An effective method for determining the ingredients of Shuanghuanglian formula in blood samples using high-resolution LC-MS coupled with background subtraction and a multiple data processing approach

Journal of Separation Science

Volumn 36, Issue 19, 2013, Pages 3191-3199

  Yan, Guang Li ^a   Zhang, Ai Hua ^a   Sun, Hui ^a   Han, Ying ^a   Shi, Hui ^a   Zhou, Ying ^a   Wang, Xi Jun ^a  

^a HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Background subtraction; Constituent identification; Principal component analysis; Shuanghuanglian formula; UPLC ESI Q TOF MS

Indexed keywords

BACKGROUND SUBTRACTION; CHEMICAL CONSTITUENTS; CONSTITUENT IDENTIFICATIONS; FLOS LONICERAE JAPONICAE; SHUANGHUANGLIAN FORMULA; TRADITIONAL CHINESE MEDICINE; ULTRA-PERFORMANCE LC; UPLC-ESI-Q-TOF-MS;

BIOMOLECULES; BLOOD; DATA PROCESSING; INDUCTIVELY COUPLED PLASMA; METABOLITES; PRINCIPAL COMPONENT ANALYSIS; RATS;

LOADING;

HERBACEOUS AGENT; ION; SHUANGHUANGLIAN FORMULA EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; BLOOD SAMPLING; CHINESE MEDICINE; CONTROLLED STUDY; DATA PROCESSING; ELECTROSPRAY; HIGH RESOLUTION LIQUID CHROMATOGRAPHY MASS SPECTROMETRY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METABOLITE; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; RAT; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

BACKGROUND SUBTRACTION; CONSTITUENT IDENTIFICATION; PRINCIPAL COMPONENT ANALYSIS; SHUANGHUANGLIAN FORMULA; UPLC-ESI-Q-TOF-MS;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; MALE; RATS; RATS, WISTAR; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84885139213     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201300529     Document Type: Article

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