-
2
-
-
84861573996
-
Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease
-
Guy CD, Suzuki A, Zdanowicz M, Abdelmalek MF, Burchette J, Unalp A, et al. Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease. Hepatology 2012;55:1711-1721.
-
(2012)
Hepatology
, vol.55
, pp. 1711-1721
-
-
Guy, C.D.1
Suzuki, A.2
Zdanowicz, M.3
Abdelmalek, M.F.4
Burchette, J.5
Unalp, A.6
-
3
-
-
84887319657
-
From NAFLD to NASH to cirrhosis-new insights into disease mechanisms
-
Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE. From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat Rev Gastroenterol Hepatol 2013;10:627-636.
-
(2013)
Nat Rev Gastroenterol Hepatol
, vol.10
, pp. 627-636
-
-
Wree, A.1
Broderick, L.2
Canbay, A.3
Hoffman, H.M.4
Feldstein, A.E.5
-
4
-
-
0035084699
-
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
-
Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001;120:1183-1192.
-
(2001)
Gastroenterology
, vol.120
, pp. 1183-1192
-
-
Sanyal, A.J.1
Campbell-Sargent, C.2
Mirshahi, F.3
Rizzo, W.B.4
Contos, M.J.5
Sterling, R.K.6
-
5
-
-
33846330186
-
Mitochondrial abnormality and oxidative stress in nonalcoholic steatohepatitis
-
Kojima H, Sakurai S, Uemura M, Fukui H, Morimoto H, Tamagawa Y. Mitochondrial abnormality and oxidative stress in nonalcoholic steatohepatitis. Alcohol Clin Exp Res 2007;31:S61-S66.
-
(2007)
Alcohol Clin Exp Res
, vol.31
, pp. S61-S66
-
-
Kojima, H.1
Sakurai, S.2
Uemura, M.3
Fukui, H.4
Morimoto, H.5
Tamagawa, Y.6
-
6
-
-
84856429876
-
Obesity, inflammation, and liver cancer
-
Sun B, Karin M. Obesity, inflammation, and liver cancer. J Hepatol 2012;56:704-713.
-
(2012)
J Hepatol
, vol.56
, pp. 704-713
-
-
Sun, B.1
Karin, M.2
-
8
-
-
84876727630
-
Hedgehog pathway and pediatric nonalcoholic fatty liver disease
-
Swiderska-Syn M, Suzuki A, Guy CD, Schwimmer JB, Abdelmalek MF, Lavine JE, et al. Hedgehog pathway and pediatric nonalcoholic fatty liver disease. Hepatology 2013;57:1814-1825.
-
(2013)
Hepatology
, vol.57
, pp. 1814-1825
-
-
Swiderska-Syn, M.1
Suzuki, A.2
Guy, C.D.3
Schwimmer, J.B.4
Abdelmalek, M.F.5
Lavine, J.E.6
-
9
-
-
84857667301
-
The role of hedgehog signaling pathway in liver regeneration
-
Cai Y, Zheng H, Gong W, Che Y, Jiang B. The role of hedgehog signaling pathway in liver regeneration. Hepatogastroenterology 2011;58:2071-2076.
-
(2011)
Hepatogastroenterology
, vol.58
, pp. 2071-2076
-
-
Cai, Y.1
Zheng, H.2
Gong, W.3
Che, Y.4
Jiang, B.5
-
10
-
-
84878527104
-
Smoothened is a master regulator of adult liver repair
-
Michelotti GA, Xie G, Swiderska M, Choi SS, Karaca G, Kruger L, et al. Smoothened is a master regulator of adult liver repair. J Clin Invest 2013;123:2380-2394.
-
(2013)
J Clin Invest
, vol.123
, pp. 2380-2394
-
-
Michelotti, G.A.1
Xie, G.2
Swiderska, M.3
Choi, S.S.4
Karaca, G.5
Kruger, L.6
-
11
-
-
84879414522
-
The mechanisms of Hedgehog signalling and its roles in development and disease
-
Briscoe J, Therond PP. The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol 2013;14:416-429.
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, pp. 416-429
-
-
Briscoe, J.1
Therond, P.P.2
-
12
-
-
51949085076
-
Hedgehog: functions and mechanisms
-
Varjosalo M, Taipale J. Hedgehog: functions and mechanisms. Genes Dev 2008;22:2454-2472.
-
(2008)
Genes Dev
, vol.22
, pp. 2454-2472
-
-
Varjosalo, M.1
Taipale, J.2
-
13
-
-
79958229659
-
Increased production of sonic hedgehog by ballooned hepatocytes
-
Rangwala F, Guy CD, Lu J, Suzuki A, Burchette JL, Abdelmalek MF, et al. Increased production of sonic hedgehog by ballooned hepatocytes. J Pathol 2011;224:401-410.
-
(2011)
J Pathol
, vol.224
, pp. 401-410
-
-
Rangwala, F.1
Guy, C.D.2
Lu, J.3
Suzuki, A.4
Burchette, J.L.5
Abdelmalek, M.F.6
-
14
-
-
77951722845
-
Signals from dying hepatocytes trigger growth of liver progenitors
-
Jung Y, Witek RP, Syn WK, Choi SS, Omenetti A, Premont R, et al. Signals from dying hepatocytes trigger growth of liver progenitors. Gut 2010;59:655-665.
-
(2010)
Gut
, vol.59
, pp. 655-665
-
-
Jung, Y.1
Witek, R.P.2
Syn, W.K.3
Choi, S.S.4
Omenetti, A.5
Premont, R.6
-
15
-
-
72749094687
-
Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis
-
Choi SS, Omenetti A, Witek RP, Moylan CA, Syn WK, Jung Y, et al. Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. Am J Physiol Gastrointest Liver Physiol 2009;297:G1093-G1106.
-
(2009)
Am J Physiol Gastrointest Liver Physiol
, vol.297
, pp. G1093-G1106
-
-
Choi, S.S.1
Omenetti, A.2
Witek, R.P.3
Moylan, C.A.4
Syn, W.K.5
Jung, Y.6
-
16
-
-
84880651918
-
Vismodegib suppresses TRAIL-mediated liver injury in a mouse model of nonalcoholic steatohepatitis
-
Hirsova P, Ibrahim SH, Bronk SF, Yagita H, Gores GJ. Vismodegib suppresses TRAIL-mediated liver injury in a mouse model of nonalcoholic steatohepatitis. PLoS One 2013;8:e70599.
-
(2013)
PLoS One
, vol.8
, pp. e70599
-
-
Hirsova, P.1
Ibrahim, S.H.2
Bronk, S.F.3
Yagita, H.4
Gores, G.J.5
-
17
-
-
55849135600
-
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans
-
Omenetti A, Porrello A, Jung Y, Yang L, Popov Y, Choi SS, et al. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest 2008;118:3331-3342.
-
(2008)
J Clin Invest
, vol.118
, pp. 3331-3342
-
-
Omenetti, A.1
Porrello, A.2
Jung, Y.3
Yang, L.4
Popov, Y.5
Choi, S.S.6
-
18
-
-
84892634002
-
Protein and mRNA expression of Shh, Smo and Gli1 and inhibition by cyclopamine in hepatocytes of rats with chronic fluorosis
-
Zhao L, Yu Y, Deng C. Protein and mRNA expression of Shh, Smo and Gli1 and inhibition by cyclopamine in hepatocytes of rats with chronic fluorosis. Toxicol Lett 2014;225:318-324.
-
(2014)
Toxicol Lett
, vol.225
, pp. 318-324
-
-
Zhao, L.1
Yu, Y.2
Deng, C.3
-
19
-
-
42149085600
-
Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer
-
Ramaiah SK, Rittling S. Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer. Toxicol Sci 2008;103:4-13.
-
(2008)
Toxicol Sci
, vol.103
, pp. 4-13
-
-
Ramaiah, S.K.1
Rittling, S.2
-
20
-
-
84891826248
-
Osteopontin: versatile modulator of liver diseases
-
Nagoshi S. Osteopontin: versatile modulator of liver diseases. Hepatol Res 2014;44:22-30.
-
(2014)
Hepatol Res
, vol.44
, pp. 22-30
-
-
Nagoshi, S.1
-
21
-
-
84860009000
-
The osteopontin level in liver, adipose tissue and serum is correlated with fibrosis in patients with alcoholic liver disease
-
Patouraux S, Bonnafous S, Voican CS, Anty R, Saint-Paul MC, Rosenthal-Allieri MA, et al. The osteopontin level in liver, adipose tissue and serum is correlated with fibrosis in patients with alcoholic liver disease. PLoS One 2012;7:e35612.
-
(2012)
PLoS One
, vol.7
, pp. e35612
-
-
Patouraux, S.1
Bonnafous, S.2
Voican, C.S.3
Anty, R.4
Saint-Paul, M.C.5
Rosenthal-Allieri, M.A.6
-
22
-
-
84935026156
-
Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice
-
Coombes JD, Swiderska-Syn M, Dolle L, Reid D, Eksteen B, Claridge L, et al. Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice. Gut 2015;64:1120-1131.
-
(2015)
Gut
, vol.64
, pp. 1120-1131
-
-
Coombes, J.D.1
Swiderska-Syn, M.2
Dolle, L.3
Reid, D.4
Eksteen, B.5
Claridge, L.6
-
23
-
-
78751479915
-
Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis
-
Syn WK, Choi SS, Liaskou E, Karaca GF, Agboola KM, Oo YH, et al. Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. Hepatology 2011;53:106-115.
-
(2011)
Hepatology
, vol.53
, pp. 106-115
-
-
Syn, W.K.1
Choi, S.S.2
Liaskou, E.3
Karaca, G.F.4
Agboola, K.M.5
Oo, Y.H.6
-
24
-
-
79251475861
-
Osteopontin: a missing link between hedgehog signaling and fibrosis in nonalcoholic steatohepatitis
-
Machado MV, Cortez-Pinto H. Osteopontin: a missing link between hedgehog signaling and fibrosis in nonalcoholic steatohepatitis. Hepatology 2011;53:382-384.
-
(2011)
Hepatology
, vol.53
, pp. 382-384
-
-
Machado, M.V.1
Cortez-Pinto, H.2
-
25
-
-
34547516561
-
Wnt signaling regulates pancreatic beta cell proliferation
-
Rulifson IC, Karnik SK, Heiser PW, ten Berge D, Chen H, Gu X, et al. Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci USA 2007;104:6247-6252.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 6247-6252
-
-
Rulifson, I.C.1
Karnik, S.K.2
Heiser, P.W.3
ten Berge, D.4
Chen, H.5
Gu, X.6
-
26
-
-
46049097373
-
Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes
-
Han C, Bowen WC, Michalopoulos GK, Wu T. Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes. J Cell Physiol 2008;216:486-497.
-
(2008)
J Cell Physiol
, vol.216
, pp. 486-497
-
-
Han, C.1
Bowen, W.C.2
Michalopoulos, G.K.3
Wu, T.4
-
27
-
-
77955697348
-
Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated inhibition of primary and transformed hepatocyte growth
-
Han C, Bowen WC, Li G, Demetris AJ, Michalopoulos GK, Wu T. Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated inhibition of primary and transformed hepatocyte growth. Hepatology 2010;52:644-655.
-
(2010)
Hepatology
, vol.52
, pp. 644-655
-
-
Han, C.1
Bowen, W.C.2
Li, G.3
Demetris, A.J.4
Michalopoulos, G.K.5
Wu, T.6
-
28
-
-
80053627289
-
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
-
Kumashiro N, Erion DM, Zhang D, Kahn M, Beddow SA, Chu X, et al. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc Natl Acad Sci USA 2011;108:16381-16385.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 16381-16385
-
-
Kumashiro, N.1
Erion, D.M.2
Zhang, D.3
Kahn, M.4
Beddow, S.A.5
Chu, X.6
-
29
-
-
78049522194
-
Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis
-
Tilg H, Moschen AR. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 2010;52:1836-1846.
-
(2010)
Hepatology
, vol.52
, pp. 1836-1846
-
-
Tilg, H.1
Moschen, A.R.2
-
30
-
-
34548746833
-
Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes
-
Joshi-Barve S, Barve SS, Amancherla K, Gobejishvili L, Hill D, Cave M, et al. Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes. Hepatology 2007;46:823-830.
-
(2007)
Hepatology
, vol.46
, pp. 823-830
-
-
Joshi-Barve, S.1
Barve, S.S.2
Amancherla, K.3
Gobejishvili, L.4
Hill, D.5
Cave, M.6
-
31
-
-
3042824524
-
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
-
Feldstein AE, Werneburg NW, Canbay A, Guicciardi ME, Bronk SF, Rydzewski R, et al. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 2004;40:185-194.
-
(2004)
Hepatology
, vol.40
, pp. 185-194
-
-
Feldstein, A.E.1
Werneburg, N.W.2
Canbay, A.3
Guicciardi, M.E.4
Bronk, S.F.5
Rydzewski, R.6
-
32
-
-
63249096236
-
Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity
-
Bertola A, Deveaux V, Bonnafous S, Rousseau D, Anty R, Wakkach A, et al. Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity. Diabetes 2009;58:125-133.
-
(2009)
Diabetes
, vol.58
, pp. 125-133
-
-
Bertola, A.1
Deveaux, V.2
Bonnafous, S.3
Rousseau, D.4
Anty, R.5
Wakkach, A.6
-
33
-
-
0037085379
-
Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation
-
Yoon JW, Kita Y, Frank DJ, Majewski RR, Konicek BA, Nobrega MA, et al. Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem 2002;277:5548-5555.
-
(2002)
J Biol Chem
, vol.277
, pp. 5548-5555
-
-
Yoon, J.W.1
Kita, Y.2
Frank, D.J.3
Majewski, R.R.4
Konicek, B.A.5
Nobrega, M.A.6
-
34
-
-
84894106141
-
Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma
-
Razumilava N, Gradilone SA, Smoot RL, Mertens JC, Bronk SF, Sirica AE, et al. Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma. J Hepatol 2014;60:599-605.
-
(2014)
J Hepatol
, vol.60
, pp. 599-605
-
-
Razumilava, N.1
Gradilone, S.A.2
Smoot, R.L.3
Mertens, J.C.4
Bronk, S.F.5
Sirica, A.E.6
-
35
-
-
80054743186
-
Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice
-
Landsman L, Parent A, Hebrok M. Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice. Proc Natl Acad Sci USA 2011;108:17010-17015.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 17010-17015
-
-
Landsman, L.1
Parent, A.2
Hebrok, M.3
-
36
-
-
30044431801
-
From fat to inflammation
-
Day CP. From fat to inflammation. Gastroenterology 2006;130:207-210.
-
(2006)
Gastroenterology
, vol.130
, pp. 207-210
-
-
Day, C.P.1
-
37
-
-
84902663562
-
Osteopontin induces ductular reaction contributing to liver fibrosis
-
Wang X, Lopategi A, Ge X, Lu Y, Kitamura N, Urtasun R, et al. Osteopontin induces ductular reaction contributing to liver fibrosis. Gut 2014;63:1805-1818.
-
(2014)
Gut
, vol.63
, pp. 1805-1818
-
-
Wang, X.1
Lopategi, A.2
Ge, X.3
Lu, Y.4
Kitamura, N.5
Urtasun, R.6
-
38
-
-
84884889335
-
Osteopontin delays resolution of liver fibrosis
-
Leung TM, Wang X, Kitamura N, Fiel MI, Nieto N. Osteopontin delays resolution of liver fibrosis. Lab Invest 2013;93:1082-1089.
-
(2013)
Lab Invest
, vol.93
, pp. 1082-1089
-
-
Leung, T.M.1
Wang, X.2
Kitamura, N.3
Fiel, M.I.4
Nieto, N.5
-
39
-
-
84865041500
-
NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease
-
Syn WK, Agboola KM, Swiderska M, Michelotti GA, Liaskou E, Pang H, et al. NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease. Gut 2012;61:1323-1329.
-
(2012)
Gut
, vol.61
, pp. 1323-1329
-
-
Syn, W.K.1
Agboola, K.M.2
Swiderska, M.3
Michelotti, G.A.4
Liaskou, E.5
Pang, H.6
-
40
-
-
3042550624
-
Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model
-
Sahai A, Malladi P, Melin-Aldana H, Green RM, Whitington PF. Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model. Am J Physiol Gastrointest Liver Physiol 2004;287:G264-G273.
-
(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.287
, pp. G264-G273
-
-
Sahai, A.1
Malladi, P.2
Melin-Aldana, H.3
Green, R.M.4
Whitington, P.F.5
-
41
-
-
84883817588
-
Interactions among bone, liver, and adipose tissue predisposing to diabesity and fatty liver
-
Musso G, Paschetta E, Gambino R, Cassader M, Molinaro F. Interactions among bone, liver, and adipose tissue predisposing to diabesity and fatty liver. Trends Mol Med 2013;19:522-535.
-
(2013)
Trends Mol Med
, vol.19
, pp. 522-535
-
-
Musso, G.1
Paschetta, E.2
Gambino, R.3
Cassader, M.4
Molinaro, F.5
|