Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 17, 2014, Pages 4658-4666

  Sancineto, Luca ^a   Iraci, Nunzio ^a   Barreca, Maria Letizia ^a   Massari, Serena ^a   Manfroni, Giuseppe ^a   Corazza, Gianmarco ^b   Cecchetti, Violetta ^a   Marcello, Alessandro ^b   Daelemans, Dirk ^c   Pannecouque, Christophe ^c   Tabarrini, Oriana ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

6 Desfluoroquinolones; Anti HIV compounds; DMLs; RT; Transactivation

Indexed keywords

11 ETHYL 8 (PIPERAZIN 1 YL) 5,11 DIHYDRO 6H DIPYRIDO[3,2 B:2',3' E][1,4]DIAZEPIN 6 ONE; 2,6 DICHLORO N [2 (ETHYLAMINO)PYRIDIN 3 YL]NICOTINAMIDE; 6 AMINO 1,4 DIHYDRO 1 METHYL 7 [4 (2 PYRIDYL) 1 PIPERAZINYL] 4 OXO 3 QUINOLINECARBOXYLIC ACID; 6 AMINO 7 [4 (11 ETHYL 6 OXO 5,11 DIHYDRO 6H DIPYRIDO[3,2 B:2',3' E][1,4]DIAZEPIN 8 YL)PIPERAZIN 1 YL] 1 METHYL 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 6 AMINO 7 [4 (11 ETHYL 6 OXO 5,11 DIHYDRO 6H DIPYRIDO[3,2 B:2',3' E][1,4]DIAZEPIN 9 YL)PIPERAZIN 1 YL] 1 METHYL 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 6 AMINO 7 [[2 [(11 ETHYL 6 OXO 5,11 DIHYDRO 6H DIPYRIDO[3,2 B:2',3' E][1,4]DIAZEPIN 8 YL)AMINO]ETHYL]AMINO] 1 METHYL 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 [4 (11 ETHYL 6 OXO 5,11 DIHYDRO 6H DIPYRIDO[3,2 B:2',3' E][1,4]DIAZEPIN 8 YL)PIPERAZIN 1 YL] 1 METHYL 6 NITRO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 [[2 [(11 ETHYL 6 OXO 5,11 DIHYDRO 6H DIPYRIDO[3,2 B:2',3' E][1,4]DIAZEPIN 8 YL)AMINO]ETHYL]AMINO] 1 METHYL 6 NITRO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 8 AMINO 11 ETHYL 5,11 DIHYDRO 6H DIPYRIDO[3,2 B:2',3' E][1,4]DIAZEPIN 6 ONE; 8 [(2 AMINOETHYL)AMINO]11 ETHYL 5,11 DIHYDRO 6H DIPYRIDO[3,2 B:2',3' E][1,4]DIAZEPIN 6 ONE; 9 CHLORO 11 ETHYL 5,11 DIHYDRO 6H DIPYRIDO[3,2 B:2',3' E][1,4]DIAZEPIN 6 ONE; ETHYL (3 NITROPYRIDIN 2 YL)AMINE; NEVIRAPINE; QUINOLONE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; LIGAND;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IC 50; LATENT VIRUS INFECTION; NONHUMAN; VIRUS REACTIVATION; VIRUS REPLICATION; VIRUS TRANSCRIPTION; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI-HIV AGENTS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV; HUMANS; LIGANDS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 84906934907     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.07.018     Document Type: Article

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