Efficient induction of functional neurons from adult human fibroblasts

Cell Cycle

Volumn 10, Issue 19, 2011, Pages 3311-3316

  Pfisterer, Ulrich ^a,c   Wood, James ^b,c   Nihlberg, Kristian ^a   Hallgren, Oskar ^a,d   Bjermer, Leif ^d   Westergren Thorsson, Gunilla ^a   Lindvall, Olle ^b,c   Parmar, Malin ^a,c  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c LUND UNIVERSITY   (Sweden)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Adult individuals; Direct conversion; Induced neurons; Lineage reprogramming; Lung fibroblasts

Indexed keywords

ADULT; ARTICLE; CARCINOGENESIS; CELL TRANSPLANTATION; FEMALE; HUMAN; HUMAN CELL; LUNG FIBROBLAST; MALE; NERVE CELL; PLURIPOTENT STEM CELL; SOMATIC CELL;

IPS;

EID: 80053446880     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.19.17584     Document Type: Article

References (23)

1. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131:861-72; DOI:10.1016/j.cell.2007.11.019; PMID:18035408.
2. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007; 318:1917-20; DOI:10.1126/science.1151526; PMID:18029452.
3. Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, et al. Modelling schizophrenia using human induced pluripotent stem cells. Nature 2011; 473:221-5; DOI:10.1038/nature09915; PMID:21490598.
4. Ebert AD, Yu J, Rose FF Jr, Mattis VB, Lorson CL, Thomson JA, et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 2009; 457:277-80; DOI:10.1038/nature07677; PMID:19098894.
5. Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, et al. Disease-specific induced pluripotent stem cells. Cell 2008; 134:877-86; DOI:10.1016/j.cell.2008.07.041; PMID:18691744.
6. Menendez S, Camus S, Izpisua Belmonte JC. p53: guardian of reprogramming. Cell Cycle 2010; 9:3887-91; DOI:10.4161/cc.9.19.13301; PMID:20948296.
7. Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S, et al. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging 2010; 2:415-31; PMID:20634564.
8. Plath K, Lowry WE. Progress in understanding reprogramming to the induced pluripotent state. Nat Rev Genet 2011; 12:253-65; DOI:10.1038/nrg2955; PMID:21415849.
9. Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, et al. Epigenetic memory in induced pluripotent stem cells. Nature 2010; 467:285-90; DOI:10.1038/ nature09342; PMID:20644535.
10. Stadtfeld M, Hochedlinger K. Induced pluripotency: history, mechanisms and applications. Genes Dev 2010; 24:2239-63; DOI:10.1101/gad.1963910; PMID:20952534.
11. Lagarkova MA, Shutova MV, Bogomazova AN, Vassina EM, Glazov EA, Zhang P, et al. Induction of pluripotency in human endothelial cells resets epigenetic profile on genome scale. Cell Cycle 2010; 9:937-46; DOI:10.4161/cc.9.5.10869; PMID:20160486.
12. Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, et al. A small-molecule inhibitor of tgfBeta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell 2009; 5:491-503; DOI:10.1016/j.stem.2009.09.012; PMID:19818703.
13. Woltjen K, Michael IP, Mohseni P, Desai R, Mileikovsky M, Hamalainen R, et al. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 2009; 458:766-70; DOI:10.1038/nature07863; PMID:19252478.
14. Kaji K, Norrby K, Paca A, Mileikovsky M, Mohseni P, Woltjen K. Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 2009; 458:771-5; DOI:10.1038/nature07864; PMID:19252477.
15. Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, et al. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 2009; 136:964-77; DOI:10.1016/j.cell.2009.02.013; PMID:19269371.
16. Sun N, Longaker MT, Wu JC. Human iPS cell-based therapy: considerations before clinical applications. Cell Cycle 2010; 9:880-5; DOI:10.4161/cc.9.5. 10827; PMID:20160515.
17. Patel M, Yang S. Advances in reprogramming somatic cells to induced pluripotent stem cells. Stem Cell Rev 2010; 6:367-80; DOI:10.1007/s12015-010- 9123-8; PMID:20336395.
18. Miura K, Okada Y, Aoi T, Okada A, Takahashi K, Okita K, et al. Variation in the safety of induced pluripotent stem cell lines. Nat Biotechnol 2009; 27:743-5; DOI:10.1038/nbt.1554; PMID:19590502.
19. Pang ZP, Yang N, Vierbuchen T, Ostermeier A, Fuentes DR, Yang TQ, et al. Induction of human neuronal cells by defined transcription factors. Nature 2011; 476:224-7; PMID:21725324.
20. Pfisterer U, Kirkeby A, Torper O, Wood J, Nelander J, Dufour A, et al. Direct conversion of human fibroblasts to dopaminergic neurons. Proc Natl Acad Sci USA 2011; 108:10343-8; DOI:10.1073/pnas.1105135108; PMID:21646515.
21. Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Sudhof TC, Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010; 463:1035-41; DOI:10.1038/nature08797; PMID:20107439.
22. Caiazzo M, Dell'anno MT, Dvoretskova E, Lazarevic D, Taverna S, Leo D, et al. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 2011; 476:224-7; PMID:21725324.
23. Nihlberg K, Andersson-Sjöland A, Tufvesson E, Erjefält JS, Bjermer L, Westergren-Thorsson G. Altered matrix production in the distal airways of individuals with asthma.Thorax. 2010; 65:670-6. PMID: 20685740