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Volumn 17, Issue 2, 2012, Pages 154-163

5-HT 2B receptors are required for serotonin-selective antidepressant actions

Author keywords

5 HT 2B receptors; antidepressants; neurogenesis; serotonin levels

Indexed keywords

1 [5 (2 THIENYLMETHOXY) 3 INDOLYL] 2 PROPANAMINE; FLUOXETINE; PAROXETINE; SEROTONIN; SEROTONIN 2B RECEPTOR; SEROTONIN UPTAKE INHIBITOR;

EID: 84856211754     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2011.159     Document Type: Article
Times cited : (161)

References (40)
  • 1
    • 31444441701 scopus 로고    scopus 로고
    • New approaches to antidepressant drug discovery: Beyond monoamines
    • DOI 10.1038/nrn1846, PII NRN1846
    • Berton O, Nestler EJ. New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 2006; 7: 137-151. (Pubitemid 43151600)
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.2 , pp. 137-151
    • Berton, O.1    Nestler, E.J.2
  • 2
    • 1242263295 scopus 로고    scopus 로고
    • From monoamines to genomic targets: A paradigm shift for drug discovery in depression
    • Wong ML, Licinio J. From monoamines to genomic targets: a paradigm shift for drug discovery in depression. Nat Rev Drug Discov 2004; 3: 136-151. (Pubitemid 38239775)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.2 , pp. 136-151
    • Wong, M.-L.1    Licinio, J.2
  • 3
    • 0033520363 scopus 로고    scopus 로고
    • How do antidepressants work? Prospects for genetic analysis of drug mechanisms
    • DOI 10.1016/S0092-8674(00)80042-2
    • Schafer WR. How do antidepressants work? Prospects for genetic analysis of drug mechanisms. Cell 1999; 98: 551-554. (Pubitemid 29418946)
    • (1999) Cell , vol.98 , Issue.5 , pp. 551-554
    • Schafer, W.R.1
  • 4
    • 0028172409 scopus 로고
    • Adenosine A3 receptors regulate serotonin transport via nitric oxide and cGMP
    • Miller KJ, Hoffman BJ. Adenosine A3 receptors regulate serotonin transport via nitric oxide and cGMP. J Biol Chem 1994; 269: 27351-27356.
    • (1994) J Biol Chem , vol.269 , pp. 27351-27356
    • Miller, K.J.1    Hoffman, B.J.2
  • 6
    • 78650825589 scopus 로고    scopus 로고
    • A population-specific HTR2B stop codon predisposes to severe impulsivity
    • Bevilacqua L, Doly S, Kaprio J, Yuan Q, Tikkanen R, Paunio T et al. A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature 2010; 468: 1061-1066.
    • (2010) Nature , vol.468 , pp. 1061-1066
    • Bevilacqua, L.1    Doly, S.2    Kaprio, J.3    Yuan, Q.4    Tikkanen, R.5    Paunio, T.6
  • 7
    • 33748648565 scopus 로고    scopus 로고
    • 2B receptor signaling in serotonergic neuronal cells
    • DOI 10.1096/fj.06-5724com
    • Launay JM, Schneider B, Loric S, Da Prada M, Kellermann O. Serotonin transport and serotonin transporter-mediated antidepressant recognition are controlled by 5-HT2B receptor signaling in serotonergic neuronal cells. FASEB J 2006; 20: 1843-1854. (Pubitemid 44933798)
    • (2006) FASEB Journal , vol.20 , Issue.11 , pp. 1843-1854
    • Launay, J.-M.1    Schneider, B.2    Loric, S.3    Da Prada, M.4    Kellermann, O.5
  • 9
    • 40849142489 scopus 로고    scopus 로고
    • 2B receptors are required for 3,4- methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro
    • DOI 10.1523/JNEUROSCI.5723-07.2008
    • Doly S, Valjent E, Setola V, Callebert J, Herve D, Launay JM et al. Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine- induced hyperlocomotion and 5-HT release in vivo and in vitro. J Neurosci 2008; 28: 2933-2940. (Pubitemid 351398883)
    • (2008) Journal of Neuroscience , vol.28 , Issue.11 , pp. 2933-2940
    • Doly, S.1    Valjent, E.2    Setola, V.3    Callebert, J.4    Herve, D.5    Launay, J.-M.6    Maroteaux, L.7
  • 10
    • 78650176305 scopus 로고    scopus 로고
    • Deconstructing antiobesity compound action: Requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects
    • Banas S, Doly S, Boutourlinsky K, Diaz S, Belmer A, Callebert J et al. Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects. Neuropsychopharmacology 2011; 36: 423-433.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 423-433
    • Banas, S.1    Doly, S.2    Boutourlinsky, K.3    Diaz, S.4    Belmer, A.5    Callebert, J.6
  • 11
    • 79958105768 scopus 로고    scopus 로고
    • Implication of 5-HT2B receptors in the serotonin syndrome
    • Diaz S, Maroteaux L. Implication of 5-HT2B receptors in the serotonin syndrome. Neuropharmacology 2011; 61: 495-502.
    • (2011) Neuropharmacology , vol.61 , pp. 495-502
    • Diaz, S.1    Maroteaux, L.2
  • 12
    • 73649115601 scopus 로고    scopus 로고
    • A longitudinal study of 5-HToutflow during chronic fluoxetine treatment using a new technique of chronic microdialysis in a highly emotional mouse strain
    • Popa D, Cerdan J, Reperant C, Guiard BP, Guilloux JP, David DJ et al. A longitudinal study of 5-HToutflow during chronic fluoxetine treatment using a new technique of chronic microdialysis in a highly emotional mouse strain. Eur J Pharmacol 2010; 628: 83-90.
    • (2010) Eur J Pharmacol , vol.628 , pp. 83-90
    • Popa, D.1    Cerdan, J.2    Reperant, C.3    Guiard, B.P.4    Guilloux, J.P.5    David, D.J.6
  • 13
    • 0033681079 scopus 로고    scopus 로고
    • Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine2C receptors
    • Cryan JF, Lucki I. Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine2C receptors. J Pharmacol Exp Ther 2000; 295: 1120-1126.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 1120-1126
    • Cryan, J.F.1    Lucki, I.2
  • 14
    • 0034670389 scopus 로고    scopus 로고
    • 5-HT4 receptors do not mediate the antidepressant-like behavioral effects of fluoxetine in a modified forced swim test
    • Cryan JF, Lucki I. 5-HT4 receptors do not mediate the antidepressant-like behavioral effects of fluoxetine in a modified forced swim test. Eur J Pharmacol 2000; 409: 295-299.
    • (2000) Eur J Pharmacol , vol.409 , pp. 295-299
    • Cryan, J.F.1    Lucki, I.2
  • 16
    • 31144476933 scopus 로고    scopus 로고
    • 2A receptor function by chronic administration of selective serotonin reuptake inhibitors
    • DOI 10.1016/j.brainres.2005.10.075, PII S0006899305015350
    • Yamauchi M, Miyara T, Matsushima T, Imanishi T. Desensitization of 5-HT2A receptor function by chronic administration of selective serotonin reuptake inhibitors. Brain Res 2006; 1067: 164-169. (Pubitemid 43133085)
    • (2006) Brain Research , vol.1067 , Issue.1 , pp. 164-169
    • Yamauchi, M.1    Miyara, T.2    Matsushima, T.3    Imanishi, T.4
  • 18
    • 77949387830 scopus 로고    scopus 로고
    • Open questions in current models of antidepressant action
    • Tanti A, Belzung C. Open questions in current models of antidepressant action. Br J Pharmacol 2010; 159: 1187-1200.
    • (2010) Br J Pharmacol , vol.159 , pp. 1187-1200
    • Tanti, A.1    Belzung, C.2
  • 22
    • 0035017384 scopus 로고    scopus 로고
    • Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice
    • DOI 10.1007/s002130100694
    • Lucki I, Dalvi A, Mayorga AJ. Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice. Psychopharmacology (Berl) 2001; 155: 315-322. (Pubitemid 32477289)
    • (2001) Psychopharmacology , vol.155 , Issue.3 , pp. 315-322
    • Lucki, I.1    Dalvi, A.2    Mayorga, A.J.3
  • 26
    • 0028151041 scopus 로고
    • Ectopic induction and reorganization of Wnt-1 expression in quail/chick chimeras
    • Bally-Cuif L, Wassef M. Ectopic induction and reorganization of Wnt-1 expression in quail/chick chimeras. Development 1994; 120: 3379-3394. (Pubitemid 24366984)
    • (1994) Development , vol.120 , Issue.12 , pp. 3379-3394
    • Bally-Cuif, L.1    Wassef, M.2
  • 27
    • 84859165369 scopus 로고    scopus 로고
    • Selective siRNA-mediated suppression of 5-HT(1A) autoreceptors evokes strong anti-depressant-like effects
    • in press
    • Bortolozzi A, Castañ é A, Semakova J, Santana N, Alvarado G, Cortés R et al. Selective siRNA-mediated suppression of 5-HT(1A) autoreceptors evokes strong anti-depressant-like effects. Mol Psychiatry 2011 (in press).
    • (2011) Mol Psychiatry
    • Bortolozzi, A.1    Castañé, A.2    Semakova, J.3    Santana, N.4    Alvarado, G.5    Cortés, R.6
  • 28
    • 0034671366 scopus 로고    scopus 로고
    • Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
    • Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 2000; 20: 9104-9110. (Pubitemid 32042912)
    • (2000) Journal of Neuroscience , vol.20 , Issue.24 , pp. 9104-9110
    • Malberg, J.E.1    Eisch, A.J.2    Nestler, E.J.3    Duman, R.S.4
  • 29
    • 56549103593 scopus 로고    scopus 로고
    • Fluoxetinemediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation
    • Li B, Zhang S, Zhang H, Nu W, Cai L, Hertz L et al. Fluoxetinemediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation. Psychopharmacology (Berl) 2008; 201: 443-458.
    • (2008) Psychopharmacology (Berl) , vol.201 , pp. 443-458
    • Li, B.1    Zhang, S.2    Zhang, H.3    Nu, W.4    Cai, L.5    Hertz, L.6
  • 30
    • 34247872922 scopus 로고    scopus 로고
    • Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test
    • DOI 10.1007/s00213-007-0728-9
    • O'Leary OF, Bechtholt AJ, Crowley JJ, Hill TE, Page ME, Lucki I. Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test. Psychopharmacology (Berl) 2007; 192: 357-371. (Pubitemid 46701581)
    • (2007) Psychopharmacology , vol.192 , Issue.3 , pp. 357-371
    • O'Leary, O.F.1    Bechtholt, A.J.2    Crowley, J.J.3    Hill, T.E.4    Page, M.E.5    Lucki, I.6
  • 31
    • 26944447116 scopus 로고    scopus 로고
    • Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter
    • DOI 10.1016/j.neuropharm.2005.08.010, PII S0028390805003102, New Perspectives in Neurotransmitter Transporter Biology
    • Kim DK, Tolliver TJ, Huang SJ, Martin BJ, Andrews AM, Wichems C et al. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology 2005; 49: 798-810. (Pubitemid 41483886)
    • (2005) Neuropharmacology , vol.49 , Issue.6 , pp. 798-810
    • Kim, D.-K.1    Tolliver, T.J.2    Huang, S.-J.3    Martin, B.J.4    Andrews, A.M.5    Wichems, C.6    Holmes, A.7    Lesch, K.-P.8    Murphy, D.L.9
  • 33
    • 73549095954 scopus 로고    scopus 로고
    • Altered function of the serotonin 1A autoreceptor and the antidepressant response
    • Blier P. Altered function of the serotonin 1A autoreceptor and the antidepressant response. Neuron 2010; 65: 1-2.
    • (2010) Neuron , vol.65 , pp. 1-2
    • Blier, P.1
  • 34
    • 65649125633 scopus 로고    scopus 로고
    • Neurogenesis-dependent and-independent effects of fluoxetine in an animal model of anxiety/depression
    • David DJ, Samuels BA, Rainer Q, Wang J-W, Marsteller D, Mendez I et al. Neurogenesis-dependent and-independent effects of fluoxetine in an animal model of anxiety/depression. Neuron 2009; 62: 479-493.
    • (2009) Neuron , vol.62 , pp. 479-493
    • David, D.J.1    Samuels, B.A.2    Rainer, Q.3    Wang, J.-W.4    Marsteller, D.5    Mendez, I.6
  • 35
    • 13944257674 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus
    • DOI 10.1523/JNEUROSCI.3741-04.2005
    • Sairanen M, Lucas G, Ernfors P, Castrén M, Castrén E. Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus. J Neurosci 2005; 25: 1089-1094. (Pubitemid 40268949)
    • (2005) Journal of Neuroscience , vol.25 , Issue.5 , pp. 1089-1094
    • Sairanen, M.1    Lucas, G.2    Ernfors, P.3    Castren, M.4    Castren, E.5
  • 36
    • 0022229760 scopus 로고
    • Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT(1A) subtype
    • DOI 10.1016/0014-2999(85)90099-8
    • Verge D, Daval G, Patey A, Gozlan H, el Mestikawy S, Hamon M. Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype. Eur J Pharmacol 1985; 113: 463-464. (Pubitemid 16249855)
    • (1985) European Journal of Pharmacology , vol.113 , Issue.3 , pp. 463-464
    • Verge, D.1    Daval, G.2    Patey, A.3
  • 37
    • 0035957507 scopus 로고    scopus 로고
    • 2 receptors differentially regulate the excitability of 5-HT-containing neurones of the guinea pig dorsal raphe nucleus in vitro
    • DOI 10.1016/S0006-8993(01)02221-1, PII S0006899301022211
    • Craven RM, Grahame-Smith DG, Newberry NR. 5-HT1A and 5-HT2 receptors differentially regulate the excitability of 5-HTcontaining neurones of the guinea pig dorsal raphe nucleus in vitro. Brain Res 2001; 899: 159-168. (Pubitemid 32324157)
    • (2001) Brain Research , vol.899 , Issue.1-2 , pp. 159-168
    • Craven, R.M.1    Grahame-Smith, D.G.2    Newberry, N.R.3
  • 38
    • 3142620973 scopus 로고    scopus 로고
    • Influence of SERTPR STin2 in the serotonin transporter gene on the effect of selective serotonin reuptake inhibitors in depression: A systematic review
    • DOI 10.1038/sj.mp.4001488
    • Smits KM, Smits LJ, Schouten JS, Stelma FF, Nelemans P, Prins MH. Influence of SERTPR and STin2 in the serotonin transporter gene on the effect of selective serotonin reuptake inhibitors in depression: a systematic review. Mol Psychiatry 2004; 9: 433-441. (Pubitemid 38903501)
    • (2004) Molecular Psychiatry , vol.9 , Issue.5 , pp. 433-441
    • Smits, K.M.1    Smits, L.J.M.2    Schouten, J.S.A.G.3    Stelma, F.F.4    Nelemans, P.5    Prins, M.H.6
  • 39
    • 33846017361 scopus 로고    scopus 로고
    • Drugs and valvular heart disease
    • Roth BL. Drugs and valvular heart disease. N Engl J Med 2007; 356: 6-9.
    • (2007) N Engl J Med , vol.356 , pp. 6-9
    • Roth, B.L.1
  • 40
    • 5344233478 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension
    • Farber HW, Loscalzo J. Pulmonary arterial hypertension. N Engl J Med 2004; 351: 1655-1665.
    • (2004) N Engl J Med , vol.351 , pp. 1655-1665
    • Farber, H.W.1    Loscalzo, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.