메뉴 건너뛰기




Volumn 21, Issue 1, 2016, Pages 49-61

Generation of functional human serotonergic neurons from fibroblasts

Author keywords

[No Author keywords available]

Indexed keywords

BETA III TUBULIN; BETA TUBULIN; CITALOPRAM; DOXYCYCLINE; FEV PROTEIN; FIBROBLAST GROWTH FACTOR 8; LENTIVIRUS VECTOR; LMX1B PROTEIN; NEUROGENIN 2; PROTEIN; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; SONIC HEDGEHOG PROTEIN; SYNAPSIN; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR MASH1; TRANSCRIPTION FACTOR NKX2.2; TRANSCRIPTOME; TRYPTOPHAN; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 1; TRYPTOPHAN HYDROXYLASE 2; UNCLASSIFIED DRUG; ASCL1 PROTEIN, HUMAN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; FEV PROTEIN, HUMAN; GATA2 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; LIM HOMEOBOX TRANSCRIPTION FACTOR 1 BETA; LIM HOMEODOMAIN PROTEIN; NERVE PROTEIN; NEUROG2 PROTEIN, HUMAN; NKX-2.2 HOMEDOMAIN PROTEIN; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR;

EID: 84951193998     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2015.161     Document Type: Article
Times cited : (111)

References (73)
  • 1
    • 84867120199 scopus 로고    scopus 로고
    • Serotonin in the modulation of neural plasticity and networks: Implications for neurodevelopmental disorders
    • Lesch KP, Waider J. Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders. Neuron 2012; 76: 175-191.
    • (2012) Neuron , vol.76 , pp. 175-191
    • Kp, L.1    Waider, J.2
  • 2
    • 84859215167 scopus 로고    scopus 로고
    • Serotonergic transcriptional networks and potential importance to mental health
    • Deneris ES, Wyler SC. Serotonergic transcriptional networks and potential importance to mental health. Nat Neurosci 2012; 15: 519-527.
    • (2012) Nat Neurosci , vol.15 , pp. 519-527
    • Deneris, E.S.1    Wyler, S.C.2
  • 3
    • 77956009908 scopus 로고    scopus 로고
    • Serotonin: A regulator of neuronal morphology and circuitry
    • Daubert EA, Condron BG. Serotonin: a regulator of neuronal morphology and circuitry. Trends Neurosci 2010; 33: 424-434.
    • (2010) Trends Neurosci , vol.33 , pp. 424-434
    • Daubert, E.A.1    Condron, B.G.2
  • 4
    • 0345258497 scopus 로고    scopus 로고
    • The developmental role of serotonin: News from mouse molecular genetics
    • Gaspar P, Cases O, Maroteaux L. The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 2003; 4: 1002-1012.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 1002-1012
    • Gaspar, P.1    Cases, O.2    Maroteaux, L.3
  • 5
    • 80155172198 scopus 로고    scopus 로고
    • Postnatal serotonin type 2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses, and specific transcriptional changes that arise following early life stress
    • Benekareddy M, Vadodaria KC, Nair AR, Vaidya VA. Postnatal serotonin type 2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses, and specific transcriptional changes that arise following early life stress. Biol Psychiatry 2011; 70: 1024-1032.
    • (2011) Biol Psychiatry , vol.70 , pp. 1024-1032
    • Benekareddy, M.1    Vadodaria, K.C.2    Nair, A.R.3    Vaidya, V.A.4
  • 6
    • 40449126563 scopus 로고    scopus 로고
    • Neurotransmitter regulation of adult neurogenesis: Putative therapeutic targets
    • Vaidya VA, Vadodaria KC, Jha S. Neurotransmitter regulation of adult neurogenesis: putative therapeutic targets. CNS Neurol Disord Drug Targets 2007; 6: 358-374.
    • (2007) CNS Neurol Disord Drug Targets , vol.6 , pp. 358-374
    • Vaidya, V.A.1    Vadodaria, K.C.2    Jha, S.3
  • 7
    • 84919959094 scopus 로고    scopus 로고
    • Serotonin and mental disorders: A concise review on molecular neuroimaging evidence
    • Lin SH, Lee LT, Yang YK. Serotonin and mental disorders: a concise review on molecular neuroimaging evidence. Clin Psychopharmacol Neurosci 2014; 12: 196-202.
    • (2014) Clin Psychopharmacol Neurosci , vol.12 , pp. 196-202
    • Lin, S.H.1    Lee, L.T.2    Yang, Y.K.3
  • 8
    • 84912066548 scopus 로고    scopus 로고
    • Life without brain serotonin: Reevaluation of serotonin function with mice deficient in brain serotonin synthesis
    • Mosienko V, Beis D, Pasqualetti M, Waider J, Matthes S, Qadri F et al. Life without brain serotonin: reevaluation of serotonin function with mice deficient in brain serotonin synthesis. Behav Brain Res 2015; 277: 78-88.
    • (2015) Behav Brain Res , vol.277 , pp. 78-88
    • Mosienko, V.1    Beis, D.2    Pasqualetti, M.3    Waider, J.4    Matthes, S.5    Qadri, F.6
  • 10
    • 84886994729 scopus 로고    scopus 로고
    • Neural stem cells: Generating and regenerating the brain
    • Gage FH, Temple S. Neural stem cells: generating and regenerating the brain. Neuron 2013; 80: 588-601.
    • (2013) Neuron , vol.80 , pp. 588-601
    • Gage, F.H.1    Temple, S.2
  • 13
    • 80155144126 scopus 로고    scopus 로고
    • Induced pluripotent stem cells (iPSCs) and neurological disease modeling: Progress and promises
    • Marchetto MC, Brennand KJ, Boyer LF, Gage FH. Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises. Hum Mol Genet 2011; 20: R109-R115.
    • (2011) Hum Mol Genet , vol.20 , pp. R109-R115
    • Marchetto, M.C.1    Brennand, K.J.2    Boyer, L.F.3    Gage, F.H.4
  • 14
    • 84877301288 scopus 로고    scopus 로고
    • Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development
    • Nicholas CR, Chen J, Tang Y, Southwell DG, Chalmers N, Vogt D et al. Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell 2013; 12: 573-586.
    • (2013) Cell Stem Cell , vol.12 , pp. 573-586
    • Nicholas, C.R.1    Chen, J.2    Tang, Y.3    Southwell, D.G.4    Chalmers, N.5    Vogt, D.6
  • 15
    • 84877271854 scopus 로고    scopus 로고
    • Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells
    • Maroof AM, Keros S, Tyson JA, Ying SW, Ganat YM, Merkle FT et al. Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell Stem Cell 2013; 12: 559-572.
    • (2013) Cell Stem Cell , vol.12 , pp. 559-572
    • Maroof, A.M.1    Keros, S.2    Tyson, J.A.3    Ying, S.W.4    Ganat, Y.M.5    Merkle, F.T.6
  • 16
    • 84877342649 scopus 로고    scopus 로고
    • Medial ganglionic eminencelike cells derived from human embryonic stem cells correct learning and memory deficits
    • Liu Y, Weick JP, Liu H, Krencik R, Zhang X, Ma L et al. Medial ganglionic eminencelike cells derived from human embryonic stem cells correct learning and memory deficits. Nat Biotechnol 2013; 31: 440-447.
    • (2013) Nat Biotechnol , vol.31 , pp. 440-447
    • Liu, Y.1    Weick, J.P.2    Liu, H.3    Krencik, R.4    Zhang, X.5    Ma, L.6
  • 17
    • 80051674431 scopus 로고    scopus 로고
    • Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
    • Caiazzo M, Dell'Anno MT, Dvoretskova E, Lazarevic D, Taverna S, Leo D et al. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 2011; 476: 224-227.
    • (2011) Nature , vol.476 , pp. 224-227
    • Caiazzo, M.1    Dell'Anno, M.T.2    Dvoretskova, E.3    Lazarevic, D.4    Taverna, S.5    Leo, D.6
  • 18
    • 84355166561 scopus 로고    scopus 로고
    • Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease
    • Kriks S, Shim JW, Piao J, Ganat YM, Wakeman DR, Xie Z et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature 2011; 480: 547-551.
    • (2011) Nature , vol.480 , pp. 547-551
    • Kriks, S.1    Shim, J.W.2    Piao, J.3    Ganat, Y.M.4    Wakeman, D.R.5    Xie, Z.6
  • 19
    • 0032577445 scopus 로고    scopus 로고
    • FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
    • Ye W, Shimamura K, Rubenstein JL, Hynes MA, RosenthalA. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 1998; 93: 755-766.
    • (1998) Cell , vol.93 , pp. 755-766
    • Ye, W.1    Shimamura, K.2    Rubenstein, J.L.3    Ma, H.4    Rosenthal, A.5
  • 20
    • 81855166231 scopus 로고    scopus 로고
    • Development of raphe serotonin neurons from specification to guidance
    • Kiyasova V, Gaspar P. Development of raphe serotonin neurons from specification to guidance. Eur J Neurosci 2011; 34: 1553-1562.
    • (2011) Eur J Neurosci , vol.34 , pp. 1553-1562
    • Kiyasova, V.1    Gaspar, P.2
  • 22
    • 0037461749 scopus 로고    scopus 로고
    • Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior
    • Hendricks TJ, Fyodorov DV, Wegman LJ, Lelutiu NB, Pehek EA, Yamamoto B et al. Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron 2003; 37: 233-247.
    • (2003) Neuron , vol.37 , pp. 233-247
    • Hendricks, T.J.1    Fyodorov, D.V.2    Wegman, L.J.3    Lelutiu, N.B.4    Pehek, E.A.5    Yamamoto, B.6
  • 23
    • 33845423914 scopus 로고    scopus 로고
    • Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity
    • Zhao ZQ, Scott M, Chiechio S, Wang JS, Renner KJ, Gereau RWt et al. Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci 2006; 26: 12781-12788.
    • (2006) J Neurosci , vol.26 , pp. 12781-12788
    • Zhao, Z.Q.1    Scott, M.2    Chiechio, S.3    Wang, J.S.4    Renner, K.J.5    Gereau, G.6
  • 24
    • 33746882090 scopus 로고    scopus 로고
    • Specification and differentiation of serotonergic neurons
    • Alenina N, Bashammakh S, Bader M. Specification and differentiation of serotonergic neurons. Stem Cell Rev 2006; 2: 5-10.
    • (2006) Stem Cell Rev , vol.2 , pp. 5-10
    • Alenina, N.1    Bashammakh, S.2    Bader, M.3
  • 25
    • 10744229091 scopus 로고    scopus 로고
    • Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice
    • Barberi T, Klivenyi P, Calingasan NY, Lee H, Kawamata H, Loonam K et al. Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. Nat Biotechnol 2003; 21: 1200-1207.
    • (2003) Nat Biotechnol , vol.21 , pp. 1200-1207
    • Barberi, T.1    Klivenyi, P.2    Calingasan, N.Y.3    Lee, H.4    Kawamata, H.5    Loonam, K.6
  • 26
    • 79957598727 scopus 로고    scopus 로고
    • Directed expression of Gata2, Mash1, and Foxa2 synergize to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells
    • Nefzger CM, Haynes JM, Pouton CW. Directed expression of Gata2, Mash1, and Foxa2 synergize to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells. Stem Cells 2011; 29: 928-939.
    • (2011) Stem Cells , vol.29 , pp. 928-939
    • Nefzger, C.M.1    Haynes, J.M.2    Pouton, C.W.3
  • 27
    • 0034044317 scopus 로고    scopus 로고
    • Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
    • Lee SH, Lumelsky N, Studer L, Auerbach JM, McKay RD. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol 2000; 18: 675-679.
    • (2000) Nat Biotechnol , vol.18 , pp. 675-679
    • Lee, S.H.1    Lumelsky, N.2    Studer, L.3    Auerbach, J.M.4    McKay, R.D.5
  • 28
    • 84862185062 scopus 로고    scopus 로고
    • A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells
    • Shimada T, Takai Y, Shinohara K, Yamasaki A, Tominaga-Yoshino K, Ogura A et al. A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells. J Neurochem 2012; 122: 81-93.
    • (2012) J Neurochem , vol.122 , pp. 81-93
    • Shimada, T.1    Takai, Y.2    Shinohara, K.3    Yamasaki, A.4    Tominaga-Yoshino, K.5    Ogura, A.6
  • 29
    • 78951494851 scopus 로고    scopus 로고
    • Forced expression of LIM homeodomain transcription factor 1b enhances differentiation of mouse embryonic stem cells into serotonergic neurons
    • Dolmazon V, Alenina N, Markossian S, Mancip J, van de Vrede Y, Fontaine E et al. Forced expression of LIM homeodomain transcription factor 1b enhances differentiation of mouse embryonic stem cells into serotonergic neurons. Stem Cells Dev 2011; 20: 301-311.
    • (2011) Stem Cells Dev , vol.20 , pp. 301-311
    • Dolmazon, V.1    Alenina, N.2    Markossian, S.3    Mancip, J.4    Van De Vrede, Y.5    Fontaine, E.6
  • 30
    • 67649298046 scopus 로고    scopus 로고
    • Optimized derivation and functional characterization of 5-HT neurons from human embryonic stem cells
    • Kumar M, Kaushalya SK, Gressens P, Maiti S, Mani S. Optimized derivation and functional characterization of 5-HT neurons from human embryonic stem cells. Stem Cells Dev 2009; 18: 615-627.
    • (2009) Stem Cells Dev , vol.18 , pp. 615-627
    • Kumar, M.1    Kaushalya, S.K.2    Gressens, P.3    Maiti, S.4    Mani, S.5
  • 31
    • 84880620666 scopus 로고    scopus 로고
    • Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency
    • Tailor J, Kittappa R, Leto K, Gates M, Borel M, Paulsen O et al. Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency. J Neurosci 2013; 33: 12407-12422.
    • (2013) J Neurosci , vol.33 , pp. 12407-12422
    • Tailor, J.1    Kittappa, R.2    Leto, K.3    Gates, M.4    Borel, M.5    Paulsen, O.6
  • 32
    • 84890435080 scopus 로고    scopus 로고
    • Onset of rosette formation during spontaneous neural differentiation of hESC and hiPSC colonies
    • Malchenko S, Xie J, de Fatima Bonaldo M, Vanin EF, Bhattacharyya BJ, Belmadani A et al. Onset of rosette formation during spontaneous neural differentiation of hESC and hiPSC colonies. Gene 2014; 534: 400-407.
    • (2014) Gene , vol.534 , pp. 400-407
    • Malchenko, S.1    Xie, J.2    De Fatima Bonaldo, M.3    Vanin, E.F.4    Bhattacharyya, B.J.5    Belmadani, A.6
  • 33
    • 80052276273 scopus 로고    scopus 로고
    • Converting human skin cells to neurons: A new tool to study and treat brain disorders?
    • Kim KS. Converting human skin cells to neurons: a new tool to study and treat brain disorders? Cell Stem Cell 2011; 9: 179-181.
    • (2011) Cell Stem Cell , vol.9 , pp. 179-181
    • Kim, K.S.1
  • 35
    • 84877337520 scopus 로고    scopus 로고
    • Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells
    • Najm FJ, Lager AM, Zaremba A, Wyatt K, Caprariello AV, Factor DC et al. Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. Nat Biotechnol 2013; 31: 426-433.
    • (2013) Nat Biotechnol , vol.31 , pp. 426-433
    • Najm, F.J.1    Lager, A.M.2    Zaremba, A.3    Wyatt, K.4    Caprariello, A.V.5    Factor, D.C.6
  • 37
    • 84880849098 scopus 로고    scopus 로고
    • Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons
    • Liu ML, Zang T, Zou Y, Chang JC, Gibson JR, Huber KM et al. Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons. Nat Commun 2013; 4: 2183.
    • (2013) Nat Commun , vol.4 , pp. 2183
    • Liu, M.L.1    Zang, T.2    Zou, Y.3    Chang, J.C.4    Gibson, J.R.5    Huber, K.M.6
  • 39
    • 84861990748 scopus 로고    scopus 로고
    • Small molecules enable highly efficient neuronal conversion of human fibroblasts
    • Ladewig J, Mertens J, Kesavan J, Doerr J, Poppe D, Glaue F et al. Small molecules enable highly efficient neuronal conversion of human fibroblasts. Nat Methods 2012; 9: 575-578.
    • (2012) Nat Methods , vol.9 , pp. 575-578
    • Ladewig, J.1    Mertens, J.2    Kesavan, J.3    Doerr, J.4    Poppe, D.5    Glaue, F.6
  • 40
    • 84870615167 scopus 로고    scopus 로고
    • Tryptophan hydroxylase 2 (TPH2) in a neuronal cell line: Modulation by cell differentiation and NRSF/rest activity
    • Gentile MT, Nawa Y, Lunardi G, Florio T, Matsui H, Colucci-D'Amato L. Tryptophan hydroxylase 2 (TPH2) in a neuronal cell line: modulation by cell differentiation and NRSF/rest activity. J Neurochem 2012; 123: 963-970.
    • (2012) J Neurochem , vol.123 , pp. 963-970
    • Gentile, M.T.1    Nawa, Y.2    Lunardi, G.3    Florio, T.4    Matsui, H.5    Colucci-D'Amato, L.6
  • 41
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells
    • Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y et al. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 2010; 143: 527-539.
    • (2010) Cell , vol.143 , pp. 527-539
    • Marchetto, M.C.1    Carromeu, C.2    Acab, A.3    Yu, D.4    Yeo, G.W.5    Mu, Y.6
  • 42
    • 84872305996 scopus 로고    scopus 로고
    • Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis
    • Vadodaria KC, Brakebusch C, Suter U, Jessberger S. Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis. J Neurosci 2013; 33: 1179-1189.
    • (2013) J Neurosci , vol.33 , pp. 1179-1189
    • Vadodaria, K.C.1    Brakebusch, C.2    Suter, U.3    Jessberger, S.4
  • 44
    • 77958471357 scopus 로고    scopus 로고
    • Differential expression analysis for sequence count data
    • Anders S, Huber W. Differential expression analysis for sequence count data. Genome Biol 2010; 11: R106.
    • (2010) Genome Biol , vol.11 , pp. R106
    • Anders, S.1    Huber, W.2
  • 45
    • 84929428248 scopus 로고    scopus 로고
    • Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro
    • Bardy C, van den Hurk M, Eames T, Marchand C, Hernandez RV et al. Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro. Proc Natl Acad Sci U S A 2015; 112: E2725-E2734.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. E2725-E2734
    • Bardy, C.1    Van Den Hurk, M.2    Eames, T.3    Marchand, C.4    Hernandez, R.V.5
  • 48
    • 79961173182 scopus 로고    scopus 로고
    • Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions
    • Ambasudhan R, Talantova M, Coleman R, Yuan X, Zhu S, Lipton SA et al. Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell 2011; 9: 113-118.
    • (2011) Cell Stem Cell , vol.9 , pp. 113-118
    • Ambasudhan, R.1    Talantova, M.2    Coleman, R.3    Yuan, X.4    Zhu, S.5    Lipton, S.A.6
  • 49
    • 83455178079 scopus 로고    scopus 로고
    • Setting a highway for converting skin into neurons
    • Broccoli V, Caiazzo M, Dell'Anno MT. Setting a highway for converting skin into neurons. J Mol Cell Biol 2011; 3: 322-323.
    • (2011) J Mol Cell Biol , vol.3 , pp. 322-323
    • Broccoli, V.1    Caiazzo, M.2    Dell'Anno, M.T.3
  • 50
    • 84886784309 scopus 로고    scopus 로고
    • Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons
    • Wapinski OL, Vierbuchen T, Qu K, Lee QY, Chanda S, Fuentes DR et al. Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell 2013; 155: 621-635.
    • (2013) Cell , vol.155 , pp. 621-635
    • Wapinski, O.L.1    Vierbuchen, T.2    Qu, K.3    Lee, Q.Y.4    Chanda, S.5    Fuentes, D.R.6
  • 51
  • 52
    • 84873641538 scopus 로고    scopus 로고
    • The disruption of Celf6, a gene identified by translational profiling of serotonergic neurons, results in autism-related behaviors
    • Dougherty JD, Maloney SE, Wozniak DF, Rieger MA, Sonnenblick L, Coppola G et al. The disruption of Celf6, a gene identified by translational profiling of serotonergic neurons, results in autism-related behaviors. J Neurosci 2013; 33: 2732-2753.
    • (2013) J Neurosci , vol.33 , pp. 2732-2753
    • Dougherty, J.D.1    Maloney, S.E.2    Wozniak, D.F.3    Ma, R.4    Sonnenblick, L.5    Coppola, G.6
  • 55
    • 84870268385 scopus 로고    scopus 로고
    • Derivation of dopaminergic neurons from pluripotent stem cells
    • Studer L. Derivation of dopaminergic neurons from pluripotent stem cells. Prog Brain Res 2012; 200: 243-263.
    • (2012) Prog Brain Res , vol.200 , pp. 243-263
    • Studer, L.1
  • 59
    • 0242694971 scopus 로고    scopus 로고
    • Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype
    • Cheng L, Chen CL, Luo P, Tan M, Qiu M, Johnson R et al. Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype. J Neurosci 2003; 23: 9961-9967.
    • (2003) J Neurosci , vol.23 , pp. 9961-9967
    • Cheng, L.1    Chen, C.L.2    Luo, P.3    Tan, M.4    Qiu, M.5    Johnson, R.6
  • 61
    • 14944356461 scopus 로고    scopus 로고
    • A differentially autoregulated Pet-1 enhancer region is a critical target of the transcriptional cascade that governs serotonin neuron development
    • Scott MM, Krueger KC, Deneris ES. A differentially autoregulated Pet-1 enhancer region is a critical target of the transcriptional cascade that governs serotonin neuron development. J Neurosci 2005; 25: 2628-2636.
    • (2005) J Neurosci , vol.25 , pp. 2628-2636
    • Scott, M.M.1    Krueger, K.C.2    Deneris, E.S.3
  • 62
    • 58149383261 scopus 로고    scopus 로고
    • Serotonergic transcription of human FEV reveals direct GATA factor interactions and fate of Pet-1-deficient serotonin neuron precursors
    • Krueger KC, Deneris ES. Serotonergic transcription of human FEV reveals direct GATA factor interactions and fate of Pet-1-deficient serotonin neuron precursors. J Neurosci 2008; 28: 12748-12758.
    • (2008) J Neurosci , vol.28 , pp. 12748-12758
    • Krueger, K.C.1    Deneris, E.S.2
  • 63
    • 8644277997 scopus 로고    scopus 로고
    • Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous
    • Marinelli S, Schnell SA, Hack SP, Christie MJ, Wessendorf MW, Vaughan CW. Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous. J Neurophysiol 2004; 92: 3532-3537.
    • (2004) J Neurophysiol , vol.92 , pp. 3532-3537
    • Marinelli, S.1    Schnell, S.A.2    Hack, S.P.3    Christie, M.J.4    Wessendorf, M.W.5    Vaughan, C.W.6
  • 64
    • 0029160159 scopus 로고
    • Evidence for a repetitive (burst) firing pattern in a sub-population of 5-hydroxytryptamine neurons in the dorsal and median raphe nuclei of the rat
    • Hajos M, Gartside SE, Villa AE, Sharp T. Evidence for a repetitive (burst) firing pattern in a sub-population of 5-hydroxytryptamine neurons in the dorsal and median raphe nuclei of the rat. Neuroscience 1995; 69: 189-197.
    • (1995) Neuroscience , vol.69 , pp. 189-197
    • Hajos, M.1    Gartside, S.E.2    Villa, A.E.3    Sharp, T.4
  • 65
    • 0142195828 scopus 로고    scopus 로고
    • Neurochemical and anatomical identification of fast- and slow-firing neurones in the rat dorsal raphe nucleus using juxtacellular labelling methods in vivo
    • Allers KA, Sharp T. Neurochemical and anatomical identification of fast- and slow-firing neurones in the rat dorsal raphe nucleus using juxtacellular labelling methods in vivo. Neuroscience 2003; 122: 193-204.
    • (2003) Neuroscience , vol.122 , pp. 193-204
    • Allers, K.A.1    Sharp, T.2
  • 66
    • 32244443202 scopus 로고    scopus 로고
    • Serotonergic neuron diversity: Identification of raphe neurons with discharges time-locked to the hippocampal theta rhythm
    • Kocsis B, Varga V, Dahan L, Sik A. Serotonergic neuron diversity: identification of raphe neurons with discharges time-locked to the hippocampal theta rhythm. Proc Natl Acad Sci USA 2006; 103: 1059-1064.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1059-1064
    • Kocsis, B.1    Varga, V.2    Dahan, L.3    Sik, A.4
  • 67
    • 0035980448 scopus 로고    scopus 로고
    • Evidence for a role of GABA interneurones in the cortical modulation of midbrain 5-hydroxytryptamine neurones
    • Varga V, Szekely AD, Csillag A, Sharp T, Hajos M. Evidence for a role of GABA interneurones in the cortical modulation of midbrain 5-hydroxytryptamine neurones. Neuroscience 2001; 106: 783-792.
    • (2001) Neuroscience , vol.106 , pp. 783-792
    • Varga, V.1    Szekely, A.D.2    Csillag, A.3    Sharp, T.4    Hajos, M.5
  • 68
    • 84874509066 scopus 로고    scopus 로고
    • The neurobiology of depression-revisiting the serotonin hypothesis. II. Genetic, epigenetic and clinical studies
    • Albert PR, Benkelfat C. The neurobiology of depression-revisiting the serotonin hypothesis. II. Genetic, epigenetic and clinical studies. Philos Trans R Soc Lond B Biol Sci 2013; 368: 20120535.
    • (2013) Philos Trans R Soc Lond B Biol Sci , vol.368 , pp. 20120535
    • Albert, P.R.1    Benkelfat, C.2
  • 69
    • 0031690726 scopus 로고    scopus 로고
    • Monoamine dysfunction and the pathophysiology and treatment of depression
    • Charney DS. Monoamine dysfunction and the pathophysiology and treatment of depression. J Clin Psychiatry 1998; 59: 11-14.
    • (1998) J Clin Psychiatry , vol.59 , pp. 11-14
    • Charney, D.S.1
  • 70
    • 0032868798 scopus 로고    scopus 로고
    • The role of serotonin in antipsychotic drug action
    • Meltzer HY. The role of serotonin in antipsychotic drug action. Neuropsychopharmacology 1999; 21: 106S-115S.
    • (1999) Neuropsychopharmacology , vol.21 , pp. 106S-115S
    • Meltzer, H.Y.1
  • 71
    • 84885605195 scopus 로고    scopus 로고
    • Chronic effects of antidepressants on serotonin release in rat raphe slice cultures: High potency of milnacipran in the augmentation of serotonin release
    • Nagayasu K, Kitaichi M, Nishitani N, Asaoka N, Shirakawa H, Nakagawa T et al. Chronic effects of antidepressants on serotonin release in rat raphe slice cultures: high potency of milnacipran in the augmentation of serotonin release. Int J Neuropsychopharmacol 2013; 16: 2295-2306.
    • (2013) Int J Neuropsychopharmacol , vol.16 , pp. 2295-2306
    • Nagayasu, K.1    Kitaichi, M.2    Nishitani, N.3    Asaoka, N.4    Shirakawa, H.5    Nakagawa, T.6
  • 72
    • 84869059676 scopus 로고    scopus 로고
    • Fluoxetine (prozac) and serotonin act on excitatory synaptic transmission to suppress single layer 2/3 pyramidal neuron-triggered cell assemblies in the human prefrontal cortex
    • Komlosi G, Molnar G, Rozsa M, Olah S, Barzo P, Tamas G. Fluoxetine (prozac) and serotonin act on excitatory synaptic transmission to suppress single layer 2/3 pyramidal neuron-triggered cell assemblies in the human prefrontal cortex. J Neurosci 2012; 32: 16369-16378.
    • (2012) J Neurosci , vol.32 , pp. 16369-16378
    • Komlosi, G.1    Molnar, G.2    Rozsa, M.3    Olah, S.4    Barzo, P.5    Tamas, G.6
  • 73
    • 0020614686 scopus 로고
    • Role of precursor availability in control of monoamine biosynthesis in brain
    • Fernstrom JD. Role of precursor availability in control of monoamine biosynthesis in brain. Physiol Rev 1983; 63: 484-546.
    • (1983) Physiol Rev , vol.63 , pp. 484-546
    • Fernstrom, J.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.