메뉴 건너뛰기




Volumn 76, Issue , 2016, Pages 86-94

Discovery and development of innovative drug from traditional medicine by integrated chinmedomics strategies in the post-genomic era

Author keywords

Biomarkers; Chinmedomics; Liquid chromatography; Mass spectrometry; Metabolomics; Traditional medicine

Indexed keywords

BIOMARKERS; DRUG PRODUCTS; GENES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACODYNAMICS;

EID: 84951082336     PISSN: 01659936     EISSN: 18793142     Source Type: Journal    
DOI: 10.1016/j.trac.2015.11.010     Document Type: Review
Times cited : (77)

References (42)
  • 1
    • 35148858517 scopus 로고    scopus 로고
    • Some Nigerian plants of dermatologic importance
    • Ajose F.O. Some Nigerian plants of dermatologic importance. Int. J. Dermatol 2007, 46:48-55.
    • (2007) Int. J. Dermatol , vol.46 , pp. 48-55
    • Ajose, F.O.1
  • 2
    • 84871263222 scopus 로고    scopus 로고
    • Systems biology technologies enable personalized traditional Chinese medicine: a systematic review
    • Wang X., et al. Systems biology technologies enable personalized traditional Chinese medicine: a systematic review. Am. J. Chin. Med 2012, 40:1109-1122.
    • (2012) Am. J. Chin. Med , vol.40 , pp. 1109-1122
    • Wang, X.1
  • 3
    • 84898959271 scopus 로고    scopus 로고
    • Chinese traditional medicine and adult neurogenesis in the hippocampus
    • Zhang E., Shen J., So K.F. Chinese traditional medicine and adult neurogenesis in the hippocampus. J. Tradit. Complement. Med 2014, 4:77-81.
    • (2014) J. Tradit. Complement. Med , vol.4 , pp. 77-81
    • Zhang, E.1    Shen, J.2    So, K.F.3
  • 4
    • 84901269295 scopus 로고    scopus 로고
    • Herbal medicines for ischemic stroke: combating inflammation as therapeutic targets
    • Gu Y., Chen J., Shen J. Herbal medicines for ischemic stroke: combating inflammation as therapeutic targets. J. Neuroimmune. Pharmacol 2014, 9:313-339.
    • (2014) J. Neuroimmune. Pharmacol , vol.9 , pp. 313-339
    • Gu, Y.1    Chen, J.2    Shen, J.3
  • 5
    • 84867336643 scopus 로고    scopus 로고
    • Potential role of metabolomic approaches for Chinese medicine syndromes and herbal medicine
    • Sun H., Zhang A., Wang X. Potential role of metabolomic approaches for Chinese medicine syndromes and herbal medicine. Phytother. Res 2012, 26:1466-1471.
    • (2012) Phytother. Res , vol.26 , pp. 1466-1471
    • Sun, H.1    Zhang, A.2    Wang, X.3
  • 6
    • 33846293668 scopus 로고    scopus 로고
    • Progress and future developing of the serum pharmacochemistry of traditional Chinese medicine
    • Wang X.J. Progress and future developing of the serum pharmacochemistry of traditional Chinese medicine. Zhongguo Zhong Yao Za Zhi 2006, 31:789-792.
    • (2006) Zhongguo Zhong Yao Za Zhi , vol.31 , pp. 789-792
    • Wang, X.J.1
  • 7
    • 33646198860 scopus 로고    scopus 로고
    • Pharmaco-metabonomic phenotyping and personalized drug treatment
    • Clayton T.A., et al. Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature 2006, 440:1073-1077.
    • (2006) Nature , vol.440 , pp. 1073-1077
    • Clayton, T.A.1
  • 8
    • 79956151568 scopus 로고    scopus 로고
    • Potential role of metabolomics apporoaches in the area of traditional Chinese medicine: as pillars of the bridge between Chinese and Western medicine
    • Wang X., et al. Potential role of metabolomics apporoaches in the area of traditional Chinese medicine: as pillars of the bridge between Chinese and Western medicine. J. Pharm. Biomed. Anal 2011, 55:859-868.
    • (2011) J. Pharm. Biomed. Anal , vol.55 , pp. 859-868
    • Wang, X.1
  • 9
    • 78649908579 scopus 로고    scopus 로고
    • Metabolomics: towards understanding traditional Chinese medicine
    • Zhang A., et al. Metabolomics: towards understanding traditional Chinese medicine. Planta Med 2010, 76:2026-2035.
    • (2010) Planta Med , vol.76 , pp. 2026-2035
    • Zhang, A.1
  • 10
    • 84863895127 scopus 로고    scopus 로고
    • Future perspectives of Chinese medical formulae: chinmedomics as an effector
    • Wang X., Zhang A., Sun H. Future perspectives of Chinese medical formulae: chinmedomics as an effector. OMICS 2012, 16:414-421.
    • (2012) OMICS , vol.16 , pp. 414-421
    • Wang, X.1    Zhang, A.2    Sun, H.3
  • 11
    • 84897980491 scopus 로고    scopus 로고
    • Potentiating therapeutic effects by enhancing synergism based on active constituents from traditional medicine
    • Zhang A., et al. Potentiating therapeutic effects by enhancing synergism based on active constituents from traditional medicine. Phytother. Res 2014, 28:526-533.
    • (2014) Phytother. Res , vol.28 , pp. 526-533
    • Zhang, A.1
  • 12
    • 84856535104 scopus 로고    scopus 로고
    • Future perspectives of personalized medicine in traditional Chinese medicine: a systems biology approach
    • Zhang A., et al. Future perspectives of personalized medicine in traditional Chinese medicine: a systems biology approach. Complement. Ther. Med 2012, 20:93-99.
    • (2012) Complement. Ther. Med , vol.20 , pp. 93-99
    • Zhang, A.1
  • 13
    • 84887409743 scopus 로고    scopus 로고
    • Pharmacological tools for the development of traditional Chinese medicine
    • Liu X., et al. Pharmacological tools for the development of traditional Chinese medicine. Trends Pharmacol. Sci 2013, 34:620-628.
    • (2013) Trends Pharmacol. Sci , vol.34 , pp. 620-628
    • Liu, X.1
  • 14
    • 84893494195 scopus 로고    scopus 로고
    • From single target to multitarget/network therapeutics in Alzheimer's therapy
    • Zheng H., et al. From single target to multitarget/network therapeutics in Alzheimer's therapy. Pharmaceuticals (Basel) 2014, 7(2):113-135.
    • (2014) Pharmaceuticals (Basel) , vol.7 , Issue.2 , pp. 113-135
    • Zheng, H.1
  • 15
    • 84906934907 scopus 로고    scopus 로고
    • Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands
    • Sancineto L., et al. Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands. Bioorg. Med. Chem 2012, 22:4658-4666.
    • (2012) Bioorg. Med. Chem , vol.22 , pp. 4658-4666
    • Sancineto, L.1
  • 16
    • 84879098265 scopus 로고    scopus 로고
    • PA-824, moxifloxacin and pyrazinamide combination therapy for tuberculosis
    • Dawson R., Diacon A. PA-824, moxifloxacin and pyrazinamide combination therapy for tuberculosis. Expert Opin. Investig. Drugs 2013, 22:927-932.
    • (2013) Expert Opin. Investig. Drugs , vol.22 , pp. 927-932
    • Dawson, R.1    Diacon, A.2
  • 17
    • 54549091125 scopus 로고    scopus 로고
    • Systems biology: Metabonomics
    • Nicholson J.K., Lindon J.C. Systems biology: Metabonomics. Nature 2008, 455:1054-1056.
    • (2008) Nature , vol.455 , pp. 1054-1056
    • Nicholson, J.K.1    Lindon, J.C.2
  • 18
    • 84863258933 scopus 로고    scopus 로고
    • Ingenuity pathways analysis of urine metabolomics phenotypes toxicity of Chuanwu in Wistar rats by UPLC-Q-TOF-HDMS coupled with pattern recognition methods
    • Dong H., et al. Ingenuity pathways analysis of urine metabolomics phenotypes toxicity of Chuanwu in Wistar rats by UPLC-Q-TOF-HDMS coupled with pattern recognition methods. Mol. Biosyst 2012, 8:1206-1221.
    • (2012) Mol. Biosyst , vol.8 , pp. 1206-1221
    • Dong, H.1
  • 19
    • 84876720410 scopus 로고    scopus 로고
    • Power of metabolomics in diagnosis and biomarker discovery of hepatocellular carcinoma
    • Zhang A., Sun H., Wang X. Power of metabolomics in diagnosis and biomarker discovery of hepatocellular carcinoma. Hepatology 2013, 57:2072-2077.
    • (2013) Hepatology , vol.57 , pp. 2072-2077
    • Zhang, A.1    Sun, H.2    Wang, X.3
  • 20
    • 84921476119 scopus 로고    scopus 로고
    • Urinary metabolic profiling of rat models revealed protective function of scoparone against alcohol induced hepatotoxicity
    • Zhang A., Sun H., Wang X. Urinary metabolic profiling of rat models revealed protective function of scoparone against alcohol induced hepatotoxicity. Sci. Rep 2014, 4:6768.
    • (2014) Sci. Rep , vol.4 , pp. 6768
    • Zhang, A.1    Sun, H.2    Wang, X.3
  • 21
    • 84864828304 scopus 로고    scopus 로고
    • Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease
    • Wang X., et al. Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease. Mol. Cell. Proteomics 2012, 11:380-381.
    • (2012) Mol. Cell. Proteomics , vol.11 , pp. 380-381
    • Wang, X.1
  • 22
    • 84864989347 scopus 로고    scopus 로고
    • Exploratory urinary metabolic biomarkers and pathways using UPLC-Q-TOF-HDMS coupled with pattern recognition approach
    • Zhang A., et al. Exploratory urinary metabolic biomarkers and pathways using UPLC-Q-TOF-HDMS coupled with pattern recognition approach. Analyst 2012, 137:4200-4208.
    • (2012) Analyst , vol.137 , pp. 4200-4208
    • Zhang, A.1
  • 23
    • 83455203337 scopus 로고    scopus 로고
    • Modern analytical techniques in metabolomics analysis
    • Zhang A., et al. Modern analytical techniques in metabolomics analysis. Analyst 2012, 137:293-300.
    • (2012) Analyst , vol.137 , pp. 293-300
    • Zhang, A.1
  • 24
    • 84881356804 scopus 로고    scopus 로고
    • Ultraperformance liquid chromatography-mass spectrometry based comprehensive metabolomics combined with pattern recognition and network analysis methods for characterization of metabolites and metabolic pathways from biological data sets
    • Zhang A.H., et al. Ultraperformance liquid chromatography-mass spectrometry based comprehensive metabolomics combined with pattern recognition and network analysis methods for characterization of metabolites and metabolic pathways from biological data sets. Anal. Chem 2013, 85:7606-7612.
    • (2013) Anal. Chem , vol.85 , pp. 7606-7612
    • Zhang, A.H.1
  • 25
    • 84855392494 scopus 로고    scopus 로고
    • Pattern recognition approaches and computational systems tools for ultra performance liquid chromatography-mass spectrometry-based comprehensive metabolomic profiling and pathways analysis of biological data sets
    • Wang X., et al. Pattern recognition approaches and computational systems tools for ultra performance liquid chromatography-mass spectrometry-based comprehensive metabolomic profiling and pathways analysis of biological data sets. Anal. Chem 2012, 84:439-442.
    • (2012) Anal. Chem , vol.84 , pp. 439-442
    • Wang, X.1
  • 26
    • 84904470744 scopus 로고    scopus 로고
    • Identification and characterization of the chemical constituents of Simiao Wan by ultra high performance liquid chromatography with mass spectrometry coupled to an automated multiple data processing method
    • Zhang A., et al. Identification and characterization of the chemical constituents of Simiao Wan by ultra high performance liquid chromatography with mass spectrometry coupled to an automated multiple data processing method. J. Sep. Sci 2014, 37(14):1742-1747.
    • (2014) J. Sep. Sci , vol.37 , Issue.14 , pp. 1742-1747
    • Zhang, A.1
  • 27
    • 84885929621 scopus 로고    scopus 로고
    • Profiling and identification of the absorbed constituents and metabolites of schisandra lignans by ultra-performance liquid chromatography coupled to mass spectrometry
    • Sun H., et al. Profiling and identification of the absorbed constituents and metabolites of schisandra lignans by ultra-performance liquid chromatography coupled to mass spectrometry. Biomed. Chromatogr 2013, 27:1511-1519.
    • (2013) Biomed. Chromatogr , vol.27 , pp. 1511-1519
    • Sun, H.1
  • 28
    • 84885139213 scopus 로고    scopus 로고
    • An effective method for determining the ingredients of Shuanghuanglian formula in blood samples using high-resolution LC-MS coupled with background subtraction and a multiple data processing approach
    • Yan G.L., et al. An effective method for determining the ingredients of Shuanghuanglian formula in blood samples using high-resolution LC-MS coupled with background subtraction and a multiple data processing approach. J. Sep. Sci 2013, 36:3191-3199.
    • (2013) J. Sep. Sci , vol.36 , pp. 3191-3199
    • Yan, G.L.1
  • 29
    • 84904470744 scopus 로고    scopus 로고
    • Identification and characterization of the chemical constituents of Simiao Wan by ultra high performance liquid chromatography with mass spectrometry coupled to an automated multiple data processing method
    • Zhang A., et al. Identification and characterization of the chemical constituents of Simiao Wan by ultra high performance liquid chromatography with mass spectrometry coupled to an automated multiple data processing method. J. Sep. Sci 2014, 37:1742-1747.
    • (2014) J. Sep. Sci , vol.37 , pp. 1742-1747
    • Zhang, A.1
  • 30
    • 84870877897 scopus 로고    scopus 로고
    • Pharmacokinetics study of multiple components absorbed in rat plasma after oral administration of Stemonae radix using ultra-performance liquid-chromatography/mass spectrometry with automated MetaboLynx software analysis
    • Sun H., et al. Pharmacokinetics study of multiple components absorbed in rat plasma after oral administration of Stemonae radix using ultra-performance liquid-chromatography/mass spectrometry with automated MetaboLynx software analysis. J. Sep. Sci 2012, 35(24):3477-3485.
    • (2012) J. Sep. Sci , vol.35 , Issue.24 , pp. 3477-3485
    • Sun, H.1
  • 31
    • 80755159455 scopus 로고    scopus 로고
    • Pharmacokinetics screening for multi-components absorbed in the rat plasma after oral administration traditional Chinese medicine formula Yin-Chen-Hao-Tang by ultra performance liquid chromatography-electrospray ionization/quadrupole-time-of-flight mass spectrometry combined with pattern recognition methods
    • Wang X., et al. Pharmacokinetics screening for multi-components absorbed in the rat plasma after oral administration traditional Chinese medicine formula Yin-Chen-Hao-Tang by ultra performance liquid chromatography-electrospray ionization/quadrupole-time-of-flight mass spectrometry combined with pattern recognition methods. Analyst 2011, 136:5068-5076.
    • (2011) Analyst , vol.136 , pp. 5068-5076
    • Wang, X.1
  • 32
    • 84922444344 scopus 로고    scopus 로고
    • Characterization of multiple constituents in rat plasma after oral administration of Shengmai San using ultra-performance liquid chromatography coupled with electrospray ionization/quadrupole-time-of-flight high-definition mass spectrometry
    • Ying H., et al. Characterization of multiple constituents in rat plasma after oral administration of Shengmai San using ultra-performance liquid chromatography coupled with electrospray ionization/quadrupole-time-of-flight high-definition mass spectrometry. Anal. Method 2015, 7:830-837.
    • (2015) Anal. Method , vol.7 , pp. 830-837
    • Ying, H.1
  • 33
    • 84915803819 scopus 로고    scopus 로고
    • Ultra-high performance liquid chromatography coupled with time-of-flight mass spectrometry screening and analysis of potential bioactive compounds from traditional chinese medicine Kai-Xin-San, using a multivariate data processing approach and the MetaboLynx tool
    • Liu C., et al. Ultra-high performance liquid chromatography coupled with time-of-flight mass spectrometry screening and analysis of potential bioactive compounds from traditional chinese medicine Kai-Xin-San, using a multivariate data processing approach and the MetaboLynx tool. RSC Advances 2015, 5:85.
    • (2015) RSC Advances , vol.5 , pp. 85
    • Liu, C.1
  • 34
    • 84862163326 scopus 로고    scopus 로고
    • Simultaneous in vivo RP-HPLC-DAD quantification of multiple-component and drug-drug interaction by pharmacokinetics, using 6,7-dimethylesculetin, geniposide and rhein as examples
    • Zhang A., et al. Simultaneous in vivo RP-HPLC-DAD quantification of multiple-component and drug-drug interaction by pharmacokinetics, using 6,7-dimethylesculetin, geniposide and rhein as examples. Biomed. Chromatogr 2012, 26:844-850.
    • (2012) Biomed. Chromatogr , vol.26 , pp. 844-850
    • Zhang, A.1
  • 35
    • 57849120057 scopus 로고    scopus 로고
    • Metabolic urinary profiling of alcohol hepatotoxicity and intervention effects of Yin Chen Hao Tang in rats using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry
    • Wang X., et al. Metabolic urinary profiling of alcohol hepatotoxicity and intervention effects of Yin Chen Hao Tang in rats using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry. J. Pharm. Biomed. Anal 2008, 48:1161-1168.
    • (2008) J. Pharm. Biomed. Anal , vol.48 , pp. 1161-1168
    • Wang, X.1
  • 36
    • 67649429275 scopus 로고    scopus 로고
    • Changes of hepatic proteome in bile duct ligated rats with hepatic fibrosis following treatment with Yin-Chen-Hao-Tang
    • Lee T.Y., et al. Changes of hepatic proteome in bile duct ligated rats with hepatic fibrosis following treatment with Yin-Chen-Hao-Tang. Int. J. Mol. Med 2009, 23:477-484.
    • (2009) Int. J. Mol. Med , vol.23 , pp. 477-484
    • Lee, T.Y.1
  • 37
    • 84871811016 scopus 로고    scopus 로고
    • Proteomics study on the hepatoprotective effects of traditional Chinese medicine formulae Yin-Chen-Hao-Tang by a combination of two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry
    • Sun H., et al. Proteomics study on the hepatoprotective effects of traditional Chinese medicine formulae Yin-Chen-Hao-Tang by a combination of two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry. J. Pharm. Biomed. Anal 2013, 75:173-179.
    • (2013) J. Pharm. Biomed. Anal , vol.75 , pp. 173-179
    • Sun, H.1
  • 38
    • 77952764437 scopus 로고    scopus 로고
    • Alleviation of hepatic oxidative stress by Chinese herbal medicine Yin-Chen-Hao-Tang in obese mice with steatosis
    • Lee T.Y., et al. Alleviation of hepatic oxidative stress by Chinese herbal medicine Yin-Chen-Hao-Tang in obese mice with steatosis. Int. J. Mol. Med 2010, 25:837-844.
    • (2010) Int. J. Mol. Med , vol.25 , pp. 837-844
    • Lee, T.Y.1
  • 39
    • 38949177709 scopus 로고    scopus 로고
    • Quality evaluation of Yin Chen Hao Tang extract based on fingerprint chromatogram and simultaneous determination of five bioactive constituents
    • Wang X., et al. Quality evaluation of Yin Chen Hao Tang extract based on fingerprint chromatogram and simultaneous determination of five bioactive constituents. J. Sep. Sci 2008, 31:9-15.
    • (2008) J. Sep. Sci , vol.31 , pp. 9-15
    • Wang, X.1
  • 40
    • 37749026053 scopus 로고    scopus 로고
    • Analysis of the constituents in the rat plasma after oral administration of Yin Chen Hao Tang by UPLC/Q-TOF-MS/MS
    • Wang X., et al. Analysis of the constituents in the rat plasma after oral administration of Yin Chen Hao Tang by UPLC/Q-TOF-MS/MS. J. Pharm. Biomed. Anal 2008, 46:477-490.
    • (2008) J. Pharm. Biomed. Anal , vol.46 , pp. 477-490
    • Wang, X.1
  • 41
    • 84876158903 scopus 로고    scopus 로고
    • Metabolomics coupled with proteomics advancing drug discovery toward more agile development of targeted combination therapies
    • Wang X., et al. Metabolomics coupled with proteomics advancing drug discovery toward more agile development of targeted combination therapies. Mol. Cell. Proteomics 2013, 12:1226-1238.
    • (2013) Mol. Cell. Proteomics , vol.12 , pp. 1226-1238
    • Wang, X.1
  • 42
    • 84860389472 scopus 로고    scopus 로고
    • An in vivo analysis of the therapeutic and synergistic properties of Chinese medicinal formula Yin-Chen-Hao-Tang based on its active constituents
    • Zhang A., et al. An in vivo analysis of the therapeutic and synergistic properties of Chinese medicinal formula Yin-Chen-Hao-Tang based on its active constituents. Fitoterapia 2011, 82:1168-1176.
    • (2011) Fitoterapia , vol.82 , pp. 1168-1176
    • Zhang, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.