Vismodegib Suppresses TRAIL-mediated Liver Injury in a Mouse Model of Nonalcoholic Steatohepatitis

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Hirsova, Petra ^a,b   Ibrahim, Samar H ^a   Bronk, Steven F ^a   Yagita, Hideo ^c   Gores, Gregory J ^a  

^a MAYO CLINIC   (United States)

^b CHARLES UNIVERSITY   (Czech Republic)

^c JUNTENDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACYL COENZYME A DESATURASE 1; ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; CARNITINE PALMITOYLTRANSFERASE I; CD14 ANTIGEN; CD68 ANTIGEN; DEATH RECEPTOR 5; DIACYLGLYCEROL ACYLTRANSFERASE 1; FAS LIGAND; FATTY ACID SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; OSTEOPONTIN; PROTEIN PATCHED 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; VISMODEGIB;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL ISOLATION; CONTROLLED STUDY; DOWN REGULATION; FATTY ACID OXIDATION; FIBROGENESIS; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIPID DIET; LIVER FIBROSIS; LIVER INJURY; MACROPHAGE; MOUSE; NICK END LABELING; NONALCOHOLIC FATTY LIVER; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANILIDES; ANIMALS; APOPTOSIS; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FATTY LIVER; HEDGEHOG PROTEINS; HUMANS; LIVER; MACROPHAGES; MICE; MICE, INBRED C57BL; PYRIDINES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 84880651918     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070599     Document Type: Article

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