Commensal Bacteria-induced interleukin 1β (IL-1β) secreted by macrophages up-regulates hepcidin expression in hepatocytes by activating the bone morphogenetic protein signaling pathway

Journal of Biological Chemistry

Volumn 290, Issue 51, 2015, Pages 30637-30647

  Shanmugam, Nanda Kumar N ^a   Chen, Kejie ^a   Cherayil, Bobby J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BONE; CELL CULTURE; CHEMICAL ACTIVATION; ENZYME INHIBITION; MACROPHAGES; MAMMALS; SIGNALING;

BACTEROIDES FRAGILIS; BIFIDOBACTERIUM LONGUM; BONE MORPHOGENETIC PROTEINS; CHEMICAL INHIBITORS; INFLAMMATORY BOWEL DISEASE; NEUTRALIZING ANTIBODIES; PRIMARY HUMAN HEPATOCYTES; SIGNALING PATHWAYS;

PROTEINS;

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; HEPCIDIN; INTERLEUKIN 1BETA; MESSENGER RNA; MYELOPID; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; IL1B PROTEIN, HUMAN; IL1B PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTEROIDES FRAGILIS; BIFIDOBACTERIUM LONGUM; CELL LINE; CELLULAR DISTRIBUTION; COMMENSAL; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HUH7 CELL LINE; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LIVER CELL; MACROPHAGE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; SUPERNATANT; UPREGULATION; ANIMAL; BIFIDOBACTERIUM; IMMUNOLOGY; INFLAMMATORY BOWEL DISEASE; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; BACTEROIDES FRAGILIS; BIFIDOBACTERIUM; BONE MORPHOGENETIC PROTEINS; CELL LINE, TUMOR; FEMALE; HEPATOCYTES; HEPCIDINS; HUMANS; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-1BETA; MACROPHAGES; MICE; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84950335447     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.689190     Document Type: Article

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