • [PubMed]
    • Comerford, K.M.; Wallace, T.J.; Karhausen, J.; Louis, N.A.; Montalto, M.C.; Colgan, S.P. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res. 2002, 62, 3387-3394. [PubMed]
    • (2002) Cancer Res. , vol.62 , pp. 3387-3394
    • Comerford, K.M.1    Wallace, T.J.2    Karhausen, J.3    Louis, N.A.4    Montalto, M.C.5    Colgan, S.P.6
  • 11
    • 2442502748 scopus 로고    scopus 로고
    • Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor a4 gene by an interaction between hypoxia-inducible factor-1 and Sp1
    • [CrossRef] [PubMed]
    • Miki, N.; Ikuta, M.; Matsui, T. hypoxia-induced activation of the retinoic acid receptor-related orphan receptor a4 gene by an interaction between hypoxia-inducible factor-1 and Sp1. J. Biol. Chem. 2004, 279, 15025-15031. [CrossRef] [PubMed]
    • (2004) J. Biol. Chem. , vol.279 , pp. 15025-15031
    • Miki, N.1    Ikuta, M.2    Matsui, T.3
  • 12
    • 84865333867 scopus 로고    scopus 로고
    • Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epitherial solid tumors
    • [CrossRef] [PubMed]
    • Ke, X.; Fei, F.; Chen, Y.; Xu, L.; Zhang, Z.; Huang, Q.; Zhang, H.; Yang, H.; Chen, Z.; Xing, J. Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epitherial solid tumors. Carcinogenesis 2012, 33, 1598-1607. [CrossRef] [PubMed]
    • (2012) Carcinogenesis , vol.33 , pp. 1598-1607
    • Ke, X.1    Fei, F.2    Chen, Y.3    Xu, L.4    Zhang, Z.5    Huang, Q.6    Zhang, H.7    Yang, H.8    Chen, Z.9    Xing, J.10
  • 13
    • 0037374179 scopus 로고    scopus 로고
    • Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer
    • [PubMed]
    • Kaluz, S.; Kaluzova, M.; Stanbridge, E.J. Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer. Cancer Res. 2003, 63, 917-922. [PubMed]
    • (2003) Cancer Res. , vol.63 , pp. 917-922
    • Kaluz, S.1    Kaluzova, M.2    Stanbridge, E.J.3
  • 15
    • 79954428147 scopus 로고    scopus 로고
    • Up-regulation of glyceraldehydes-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells
    • [CrossRef] [PubMed]
    • Higashimura, Y.; Nakajima, Y.; Yamaji, R.; Harada, N.; Shibasaki, F.; Nakano, Y.; Inui, H. Up-regulation of glyceraldehydes-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells. Arch. Biochem. Biophys. 2011, 509, 1-8. [CrossRef] [PubMed]
    • (2011) Arch. Biochem. Biophys. , vol.509 , pp. 1-8
    • Higashimura, Y.1    Nakajima, Y.2    Yamaji, R.3    Harada, N.4    Shibasaki, F.5    Nakano, Y.6    Inui, H.7
  • 16
    • 49649100035 scopus 로고    scopus 로고
    • Insulin-dependent leptin expression in breast cancer cells
    • [CrossRef] [PubMed]
    • Bartella, V.; Cascio, S.; Fiorio, E.; Auriemma, A.; Russo, A.; Surmacz, E. Insulin-dependent leptin expression in breast cancer cells. Cancer Res. 2008, 68, 4919-4927. [CrossRef] [PubMed]
    • (2008) Cancer Res. , vol.68 , pp. 4919-4927
    • Bartella, V.1    Cascio, S.2    Fiorio, E.3    Auriemma, A.4    Russo, A.5    Surmacz, E.6
  • 17
    • 84882379413 scopus 로고    scopus 로고
    • Transcription factors Sp1 and HIF2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epitherial cells during hypoxia
    • [CrossRef] [PubMed]
    • Xie, L.; Collins, J.F. Transcription factors Sp1 and HIF2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epitherial cells during hypoxia. J. Biol. Chem. 2013, 288, 23943-23952. [CrossRef] [PubMed]
    • (2013) J. Biol. Chem. , vol.288 , pp. 23943-23952
    • Xie, L.1    Collins, J.F.2
  • 19
    • 13944252559 scopus 로고    scopus 로고
    • Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2α in von Hippel-Lindau renal cell carcinoma
    • [CrossRef] [PubMed]
    • Petrella, B.L.; Lohi, J.; Brinckerhoff, C.E. Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2α in von Hippel-Lindau renal cell carcinoma. Oncogene 2005, 24, 1043-1052. [CrossRef] [PubMed]
    • (2005) Oncogene , vol.24 , pp. 1043-1052
    • Petrella, B.L.1    Lohi, J.2    Brinckerhoff, C.E.3
  • 20
    • 80052226694 scopus 로고    scopus 로고
    • Translational and transcriptional control of Sp1 against ischemia through a hydrogen peroxide-activated internal ribosomal entry site pathway
    • [CrossRef] [PubMed]
    • Yeh, S.H.; Yang, W.B.; Gean, P.W.; Hsu, C.Y.; Tseng, J.T.; Su, T.P.; Chang, W.C.; Hung, J.J. Translational and transcriptional control of Sp1 against ischemia through a hydrogen peroxide-activated internal ribosomal entry site pathway. Nucleic Acids Res. 2011, 39, 5412-5423. [CrossRef] [PubMed]
    • (2011) Nucleic Acids Res. , vol.39 , pp. 5412-5423
    • Yeh, S.H.1    Yang, W.B.2    Gean, P.W.3    Hsu, C.Y.4    Tseng, J.T.5    Su, T.P.6    Chang, W.C.7    Hung, J.J.8
  • 21
    • 84870389718 scopus 로고    scopus 로고
    • Transcriptional regulation of specific protein 1 (SP1) by hypoxia-inducible factor 1 alpha (HIF-1α) leads to PRNP expression and neuroprotection from toxic prion peptide
    • [CrossRef] [PubMed]
    • Jeong, J.-K.; Park, S.-Y. Transcriptional regulation of specific protein 1 (SP1) by hypoxia-inducible factor 1 alpha (HIF-1α) leads to PRNP expression and neuroprotection from toxic prion peptide. Biochem. Biophys. Res. Commun. 2012, 429, 93-98. [CrossRef] [PubMed]
    • (2012) Biochem. Biophys. Res. Commun. , vol.429 , pp. 93-98
    • Jeong, J.-K.1    Park, S.-Y.2
  • 22
    • 70350456139 scopus 로고    scopus 로고
    • Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia
    • [CrossRef] [PubMed]
    • Szalad, A.; Katakowski, M.; Zheng, X.; Jiang, F.; Chopp, M. Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia. J. Exp. Clin. Cancer Res. 2009, 28, 129. [CrossRef] [PubMed]
    • (2009) J. Exp. Clin. Cancer Res. , vol.28 , pp. 129
    • Szalad, A.1    Katakowski, M.2    Zheng, X.3    Jiang, F.4    Chopp, M.5
  • 25
    • 84857782590 scopus 로고    scopus 로고
    • Sequential activation of hypoxia-inducible factor 1 and specificity protein 1 is required for hypoxia-induced transcriptional stimulation of Abcc8
    • [CrossRef] [PubMed]
    • Woo, S.K.; Kwon, M.S.; Geng, Z.; Chen, Z.; Ivanov, A.; Bhatta, S.; Gerzanich, V.; Simard, J.M. Sequential activation of hypoxia-inducible factor 1 and specificity protein 1 is required for hypoxia-induced transcriptional stimulation of Abcc8. J. Cereb. Blood Flow Metab. 2012, 32, 525-536. [CrossRef] [PubMed]
    • (2012) J. Cereb. Blood Flow Metab. , vol.32 , pp. 525-536
    • Woo, S.K.1    Kwon, M.S.2    Geng, Z.3    Chen, Z.4    Ivanov, A.5    Bhatta, S.6    Gerzanich, V.7    Simard, J.M.8
  • 27
    • 0032476059 scopus 로고    scopus 로고
    • Hypoxia regulates β-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element
    • [CrossRef] [PubMed]
    • Discher, D.J.; Bishopric, N.H.; Wu, X.; Peterson, C.A.; Webster, K.A. Hypoxia regulates β-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element. J. Biol. Chem. 1998, 273, 26087-26093. [CrossRef] [PubMed]
    • (1998) J. Biol. Chem. , vol.273 , pp. 26087-26093
    • Discher, D.J.1    Bishopric, N.H.2    Wu, X.3    Peterson, C.A.4    Webster, K.A.5
  • 28
    • 0035884402 scopus 로고    scopus 로고
    • Central role of p53 on regulation of vascular permeability factor/vascular endothelial factor (VPF/VEGF) expression in mammary carcinoma
    • [PubMed]
    • Pal, S.; Datta, K.; Mukhopadhyay, D. Central role of p53 on regulation of vascular permeability factor/vascular endothelial factor (VPF/VEGF) expression in mammary carcinoma. Cancer Res. 2001, 61, 6952-6957. [PubMed]
    • (2001) Cancer Res. , vol.61 , pp. 6952-6957
    • Pal, S.1    Datta, K.2    Mukhopadhyay, D.3
  • 29
    • 79959968571 scopus 로고    scopus 로고
    • Molecular mechanism of HIF-1-independent VEGF expression in a hepatocellular carcinoma cell line
    • [PubMed]
    • Choi, S.B.; Park, J.B.; Song, T.-J.; Choi, S.Y. Molecular mechanism of HIF-1-independent VEGF expression in a hepatocellular carcinoma cell line. Int. J. Mol. Med. 2011, 28, 449-454. [PubMed]
    • (2011) Int. J. Mol. Med. , vol.28 , pp. 449-454
    • Choi, S.B.1    Park, J.B.2    Song, T.-J.3    Choi, S.Y.4
  • 30
    • 33749472340 scopus 로고    scopus 로고
    • Nelfinavir down-regulates hypoxia-inducible factor 1α and VEGF expression and increases tumor oxygenation: Implications for radiotherapy
    • [CrossRef] [PubMed]
    • Pore, N.; Gupta, A.K.; Cerniglia, G.J.; Jiang, Z.; Bernhard, E.J.; Evans, S.M.; Koch, C.J.; Hahn, S.M.; Maity, A. Nelfinavir down-regulates hypoxia-inducible factor 1α and VEGF expression and increases tumor oxygenation: Implications for radiotherapy. Cancer Res. 2006, 66, 9252-9259. [CrossRef] [PubMed]
    • (2006) Cancer Res. , vol.66 , pp. 9252-9259
    • Pore, N.1    Gupta, A.K.2    Cerniglia, G.J.3    Jiang, Z.4    Bernhard, E.J.5    Evans, S.M.6    Koch, C.J.7    Hahn, S.M.8    Maity, A.9
  • 31
    • 78650236478 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor-1α expression by mitochondrial NADP+-dependent isocitrate dehydrogenase
    • [CrossRef] [PubMed]
    • Kim, S.Y.; Park, J.-W. Modulation of hypoxia-inducible factor-1α expression by mitochondrial NADP+-dependent isocitrate dehydrogenase. Biochimie 2010, 92, 1908-1913. [CrossRef] [PubMed]
    • (2010) Biochimie , vol.92 , pp. 1908-1913
    • Kim, S.Y.1    Park, J.-W.2
  • 32
    • 33744948425 scopus 로고    scopus 로고
    • Hypoxia regulates cross-talk between Syk and Lck leading to breast cancer progression and angiogenesis
    • [CrossRef] [PubMed]
    • Chakraborty, G.; Rangaswami, H.; Jain, S.; Kundu, G.C. Hypoxia regulates cross-talk between Syk and Lck leading to breast cancer progression and angiogenesis. J. Biol. Chem. 2006, 281, 11322-11331. [CrossRef] [PubMed]
    • (2006) J. Biol. Chem. , vol.281 , pp. 11322-11331
    • Chakraborty, G.1    Rangaswami, H.2    Jain, S.3    Kundu, G.C.4
  • 33
    • 0037103797 scopus 로고    scopus 로고
    • Hypoxia/reoxygenation induction of monocyte chemoattractant protein-1 in melanoma cells: Involvement of nuclear factor-kB, stimulatory protein-1 transcription factors and mitogen-activated protein kinase pathways
    • [CrossRef] [PubMed]
    • Kunz, M.; Bloss, G.; Gillitzer, R.; Gross, G.; Goebeller, M.; Rapp, U.R.; Ludwig, S. Hypoxia/reoxygenation induction of monocyte chemoattractant protein-1 in melanoma cells: Involvement of nuclear factor-kB, stimulatory protein-1 transcription factors and mitogen-activated protein kinase pathways. Biochem. J. 2002, 366, 299-306. [CrossRef] [PubMed]
    • (2002) Biochem. J. , vol.366 , pp. 299-306
    • Kunz, M.1    Bloss, G.2    Gillitzer, R.3    Gross, G.4    Goebeller, M.5    Rapp, U.R.6    Ludwig, S.7
  • 35
    • 48849107453 scopus 로고    scopus 로고
    • Induction of truncated form of tenascin-X (XB-S) through dissociation of HDAC1 from SP-1/HDAC1 complex in response to hypoxic conditions
    • [CrossRef] [PubMed]
    • Kato, A.; Endo, T.; Abiko, S.; Ariga, H.; Matsumoto, K. Induction of truncated form of tenascin-X (XB-S) through dissociation of HDAC1 from SP-1/HDAC1 complex in response to hypoxic conditions. Exp. Cell Res. 2008, 314, 2661-2673. [CrossRef] [PubMed]
    • (2008) Exp. Cell Res. , vol.314 , pp. 2661-2673
    • Kato, A.1    Endo, T.2    Abiko, S.3    Ariga, H.4    Matsumoto, K.5
  • 36
    • 84883303719 scopus 로고    scopus 로고
    • PIASy mediates hypoxia-induced SIRT1 transcriptionalrepression and epithelial-to-mesenchymal transition in ovarian cancer cells
    • [CrossRef] [PubMed]
    • Sun, L.; Li, H.; Chen, J.; Iwasaki, Y.; Kubota, T.; Matsuoka, M.; Shen, A.; Chen, Q.; Xu, Y. PIASy mediates hypoxia-induced SIRT1 transcriptionalrepression and epithelial-to-mesenchymal transition in ovarian cancer cells. J. Cell Sci. 2013, 126, 3939-3947. [CrossRef] [PubMed]
    • (2013) J. Cell Sci. , vol.126 , pp. 3939-3947
    • Sun, L.1    Li, H.2    Chen, J.3    Iwasaki, Y.4    Kubota, T.5    Matsuoka, M.6    Shen, A.7    Chen, Q.8    Xu, Y.9
  • 38
    • 79954550386 scopus 로고    scopus 로고
    • HIF-1α depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs
    • [CrossRef] [PubMed]
    • Culver, C.; Melvin, A.; Mudie, S.; Rocha, S. HIF-1α depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs. Cell Cycle 2011, 10, 1249-1260. [CrossRef] [PubMed]
    • (2011) Cell Cycle , vol.10 , pp. 1249-1260
    • Culver, C.1    Melvin, A.2    Mudie, S.3    Rocha, S.4
  • 39
    • 0025891698 scopus 로고
    • DNA looping between sites for transcriptional activation: Self-association of DNA-bound Sp1
    • [CrossRef] [PubMed]
    • Su, W.; Jackson, S.; Tijan, R.; Echols, H. DNA looping between sites for transcriptional activation: Self-association of DNA-bound Sp1. Genes Dev. 1991, 5, 820-826. [CrossRef] [PubMed]
    • (1991) Genes Dev. , vol.5 , pp. 820-826
    • Su, W.1    Jackson, S.2    Tijan, R.3    Echols, H.4
  • 40
    • 84887437551 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide type 1receptor (PAC1) gene is suppressed by transglutaminase 2 activation
    • [CrossRef] [PubMed]
    • Miura, A.; Kambe, Y.; Inoue, K.; Tatsukawa, H.; Kurihara, T.; Griffin, M.; Kojima, S.; Miyata, A. Pituitary adenylate cyclase-activating polypeptide type 1receptor (PAC1) gene is suppressed by transglutaminase 2 activation. J. Biol. Chem. 2013, 288, 32720-32730. [CrossRef] [PubMed]
    • (2013) J. Biol. Chem. , vol.288 , pp. 32720-32730
    • Miura, A.1    Kambe, Y.2    Inoue, K.3    Tatsukawa, H.4    Kurihara, T.5    Griffin, M.6    Kojima, S.7    Miyata, A.8
  • 43
    • 35148883007 scopus 로고    scopus 로고
    • Egr-1 mediates hypoxia-inducible transcription of the NDRG1 gene through an overlapping Egr-1/Sp1 binding site in the promoter
    • [CrossRef] [PubMed]
    • Zhang, P.; Tchou-Wong, K.M.; Costa, M. Egr-1 mediates hypoxia-inducible transcription of the NDRG1 gene through an overlapping Egr-1/Sp1 binding site in the promoter. Cancer Res. 2007, 67, 9125-9133. [CrossRef] [PubMed]
    • (2007) Cancer Res. , vol.67 , pp. 9125-9133
    • Zhang, P.1    Tchou-Wong, K.M.2    Costa, M.3
  • 44
    • 85042572817 scopus 로고    scopus 로고
    • Suppressing the TF-fVII pathway at the gene expression level: A strategy to inhibit aberrant signaling cascades associated with cancer cells
    • Koizume, S.; Miyagi, Y. Suppressing the TF-fVII pathway at the gene expression level: A strategy to inhibit aberrant signaling cascades associated with cancer cells. Cancer Cell Microenviron. 2015, 2, e734.
    • (2015) Cancer Cell Microenviron. , vol.2
    • Koizume, S.1    Miyagi, Y.2
  • 46
    • 15244344206 scopus 로고    scopus 로고
    • HIF-1α induces genetic instability by transcriptionally downregulating MutSα expression
    • [CrossRef] [PubMed]
    • Koshiji, M.; To, K.K.-W.; Hammer, S.; Kumamoto, K.; Harris, A.L.; Modrich, P.; Huang, L.E. HIF-1α induces genetic instability by transcriptionally downregulating MutSα expression. Mol. Cell 2005, 17, 793-803. [CrossRef] [PubMed]
    • (2005) Mol. Cell , vol.17 , pp. 793-803
    • Koshiji, M.1    To, K.K.-W.2    Hammer, S.3    Kumamoto, K.4    Harris, A.L.5    Modrich, P.6    Huang, L.E.7
  • 47
    • 33750202279 scopus 로고    scopus 로고
    • The phosphorylation status of PAS-B distinguishes HIF-1α from HIF-2α in NBS1 repression
    • [CrossRef] [PubMed]
    • To, K.K.-W.; Sedelnikova, O.A.; Samons, M.; Bonner, W.M.; Huang, L.E. The phosphorylation status of PAS-B distinguishes HIF-1α from HIF-2α in NBS1 repression. EMBO J. 2006, 25, 4784-4794. [CrossRef] [PubMed]
    • (2006) EMBO J. , vol.25 , pp. 4784-4794
    • To, K.K.-W.1    Sedelnikova, O.A.2    Samons, M.3    Bonner, W.M.4    Huang, L.E.5
  • 48
    • 34047156190 scopus 로고    scopus 로고
    • HIF-2α promotes hypoxic cell proliferation by enhancing c-Myc transcriptional activity
    • [CrossRef] [PubMed]
    • Gordan, J.D.; Bertout, J.A.; Hu, C-J.; Diehl, J.A.; Simon, M.C. HIF-2α promotes hypoxic cell proliferation by enhancing c-Myc transcriptional activity. Cancer Cell 2007, 11, 335-347. [CrossRef] [PubMed]
    • (2007) Cancer Cell , vol.11 , pp. 335-347
    • Gordan, J.D.1    Bertout, J.A.2    Hu, C.-J.3    Diehl, J.A.4    Simon, M.C.5
  • 49
    • 84863223765 scopus 로고    scopus 로고
    • HIF2α-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells
    • [CrossRef] [PubMed]
    • Koizume, S.; Ito, S.; Miyagi, E.; Hirahara, F.; Nakamura, Y.; Sakuma, Y.; Osaka, H.; Takano, Y.; Ruf, W.; Miyagi, Y. HIF2α-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells. Nucleic Acids Res. 2012, 40, 5389-5401. [CrossRef] [PubMed]
    • (2012) Nucleic Acids Res. , vol.40 , pp. 5389-5401
    • Koizume, S.1    Ito, S.2    Miyagi, E.3    Hirahara, F.4    Nakamura, Y.5    Sakuma, Y.6    Osaka, H.7    Takano, Y.8    Ruf, W.9    Miyagi, Y.10
  • 50
    • 84927555901 scopus 로고    scopus 로고
    • Lipid starvation and hypoxia synergistically activates ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer
    • [CrossRef] [PubMed]
    • Koizume, S.; Ito, S.; Nakamura, Y.; Yoshihara, M.; Furuya, M.; Yamada, R.; Miyagi, E.; Hirahara, F.; Takano, Y.; Miyagi, Y. Lipid starvation and hypoxia synergistically activates ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer. Mol. Cancer 2015, 14, 77. [CrossRef] [PubMed]
    • (2015) Mol. Cancer , vol.14 , pp. 77
    • Koizume, S.1    Ito, S.2    Nakamura, Y.3    Yoshihara, M.4    Furuya, M.5    Yamada, R.6    Miyagi, E.7    Hirahara, F.8    Takano, Y.9    Miyagi, Y.10
  • 51
    • 84908333251 scopus 로고    scopus 로고
    • EPAS-1 mediates SP-1-dependent FBI-1 expression and regulates tumor cell survival and proliferation
    • [CrossRef] [PubMed]
    • Wang, X.; Cao, P.; Li, Z.;Wu, D.;Wang, X.; Liang, G. EPAS-1 mediates SP-1-dependent FBI-1 expression and regulates tumor cell survival and proliferation. Int. J. Mol. Sci. 2014, 15, 15689-15699. [CrossRef] [PubMed]
    • (2014) Int. J. Mol. Sci. , vol.15 , pp. 15689-15699
    • Wang, X.1    Cao, P.2    Li, Z.3    Wu, D.4    Wang, X.5    Liang, G.6
  • 52
    • 84930938538 scopus 로고    scopus 로고
    • Anti-apoptotic genes are synergistically activated in OVSAYO cells cultured under conditions of serum starvation and hypoxia
    • [CrossRef] [PubMed]
    • Koizume, S.; Miyagi, Y. Anti-apoptotic genes are synergistically activated in OVSAYO cells cultured under conditions of serum starvation and hypoxia. Genom. Data 2015, 5, 129-131. [CrossRef] [PubMed]
    • (2015) Genom. Data , vol.5 , pp. 129-131
    • Koizume, S.1    Miyagi, Y.2
  • 53
    • 70450278715 scopus 로고    scopus 로고
    • Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1α gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway
    • [CrossRef] [PubMed]
    • Koshikawa, N.; Hayashi, J.; Nakagawara, A.; Takenaga, K. Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1α gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway. J. Biol. Chem. 2009, 48, 33185-33194. [CrossRef] [PubMed]
    • (2009) J. Biol. Chem. , vol.48 , pp. 33185-33194
    • Koshikawa, N.1    Hayashi, J.2    Nakagawara, A.3    Takenaga, K.4
  • 54
    • 84857436181 scopus 로고    scopus 로고
    • Roles of Sp1 transcription factors in the regulation of cancer cell metabolism
    • [CrossRef] [PubMed]
    • Archer, M.C. Roles of Sp1 transcription factors in the regulation of cancer cell metabolism. Genes Cancer 2011, 2, 712-719. [CrossRef] [PubMed]
    • (2011) Genes Cancer , vol.2 , pp. 712-719
    • Archer, M.C.1
  • 56
    • 35448982386 scopus 로고    scopus 로고
    • Dual effect of echinomycin on hypoxia-inducible factor-1 activity under normoxic and hypoxic conditions
    • [CrossRef] [PubMed]
    • Vlaminck, B.; Toffoli, S.; Ghislain, B.; Demazy, C.; Raes, M.; Michiels, C. Dual effect of echinomycin on hypoxia-inducible factor-1 activity under normoxic and hypoxic conditions. FEBS J. 2007, 274, 5533-5542. [CrossRef] [PubMed]
    • (2007) FEBS J. , vol.274 , pp. 5533-5542
    • Vlaminck, B.1    Toffoli, S.2    Ghislain, B.3    Demazy, C.4    Raes, M.5    Michiels, C.6
  • 57
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • [CrossRef] [PubMed]
    • Semenza, G.L. Hypoxia-inducible factors in physiology and medicine. Cell 2012, 148, 399-408. [CrossRef] [PubMed]
    • (2012) Cell , vol.148 , pp. 399-408
    • Semenza, G.L.1
  • 58
    • 84896281040 scopus 로고    scopus 로고
    • Transcriptional repression of hypoxia-inducible factor-1 (HIF-1) by the protein arginine methyltransferase PRMT1
    • [CrossRef] [PubMed]
    • Lafleur, V.N.; Richard, S.; Richard, D.E. Transcriptional repression of hypoxia-inducible factor-1 (HIF-1) by the protein arginine methyltransferase PRMT1. Mol. Biol. Cell 2014, 25, 925-935. [CrossRef] [PubMed]
    • (2014) Mol. Biol. Cell , vol.25 , pp. 925-935
    • Lafleur, V.N.1    Richard, S.2    Richard, D.E.3
  • 59
  • 61
    • 84864026646 scopus 로고    scopus 로고
    • The interplay between retinoic acid receptor-related orphan receptors and human diseases
    • [CrossRef] [PubMed]
    • Ranhotra, H.S. The interplay between retinoic acid receptor-related orphan receptors and human diseases. J. Recept. Signal Transduct. Res. 2012, 32, 181-189. [CrossRef] [PubMed]
    • (2012) J. Recept. Signal Transduct. Res. , vol.32 , pp. 181-189
    • Ranhotra, H.S.1
  • 62
    • 73349137289 scopus 로고    scopus 로고
    • Emerging roles of Kruppel-like factor 6 and Kruppel-like factor 6 splice variant 1 in ovarian cancer progression and treatment
    • [CrossRef] [PubMed]
    • DiFeo, A.; Narla, G.; Martignetti, J.A. Emerging roles of Kruppel-like factor 6 and Kruppel-like factor 6 splice variant 1 in ovarian cancer progression and treatment. Mt. Sinai J. Med. 2009, 76, 557-566. [CrossRef] [PubMed]
    • (2009) Mt. Sinai J. Med. , vol.76 , pp. 557-566
    • DiFeo, A.1    Narla, G.2    Martignetti, J.A.3
  • 63
    • 76649107927 scopus 로고    scopus 로고
    • The emerging role of Krüppel-like factors in endocrine-responsive cancers of female reproductive tissues
    • [CrossRef] [PubMed]
    • Simmen, R.C.M.; Pabona, J.M.P.; Velarde, M.C.; Simmons, C.; Rahal, O.; Simmen, F.A. The emerging role of Krüppel-like factors in endocrine-responsive cancers of female reproductive tissues. J. Endocrinol. 2010, 204, 223-231. [CrossRef] [PubMed]
    • (2010) J. Endocrinol. , vol.204 , pp. 223-231
    • Simmen, R.C.M.1    Pabona, J.M.P.2    Velarde, M.C.3    Simmons, C.4    Rahal, O.5    Simmen, F.A.6
  • 64
    • 12344252237 scopus 로고    scopus 로고
    • AP-1 subunits: Quarrel and harmony among siblings
    • [CrossRef] [PubMed]
    • Hess, J.; Angel, P.; Schorpp-Kistner, M. AP-1 subunits: Quarrel and harmony among siblings. J. Cell Sci. 2004, 117, 5965-5973. [CrossRef] [PubMed]
    • (2004) J. Cell Sci. , vol.117 , pp. 5965-5973
    • Hess, J.1    Angel, P.2    Schorpp-Kistner, M.3
  • 65
    • 77949916262 scopus 로고    scopus 로고
    • AP-1-the Jun proteins: Oncogene or tumor suppressors in disguise?
    • Shaurian, E. AP-1-the Jun proteins: Oncogene or tumor suppressors in disguise? Cell Signal. 2010, 22, 894-899.
    • (2010) Cell Signal. , vol.22 , pp. 894-899
    • Shaurian, E.1
  • 67
    • 84920913704 scopus 로고    scopus 로고
    • Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer
    • [CrossRef] [PubMed]
    • Dowling, P.; Hughes, D.J.; Larkin, A.M.; Meiller, J.; Henry, M.; Meleady, P.; Lynch, V.; Pardini, B.; Naccarati, A.; Levy, M.; et al. Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer. Clin. Chim. Acta 2015, 441, 133-141. [CrossRef] [PubMed]
    • (2015) Clin. Chim. Acta , vol.441 , pp. 133-141
    • Dowling, P.1    Hughes, D.J.2    Larkin, A.M.3    Meiller, J.4    Henry, M.5    Meleady, P.6    Lynch, V.7    Pardini, B.8    Naccarati, A.9    Levy, M.10
  • 68
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • [CrossRef] [PubMed]
    • Koppenol, W.H.; Bounds, P.L.; Dang, C.V. Otto Warburg's contributions to current concepts of cancer metabolism. Nat. Rev. Cancer 2011, 11, 325-337. [CrossRef] [PubMed]
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 69
    • 77954697566 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase 1 and 2 mutations in cancer: Alterations at crossroads of cellular metabolism
    • [CrossRef] [PubMed]
    • Reitman, Z.J.; Yan, H. Isocitrate dehydrogenase 1 and 2 mutations in cancer: Alterations at crossroads of cellular metabolism. J. Natl. Cancer Inst. 2010, 102, 932-941. [CrossRef] [PubMed]
    • (2010) J. Natl. Cancer Inst. , vol.102 , pp. 932-941
    • Reitman, Z.J.1    Yan, H.2
  • 71
    • 84855181728 scopus 로고    scopus 로고
    • How do tenacins influence the birth and life of a malignant cell?
    • [CrossRef] [PubMed]
    • Brellier, F.; Chiquet-Ehrismann, R. How do tenacins influence the birth and life of a malignant cell? J. Cell. Mol. Med. 2012, 16, 32-40. [CrossRef] [PubMed]
    • (2012) J. Cell. Mol. Med. , vol.16 , pp. 32-40
    • Brellier, F.1    Chiquet-Ehrismann, R.2
  • 72
    • 84952012375 scopus 로고    scopus 로고
    • High-level secretion of tissue factor-rich extracellular vesicles from ovarian cancer cells mediated by filamin-A and protease-activated receptors
    • [CrossRef] [PubMed]
    • Koizume, S.; Ito, S.; Yoshioka, Y.; Kanayama, T.; Nakamura, Y.; Yoshihara, M.; Yamada, R.; Ochiya, T.; Ruf,W.; Miyagi, E.; et al. High-level secretion of tissue factor-rich extracellular vesicles from ovarian cancer cells mediated by filamin-A and protease-activated receptors. Thromb. Haemost. 2015. [CrossRef] [PubMed]
    • (2015) Thromb. Haemost.
    • Koizume, S.1    Ito, S.2    Yoshioka, Y.3    Kanayama, T.4    Nakamura, Y.5    Yoshihara, M.6    Yamada, R.7    Ochiya, T.8    Ruf, W.9    Miyagi, E.10
  • 73
    • 84929716213 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms underlying oxygen-dependent radiosensitivity
    • [CrossRef] [PubMed]
    • Liu, C.; Lin, Q.; Yun, Z. Cellular and molecular mechanisms underlying oxygen-dependent radiosensitivity. Radiat. Res. 2015, 183, 487-496. [CrossRef] [PubMed]
    • (2015) Radiat. Res. , vol.183 , pp. 487-496
    • Liu, C.1    Lin, Q.2    Yun, Z.3
  • 74
    • 79957534572 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer therapy
    • [CrossRef] [PubMed]
    • Wilson,W.R.; Hay, M.P. Targeting hypoxia in cancer therapy. Nat. Rev. Cancer 2011, 11, 393-410. [CrossRef] [PubMed]
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 393-410
    • Wilson, W.R.1    Hay, M.P.2
  • 75
    • 84883501150 scopus 로고    scopus 로고
    • HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
    • [CrossRef] [PubMed]
    • Semenza, G.L. HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. J. Clin. Investig. 2013, 123, 3664-3671. [CrossRef] [PubMed]
    • (2013) J. Clin. Investig. , vol.123 , pp. 3664-3671
    • Semenza, G.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.