Pharmacokinetics study of multiple components absorbed in rat plasma after oral administration of Stemonae radix using ultra-performance liquid-chromatography/mass spectrometry with automated MetaboLynx software analysis

Journal of Separation Science

Volumn 35, Issue 24, 2012, Pages 3477-3485

  Sun, Hui ^a   Dong, Wei ^a   Zhang, Aihua ^a   Wang, Weiming ^a   Wang, Xijun ^a  

^a HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

High definition mass spectrometry; Metabolites; Pharmacokinetics; Stemona tuberosa Lour; Stemonae radix; Traditional Chinese medicine

Indexed keywords

ACTION MECHANISMS; AUTOMATED ANALYSIS; AUTOMATED DATA ANALYSIS; BIOACTIVE COMPONENTS; DRUG DISCOVERY; HIGH DEFINITION; IN-VIVO; MEDICINAL HERB; MULTIPLE COMPONENTS; NATURAL PRODUCTS; ONGOING CHANGES; ORAL ADMINISTRATION; PARENT COMPOUNDS; PHARMACOLOGICAL EFFECTS; POTENTIAL EFFICACY; RAT PLASMA; SOFTWARE ANALYSIS; STEMONA TUBEROSA LOUR; STEMONAE RADIX; TIME COURSE; TRADITIONAL CHINESE MEDICINE;

AUTOMATION; BODY FLUIDS; MASS SPECTROMETRY; METABOLITES; TUBES (COMPONENTS);

PHARMACOKINETICS;

ANTIPARASITIC AGENT; ANTITUSSIVE AGENT; BIOLOGICAL MARKER; CROOMINE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; STEMONA TUBEROSA EXTRACT; TUBEROSTEMONINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOMATION; CHINESE MEDICINE; CONTROLLED STUDY; DATA ANALYSIS SOFTWARE; IN VIVO STUDY; MALE; MEDICINAL PLANT; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RELIABILITY; STEMONA TUBEROSA; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, LIQUID; MALE; MASS SPECTROMETRY; PLANT EXTRACTS; RATS; RATS, WISTAR; SOFTWARE; STEMONACEAE;

RATTUS; STEMONA TUBEROSA;

EID: 84870877897     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201200791     Document Type: Article

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