PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells

Journal of Cell Science

Volumn 126, Issue 17, 2013, Pages 3939-3947

  Sun, Lina ^a   Li, He ^a   Chen, Junliang ^a   Iwasaki, Yasumasa ^b   Kubota, Toru ^c   Matsuoka, Mayumi ^c   Shen, Aiguo ^d   Chen, Qi ^a   Xu, Yong ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b KOCHI UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d NANTONG UNIVERSITY   (China)

Author keywords

EMT; Ovarian cancer; PIAS4; PIASy; SIRT1 transcription; SUMOylation

Indexed keywords

PROTEIN INHIBITOR OF ACTIVATED STAT; RESVERATROL; SIRTUIN 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SP1; UBIQUITIN PROTEIN LIGASE E3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CANCER TISSUE; CELL HYPOXIA; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOBARISM; IN VITRO STUDY; IN VIVO STUDY; METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; SUMOYLATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

EMT; OVARIAN CANCER; PIAS4; PIASY; SIRT1 TRANSCRIPTION; SUMOYLATION;

ANIMALS; CELL HYPOXIA; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HEK293 CELLS; HUMANS; MALE; MICE; MICE, NUDE; NEOPLASM METASTASIS; OVARIAN NEOPLASMS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN INHIBITORS OF ACTIVATED STAT; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIRTUIN 1; SP1 TRANSCRIPTION FACTOR; SUMOYLATION; TRANSCRIPTION, GENETIC;

EID: 84883303719     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.127381     Document Type: Article

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