Tumor necrosis factor α inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitis

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Shanmugam, Nanda Kumar N ^a   Ellenbogen, Shiri ^a   Trebicka, Estela ^a   Wang, Lijian ^a   Mukhopadhyay, Subhankar ^a,b   Lacy Hulbert, Adam ^a,c   Gallini, Carey Ann ^d   Garrett, Wendy S ^c,d   Cherayil, Bobby J ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN SULFATE; HEPCIDIN; IRON; IRON REGULATORY FACTOR; MESSENGER RNA; RAG2 PROTEIN; SMAD1 PROTEIN; TRANSCRIPTION FACTOR T BET; TUMOR NECROSIS FACTOR ALPHA; ANTIMICROBIAL CATIONIC PEPTIDE; BONE MORPHOGENETIC PROTEIN; SMAD PROTEIN;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MODEL; DOWN REGULATION; FEMALE; IN VIVO STUDY; INHIBITION KINETICS; INNATE IMMUNITY; IRON KINETICS; LIVER CELL; LIVER CELL CULTURE; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; T LYMPHOCYTE; UPREGULATION; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL LINE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE MUTANT; SIGNAL TRANSDUCTION;

MURINAE; MUS;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BONE MORPHOGENETIC PROTEINS; CELL LINE; COLITIS; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IRON; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; SIGNAL TRANSDUCTION; SMAD PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84861685224     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038136     Document Type: Article

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