The role of Hedgehog signaling pathway in liver regeneration

Hepato-Gastroenterology

Volumn 58, Issue 112, 2011, Pages 2071-2076

  Cai, Yidong ^a,b   Zheng, Haoxuan ^a   Gong, Wei ^a   Che, Yufang ^a   Jiang, Bo ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b XIYUAN HOSPITAL   (China)

Author keywords

Hedgehog signaling pathway; Liver regeneration

Indexed keywords

MESSENGER RNA; PROTEIN PATCHED; RETRORSINE; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LIVER HOMOGENATE; LIVER REGENERATION; MALE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; HEDGEHOG PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LIVER REGENERATION; MALE; RATS; RATS, INBRED F344; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84857667301     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: 10.5754/hge11155     Document Type: Article

References (43)

1. Zeini M, Hortelano S, Través PG, et al.: Assessment of a dual regulatory role for NO in liver regeneration after partial hepatectomy: protection against apoptosis and retardation of hepatocyte proliferation. FASEB J 2005; 19:995-997. (Pubitemid 40827729)
2. Pahlavan PS, Feldmann Jr. RE, Zavos C, Kountouras J: Prometheus' Challenge: Molecular, Cellular and Systemic Aspects of Liver Regeneration. J Surg Res 2006; 134:238-251. (Pubitemid 44092799)
3. Coelho MC, Tannuri U, Tannuri AC, et al.: Expression of interleukin 6 and apoptosis-related genes in suckling and weaning rat models of hepatectomy and liver regeneration. J Ped Surg 2007; 42:613-619. (Pubitemid 46589520)
4. Alwayn IP, Verbesey JE, Kim S, et al.: A Critical Role for Matrix Metalloproteinases in Liver Regeneration. J Surg Res 2008; 145:192-198.
5. Pennisi PA, Kopchick JJ, Thorgeirsson S, LeRoith D, Yakar S: Role of growth hormone (GH) in liver regeneration. Endocrinology 2004; 145:4748-4755. (Pubitemid 39281469)
6. Duret C, Gerbal-Chaloin S, et al.: Isolation, characterization, and differentiation to hepatocyte-like cells of nonparenchymal epithelial cells from adult human liver. Stem Cells 2007; 25:1779-1790. (Pubitemid 47121857)
7. Best DH, Coleman WB: Bile duct destruction by 4,4′- diaminodiphenylmethane does not block the small hepatocyte-like progenitor cell response in retrorsine-exposed rats. Hepatology 2007; 46:1611-1619. (Pubitemid 350155542)
8. Ronco MT, Francés D, Alvarez M, et al.: Vascular endothelial growth factor and nitric oxide in rat liver regeneration. Life Sciences 2007; 81:750-755. (Pubitemid 47285196)
9. Takushi Y, Shiraishi M, Nozato E, et al.: Expression of antiapoptotic protein, bcl-2, in liver regeneration after a partial hepatectomy. J Surg Res 2006; 134:93-101. (Pubitemid 43866815)
10. Stoick-Cooper CL, Moon RT, Weidinger G: Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine. Genes & Dev 2007; 21:1292-1315. (Pubitemid 46871034)
11. Hervold K, Martin A, Kirkpatrick RA, et al.: HSP Database a repository of current annotation efforts and resources for the Hh research community. Nucleic Acids Research 2007; 35, Database issue D595-D598.
12. Varjosalo M, Taipale J: Hedgehog signaling J Cell Sci 2007; 120:3-6. (Pubitemid 46206643)
13. Evangelista M, Tian H, de Sauvage FJ: The HSP in Cancer. Clin Cancer Res 2006; 12:5934-5928.
14. Huangfu D, Anderson KV: Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development 2006; 133:3-14. (Pubitemid 43169315)
15. Lum L, Beachy PA: The hedgehog response network: sensors, switches and routers. Science 2004; 304:1755-1759. (Pubitemid 38787882)
16. Ingham PW, McMahon AP: Hedgehog signaling in animal development: paradigms and principles. Genes & Dev 2001; 15:3059-3087. (Pubitemid 33115673)
17. Altaba AR, Mas C, Stecca B: The Gli code: an information nexus regulating cell fate, sternness and cancer. Trends Cell Biol 2007; 17:438-447.
18. Goetz JA, Singh S, Suber LM, et al.: A highly conserved aminoterminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form. J Biol Chem 2006; 281:4087-4093. (Pubitemid 43847834)
19. Denef N, Neubuser D, Perez L, et al.: Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 2000; 102:521-31.
20. Villavicencio EH, Walterhouse DO, Iannaccone PM: The sonic hedgehog-patched-gli pathway in human development and disease. Am J Hum Genet 2000; 67:1047-1054.
21. Stepan V, Ramamoorthy S, Nitsche H, et al.: Regulation and Function of the Sonic Hedgehog Signal Transduction Pathway in Isolated Gastric Parietal Cells. J Biol Chem 2005; 280:15700-15708. (Pubitemid 40616689)
22. Xie J: Implications of hedgehog signaling antagonists for cancer therapy. Acta Biochim Biophys Sin 2008; 40:670-680.
23. Chi S, Huang S, Li C, et al.: Activation of the hedgehog pathway in a subset of lung cancers. Cancer Lett 2006; 244:53-60. (Pubitemid 44485862)
24. Ma X, Sheng T, Zhang Y, et al.: Hedgehog signaling is activated in subsets of esophageal cancers. Int. J. Cancer 2006; 118:139-148. (Pubitemid 41681590)
25. Ma X, Chen K, Huang S, et al: Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis 2005; 26:1698-1705. (Pubitemid 41487985)
26. Kayed H, Kleeff J, Keleg S, et al.: Distribution of Indian hedgehog and its receptors Patched and Smoothened in human chronic pancreatitis. J Endocrinol 2003; 178:467-478. (Pubitemid 37220173)
27. Sanchez P, Hernandez AM, Stecca B, et al.: Inhibition of prostate cancer proliferation by interference with Sonic Hedgehog-GLI1 signaling. Proc Natl Acad Sci USA 2004; 101:12561-6. (Pubitemid 39122063)
28. Huang S, He J, et al.: Activation of the hedgehog pathway in human hepatocellular carcinomas. Carcinogenesis 2006; 27:1334-1340. (Pubitemid 43985408)
29. Patil MA, Zhang J, Ho C, et al.: Hedgehog signaling in human hepatocellular carcinoma. Cancer Biol 2006; 5:111-117. (Pubitemid 43234987)
30. Sicklick JK, Li YX, et al.: Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. Carcinogenesis 2006; 27:748-757.
31. Kim Y, Yoon JW, Xiao X, et al.: Marcusson. Selective Down-Regulation of Glioma-Associated Oncogene 2 Inhibits the Proliferation of Hepatocellular Carcinoma Cells. Cancer Res 2007; 67:3583-93. (Pubitemid 46762142)
32. Yang L, Wang Y, Mao H, et al.: Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. J Hepatol 2008; 48:98-106. (Pubitemid 350191986)
33. Sicklick JK, Li YX, Choi SS, et al.: Role for Hedgehog signaling in hepatic stellate cell activation and viability. Lab Invest 2005; 85:1368-1380. (Pubitemid 41509385)
34. Best DH, Coleman WB: Treatment with 2-AAF blocks the small hepatocyte-like progenitor cell response in retrorsine-exposed rats. Journal of Hepatology 2007; 46:1055-1063. (Pubitemid 46680361)
35. Gordon GJ, Coleman WB, Grisham JW: Temporal analysis of hepatocyte differentiation by small hepatocyte-like progenitor cells during liver regeneration in retrorsine-exposed rats. Am J Pathol 2000; 157:771-786. (Pubitemid 32109370)
36. Higgins GM, Anderson RM: Experimental pathology of the liver. I: restoration of the liver of the white rat following partial surgical removal. Arch Pathol 1931; 12:186-202.
37. Palmes D, Spiegel HU: Animal models of liver regeneration. Biomaterials 2004; 25:1601-1611. (Pubitemid 38091539)
38. van den Brink GR, Hardwick JC, Tytgat GN, et al.: Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. Gastroenterology 2001; 121:317-328. (Pubitemid 32729379)
39. Sicklick JL, Li YX, Melhem A, et al.: Hedgehog signaling maintains resident hepatic progenitors throughout life. Am J Physiol Gastrointest Liver Physiol 2006; 290:859-870.
40. Marigo V, Roberts DJ, Lee SM, et al.: Cloning expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog. Genomics 1995; 28:44-51.
41. Buhman KK, Wang LC, Tang Y, et al.: Inhibition of Hedgehog signaling protects adult mice from diet-induced weight gain. J Nutr 2004; 134:2979-2984. (Pubitemid 39470072)
42. Deutsch G, Jung J, Zheng M, Lora J, Zaret KS: A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development 2001; 128:871-881. (Pubitemid 32288198)
43. King PJ, Guasti L, Laufer E: Hedgehog signaling in endocrine development and disease. Journal of Endocrinology 2008; 198:439-450.