Structure of cytochrome P450 PimD suggests epoxidation of the polyene macrolide pimaricin occurs via a hydroperoxoferric intermediate

Chemistry and Biology

Volumn 17, Issue 8, 2010, Pages 841-851

  Kells, Petrea M ^a   Ouellet, Hugues ^a   Santos Aberturas, Javier ^b   Aparicio, Jesus F ^b   Podust, Larissa M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF LEÓN   (Spain)

Author keywords

CHEMBIO; PROTEINS

Indexed keywords

ANTIINFECTIVE AGENT; BENZENE; CYTOCHROME P450; EPOXIDE; NATAMYCIN; PEROXYNITROUS ACID; PROTON;

AMINO ACID SEQUENCE; ARTICLE; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BENZENE; BIOCATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; EPOXY COMPOUNDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NATAMYCIN; PEROXYNITROUS ACID; PROTEIN CONFORMATION; PROTONS; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 77956013893     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2010.05.026     Document Type: Article

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