메뉴 건너뛰기




Volumn 277, Issue , 2015, Pages 78-88

Life without brain serotonin: Reevaluation of serotonin function with mice deficient in brain serotonin synthesis

Author keywords

Animal model; Behavior; Serotonin; Serotonin receptors; Serotonin transporter; Tryptophan hydroxylase 2

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 4 AMINOBUTYRIC ACID; 5 HYDROXYINDOLEACETIC ACID; DOPAMINE; GLUTAMIC ACID; HOMOVANILLIC ACID; NORADRENALIN; NORMETADRENALIN; SEROTONIN; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; TRYPTOPHAN HYDROXYLASE 2; TRYPTOPHAN HYDROXYLASE;

EID: 84912066548     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2014.06.005     Document Type: Review
Times cited : (91)

References (99)
  • 1
    • 0022485159 scopus 로고
    • An improved radioenzymatic assay for plasma norepinephrine using purified phenylethanolamine N-methyltransferase
    • Henry D.P., Bowsher R.R. An improved radioenzymatic assay for plasma norepinephrine using purified phenylethanolamine N-methyltransferase. Life Sci 1986, 38(16):1473-1483.
    • (1986) Life Sci , vol.38 , Issue.16 , pp. 1473-1483
    • Henry, D.P.1    Bowsher, R.R.2
  • 2
    • 0020319156 scopus 로고
    • The effect of some precursor amino acids and enzyme inhibitors on the mouse striatal concentration of tyramines and homovanillic acid
    • Juorio A.V., Boulton A.A. The effect of some precursor amino acids and enzyme inhibitors on the mouse striatal concentration of tyramines and homovanillic acid. J Neurochem 1982, 39(3):859-863.
    • (1982) J Neurochem , vol.39 , Issue.3 , pp. 859-863
    • Juorio, A.V.1    Boulton, A.A.2
  • 3
    • 0024322129 scopus 로고
    • Release of some endogenous trace amines from rat striatal slices in the presence and absence of a monoamine oxidase inhibitor
    • Dyck L.E. Release of some endogenous trace amines from rat striatal slices in the presence and absence of a monoamine oxidase inhibitor. Life Sci 1989, 44(17):1149-1156.
    • (1989) Life Sci , vol.44 , Issue.17 , pp. 1149-1156
    • Dyck, L.E.1
  • 4
    • 0032852842 scopus 로고    scopus 로고
    • Tetrahydropterin-dependent amino acid hydroxylases
    • Fitzpatrick P.F. Tetrahydropterin-dependent amino acid hydroxylases. Annu Rev Biochem 1999, 68:355-381.
    • (1999) Annu Rev Biochem , vol.68 , pp. 355-381
    • Fitzpatrick, P.F.1
  • 5
    • 0034723057 scopus 로고    scopus 로고
    • Pharmacogenetics and the serotonin system: initial studies and future directions
    • Veenstra-VanderWeele J., Anderson G.M., Cook E.H. Pharmacogenetics and the serotonin system: initial studies and future directions. Eur J Pharmacol 2000, 410(2-3):165-181.
    • (2000) Eur J Pharmacol , vol.410 , Issue.2-3 , pp. 165-181
    • Veenstra-VanderWeele, J.1    Anderson, G.M.2    Cook, E.H.3
  • 6
    • 0026086899 scopus 로고
    • Molecular cloning and characterization of cDNA encoding tryptophan hydroxylase from rat central serotonergic neurons
    • Kim K.S., Wessel T.C., Stone D.M., Carver C.H., Joh T.H., Park D.H. Molecular cloning and characterization of cDNA encoding tryptophan hydroxylase from rat central serotonergic neurons. Brain Res Mol Brain Res 1991, 9(4):277-283.
    • (1991) Brain Res Mol Brain Res , vol.9 , Issue.4 , pp. 277-283
    • Kim, K.S.1    Wessel, T.C.2    Stone, D.M.3    Carver, C.H.4    Joh, T.H.5    Park, D.H.6
  • 7
    • 0141922899 scopus 로고    scopus 로고
    • A unique central tryptophan hydroxylase isoform
    • Walther D.J., Bader M. A unique central tryptophan hydroxylase isoform. Biochem Pharmacol 2003, 66(9):1673-1680.
    • (2003) Biochem Pharmacol , vol.66 , Issue.9 , pp. 1673-1680
    • Walther, D.J.1    Bader, M.2
  • 10
    • 60749103570 scopus 로고    scopus 로고
    • Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice
    • Gutknecht L., Kriegebaum C., Waider J., Schmitt A., Lesch K.P. Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice. Eur Neuropsychopharmacol 2009, 19(4):266-282.
    • (2009) Eur Neuropsychopharmacol , vol.19 , Issue.4 , pp. 266-282
    • Gutknecht, L.1    Kriegebaum, C.2    Waider, J.3    Schmitt, A.4    Lesch, K.P.5
  • 11
    • 69449083603 scopus 로고    scopus 로고
    • A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure
    • Yadav V.K., Oury F., Suda N., Liu Z.W., Gao X.B., Confavreux C., et al. A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell 2009, 138(5):976-989.
    • (2009) Cell , vol.138 , Issue.5 , pp. 976-989
    • Yadav, V.K.1    Oury, F.2    Suda, N.3    Liu, Z.W.4    Gao, X.B.5    Confavreux, C.6
  • 12
    • 1042277736 scopus 로고    scopus 로고
    • Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland
    • Patel P.D., Pontrello C., Burke S. Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland. Biol Psychiatry 2004, 55(4):428-433.
    • (2004) Biol Psychiatry , vol.55 , Issue.4 , pp. 428-433
    • Patel, P.D.1    Pontrello, C.2    Burke, S.3
  • 13
    • 33646542677 scopus 로고    scopus 로고
    • Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies
    • Sakowski S.A., Geddes T.J., Thomas D.M., Levi E., Hatfield J.S., Kuhn D.M. Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies. Brain Res 2006, 1085(1):11-18.
    • (2006) Brain Res , vol.1085 , Issue.1 , pp. 11-18
    • Sakowski, S.A.1    Geddes, T.J.2    Thomas, D.M.3    Levi, E.4    Hatfield, J.S.5    Kuhn, D.M.6
  • 14
    • 33750725388 scopus 로고    scopus 로고
    • Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: a post-mortem study
    • Zill P., Buttner A., Eisenmenger W., Moller H.J., Ackenheil M., Bondy B. Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: a post-mortem study. J Psychiatr Res 2007, 41(1-2):168-173.
    • (2007) J Psychiatr Res , vol.41 , Issue.1-2 , pp. 168-173
    • Zill, P.1    Buttner, A.2    Eisenmenger, W.3    Moller, H.J.4    Ackenheil, M.5    Bondy, B.6
  • 15
    • 84879485147 scopus 로고    scopus 로고
    • Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense
    • (Discussion 280)
    • Gershon M.D. Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Trans Am Clin Climatol Assoc 2012, 123:268-280. (Discussion 280).
    • (2012) Trans Am Clin Climatol Assoc , vol.123 , pp. 268-280
    • Gershon, M.D.1
  • 16
    • 84865274050 scopus 로고    scopus 로고
    • Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test
    • Clark J.A., Alves S., Gundlah C., Rocha B., Birzin E.T., Cai S.J., et al. Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test. Neuropharmacology 2012, 63(6):1051-1063.
    • (2012) Neuropharmacology , vol.63 , Issue.6 , pp. 1051-1063
    • Clark, J.A.1    Alves, S.2    Gundlah, C.3    Rocha, B.4    Birzin, E.T.5    Cai, S.J.6
  • 17
    • 16844383875 scopus 로고    scopus 로고
    • Estrogen receptor-beta regulates tryptophan hydroxylase-1 expression in the murine midbrain raphe
    • Gundlah C., Alves S.E., Clark J.A., Pai L.Y., Schaeffer J.M., Rohrer S.P. Estrogen receptor-beta regulates tryptophan hydroxylase-1 expression in the murine midbrain raphe. Biol Psychiatry 2005, 57(8):938-942.
    • (2005) Biol Psychiatry , vol.57 , Issue.8 , pp. 938-942
    • Gundlah, C.1    Alves, S.E.2    Clark, J.A.3    Pai, L.Y.4    Schaeffer, J.M.5    Rohrer, S.P.6
  • 18
    • 24144444539 scopus 로고    scopus 로고
    • Tissue-specific expression of tryptophan hydroxylase mRNAs in the rat midbrain: anatomical evidence and daily profiles
    • Malek Z.S., Dardente H., Pevet P., Raison S. Tissue-specific expression of tryptophan hydroxylase mRNAs in the rat midbrain: anatomical evidence and daily profiles. Eur J Neurosci 2005, 22(4):895-901.
    • (2005) Eur J Neurosci , vol.22 , Issue.4 , pp. 895-901
    • Malek, Z.S.1    Dardente, H.2    Pevet, P.3    Raison, S.4
  • 19
    • 32544455435 scopus 로고    scopus 로고
    • Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels
    • Nakamura K., Sugawara Y., Sawabe K., Ohashi A., Tsurui H., Xiu Y., et al. Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. J Neurosci 2006, 26(2):530-534.
    • (2006) J Neurosci , vol.26 , Issue.2 , pp. 530-534
    • Nakamura, K.1    Sugawara, Y.2    Sawabe, K.3    Ohashi, A.4    Tsurui, H.5    Xiu, Y.6
  • 20
    • 84884672306 scopus 로고    scopus 로고
    • Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation
    • Migliarini S., Pacini G., Pelosi B., Lunardi G., Pasqualetti M. Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation. Mol Psychiatry 2013, 18(10):1106-1118.
    • (2013) Mol Psychiatry , vol.18 , Issue.10 , pp. 1106-1118
    • Migliarini, S.1    Pacini, G.2    Pelosi, B.3    Lunardi, G.4    Pasqualetti, M.5
  • 21
    • 77956230326 scopus 로고    scopus 로고
    • Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life
    • Kriegebaum C., Song N.N., Gutknecht L., Huang Y., Schmitt A., Reif A., et al. Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochem Int 2010, 57(5):512-517.
    • (2010) Neurochem Int , vol.57 , Issue.5 , pp. 512-517
    • Kriegebaum, C.1    Song, N.N.2    Gutknecht, L.3    Huang, Y.4    Schmitt, A.5    Reif, A.6
  • 22
    • 67649854385 scopus 로고    scopus 로고
    • Growth retardation and altered autonomic control in mice lacking brain serotonin
    • Alenina N., Kikic D., Todiras M., Mosienko V., Qadri F., Plehm R., et al. Growth retardation and altered autonomic control in mice lacking brain serotonin. Proc Nat Acad Sci USA 2009, 106(25):10332-10337.
    • (2009) Proc Nat Acad Sci USA , vol.106 , Issue.25 , pp. 10332-10337
    • Alenina, N.1    Kikic, D.2    Todiras, M.3    Mosienko, V.4    Qadri, F.5    Plehm, R.6
  • 23
    • 84862023357 scopus 로고    scopus 로고
    • Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity
    • Angoa-Perez M., Kane M.J., Briggs D.I., Sykes C.E., Shah M.M., Francescutti D.M., et al. Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity. J Neurochem 2012, 121(6):974-984.
    • (2012) J Neurochem , vol.121 , Issue.6 , pp. 974-984
    • Angoa-Perez, M.1    Kane, M.J.2    Briggs, D.I.3    Sykes, C.E.4    Shah, M.M.5    Francescutti, D.M.6
  • 24
    • 49749117799 scopus 로고    scopus 로고
    • Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice
    • Gutknecht L., Waider J., Kraft S., Kriegebaum C., Holtmann B., Reif A., et al. Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. J Neural Transm 2008, 115(8):1127-1132.
    • (2008) J Neural Transm , vol.115 , Issue.8 , pp. 1127-1132
    • Gutknecht, L.1    Waider, J.2    Kraft, S.3    Kriegebaum, C.4    Holtmann, B.5    Reif, A.6
  • 25
    • 79953733493 scopus 로고    scopus 로고
    • Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice
    • Liu Y., Jiang Y., Si Y., Kim J.Y., Chen Z.F., Rao Y. Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice. Nature 2011, 472(7341):95-99.
    • (2011) Nature , vol.472 , Issue.7341 , pp. 95-99
    • Liu, Y.1    Jiang, Y.2    Si, Y.3    Kim, J.Y.4    Chen, Z.F.5    Rao, Y.6
  • 26
    • 84896300796 scopus 로고    scopus 로고
    • Dorsal raphe neurons signal reward through 5-HT and glutamate
    • Liu Z., Zhou J., Li Y., Hu F., Lu Y., Ma M., et al. Dorsal raphe neurons signal reward through 5-HT and glutamate. Neuron 2014, 81(6):1360-1374.
    • (2014) Neuron , vol.81 , Issue.6 , pp. 1360-1374
    • Liu, Z.1    Zhou, J.2    Li, Y.3    Hu, F.4    Lu, Y.5    Ma, M.6
  • 27
    • 54849404294 scopus 로고    scopus 로고
    • Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants
    • Savelieva K.V., Zhao S., Pogorelov V.M., Rajan I., Yang Q., Cullinan E., et al. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PLoS One 2008, 3(10):e3301.
    • (2008) PLoS One , vol.3 , Issue.10 , pp. e3301
    • Savelieva, K.V.1    Zhao, S.2    Pogorelov, V.M.3    Rajan, I.4    Yang, Q.5    Cullinan, E.6
  • 28
    • 84859215897 scopus 로고    scopus 로고
    • Deciphering a neuronal circuit that mediates appetite
    • Wu Q., Clark M.S., Palmiter R.D. Deciphering a neuronal circuit that mediates appetite. Nature 2012, 483(7391):594-597.
    • (2012) Nature , vol.483 , Issue.7391 , pp. 594-597
    • Wu, Q.1    Clark, M.S.2    Palmiter, R.D.3
  • 30
    • 84861653106 scopus 로고    scopus 로고
    • Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin
    • Mosienko V., Bert B., Beis D., Matthes S., Fink H., Bader M., et al. Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin. Transl Psychiatry 2012, 2:e122.
    • (2012) Transl Psychiatry , vol.2 , pp. e122
    • Mosienko, V.1    Bert, B.2    Beis, D.3    Matthes, S.4    Fink, H.5    Bader, M.6
  • 31
    • 84865089657 scopus 로고    scopus 로고
    • Impacts of brain serotonin deficiency following Tph2 inactivation on development and Raphe neuron serotonergic specification
    • Gutknecht L., Araragi N., Merker S., Waider J., Sommerlandt F.M., Mlinar B., et al. Impacts of brain serotonin deficiency following Tph2 inactivation on development and Raphe neuron serotonergic specification. PLoS One 2012, 7(8):e43157.
    • (2012) PLoS One , vol.7 , Issue.8 , pp. e43157
    • Gutknecht, L.1    Araragi, N.2    Merker, S.3    Waider, J.4    Sommerlandt, F.M.5    Mlinar, B.6
  • 32
    • 84881592305 scopus 로고    scopus 로고
    • Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis
    • Araragi N., Mlinar B., Baccini G., Gutknecht L., Lesch K.P., Corradetti R. Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis. Front Pharmacol 2013, 4:97.
    • (2013) Front Pharmacol , vol.4 , pp. 97
    • Araragi, N.1    Mlinar, B.2    Baccini, G.3    Gutknecht, L.4    Lesch, K.P.5    Corradetti, R.6
  • 33
    • 84878974699 scopus 로고    scopus 로고
    • Serotonin signaling in the brain of adult female mice is required for sexual preference
    • Zhang S., Liu Y., Rao Y. Serotonin signaling in the brain of adult female mice is required for sexual preference. Proc Nat Acad Sci USA 2013, 110(24):9968-9973.
    • (2013) Proc Nat Acad Sci USA , vol.110 , Issue.24 , pp. 9968-9973
    • Zhang, S.1    Liu, Y.2    Rao, Y.3
  • 34
    • 84883680045 scopus 로고    scopus 로고
    • Animal models of the serotonin syndrome: a systematic review
    • Haberzettl R., Bert B., Fink H., Fox M.A. Animal models of the serotonin syndrome: a systematic review. Behav Brain Res 2013, 256:328-345.
    • (2013) Behav Brain Res , vol.256 , pp. 328-345
    • Haberzettl, R.1    Bert, B.2    Fink, H.3    Fox, M.A.4
  • 35
    • 56349119282 scopus 로고    scopus 로고
    • Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice
    • Fox M.A., Jensen C.L., French H.T., Stein A.R., Huang S.J., Tolliver T.J., et al. Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice. Psychopharmacology (Berl) 2008, 201(2):203-218.
    • (2008) Psychopharmacology (Berl) , vol.201 , Issue.2 , pp. 203-218
    • Fox, M.A.1    Jensen, C.L.2    French, H.T.3    Stein, A.R.4    Huang, S.J.5    Tolliver, T.J.6
  • 36
    • 0036213738 scopus 로고    scopus 로고
    • Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors
    • Sanacora G., Mason G.F., Rothman D.L., Krystal J.H. Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors. Am J Psychiatry 2002, 159(4):663-665.
    • (2002) Am J Psychiatry , vol.159 , Issue.4 , pp. 663-665
    • Sanacora, G.1    Mason, G.F.2    Rothman, D.L.3    Krystal, J.H.4
  • 37
    • 0033022999 scopus 로고    scopus 로고
    • The role of the hippocampus and 5-HT/GABA interaction in the central effects of benzodiazepine receptor ligands
    • Nazar M., Siemiatkowski M., Czlonkowska A., Sienkiewicz-Jarosz H., Plaznik A. The role of the hippocampus and 5-HT/GABA interaction in the central effects of benzodiazepine receptor ligands. J Neural Transm 1999, 106(5-6):369-381.
    • (1999) J Neural Transm , vol.106 , Issue.5-6 , pp. 369-381
    • Nazar, M.1    Siemiatkowski, M.2    Czlonkowska, A.3    Sienkiewicz-Jarosz, H.4    Plaznik, A.5
  • 38
    • 0037370134 scopus 로고    scopus 로고
    • Serotonin-GABA interactions in the modulation of mu- and kappa-opioid analgesia
    • Nemmani K.V., Mogil J.S. Serotonin-GABA interactions in the modulation of mu- and kappa-opioid analgesia. Neuropharmacology 2003, 44(3):304-310.
    • (2003) Neuropharmacology , vol.44 , Issue.3 , pp. 304-310
    • Nemmani, K.V.1    Mogil, J.S.2
  • 39
    • 0142195828 scopus 로고    scopus 로고
    • Neurochemical and anatomical identification of fast- and slow-firing neurones in the rat dorsal raphe nucleus using juxtacellular labelling methods in vivo
    • Allers K.A., Sharp T. Neurochemical and anatomical identification of fast- and slow-firing neurones in the rat dorsal raphe nucleus using juxtacellular labelling methods in vivo. Neuroscience 2003, 122(1):193-204.
    • (2003) Neuroscience , vol.122 , Issue.1 , pp. 193-204
    • Allers, K.A.1    Sharp, T.2
  • 40
    • 79958132580 scopus 로고    scopus 로고
    • Raphe serotonin neurons are not homogenous: electrophysiological, morphological and neurochemical evidence
    • Calizo L.H., Akanwa A., Ma X., Pan Y.Z., Lemos J.C., Craige C., et al. Raphe serotonin neurons are not homogenous: electrophysiological, morphological and neurochemical evidence. Neuropharmacology 2011, 61(3):524-543.
    • (2011) Neuropharmacology , vol.61 , Issue.3 , pp. 524-543
    • Calizo, L.H.1    Akanwa, A.2    Ma, X.3    Pan, Y.Z.4    Lemos, J.C.5    Craige, C.6
  • 41
    • 2642582531 scopus 로고    scopus 로고
    • Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus
    • Day H.E., Greenwood B.N., Hammack S.E., Watkins L.R., Fleshner M., Maier S.F., et al. Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. J Comp Neurol 2004, 474(3):364-378.
    • (2004) J Comp Neurol , vol.474 , Issue.3 , pp. 364-378
    • Day, H.E.1    Greenwood, B.N.2    Hammack, S.E.3    Watkins, L.R.4    Fleshner, M.5    Maier, S.F.6
  • 42
    • 0037198405 scopus 로고    scopus 로고
    • Possible glutamatergic/aspartatergic projections to the supramammillary nucleus and their origins in the rat studied by selective [(3)H]d-aspartate labelling and immunocytochemistry
    • Kiss J., Csaki A., Bokor H., Kocsis K., Kocsis B. Possible glutamatergic/aspartatergic projections to the supramammillary nucleus and their origins in the rat studied by selective [(3)H]d-aspartate labelling and immunocytochemistry. Neuroscience 2002, 111(3):671-691.
    • (2002) Neuroscience , vol.111 , Issue.3 , pp. 671-691
    • Kiss, J.1    Csaki, A.2    Bokor, H.3    Kocsis, K.4    Kocsis, B.5
  • 43
    • 0020033366 scopus 로고
    • Identification of serotonin and non-serotonin-containing neurons of the mid-brain raphe projecting to the entorhinal area and the hippocampal formation. A combined immunohistochemical and fluorescent retrograde tracing study in the rat brain
    • Kohler C., Steinbusch H. Identification of serotonin and non-serotonin-containing neurons of the mid-brain raphe projecting to the entorhinal area and the hippocampal formation. A combined immunohistochemical and fluorescent retrograde tracing study in the rat brain. Neuroscience 1982, 7(4):951-975.
    • (1982) Neuroscience , vol.7 , Issue.4 , pp. 951-975
    • Kohler, C.1    Steinbusch, H.2
  • 44
    • 0035048317 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 mediates mu-opioid receptor desensitization in GABAergic neurons of the nucleus raphe magnus
    • Li A.H., Wang H.L. G protein-coupled receptor kinase 2 mediates mu-opioid receptor desensitization in GABAergic neurons of the nucleus raphe magnus. J Neurochem 2001, 77(2):435-444.
    • (2001) J Neurochem , vol.77 , Issue.2 , pp. 435-444
    • Li, A.H.1    Wang, H.L.2
  • 45
    • 0033792971 scopus 로고    scopus 로고
    • Reciprocal innervation between serotonergic and GABAergic neurons in raphe nuclei of the rat
    • Bagdy E., Kiraly I., Harsing L.G. Reciprocal innervation between serotonergic and GABAergic neurons in raphe nuclei of the rat. Neurochem Res 2000, 25(11):1465-1473.
    • (2000) Neurochem Res , vol.25 , Issue.11 , pp. 1465-1473
    • Bagdy, E.1    Kiraly, I.2    Harsing, L.G.3
  • 46
    • 70350211440 scopus 로고    scopus 로고
    • Activation of serotonin 5-HT(1B) receptor in the dorsal raphe nucleus affects REM sleep in the rat
    • Monti J.M., Jantos H., Lagos P. Activation of serotonin 5-HT(1B) receptor in the dorsal raphe nucleus affects REM sleep in the rat. Behav Brain Res 2010, 206(1):8-16.
    • (2010) Behav Brain Res , vol.206 , Issue.1 , pp. 8-16
    • Monti, J.M.1    Jantos, H.2    Lagos, P.3
  • 47
    • 0021057747 scopus 로고
    • Evidence for a GABAergic inhibitory influence on serotonergic neurons originating from the dorsal raphe
    • Nishikawa T., Scatton B. Evidence for a GABAergic inhibitory influence on serotonergic neurons originating from the dorsal raphe. Brain Res 1983, 279(1-2):325-329.
    • (1983) Brain Res , vol.279 , Issue.1-2 , pp. 325-329
    • Nishikawa, T.1    Scatton, B.2
  • 48
    • 0020034196 scopus 로고
    • Gamma-Aminobutyric acid (GABA) receptor stimulation. III. Effect of progabide (SL 76002) on norepinephrine, dopamine and 5-hydroxytryptamine turnover in rat brain areas
    • Scatton B., Zivkovic B., Dedek J., Lloyd K.G., Constantinidis J., Tissot R., et al. gamma-Aminobutyric acid (GABA) receptor stimulation. III. Effect of progabide (SL 76002) on norepinephrine, dopamine and 5-hydroxytryptamine turnover in rat brain areas. J Pharmacol Exp Ther 1982, 220(3):678-688.
    • (1982) J Pharmacol Exp Ther , vol.220 , Issue.3 , pp. 678-688
    • Scatton, B.1    Zivkovic, B.2    Dedek, J.3    Lloyd, K.G.4    Constantinidis, J.5    Tissot, R.6
  • 49
    • 0031596783 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine2 receptor facilitates GABAergic neurotransmission in rat hippocampus
    • Shen R.Y., Andrade R. 5-Hydroxytryptamine2 receptor facilitates GABAergic neurotransmission in rat hippocampus. J Pharmacol Exp Ther 1998, 285(2):805-812.
    • (1998) J Pharmacol Exp Ther , vol.285 , Issue.2 , pp. 805-812
    • Shen, R.Y.1    Andrade, R.2
  • 50
    • 0032589812 scopus 로고    scopus 로고
    • 5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex
    • Abi-Saab W.M., Bubser M., Roth R.H., Deutch A.Y. 5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex. Neuropsychopharmacology 1999, 20(1):92-96.
    • (1999) Neuropsychopharmacology , vol.20 , Issue.1 , pp. 92-96
    • Abi-Saab, W.M.1    Bubser, M.2    Roth, R.H.3    Deutch, A.Y.4
  • 51
    • 33845231964 scopus 로고    scopus 로고
    • In vivo evidence that 5-HT(2C) receptors inhibit 5-HT neuronal activity via a GABAergic mechanism
    • Boothman L., Raley J., Denk F., Hirani E., Sharp T. In vivo evidence that 5-HT(2C) receptors inhibit 5-HT neuronal activity via a GABAergic mechanism. Br J Pharmacol 2006, 149(7):861-869.
    • (2006) Br J Pharmacol , vol.149 , Issue.7 , pp. 861-869
    • Boothman, L.1    Raley, J.2    Denk, F.3    Hirani, E.4    Sharp, T.5
  • 52
    • 0034604778 scopus 로고    scopus 로고
    • Serotonin 5-HT(2) receptors activate local GABA inhibitory inputs to serotonergic neurons of the dorsal raphe nucleus
    • Liu R., Jolas T., Aghajanian G. Serotonin 5-HT(2) receptors activate local GABA inhibitory inputs to serotonergic neurons of the dorsal raphe nucleus. Brain Res 2000, 873(1):34-45.
    • (2000) Brain Res , vol.873 , Issue.1 , pp. 34-45
    • Liu, R.1    Jolas, T.2    Aghajanian, G.3
  • 54
    • 77955060200 scopus 로고    scopus 로고
    • Cortical GABA, striatal dopamine and midbrain serotonin as the key players in compulsive and anxiety disorders-results from in vivo imaging studies
    • Nikolaus S., Antke C., Beu M., Muller H.W. Cortical GABA, striatal dopamine and midbrain serotonin as the key players in compulsive and anxiety disorders-results from in vivo imaging studies. Rev Neurosci 2010, 21(2):119-139.
    • (2010) Rev Neurosci , vol.21 , Issue.2 , pp. 119-139
    • Nikolaus, S.1    Antke, C.2    Beu, M.3    Muller, H.W.4
  • 55
    • 67849133186 scopus 로고    scopus 로고
    • Brain structures implicated in the four-plate test in naive and experienced Swiss mice using injection of diazepam and the 5-HT2A agonist DOI
    • Petit-Demouliere B., Masse F., Cogrel N., Hascoet M., Bourin M. Brain structures implicated in the four-plate test in naive and experienced Swiss mice using injection of diazepam and the 5-HT2A agonist DOI. Behav Brain Res 2009, 204(1):200-205.
    • (2009) Behav Brain Res , vol.204 , Issue.1 , pp. 200-205
    • Petit-Demouliere, B.1    Masse, F.2    Cogrel, N.3    Hascoet, M.4    Bourin, M.5
  • 56
    • 34247514888 scopus 로고    scopus 로고
    • Serotonin modulates the response of embryonic thalamocortical axons to netrin-1
    • Bonnin A., Torii M., Wang L., Rakic P., Levitt P. Serotonin modulates the response of embryonic thalamocortical axons to netrin-1. Nat Neurosci 2007, 10(5):588-597.
    • (2007) Nat Neurosci , vol.10 , Issue.5 , pp. 588-597
    • Bonnin, A.1    Torii, M.2    Wang, L.3    Rakic, P.4    Levitt, P.5
  • 57
    • 4644222747 scopus 로고    scopus 로고
    • Roles for serotonin in neurodevelopment: more than just neural transmission
    • Di Pino G., Moessner R., Lesch P., Lauder J., Persico A. Roles for serotonin in neurodevelopment: more than just neural transmission. Curr Neuropharmacol 2004, 2:403-418.
    • (2004) Curr Neuropharmacol , vol.2 , pp. 403-418
    • Di Pino, G.1    Moessner, R.2    Lesch, P.3    Lauder, J.4    Persico, A.5
  • 58
    • 0345258497 scopus 로고    scopus 로고
    • The developmental role of serotonin: news from mouse molecular genetics
    • Gaspar P., Cases O., Maroteaux L. The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 2003, 4(12):1002-1012.
    • (2003) Nat Rev Neurosci , vol.4 , Issue.12 , pp. 1002-1012
    • Gaspar, P.1    Cases, O.2    Maroteaux, L.3
  • 60
    • 60549089578 scopus 로고    scopus 로고
    • Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6
    • Riccio O., Potter G., Walzer C., Vallet P., Szabo G., Vutskits L., et al. Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6. Mol Psychiatry 2009, 14(3):280-290.
    • (2009) Mol Psychiatry , vol.14 , Issue.3 , pp. 280-290
    • Riccio, O.1    Potter, G.2    Walzer, C.3    Vallet, P.4    Szabo, G.5    Vutskits, L.6
  • 61
    • 84876707550 scopus 로고    scopus 로고
    • GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice
    • Waider J., Proft F., Langlhofer G., Asan E., Lesch K.P., Gutknecht L. GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice. Histochem Cell Biol 2013, 139(2):267-281.
    • (2013) Histochem Cell Biol , vol.139 , Issue.2 , pp. 267-281
    • Waider, J.1    Proft, F.2    Langlhofer, G.3    Asan, E.4    Lesch, K.P.5    Gutknecht, L.6
  • 62
    • 17444447575 scopus 로고    scopus 로고
    • Structural basis of the cholinergic and serotonergic modulation of GABAergic neurons in the hippocampus
    • Gulyas A.I., Acsady L., Freund T.F. Structural basis of the cholinergic and serotonergic modulation of GABAergic neurons in the hippocampus. Neurochem Int 1999, 34(5):359-372.
    • (1999) Neurochem Int , vol.34 , Issue.5 , pp. 359-372
    • Gulyas, A.I.1    Acsady, L.2    Freund, T.F.3
  • 63
    • 85028100549 scopus 로고    scopus 로고
    • Serotonin and prefrontal cortex function: neurons, networks, and circuits
    • Puig M.V., Gulledge A.T. Serotonin and prefrontal cortex function: neurons, networks, and circuits. Mol Neurobiol 2011, 44(3):449-464.
    • (2011) Mol Neurobiol , vol.44 , Issue.3 , pp. 449-464
    • Puig, M.V.1    Gulledge, A.T.2
  • 64
    • 77953144335 scopus 로고    scopus 로고
    • Subtype-selective GABA(A) receptor modulation yields a novel pharmacological profile: the design and development of TPA023
    • Atack J.R. Subtype-selective GABA(A) receptor modulation yields a novel pharmacological profile: the design and development of TPA023. Adv Pharmacol 2009, 57:137-185.
    • (2009) Adv Pharmacol , vol.57 , pp. 137-185
    • Atack, J.R.1
  • 66
    • 3943092619 scopus 로고    scopus 로고
    • Genetic approaches to the study of anxiety
    • Gordon J.A., Hen R. Genetic approaches to the study of anxiety. Annu Rev Neurosci 2004, 27:193-222.
    • (2004) Annu Rev Neurosci , vol.27 , pp. 193-222
    • Gordon, J.A.1    Hen, R.2
  • 67
    • 0034613173 scopus 로고    scopus 로고
    • Molecular and neuronal substrate for the selective attenuation of anxiety
    • Low K., Crestani F., Keist R., Benke D., Brunig I., Benson J.A., et al. Molecular and neuronal substrate for the selective attenuation of anxiety. Science (New York, NY) 2000, 290(5489):131-134.
    • (2000) Science (New York, NY) , vol.290 , Issue.5489 , pp. 131-134
    • Low, K.1    Crestani, F.2    Keist, R.3    Benke, D.4    Brunig, I.5    Benson, J.A.6
  • 68
    • 0033592682 scopus 로고    scopus 로고
    • Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes
    • Rudolph U., Crestani F., Benke D., Brunig I., Benson J.A., Fritschy J.M., et al. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature 1999, 401(6755):796-800.
    • (1999) Nature , vol.401 , Issue.6755 , pp. 796-800
    • Rudolph, U.1    Crestani, F.2    Benke, D.3    Brunig, I.4    Benson, J.A.5    Fritschy, J.M.6
  • 70
    • 84867328459 scopus 로고    scopus 로고
    • Alpha2-containing GABA(A) receptors: a target for the development of novel treatment strategies for CNS disorders
    • Engin E., Liu J., Rudolph U. Alpha2-containing GABA(A) receptors: a target for the development of novel treatment strategies for CNS disorders. Pharmacol Ther 2012, 136(2):142-152.
    • (2012) Pharmacol Ther , vol.136 , Issue.2 , pp. 142-152
    • Engin, E.1    Liu, J.2    Rudolph, U.3
  • 71
    • 84912091946 scopus 로고    scopus 로고
    • Interactions of serotonin and diazepam on behavioral inhibition in tryptophan hydroxylase 2 deficient mice
    • Society for Neuroscience, Washington, (Online)
    • Beis D., Mosienko V., Bader M., Alenina N. Interactions of serotonin and diazepam on behavioral inhibition in tryptophan hydroxylase 2 deficient mice. Program nr. 302.17, 2011 Neuroscience Meeting Planner 2011, Society for Neuroscience, Washington, (Online).
    • (2011) Program nr. 302.17, 2011 Neuroscience Meeting Planner
    • Beis, D.1    Mosienko, V.2    Bader, M.3    Alenina, N.4
  • 73
    • 0033991116 scopus 로고    scopus 로고
    • Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS
    • Clemett D.A., Punhani T., Duxon M.S., Blackburn T.P., Fone K.C. Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS. Neuropharmacology 2000, 39(1):123-132.
    • (2000) Neuropharmacology , vol.39 , Issue.1 , pp. 123-132
    • Clemett, D.A.1    Punhani, T.2    Duxon, M.S.3    Blackburn, T.P.4    Fone, K.C.5
  • 74
    • 0024722805 scopus 로고
    • 5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system
    • Molineaux S.M., Jessell T.M., Axel R., Julius D. 5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system. Proc Nat Acad Sci USA 1989, 86(17):6793-6797.
    • (1989) Proc Nat Acad Sci USA , vol.86 , Issue.17 , pp. 6793-6797
    • Molineaux, S.M.1    Jessell, T.M.2    Axel, R.3    Julius, D.4
  • 75
    • 0028176806 scopus 로고
    • Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors
    • Pompeiano M., Palacios J.M., Mengod G. Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain Res Mol Brain Res 1994, 23(1-2):163-178.
    • (1994) Brain Res Mol Brain Res , vol.23 , Issue.1-2 , pp. 163-178
    • Pompeiano, M.1    Palacios, J.M.2    Mengod, G.3
  • 76
    • 0030612256 scopus 로고    scopus 로고
    • Distribution of the 5-hydroxytryptamine2C receptor protein in adult rat brain and spinal cord determined using a receptor-directed antibody: effect of 5,7-dihydroxytryptamine
    • Sharma A., Punhani T., Fone K.C. Distribution of the 5-hydroxytryptamine2C receptor protein in adult rat brain and spinal cord determined using a receptor-directed antibody: effect of 5,7-dihydroxytryptamine. Synapse 1997, 27(1):45-56.
    • (1997) Synapse , vol.27 , Issue.1 , pp. 45-56
    • Sharma, A.1    Punhani, T.2    Fone, K.C.3
  • 77
    • 0028985633 scopus 로고
    • Comparative localization of serotonin1A, 1C, and 2 receptor subtype mRNAs in rat brain
    • Wright D.E., Seroogy K.B., Lundgren K.H., Davis B.M., Jennes L. Comparative localization of serotonin1A, 1C, and 2 receptor subtype mRNAs in rat brain. J Comp Neurol 1995, 351(3):357-373.
    • (1995) J Comp Neurol , vol.351 , Issue.3 , pp. 357-373
    • Wright, D.E.1    Seroogy, K.B.2    Lundgren, K.H.3    Davis, B.M.4    Jennes, L.5
  • 78
    • 77954132615 scopus 로고    scopus 로고
    • The central serotonin 2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity
    • Auclair A.L., Cathala A., Sarrazin F., Depoortere R., Piazza P.V., Newman-Tancredi A., et al. The central serotonin 2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity. J Neurochem 2010, 114(5):1323-1332.
    • (2010) J Neurochem , vol.114 , Issue.5 , pp. 1323-1332
    • Auclair, A.L.1    Cathala, A.2    Sarrazin, F.3    Depoortere, R.4    Piazza, P.V.5    Newman-Tancredi, A.6
  • 79
    • 78651289938 scopus 로고    scopus 로고
    • The role of endogenous serotonin in methamphetamine-induced neurotoxicity to dopamine nerve endings of the striatum
    • Thomas D.M., Angoa Perez M., Francescutti-Verbeem D.M., Shah M.M., Kuhn D.M. The role of endogenous serotonin in methamphetamine-induced neurotoxicity to dopamine nerve endings of the striatum. J Neurochem 2010, 115(3):595-605.
    • (2010) J Neurochem , vol.115 , Issue.3 , pp. 595-605
    • Thomas, D.M.1    Angoa Perez, M.2    Francescutti-Verbeem, D.M.3    Shah, M.M.4    Kuhn, D.M.5
  • 80
    • 0028535338 scopus 로고
    • Molecular physiology of norepinephrine and serotonin transporters
    • Blakely R.D., De Felice L.J., Hartzell H.C. Molecular physiology of norepinephrine and serotonin transporters. J Exp Biol 1994, 196:263-281.
    • (1994) J Exp Biol , vol.196 , pp. 263-281
    • Blakely, R.D.1    De Felice, L.J.2    Hartzell, H.C.3
  • 81
    • 33750075014 scopus 로고    scopus 로고
    • Activation, internalization, and recycling of the serotonin 2A receptor by dopamine
    • Bhattacharyya S., Raote I., Bhattacharya A., Miledi R., Panicker M.M. Activation, internalization, and recycling of the serotonin 2A receptor by dopamine. Proc Nat Acad Sci USA 2006, 103(41):15248-15253.
    • (2006) Proc Nat Acad Sci USA , vol.103 , Issue.41 , pp. 15248-15253
    • Bhattacharyya, S.1    Raote, I.2    Bhattacharya, A.3    Miledi, R.4    Panicker, M.M.5
  • 82
    • 84871533108 scopus 로고    scopus 로고
    • Functional selectivity in serotonin receptor 2A (5-HT2A) endocytosis, recycling, and phosphorylation
    • Raote I., Bhattacharyya S., Panicker M.M. Functional selectivity in serotonin receptor 2A (5-HT2A) endocytosis, recycling, and phosphorylation. Mol Pharmacol 2013, 83(1):42-50.
    • (2013) Mol Pharmacol , vol.83 , Issue.1 , pp. 42-50
    • Raote, I.1    Bhattacharyya, S.2    Panicker, M.M.3
  • 84
    • 84875732051 scopus 로고    scopus 로고
    • Mice genetically depleted of brain serotonin display social impairments, communication deficits and repetitive behaviors: possible relevance to autism
    • Kane M.J., Angoa-Perez M., Briggs D.I., Sykes C.E., Francescutti D.M., Rosenberg D.R., et al. Mice genetically depleted of brain serotonin display social impairments, communication deficits and repetitive behaviors: possible relevance to autism. PLoS One 2012, 7(11):e48975.
    • (2012) PLoS One , vol.7 , Issue.11 , pp. e48975
    • Kane, M.J.1    Angoa-Perez, M.2    Briggs, D.I.3    Sykes, C.E.4    Francescutti, D.M.5    Rosenberg, D.R.6
  • 85
    • 34548828248 scopus 로고    scopus 로고
    • Arrest of 5HT neuron differentiation delays respiratory maturation and impairs neonatal homeostatic responses to environmental challenges
    • Erickson J.T., Shafer G., Rossetti M.D., Wilson C.G., Deneris E.S. Arrest of 5HT neuron differentiation delays respiratory maturation and impairs neonatal homeostatic responses to environmental challenges. Respir Physiol Neurobiol 2007, 159(1):85-101.
    • (2007) Respir Physiol Neurobiol , vol.159 , Issue.1 , pp. 85-101
    • Erickson, J.T.1    Shafer, G.2    Rossetti, M.D.3    Wilson, C.G.4    Deneris, E.S.5
  • 86
    • 84893833300 scopus 로고    scopus 로고
    • Ventilatory long-term facilitation is evident after initial and repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin
    • Hickner S., Hussain N., Angoa-Perez M., Francescutti D.M., Kuhn D.M., Mateika J.H. Ventilatory long-term facilitation is evident after initial and repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin. J Appl Physiol (1985) 2014, 116(3):240-250.
    • (2014) J Appl Physiol (1985) , vol.116 , Issue.3 , pp. 240-250
    • Hickner, S.1    Hussain, N.2    Angoa-Perez, M.3    Francescutti, D.M.4    Kuhn, D.M.5    Mateika, J.H.6
  • 87
    • 40449113428 scopus 로고    scopus 로고
    • Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons
    • Hodges M.R., Tattersall G.J., Harris M.B., McEvoy S.D., Richerson D.N., Deneris E.S., et al. Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons. J Neurosci 2008, 28(10):2495-2505.
    • (2008) J Neurosci , vol.28 , Issue.10 , pp. 2495-2505
    • Hodges, M.R.1    Tattersall, G.J.2    Harris, M.B.3    McEvoy, S.D.4    Richerson, D.N.5    Deneris, E.S.6
  • 88
    • 84912069526 scopus 로고    scopus 로고
    • Genetic disruption of brain serotonin content in mice produces leanness with hyperphagia and elevated physical activity but minimal skeletal changes. Abstract Nr. SUN-94, 2012
    • The Endocrine Society, Houston, TX, (Online)
    • Brommage R., Smith D.D., Liu J., Yu W., Yang Q.M., Powell D.R. Genetic disruption of brain serotonin content in mice produces leanness with hyperphagia and elevated physical activity but minimal skeletal changes. Abstract Nr. SUN-94, 2012. ENDO meeting 2012, The Endocrine Society, Houston, TX, (Online).
    • (2012) ENDO meeting
    • Brommage, R.1    Smith, D.D.2    Liu, J.3    Yu, W.4    Yang, Q.M.5    Powell, D.R.6
  • 90
    • 33846246036 scopus 로고    scopus 로고
    • Serotonergic drugs: effects on appetite expression and use for the treatment of obesity
    • Halford J.C., Harrold J.A., Boyland E.J., Lawton C.L., Blundell J.E. Serotonergic drugs: effects on appetite expression and use for the treatment of obesity. Drugs 2007, 67(1):27-55.
    • (2007) Drugs , vol.67 , Issue.1 , pp. 27-55
    • Halford, J.C.1    Harrold, J.A.2    Boyland, E.J.3    Lawton, C.L.4    Blundell, J.E.5
  • 91
    • 80054094062 scopus 로고    scopus 로고
    • Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion
    • Fernandez S.P., Gaspar P. Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion. Neuropharmacology 2012, 62(1):144-154.
    • (2012) Neuropharmacology , vol.62 , Issue.1 , pp. 144-154
    • Fernandez, S.P.1    Gaspar, P.2
  • 92
    • 84864234417 scopus 로고    scopus 로고
    • Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviour
    • Lesch K.P., Araragi N., Waider J., van den Hove D., Gutknecht L. Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviour. Philos Trans R Soc Lond B: Biol Sci 2012, 367(1601):2426-2443.
    • (2012) Philos Trans R Soc Lond B: Biol Sci , vol.367 , Issue.1601 , pp. 2426-2443
    • Lesch, K.P.1    Araragi, N.2    Waider, J.3    van den Hove, D.4    Gutknecht, L.5
  • 93
    • 84867120199 scopus 로고    scopus 로고
    • Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders
    • Lesch K.P., Waider J. Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders. Neuron 2012, 76(1):175-191.
    • (2012) Neuron , vol.76 , Issue.1 , pp. 175-191
    • Lesch, K.P.1    Waider, J.2
  • 94
    • 84912091945 scopus 로고    scopus 로고
    • Tryptophan hydroxylase 2 (Tph2) knockout mice reveal a critical role for brain serotonin (5-HT) in postnatal development and in adult behaviour
    • Society for Neuroscience, Chicago, IL, (Online)
    • Migliarini S., Pacini G., Pelosi B., Errico B., Lunardi G., Usiello A., Paqualetti M. Tryptophan hydroxylase 2 (Tph2) knockout mice reveal a critical role for brain serotonin (5-HT) in postnatal development and in adult behaviour. Program nr. 61.3, 2009 Neuroscience Meeting Planner 2009, Society for Neuroscience, Chicago, IL, (Online).
    • (2009) Program nr. 61.3, 2009 Neuroscience Meeting Planner
    • Migliarini, S.1    Pacini, G.2    Pelosi, B.3    Errico, B.4    Lunardi, G.5    Usiello, A.6    Paqualetti, M.7
  • 95
    • 50249125895 scopus 로고    scopus 로고
    • Serotonergic transcriptional programming determines maternal behavior and offspring survival
    • Lerch-Haner J.K., Frierson D., Crawford L.K., Beck S.G., Deneris E.S. Serotonergic transcriptional programming determines maternal behavior and offspring survival. Nat Neurosci 2008, 11(9):1001-1003.
    • (2008) Nat Neurosci , vol.11 , Issue.9 , pp. 1001-1003
    • Lerch-Haner, J.K.1    Frierson, D.2    Crawford, L.K.3    Beck, S.G.4    Deneris, E.S.5
  • 96
    • 84877267860 scopus 로고    scopus 로고
    • Serotonin is required for exercise-induced adult hippocampal neurogenesis
    • Klempin F., Beis D., Mosienko V., Kempermann G., Bader M., Alenina N. Serotonin is required for exercise-induced adult hippocampal neurogenesis. J Neurosci 2013, 33(19):8270-8275.
    • (2013) J Neurosci , vol.33 , Issue.19 , pp. 8270-8275
    • Klempin, F.1    Beis, D.2    Mosienko, V.3    Kempermann, G.4    Bader, M.5    Alenina, N.6
  • 97
    • 26044460006 scopus 로고    scopus 로고
    • The ascent of mouse: advances in modelling human depression and anxiety
    • Cryan J.F., Holmes A. The ascent of mouse: advances in modelling human depression and anxiety. Nat Rev Drug Discovery 2005, 4(9):775-790.
    • (2005) Nat Rev Drug Discovery , vol.4 , Issue.9 , pp. 775-790
    • Cryan, J.F.1    Holmes, A.2
  • 98
    • 2042546746 scopus 로고    scopus 로고
    • In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice
    • Cryan J.F., Mombereau C. In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. Mol Psychiatry 2004, 9(4):326-357.
    • (2004) Mol Psychiatry , vol.9 , Issue.4 , pp. 326-357
    • Cryan, J.F.1    Mombereau, C.2
  • 99
    • 79960937702 scopus 로고    scopus 로고
    • Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition
    • Ray R.S., Corcoran A.E., Brust R.D., Kim J.C., Richerson G.B., Nattie E., et al. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition. Science (New York, NY) 2011, 333(6042):637-642.
    • (2011) Science (New York, NY) , vol.333 , Issue.6042 , pp. 637-642
    • Ray, R.S.1    Corcoran, A.E.2    Brust, R.D.3    Kim, J.C.4    Richerson, G.B.5    Nattie, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.