메뉴 건너뛰기




Volumn 28, Issue 3, 2011, Pages 449-454

Molecular mechanism of HIF-1-independent VEGF expression in a hepatocellular carcinoma cell line

Author keywords

Angiogenesis; Hep3B cell line; Hepatocellular carcinoma; Hypoxia inducible factor 1; SP1; Vascular endothelial growth factor

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; TRANSCRIPTION FACTOR SP1; VASCULOTROPIN;

EID: 79959968571     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.719     Document Type: Article
Times cited : (40)

References (37)
  • 1
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris AL: Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 2
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • Hockel M and Vaupel P: Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 93: 266-276, 2001. (Pubitemid 32219813)
    • (2001) Journal of the National Cancer Institute , vol.93 , Issue.4 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 3
    • 36749029349 scopus 로고    scopus 로고
    • Significance of HIF-1-active cells in angiogenesis and radioresistance
    • DOI 10.1038/sj.onc.1210556, PII 1210556
    • Harada H, Kizaka-Kondoh S, Li G, et al: Significance of HIF-1-active cells in angiogenesis and radioresistance. Oncogene 26: 7508-7516, 2007. (Pubitemid 350207705)
    • (2007) Oncogene , vol.26 , Issue.54 , pp. 7508-7516
    • Harada, H.1    Kizaka-Kondoh, S.2    Li, G.3    Itasaka, S.4    Shibuya, K.5    Inoue, M.6    Hiraoka, M.7
  • 4
    • 37149004184 scopus 로고    scopus 로고
    • From molecular biology to targeted therapies for hepatocellular carcinoma: The future is now
    • DOI 10.1159/000111705
    • Pang RW and Poon RT: From molecular biology to targeted therapies for hepatocellular carcinoma: the future is now. Oncology 72 (Suppl 1): 30-44, 2007. (Pubitemid 350256663)
    • (2007) Oncology , vol.72 , Issue.SUPPL. 1 , pp. 30-44
    • Pang, R.W.C.1    Poon, R.T.P.2
  • 5
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP and LeCouter J: The biology of VEGF and its receptors. Nat Med 9: 669-676, 2003.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 6
    • 0036432994 scopus 로고    scopus 로고
    • Hypoxia-induced angiogenesis in human hepatocellular carcinoma
    • Kim KR, Moon HE and Kim KW: Hypoxia-induced angiogenesis in human hepatocellular carcinoma. J Mol Med 80: 703-714, 2002.
    • (2002) J Mol Med , vol.80 , pp. 703-714
    • Kim, K.R.1    Moon, H.E.2    Kim, K.W.3
  • 7
    • 28444476260 scopus 로고    scopus 로고
    • Angiogenic inhibitors: A new therapeutic strategy in oncology
    • DOI 10.1038/ncponc0342, PII N0342
    • Gasparini G, Longo R, Toi M and Ferrara N: Angiogenic inhibitors: a new therapeutic strategy in oncology. Nat Clin Pract Oncol 2: 562-577, 2005. (Pubitemid 41721816)
    • (2005) Nature Clinical Practice Oncology , vol.2 , Issue.11 , pp. 562-577
    • Gasparini, G.1    Longo, R.2    Toi, M.3    Ferrara, N.4
  • 8
    • 33947302545 scopus 로고    scopus 로고
    • Hypoxia accelerates cancer invasion of hepatoma cells by upregulating MMP expression in an HIF-1α-independent manner
    • Miyoshi A, Kitajima Y, Ide T, et al: Hypoxia accelerates cancer invasion of hepatoma cells by upregulating MMP expression in an HIF-1α-independent manner. Int J Oncol 29: 1533-1539, 2006.
    • (2006) Int J Oncol , vol.29 , pp. 1533-1539
    • Miyoshi, A.1    Kitajima, Y.2    Ide, T.3
  • 9
    • 0030044039 scopus 로고    scopus 로고
    • Post-transcriptional regulation of vascular endothelial growth factor by hypoxia
    • DOI 10.1074/jbc.271.5.2746
    • Levy AP, Levy NS and Goldberg MA: Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J Biol Chem 271: 2746-2753, 1996. (Pubitemid 26047892)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.5 , pp. 2746-2753
    • Levy, A.P.1    Levy, N.S.2    Goldberg, M.A.3
  • 10
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1alpha is required for solid tumor formation and embryonic vascularization
    • DOI 10.1093/emboj/17.11.3005
    • Ryan HE, Lo J and Johnson RS: HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 17: 3005-3015, 1998. (Pubitemid 28254373)
    • (1998) EMBO Journal , vol.17 , Issue.11 , pp. 3005-3015
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 11
    • 33645499486 scopus 로고    scopus 로고
    • EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms
    • Pore N, Jiang Z, Gupta A, Cerniglia G, Kao GD and Maity A: EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms. Cancer Res 66: 3197-3204, 2006.
    • (2006) Cancer Res , vol.66 , pp. 3197-3204
    • Pore, N.1    Jiang, Z.2    Gupta, A.3    Cerniglia, G.4    Kao, G.D.5    Maity, A.6
  • 12
    • 0034682783 scopus 로고    scopus 로고
    • Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
    • Cockman ME, Masson N, Mole DR, et al: Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J Biol Chem 275: 25733-25741, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 25733-25741
    • Cockman, M.E.1    Masson, N.2    Mole, D.R.3
  • 13
    • 0034641615 scopus 로고    scopus 로고
    • Activation of HIF1 alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
    • Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC and Conaway JW: Activation of HIF1 alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci USA 97: 10430-10435, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10430-10435
    • Kamura, T.1    Sato, S.2    Iwai, K.3    Czyzyk-Krzeska, M.4    Conaway, R.C.5    Conaway, J.W.6
  • 15
    • 0034006016 scopus 로고    scopus 로고
    • HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
    • Semenza GL: HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88: 1474-1480, 2000.
    • (2000) J Appl Physiol , vol.88 , pp. 1474-1480
    • Semenza, G.L.1
  • 16
    • 33846199233 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Central regulators of the tumor phenotype
    • DOI 10.1016/j.gde.2006.12.006, PII S0959437X06002401, Genetic and Cellular mechanisms of oncogenesis
    • Gordan JD and Simon MC: Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev 17: 71-77, 2007. (Pubitemid 46109295)
    • (2007) Current Opinion in Genetics and Development , vol.17 , Issue.1 , pp. 71-77
    • Gordan, J.D.1    Simon, M.C.2
  • 18
    • 0035164117 scopus 로고    scopus 로고
    • Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma
    • DOI 10.1136/gut.48.1.87
    • von Marschall Z, Cramer T, Hocker M, Finkenzeller G, Wiedenmann B and Rosewicz S: Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma. Gut 48: 87-96, 2001. (Pubitemid 32042647)
    • (2001) Gut , vol.48 , Issue.1 , pp. 87-96
    • Von Marschall, Z.1    Cramer, T.2    Hocker, M.3    Finkenzeller, G.4    Wiedenmann, B.5    Rosewicz, S.6
  • 19
    • 0035132143 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor predicts venous invasion in hepatocellular carcinoma: A prospective study
    • DOI 10.1097/00000658-200102000-00012
    • Poon RT, Ng IO, Lau C, et al: Serum vascular endothelial growth factor predicts venous invasion in hepatocellular carcinoma: a prospective study. Ann Surg 233: 227-235, 2001. (Pubitemid 32106077)
    • (2001) Annals of Surgery , vol.233 , Issue.2 , pp. 227-235
    • Poon, R.T.-P.1    Ng, I.O.-L.2    Lau, C.3    Zhu, L.-X.4    Yu, W.-C.5    Lo, C.-M.6    Fan, S.-T.7    Wong, J.8
  • 20
    • 0043163428 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery
    • DOI 10.1245/ASO.2003.10.002
    • Chao Y, Li CP, Chau GY, et al: Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery. Ann Surg Oncol 10: 355-362, 2003. (Pubitemid 40486931)
    • (2003) Annals of Surgical Oncology , vol.10 , Issue.4 , pp. 355-362
    • Chao, Y.1    Li, C.-P.2    Chau, G.-Y.3    Chen, C.-P.4    King, K.-L.5    Lui, W.-Y.6    Yen, S.-H.7    Chang, F.-Y.8    Chan, W.-K.9    Lee, S.-D.10
  • 23
    • 33846432431 scopus 로고    scopus 로고
    • Expression and clinical significance of HIF-1α protein in hepatocellular carcinoma tissues
    • In Chinese
    • Ding L, Chen XP and Wang HP: Expression and clinical significance of HIF-1α protein in hepatocellular carcinoma tissues. Zhonghua Gan Zang Bing Za Zhi 12: 656-659, 2004 (In Chinese).
    • (2004) Zhonghua Gan Zang Bing Za Zhi , vol.12 , pp. 656-659
    • Ding, L.1    Chen, X.P.2    Wang, H.P.3
  • 24
    • 17144364359 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in hepatocellular carcinoma: Impact on neovascularization and survival
    • Huang GW, Yang LY and Lu WQ: Expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in hepatocellular carcinoma: Impact on neovascularization and survival. World J Gastroenterol 11: 1705-1708, 2005.
    • (2005) World J Gastroenterol , vol.11 , pp. 1705-1708
    • Huang, G.W.1    Yang, L.Y.2    Lu, W.Q.3
  • 25
    • 2942534509 scopus 로고    scopus 로고
    • Activin A stimulates vascular endothelial growth factor gene transcription in human hepatocellular carcinoma cells
    • Wagner K, Peters M, Scholz A, et al: Activin A stimulates vascular endothelial growth factor gene transcription in human hepatocellular carcinoma cells. Gastroenterology 126: 1828-1843, 2004.
    • (2004) Gastroenterology , vol.126 , pp. 1828-1843
    • Wagner, K.1    Peters, M.2    Scholz, A.3
  • 26
    • 1642329821 scopus 로고    scopus 로고
    • Hypoxia-Inducible Factor-1-Independent Regulation of Vascular Endothelial Growth Factor by Hypoxia in Colon Cancer
    • DOI 10.1158/0008-5472.CAN-03-3017
    • Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O and Chung DC: Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res 64: 1765-1772, 2004. (Pubitemid 38428700)
    • (2004) Cancer Research , vol.64 , Issue.5 , pp. 1765-1772
    • Mizukami, Y.1    Li, J.2    Zhang, X.3    Zimmer, M.A.4    Iliopoulos, O.5    Chung, D.C.6
  • 27
    • 33746899015 scopus 로고    scopus 로고
    • Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway
    • DOI 10.1158/1541-7786.MCR-05-0234
    • Pore N, Jiang Z, Shu HK, Bernhard E, Kao GD and Maity A: Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway. Mol Cancer Res 4 471-479, 2006. (Pubitemid 44197042)
    • (2006) Molecular Cancer Research , vol.4 , Issue.7 , pp. 471-479
    • Pore, N.1    Jiang, Z.2    Shu, H.-K.3    Bernhard, E.4    Kao, G.D.5    Maity, A.6
  • 28
    • 0032558822 scopus 로고    scopus 로고
    • Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
    • Haas-Kogan D, Shalev N, Wong M, Mills G, Yount G and Stokoe D: Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Curr Biol 8: 1195-1198, 1998. (Pubitemid 28494720)
    • (1998) Current Biology , vol.8 , Issue.21 , pp. 1195-1198
    • Haas-Kogan, D.1    Shalev, N.2    Wong, M.3    Mills, G.4    Yount, G.5    Stokoe, D.6
  • 29
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • DOI 10.1073/pnas.96.8.4240
    • Cantley LC and Neel BG: New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 96: 4240-4245, 1999. (Pubitemid 29190320)
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , Issue.8 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 30
    • 0034921007 scopus 로고    scopus 로고
    • Tumor suppressor PTEN: Modulator of cell signaling, growth, migration and apoptosis
    • Yamada KM and Araki M: Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. J Cell Sci 114: 2375-2382, 2001. (Pubitemid 32684793)
    • (2001) Journal of Cell Science , vol.114 , Issue.13 , pp. 2375-2382
    • Yamada, K.M.1    Araki, M.2
  • 31
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner E, Taghavi P, Chiles K, Mahon PC and Semenza GL: HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 21: 3995-4004, 2001.
    • (2001) Mol Cell Biol , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 32
    • 0038004462 scopus 로고    scopus 로고
    • Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3′-kinase/protein kinase B in prostate cancer cells
    • Mabjeesh NJ, Willard MT, Frederickson CE, Zhong H and Simons JW: Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3′-kinase/protein kinase B in prostate cancer cells. Clin Cancer Res 9: 2416-2425, 2003. (Pubitemid 36842080)
    • (2003) Clinical Cancer Research , vol.9 , Issue.7 , pp. 2416-2425
    • Mabjeesh, N.J.1    Willard, M.T.2    Frederickson, C.E.3    Zhong, H.4    Simons, J.W.5
  • 33
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D, et al: Modulation of hypoxia-inducible factor lalpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60: 1541-1545, 2000. (Pubitemid 30183422)
    • (2000) Cancer Research , vol.60 , Issue.6 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.-M.6    Simons, J.W.7    Semenza, G.L.8
  • 34
    • 0037374179 scopus 로고    scopus 로고
    • Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer
    • Kaluz S, Kaluzova M and Stanbridge EJ: Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer. Cancer Res 63: 917-922, 2003.
    • (2003) Cancer Res , vol.63 , pp. 917-922
    • Kaluz, S.1    Kaluzova, M.2    Stanbridge, E.J.3
  • 35
    • 0037134442 scopus 로고    scopus 로고
    • Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension
    • DOI 10.1074/jbc.M200017200
    • Alvarez-Tejado M, Alfranca A, Aragones J, Vara A, Landazuri MO and del Peso L: Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. J Biol Chem 277: 13508-13517, 2002. (Pubitemid 34967948)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.16 , pp. 13508-13517
    • Alvarez-Tejado, M.1    Alfranca, A.2    Aragones, J.3    Vara, A.4    Landazuri, M.O.5    Del, P.L.6
  • 36
    • 0037177867 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1alpha nor sufficient for HIF-1-dependent target gene transcription
    • DOI 10.1074/jbc.M111162200
    • Arsham AM, Plas DR, Thompson CB and Simon MC: Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. J Biol Chem 277: 15162-15170, 2002. (Pubitemid 34952595)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.17 , pp. 15162-15170
    • Arsham, A.M.1    Plas, D.R.2    Thompson, C.B.3    Celeste, S.M.4
  • 37
    • 0346435098 scopus 로고    scopus 로고
    • Down-regulation of Sp1 Activity through Modulation of O-Glycosylation by Treatment with a Low Glucose Mimetic, 2-Deoxyglucose
    • DOI 10.1074/jbc.M307332200
    • Kang HT, Ju JW, Cho JW and Hwang ES: Down-regulation of Sp1 activity through modulation of O-glycosylation by treatment with a low glucose mimetic, 2-deoxyglucose. J Biol Chem 278: 51223-51231, 2003. (Pubitemid 38020359)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.51 , pp. 51223-51231
    • Kang, H.T.1    Ju, J.W.2    Cho, J.W.3    Hwang, E.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.