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Volumn 6, Issue 37, 2015, Pages 39521-39537

Novel agents for advanced pancreatic cancer

Author keywords

IGF 1R; Pancreatic cancer

Indexed keywords

AFLIBERCEPT; AXITINIB; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; CISPLATIN; CIXUTUMUMAB; CONATUMUMAB; DALOTUZUMAB; ERLOTINIB; EVEROLIMUS; EXATECAN; FLUOROURACIL; FOLINIC ACID; GANITUMAB; GEMCITABINE; IRINOTECAN; OXALIPLATIN; PACLITAXEL; PEMETREXED; PLACEBO; RIGOSERTIB; SOMATOMEDIN B; SOMATOMEDIN C; SORAFENIB; SUNITINIB; TIGATUZUMAB; TIPIFARNIB; TRAMETINIB; UNINDEXED DRUG; ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; MOLECULAR LIBRARY; MONOCLONAL ANTIBODY;

EID: 84950160313     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3999     Document Type: Article
Times cited : (29)

References (147)
  • 3
    • 84869496369 scopus 로고    scopus 로고
    • Global burden of cancer: opportunities for prevention
    • Jemal A. Global burden of cancer: opportunities for prevention. Lancet. 2012; 380:1797-1799.
    • (2012) Lancet , vol.380 , pp. 1797-1799
    • Jemal, A.1
  • 4
    • 84885174025 scopus 로고    scopus 로고
    • Modest improvement in overall survival for patients with metastatic pancreatic cancer: a trend analysis using the surveillance, epidemiology, and end results registry from 1988 to 2008
    • Worni M, Guller U, White RR, Castleberry AW, Pietrobon R, Cerny T, Gloor B, Koeberle D. Modest improvement in overall survival for patients with metastatic pancreatic cancer: a trend analysis using the surveillance, epidemiology, and end results registry from 1988 to 2008. Pancreas. 2013; 42:1157-1163.
    • (2013) Pancreas , vol.42 , pp. 1157-1163
    • Worni, M.1    Guller, U.2    White, R.R.3    Castleberry, A.W.4    Pietrobon, R.5    Cerny, T.6    Gloor, B.7    Koeberle, D.8
  • 8
    • 33845998896 scopus 로고    scopus 로고
    • The pancreatic stellate cell: a star on the rise in pancreatic diseases
    • Omary MB, Lugea A, Lowe AW, Pandol SJ. The pancreatic stellate cell: a star on the rise in pancreatic diseases. J Clin Invest. 2007; 117:50-59.
    • (2007) J Clin Invest , vol.117 , pp. 50-59
    • Omary, M.B.1    Lugea, A.2    Lowe, A.W.3    Pandol, S.J.4
  • 10
    • 2342629331 scopus 로고    scopus 로고
    • The pancreatic duct and its arteriovenous relationship: an underutilized aid in the diagnosis and distinction of pancreatic adenocarcinoma from pancreatic intraepithelial neoplasia. A study of 126 pancreatectomy specimens
    • Sharma S, Green KB. The pancreatic duct and its arteriovenous relationship: an underutilized aid in the diagnosis and distinction of pancreatic adenocarcinoma from pancreatic intraepithelial neoplasia. A study of 126 pancreatectomy specimens. Am J Surg Pathol. 2004; 28:613-620.
    • (2004) Am J Surg Pathol , vol.28 , pp. 613-620
    • Sharma, S.1    Green, K.B.2
  • 12
    • 70249099504 scopus 로고    scopus 로고
    • A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer: Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer
    • Ueno H, Kosuge T, Matsuyama Y, Yamamoto J, Nakao A, Egawa S, Doi R, Monden M, Hatori T, Tanaka M, Shimada M, Kanemitsu K. A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer: Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer. Br J Cancer. 2009; 101:908-915.
    • (2009) Br J Cancer , vol.101 , pp. 908-915
    • Ueno, H.1    Kosuge, T.2    Matsuyama, Y.3    Yamamoto, J.4    Nakao, A.5    Egawa, S.6    Doi, R.7    Monden, M.8    Hatori, T.9    Tanaka, M.10    Shimada, M.11    Kanemitsu, K.12
  • 13
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Hidalgo M. Pancreatic cancer. N Engl J Med. 2010; 362:1605-1617.
    • (2010) N Engl J Med , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 16
    • 84898922484 scopus 로고    scopus 로고
    • Targeting hedgehog signaling in myelofibrosis and other hematologic malignancies
    • Tibes R, Mesa R. Targeting hedgehog signaling in myelofibrosis and other hematologic malignancies. Journal of Hematology & Oncology. 2014; 7:18.
    • (2014) Journal of Hematology & Oncology , vol.7 , pp. 18
    • Tibes, R.1    Mesa, R.2
  • 18
    • 65649120430 scopus 로고    scopus 로고
    • In vitro and in vivo radiosensitization with AZD6244 (ARRY-142886), an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase
    • Chung EJ, Brown AP, Asano H, Mandler M, Burgan WE, Carter D, Camphausen K, Citrin D. In vitro and in vivo radiosensitization with AZD6244 (ARRY-142886), an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase. Clin Cancer Res. 2009; 15:3050-3057.
    • (2009) Clin Cancer Res , vol.15 , pp. 3050-3057
    • Chung, E.J.1    Brown, A.P.2    Asano, H.3    Mandler, M.4    Burgan, W.E.5    Carter, D.6    Camphausen, K.7    Citrin, D.8
  • 20
    • 84864346162 scopus 로고    scopus 로고
    • A phase II open-label randomized study to assess the efficacy and safety of selumetinib (AZD6244 [ARRY-142886]) versus capecitabine in patients with advanced or metastatic pancreatic cancer who have failed first-line gemcitabine therapy
    • Bodoky G, Timcheva C, Spigel DR, La Stella PJ, Ciuleanu TE, Pover G, Tebbutt NC. A phase II open-label randomized study to assess the efficacy and safety of selumetinib (AZD6244 [ARRY-142886]) versus capecitabine in patients with advanced or metastatic pancreatic cancer who have failed first-line gemcitabine therapy. Invest New Drugs. 2012; 30:1216-1223.
    • (2012) Invest New Drugs , vol.30 , pp. 1216-1223
    • Bodoky, G.1    Timcheva, C.2    Spigel, D.R.3    La Stella, P.J.4    Ciuleanu, T.E.5    Pover, G.6    Tebbutt, N.C.7
  • 21
    • 84893468215 scopus 로고    scopus 로고
    • Kras as a key oncogene and therapeutic target in pancreatic cancer
    • Collins MA, Pasca di Magliano M. Kras as a key oncogene and therapeutic target in pancreatic cancer. Front Physiol. 2013; 4:407.
    • (2013) Front Physiol , vol.4 , pp. 407
    • Collins, M.A.1    Pasca di Magliano, M.2
  • 25
    • 68949114505 scopus 로고    scopus 로고
    • Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group
    • Poplin E, Feng Y, Berlin J, Rothenberg ML, Hochster H, Mitchell E, Alberts S, O'Dwyer P, Haller D, Catalano P, Cella D, Benson AB 3rd. Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group. J Clin Oncol. 2009; 27:3778-3785.
    • (2009) J Clin Oncol , vol.27 , pp. 3778-3785
    • Poplin, E.1    Feng, Y.2    Berlin, J.3    Rothenberg, M.L.4    Hochster, H.5    Mitchell, E.6    Alberts, S.7    O'Dwyer, P.8    Haller, D.9    Catalano, P.10    Cella, D.11    Benson, A.B.12
  • 29
    • 0036682041 scopus 로고    scopus 로고
    • Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297
    • Berlin JD, Catalano P, Thomas JP, Kugler JW, Haller DG, Benson AB 3rd. Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol. 2002; 20:3270-3275.
    • (2002) J Clin Oncol , vol.20 , pp. 3270-3275
    • Berlin, J.D.1    Catalano, P.2    Thomas, J.P.3    Kugler, J.W.4    Haller, D.G.5    Benson, A.B.6
  • 36
    • 84879952361 scopus 로고    scopus 로고
    • Randomised, placebo-controlled, double-blind, parallelgroup phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer
    • Rougier P, Riess H, Manges R, Karasek P, Humblet Y, Barone C, Santoro A, Assadourian S, Hatteville L, Philip PA. Randomised, placebo-controlled, double-blind, parallelgroup phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer. Eur J Cancer. 2013; 49:2633-2642.
    • (2013) Eur J Cancer , vol.49 , pp. 2633-2642
    • Rougier, P.1    Riess, H.2    Manges, R.3    Karasek, P.4    Humblet, Y.5    Barone, C.6    Santoro, A.7    Assadourian, S.8    Hatteville, L.9    Philip, P.A.10
  • 39
    • 84904063663 scopus 로고    scopus 로고
    • A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas
    • Infante JR, Somer BG, Park JO, Li CP, Scheulen ME, Kasubhai SM, Oh DY, Liu Y, Redhu S, Steplewski K, Le N. A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas. Eur J Cancer. 2014; 50:2072-2081.
    • (2014) Eur J Cancer , vol.50 , pp. 2072-2081
    • Infante, J.R.1    Somer, B.G.2    Park, J.O.3    Li, C.P.4    Scheulen, M.E.5    Kasubhai, S.M.6    Oh, D.Y.7    Liu, Y.8    Redhu, S.9    Steplewski, K.10    Le, N.11
  • 41
    • 44849120686 scopus 로고    scopus 로고
    • A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes
    • Yada A, Yazawa M, Ishida S, Yoshida H, Ichikawa K, Kurakata S, Fujiwara K. A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes. Ann Oncol. 2008; 19:1060-1067.
    • (2008) Ann Oncol , vol.19 , pp. 1060-1067
    • Yada, A.1    Yazawa, M.2    Ishida, S.3    Yoshida, H.4    Ichikawa, K.5    Kurakata, S.6    Fujiwara, K.7
  • 43
    • 0033667778 scopus 로고    scopus 로고
    • FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
    • Sprick MR, Weigand MA, Rieser E, Rauch CT, Juo P, Blenis J, Krammer PH, Walczak H. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity. 2000; 12:599-609.
    • (2000) Immunity , vol.12 , pp. 599-609
    • Sprick, M.R.1    Weigand, M.A.2    Rieser, E.3    Rauch, C.T.4    Juo, P.5    Blenis, J.6    Krammer, P.H.7    Walczak, H.8
  • 44
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 1998; 94:491-501.
    • (1998) Cell , vol.94 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.J.3    Yuan, J.4
  • 45
    • 33751012407 scopus 로고    scopus 로고
    • Treatment with gemcitabine and TRA-8 antideath receptor-5 mAb reduces pancreatic adenocarcinoma cell viability in vitro and growth in vivo
    • discussion 1300
    • DeRosier LC, Huang ZQ, Sellers JC, Buchsbaum DJ, Vickers SM. Treatment with gemcitabine and TRA-8 antideath receptor-5 mAb reduces pancreatic adenocarcinoma cell viability in vitro and growth in vivo. J Gastrointest Surg. 2006; 10:1291-1300. discussion 1300.
    • (2006) J Gastrointest Surg , vol.10 , pp. 1291-1300
    • DeRosier, L.C.1    Huang, Z.Q.2    Sellers, J.C.3    Buchsbaum, D.J.4    Vickers, S.M.5
  • 49
    • 0026528966 scopus 로고
    • Enhancement of transforming potential of human insulinlike growth factor 1 receptor by N-terminal truncation and fusion to avian sarcoma virus UR2 gag sequence
    • Liu D, Rutter WJ, Wang LH. Enhancement of transforming potential of human insulinlike growth factor 1 receptor by N-terminal truncation and fusion to avian sarcoma virus UR2 gag sequence. Journal of virology. 1992; 66:374-385.
    • (1992) Journal of virology , vol.66 , pp. 374-385
    • Liu, D.1    Rutter, W.J.2    Wang, L.H.3
  • 50
    • 0027453779 scopus 로고
    • Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions
    • Liu D, Zong CS, Wang LH. Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions. Journal of virology. 1993; 67:6835-6840.
    • (1993) Journal of virology , vol.67 , pp. 6835-6840
    • Liu, D.1    Zong, C.S.2    Wang, L.H.3
  • 51
    • 0027402605 scopus 로고
    • Modulating effects of the extracellular sequence of the human insulinlike growth factor I receptor on its transforming and tumorigenic potential
    • Liu D, Rutter WJ, Wang LH. Modulating effects of the extracellular sequence of the human insulinlike growth factor I receptor on its transforming and tumorigenic potential. Journal of virology. 1993; 67:9-18.
    • (1993) Journal of virology , vol.67 , pp. 9-18
    • Liu, D.1    Rutter, W.J.2    Wang, L.H.3
  • 52
    • 0002607682 scopus 로고
    • Oncogenes, Protein Tyrosine Kinases, and Signal Transduction
    • Liu D, Wang LH. Oncogenes, Protein Tyrosine Kinases, and Signal Transduction. Journal of biomedical science. 1994; 1:65-82.
    • (1994) Journal of biomedical science , vol.1 , pp. 65-82
    • Liu, D.1    Wang, L.H.2
  • 54
    • 0028997487 scopus 로고
    • Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles
    • Bergmann U, Funatomi H, Yokoyama M, Beger HG, Korc M. Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles. Cancer Res. 1995; 55:2007-2011.
    • (1995) Cancer Res , vol.55 , pp. 2007-2011
    • Bergmann, U.1    Funatomi, H.2    Yokoyama, M.3    Beger, H.G.4    Korc, M.5
  • 55
    • 64249110119 scopus 로고    scopus 로고
    • Molecular mechanisms involved in activity of h7C10, a humanized monoclonal antibody, to IGF-1 receptor
    • Broussas M, Dupont J, Gonzalez A, Blaecke A, Fournier M, Corvaia N, Goetsch L. Molecular mechanisms involved in activity of h7C10, a humanized monoclonal antibody, to IGF-1 receptor. Int J Cancer. 2009; 124:2281-2293.
    • (2009) Int J Cancer , vol.124 , pp. 2281-2293
    • Broussas, M.1    Dupont, J.2    Gonzalez, A.3    Blaecke, A.4    Fournier, M.5    Corvaia, N.6    Goetsch, L.7
  • 56
    • 34248170187 scopus 로고    scopus 로고
    • Functional responses and in vivo anti-tumour activity of h7C10: a humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors
    • Pandini G, Wurch T, Akla B, Corvaia N, Belfiore A, Goetsch L. Functional responses and in vivo anti-tumour activity of h7C10: a humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors. Eur J Cancer. 2007; 43:1318-1327.
    • (2007) Eur J Cancer , vol.43 , pp. 1318-1327
    • Pandini, G.1    Wurch, T.2    Akla, B.3    Corvaia, N.4    Belfiore, A.5    Goetsch, L.6
  • 58
    • 10344247119 scopus 로고    scopus 로고
    • A recombinant humanized antiinsulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and antiepidermal growth factor receptor therapy against human cancer xenografts
    • Goetsch L, Gonzalez A, Leger O, Beck A, Pauwels PJ, Haeuw JF, Corvaia N. A recombinant humanized antiinsulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and antiepidermal growth factor receptor therapy against human cancer xenografts. Int J Cancer. 2005; 113:316-328.
    • (2005) Int J Cancer , vol.113 , pp. 316-328
    • Goetsch, L.1    Gonzalez, A.2    Leger, O.3    Beck, A.4    Pauwels, P.J.5    Haeuw, J.F.6    Corvaia, N.7
  • 60
    • 79960219919 scopus 로고    scopus 로고
    • Randomized phase II study of gemcitabine (G) plus anti-IGF-1R antibody MK-0646, G plus erlotinib (E) plus MK-0646 and G plus E for advanced pancreatic cancer
    • Javle M VG, et al. Randomized phase II study of gemcitabine (G) plus anti-IGF-1R antibody MK-0646, G plus erlotinib (E) plus MK-0646 and G plus E for advanced pancreatic cancer. J Clin Oncol. 29:2011.
    • J Clin Oncol , vol.29 , pp. 2011
    • Javle, M.1    Bathini, V.G.2
  • 62
  • 63
    • 68649085369 scopus 로고    scopus 로고
    • A phase Ib study to evaluate the safety and efficacy of AMG 655 in combination with gemcitabine (G) in patients (pts) with metastatic pancreatic cancer (PC)
    • Kindler HL GL, Stephenson J, et al. A phase Ib study to evaluate the safety and efficacy of AMG 655 in combination with gemcitabine (G) in patients (pts) with metastatic pancreatic cancer (PC). J Clin Oncol. 2009; 27.
    • (2009) J Clin Oncol , pp. 27
    • Kindler, H.L.1    Garbo, L.2    Stephenson, J.3
  • 67
    • 35148889523 scopus 로고    scopus 로고
    • A phase I, first in man study of weekly IMC-A12, a fully human insulin-like growth factor receptor IgG1 monoclonal antibody in patients with advanced solid tumors
    • Higano CS YE, Whiting SH, et al. A phase I, first in man study of weekly IMC-A12, a fully human insulin-like growth factor receptor IgG1 monoclonal antibody in patients with advanced solid tumors. ASCO. 2007; A269 2009.
    • (2009) ASCO. 2007 , pp. A269
    • Higano, C.S.1    Yu, Y.E.2    Whiting, S.H.3
  • 68
    • 84908500883 scopus 로고    scopus 로고
    • Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWOG S0727)
    • Philip PA, Goldman B, Ramanathan RK, Lenz HJ, Lowy AM, Whitehead RP, Wakatsuki T, Iqbal S, Gaur R, Benedetti JK, Blanke CD. Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWOG S0727). Cancer. 2014; 120:2980-2985.
    • (2014) Cancer , vol.120 , pp. 2980-2985
    • Philip, P.A.1    Goldman, B.2    Ramanathan, R.K.3    Lenz, H.J.4    Lowy, A.M.5    Whitehead, R.P.6    Wakatsuki, T.7    Iqbal, S.8    Gaur, R.9    Benedetti, J.K.10    Blanke, C.D.11
  • 71
    • 84856287736 scopus 로고    scopus 로고
    • A humanized anti-IGF-1R monoclonal antibody (R1507) and/or metformin enhance gemcitabine-induced apoptosis in pancreatic cancer cells
    • Kawanami T, Takiguchi S, Ikeda N, Funakoshi A. A humanized anti-IGF-1R monoclonal antibody (R1507) and/or metformin enhance gemcitabine-induced apoptosis in pancreatic cancer cells. Oncol Rep. 2012; 27:867-872.
    • (2012) Oncol Rep , vol.27 , pp. 867-872
    • Kawanami, T.1    Takiguchi, S.2    Ikeda, N.3    Funakoshi, A.4
  • 72
    • 84950113573 scopus 로고    scopus 로고
    • Effect of R1507, an anti-IGF-1R monocolonal antibody, on sensitization of pancreatic cancer cell lines to mTOR inhibition
    • Dragovich T BA, Pineda C, et al. Effect of R1507, an anti-IGF-1R monocolonal antibody, on sensitization of pancreatic cancer cell lines to mTOR inhibition. 2010 Gastrointestinal Cancers Symposium Abstract 177.
    • 2010 Gastrointestinal Cancers Symposium Abstract
    • Dragovich, T.1    Miller, B.A.2    Pineda, C.3
  • 76
    • 62749184977 scopus 로고    scopus 로고
    • Prostate stem cell antigen: a prospective therapeutic and diagnostic target
    • Raff AB, Gray A, Kast WM. Prostate stem cell antigen: a prospective therapeutic and diagnostic target. Cancer Lett. 2009; 277:126-132.
    • (2009) Cancer Lett , vol.277 , pp. 126-132
    • Raff, A.B.1    Gray, A.2    Kast, W.M.3
  • 77
    • 0035956985 scopus 로고    scopus 로고
    • Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts
    • Saffran DC, Raitano AB, Hubert RS, Witte ON, Reiter RE, Jakobovits A. Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts. Proc Natl Acad Sci U S A. 2001; 98:2658-2663.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 2658-2663
    • Saffran, D.C.1    Raitano, A.B.2    Hubert, R.S.3    Witte, O.N.4    Reiter, R.E.5    Jakobovits, A.6
  • 78
    • 27144471037 scopus 로고    scopus 로고
    • Anti-prostate stem cell antigen monoclonal antibody 1G8 induces cell death in vitro and inhibits tumor growth in vivo via a Fc-independent mechanism
    • Gu Z, Yamashiro J, Kono E, Reiter RE. Anti-prostate stem cell antigen monoclonal antibody 1G8 induces cell death in vitro and inhibits tumor growth in vivo via a Fc-independent mechanism. Cancer Res. 2005; 65:9495-9500.
    • (2005) Cancer Res , vol.65 , pp. 9495-9500
    • Gu, Z.1    Yamashiro, J.2    Kono, E.3    Reiter, R.E.4
  • 81
    • 84938081971 scopus 로고    scopus 로고
    • Phase Ib of anticancer stem cell antibody OMP-59R5 (anti-Notch2/3) in combination with nab-paclitaxel and gemcitabine (Nab-P+Gem) in patients (pts) with untreated metastatic pancreatic cancer (mPC)
    • O'Reilly E SL, Bendell J, et al. Phase Ib of anticancer stem cell antibody OMP-59R5 (anti-Notch2/3) in combination with nab-paclitaxel and gemcitabine (Nab-P+Gem) in patients (pts) with untreated metastatic pancreatic cancer (mPC). J Clin Oncol. 32, 2014.
    • (2014) J Clin Oncol , vol.32
    • O'Reilly, E.1    Smith, L.2    Bendell, J.3
  • 83
    • 84950120183 scopus 로고    scopus 로고
    • Final results of a phase 1b of OMP-59R5 (anti-notch2/3/stem cell antibody) in combination with nab-paclitaxel and gemcitabine (Nab-P + Gem) in patients with untreated metastatic pancreatic cancer
    • Bendell J CA, Smith L, et al. Final results of a phase 1b of OMP-59R5 (anti-notch2/3/stem cell antibody) in combination with nab-paclitaxel and gemcitabine (Nab-P + Gem) in patients with untreated metastatic pancreatic cancer. Annals of Oncology. 2014; 25. iv210-iv253 10.1093/annonc/mdu334.2014.
    • (2014) Annals of Oncology , vol.25 , pp. iv210-iv225
    • Bendell, J.1    Cohn, A.2    Smith, L.3
  • 85
    • 0347123435 scopus 로고    scopus 로고
    • Mucins in cancer: protection and control of the cell surface
    • Hollingsworth MA, Swanson BJ. Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer. 2004; 4:45-60.
    • (2004) Nat Rev Cancer , vol.4 , pp. 45-60
    • Hollingsworth, M.A.1    Swanson, B.J.2
  • 90
    • 2442693937 scopus 로고    scopus 로고
    • The MUC1 oncoprotein activates the anti-apoptotic phosphoinositide 3-kinase/Akt and Bcl-xL pathways in rat 3Y1 fibroblasts
    • Raina D, Kharbanda S, Kufe D. The MUC1 oncoprotein activates the anti-apoptotic phosphoinositide 3-kinase/Akt and Bcl-xL pathways in rat 3Y1 fibroblasts. J Biol Chem. 2004; 279:20607-20612.
    • (2004) J Biol Chem , vol.279 , pp. 20607-20612
    • Raina, D.1    Kharbanda, S.2    Kufe, D.3
  • 91
    • 13844262819 scopus 로고    scopus 로고
    • Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
    • Wei X, Xu H, Kufe D. Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Cancer Cell. 2005; 7:167-178.
    • (2005) Cancer Cell , vol.7 , pp. 167-178
    • Wei, X.1    Xu, H.2    Kufe, D.3
  • 92
    • 0028281327 scopus 로고
    • Characterization of monoclonal antibody PAM4 reactive with a pancreatic cancer mucin
    • Gold DV, Lew K, Maliniak R, Hernandez M, Cardillo T. Characterization of monoclonal antibody PAM4 reactive with a pancreatic cancer mucin. Int J Cancer. 1994; 57:204-210.
    • (1994) Int J Cancer , vol.57 , pp. 204-210
    • Gold, D.V.1    Lew, K.2    Maliniak, R.3    Hernandez, M.4    Cardillo, T.5
  • 93
    • 0031010328 scopus 로고    scopus 로고
    • Radioimmunotherapy of experimental pancreatic cancer with 131I-labeled monoclonal antibody PAM4
    • Gold DV, Cardillo T, Vardi Y, Blumenthal R. Radioimmunotherapy of experimental pancreatic cancer with 131I-labeled monoclonal antibody PAM4. Int J Cancer. 1997; 71:660-667.
    • (1997) Int J Cancer , vol.71 , pp. 660-667
    • Gold, D.V.1    Cardillo, T.2    Vardi, Y.3    Blumenthal, R.4
  • 94
    • 0034800607 scopus 로고    scopus 로고
    • Therapeutic advantage of (90)yttrium-versus (131)iodine-labeled PAM4 antibody in experimental pancreatic cancer
    • Cardillo TM, Ying Z, Gold DV. Therapeutic advantage of (90)yttrium-versus (131)iodine-labeled PAM4 antibody in experimental pancreatic cancer. Clin Cancer Res. 2001; 7:3186-3192.
    • (2001) Clin Cancer Res , vol.7 , pp. 3186-3192
    • Cardillo, T.M.1    Ying, Z.2    Gold, D.V.3
  • 95
    • 0037137849 scopus 로고    scopus 로고
    • Combined gemcitabine and radioimmunotherapy for the treatment of pancreatic cancer
    • Cardillo TM, Blumenthal R, Ying Z, Gold DV. Combined gemcitabine and radioimmunotherapy for the treatment of pancreatic cancer. Int J Cancer. 2002; 97:386-392.
    • (2002) Int J Cancer , vol.97 , pp. 386-392
    • Cardillo, T.M.1    Blumenthal, R.2    Ying, Z.3    Gold, D.V.4
  • 96
    • 1542405316 scopus 로고    scopus 로고
    • Combined 90Yttrium-DOTA-labeled PAM4 antibody radioimmunotherapy and gemcitabine radiosensitization for the treatment of a human pancreatic cancer xenograft
    • Gold DV, Modrak DE, Schutsky K, Cardillo TM. Combined 90Yttrium-DOTA-labeled PAM4 antibody radioimmunotherapy and gemcitabine radiosensitization for the treatment of a human pancreatic cancer xenograft. Int J Cancer. 2004; 109:618-626.
    • (2004) Int J Cancer , vol.109 , pp. 618-626
    • Gold, D.V.1    Modrak, D.E.2    Schutsky, K.3    Cardillo, T.M.4
  • 97
    • 0141679534 scopus 로고    scopus 로고
    • Lowdose radioimmunotherapy ((90)Y-PAM4) combined with gemcitabine for the treatment of experimental pancreatic cancer
    • Gold DV, Schutsky K, Modrak D, Cardillo TM. Lowdose radioimmunotherapy ((90)Y-PAM4) combined with gemcitabine for the treatment of experimental pancreatic cancer. Clin Cancer Res. 2003; 9:3929S-3937S.
    • (2003) Clin Cancer Res , vol.9 , pp. 3929S-3937S
    • Gold, D.V.1    Schutsky, K.2    Modrak, D.3    Cardillo, T.M.4
  • 99
    • 84924256234 scopus 로고    scopus 로고
    • Feasibility and results of a randomized phase lb study of fractionated 90Y-clivatuzumab tetraxetan in patients with metastatic pancreatic cancer having two or more prior therapies
    • Picozzi V RR, Lowery M, et al. Feasibility and results of a randomized phase lb study of fractionated 90Y-clivatuzumab tetraxetan in patients with metastatic pancreatic cancer having two or more prior therapies. J Clin Oncol. 32:5s2014.
    • (2014) J Clin Oncol , vol.32 , Issue.5
    • Picozzi, V.R.R.1    Lowery, M.2
  • 103
    • 84860709668 scopus 로고    scopus 로고
    • Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway
    • Lu JT, Zhao WD, He W, Wei W. Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway. Acta Pharmacol Sin. 2012; 33:691-700.
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 691-700
    • Lu, J.T.1    Zhao, W.D.2    He, W.3    Wei, W.4
  • 104
    • 84868616969 scopus 로고    scopus 로고
    • Regulation of DNA damage following termination of Hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancer
    • Agyeman A, Mazumdar T, Houghton JA. Regulation of DNA damage following termination of Hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancer. Oncotarget. 2012; 3:854-868.
    • (2012) Oncotarget , vol.3 , pp. 854-868
    • Agyeman, A.1    Mazumdar, T.2    Houghton, J.A.3
  • 105
    • 84873099101 scopus 로고    scopus 로고
    • Progress from clinical trials and emerging non-conventional therapies for the treatment of Medulloblastomas
    • Ajeawung NF, Wang HY, Kamnasaran D. Progress from clinical trials and emerging non-conventional therapies for the treatment of Medulloblastomas. Cancer Lett. 2013; 330:130-140.
    • (2013) Cancer Lett , vol.330 , pp. 130-140
    • Ajeawung, N.F.1    Wang, H.Y.2    Kamnasaran, D.3
  • 106
    • 84867116494 scopus 로고    scopus 로고
    • Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway
    • Ramaswamy B, Lu Y, Teng KY, Nuovo G, Li X, Shapiro CL, Majumder S. Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway. Cancer Res. 2012; 72:5048-5059.
    • (2012) Cancer Res , vol.72 , pp. 5048-5059
    • Ramaswamy, B.1    Lu, Y.2    Teng, K.Y.3    Nuovo, G.4    Li, X.5    Shapiro, C.L.6    Majumder, S.7
  • 107
    • 84863230921 scopus 로고    scopus 로고
    • Activation of Hedgehog pathway in gastrointestinal cancers
    • Yang L, Su X, Xie J. Activation of Hedgehog pathway in gastrointestinal cancers. Vitam Horm. 2012; 88:461-472.
    • (2012) Vitam Horm , vol.88 , pp. 461-472
    • Yang, L.1    Su, X.2    Xie, J.3
  • 108
    • 84870940346 scopus 로고    scopus 로고
    • Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch
    • Bertrand FE, Angus CW, Partis WJ, Sigounas G. Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch. Cell Cycle. 2012; 11:4344-4351.
    • (2012) Cell Cycle , vol.11 , pp. 4344-4351
    • Bertrand, F.E.1    Angus, C.W.2    Partis, W.J.3    Sigounas, G.4
  • 111
    • 70949096151 scopus 로고    scopus 로고
    • The hedgehog pathway and pancreatic cancer
    • Hidalgo M, Maitra A. The hedgehog pathway and pancreatic cancer. N Engl J Med. 2009; 361:2094-2096.
    • (2009) N Engl J Med , vol.361 , pp. 2094-2096
    • Hidalgo, M.1    Maitra, A.2
  • 112
    • 80555145216 scopus 로고    scopus 로고
    • Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms
    • Singh BN, Fu J, Srivastava RK, Shankar S. Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PLoS One. 2011; 6:e27306.
    • (2011) PLoS One , vol.6
    • Singh, B.N.1    Fu, J.2    Srivastava, R.K.3    Shankar, S.4
  • 113
    • 67650289584 scopus 로고    scopus 로고
    • Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
    • Scales SJ, de Sauvage FJ. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci. 2009; 30:303-312.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 303-312
    • Scales, S.J.1    de Sauvage, F.J.2
  • 114
    • 84880071454 scopus 로고    scopus 로고
    • Final analysis of a phase IB/randomized phase II study of gemcitabine (G) plus placebo (P) or vismodegib (V), a hedgehog (Hh) pathway inhibitor, in patients (pts) with metastatic pancreatic cancer (PC): A University of Chicago phase II consortium study
    • Catenacci D BN, Nattam S, et al. Final analysis of a phase IB/randomized phase II study of gemcitabine (G) plus placebo (P) or vismodegib (V), a hedgehog (Hh) pathway inhibitor, in patients (pts) with metastatic pancreatic cancer (PC): A University of Chicago phase II consortium study. J Clin Oncol. 31, 2013.
    • (2013) J Clin Oncol , vol.31
    • Catenacci, D.B.N.1    Nattam, S.2
  • 115
    • 84903143748 scopus 로고    scopus 로고
    • A phase II study of vismodegib, a hedgehog (Hh) pathway inhibitor, combined with gemcitabine and nab-paclitaxel (nab-P) in patients (pts) with untreated metastatic pancreatic ductal adenocarcinoma (PDA)
    • De Jesus-Acosta A ODP, Ramanathan R, et al. A phase II study of vismodegib, a hedgehog (Hh) pathway inhibitor, combined with gemcitabine and nab-paclitaxel (nab-P) in patients (pts) with untreated metastatic pancreatic ductal adenocarcinoma (PDA). J Clin Oncol. 32, 2014.
    • (2014) J Clin Oncol , vol.32
    • De Jesus-Acosta, A.1    O'Dwyer, P.2    Ramanathan, R.3
  • 119
    • 68649120877 scopus 로고    scopus 로고
    • Oral tyrosine kinase inhibitor masitinib in combination with gemcitabine in patients with advanced pancreatic cancer: A multicenter phase II study
    • Hammel F MF, Deplanque G, et al. Oral tyrosine kinase inhibitor masitinib in combination with gemcitabine in patients with advanced pancreatic cancer: A multicenter phase II study. J Clin Oncol. 27:15s, 2009.
    • (2009) J Clin Oncol , vol.27 , Issue.15
    • Hammel, F.1    Mornex, F.2    Deplanque, G.3
  • 120
    • 84929321103 scopus 로고    scopus 로고
    • Masitinib in nonresectable pancreatic cancer: Results of a phase III randomized placebo-controlled trial
    • Deplanque G DM, Hebbar M, et al. Masitinib in nonresectable pancreatic cancer: Results of a phase III randomized placebo-controlled trial. J Clin Oncol. 31, 2013.
    • (2013) J Clin Oncol , vol.31
    • Deplanque, G.1    Demarchi, M.2    Hebbar, M.3
  • 123
    • 84880053768 scopus 로고    scopus 로고
    • Dual MEK/EGFR inhibition for advanced, chemotherapy-refractory pancreatic cancer: A multicenter phase II trial of selumetinib (AZD6244; ARRY-142886) plus erlotinib
    • Ko A TM, Bekaii-Saab T, et al. Dual MEK/EGFR inhibition for advanced, chemotherapy-refractory pancreatic cancer: A multicenter phase II trial of selumetinib (AZD6244; ARRY-142886) plus erlotinib. J Clin Oncol. 31, 2013.
    • (2013) J Clin Oncol , vol.31
    • Ko, A.1    Tempero, M.2    Bekaii-Saab, T.3
  • 124
    • 54549086723 scopus 로고    scopus 로고
    • Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530
    • Chang YM, Bai L, Liu S, Yang JC, Kung HJ, Evans CP. Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530. Oncogene. 2008; 27:6365-6375.
    • (2008) Oncogene , vol.27 , pp. 6365-6375
    • Chang, Y.M.1    Bai, L.2    Liu, S.3    Yang, J.C.4    Kung, H.J.5    Evans, C.P.6
  • 127
    • 78751480476 scopus 로고    scopus 로고
    • MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy
    • Yoon J, Koo KH, Choi KY. MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy. Cancer Res. 2011; 71:445-453.
    • (2011) Cancer Res , vol.71 , pp. 445-453
    • Yoon, J.1    Koo, K.H.2    Choi, K.Y.3
  • 128
    • 84880059449 scopus 로고    scopus 로고
    • Pimasertib plus gemcitabine in metastatic pancreatic adenocarcinoma: Results of a safety run-in part of a phase II trial
    • Verslype C HP, Hidalgo M, et al. Pimasertib plus gemcitabine in metastatic pancreatic adenocarcinoma: Results of a safety run-in part of a phase II trial. J Clin Oncol. 31, 2013.
    • (2013) J Clin Oncol , vol.31
    • Verslype, C.1    Gerber, H.P.2    Hidalgo, M.3
  • 130
    • 77957164869 scopus 로고    scopus 로고
    • Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts
    • Chang Q, Chapman MS, Miner JN, Hedley DW. Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts. BMC Cancer. 2010; 10:515.
    • (2010) BMC Cancer , vol.10 , pp. 515
    • Chang, Q.1    Chapman, M.S.2    Miner, J.N.3    Hedley, D.W.4
  • 131
    • 84905169057 scopus 로고    scopus 로고
    • Phase II study of refametinib (BAY 86-9766), an allosteric dual MEK 1/2 inhibitor, and gemcitabine in patients with unresectable, locally advanced, or metastatic pancreatic cancer
    • Van Laethem J JJ, Heinemann V, et al. Phase II study of refametinib (BAY 86-9766), an allosteric dual MEK 1/2 inhibitor, and gemcitabine in patients with unresectable, locally advanced, or metastatic pancreatic cancer. J Clin Oncol. 32:5s, 2014.
    • (2014) J Clin Oncol , vol.32 , Issue.5
    • Van Laethem, J.1    Rinehart, J.J.2    Heinemann, V.3
  • 133
    • 84947566680 scopus 로고    scopus 로고
    • Phase Ib study evaluating safety and pharmacokinetics (PK) of the oral transforming growth factor-beta (TGF-ß) receptor I kinase inhibitor LY2157299 monohydrate (LY) when combined with gemcitabine in patients with advanced cancer
    • Kozloff M CR, Nadal T, et al. Phase Ib study evaluating safety and pharmacokinetics (PK) of the oral transforming growth factor-beta (TGF-ß) receptor I kinase inhibitor LY2157299 monohydrate (LY) when combined with gemcitabine in patients with advanced cancer. J Clin Oncol. 31, 2013.
    • (2013) J Clin Oncol , vol.31
    • Kozloff, M.1    Carbonero, R.2    Nadal, T.3
  • 134
    • 79959277790 scopus 로고    scopus 로고
    • Novel PARP inhibitors with potent antitumor activity as single-agent and combination therapies
    • A121. 2009
    • Wang B CD, Feng Y, et al. Novel PARP inhibitors with potent antitumor activity as single-agent and combination therapies. Mol Cancer Ther. 2009; 8:A121. 2009.
    • (2009) Mol Cancer Ther , vol.8
    • Wang, B.1    Davis, C.D.2    Feng, Y.3
  • 135
    • 84880316545 scopus 로고    scopus 로고
    • First-in-human trial of novel oral PARP inhibitor BMN 673 in patients with solid tumors
    • De Bono J ML, Gonzalez M, et al. First-in-human trial of novel oral PARP inhibitor BMN 673 in patients with solid tumors. J Clin Oncol. 31, 2013.
    • (2013) J Clin Oncol , vol.31
    • De Bono, J.M.L.1    Gonzalez, M.2
  • 137
    • 84907955592 scopus 로고    scopus 로고
    • The use of PARP inhibitors as single agents and as chemosensitizers in sporadic pancreatic cancer
    • De Soto J MR. The use of PARP inhibitors as single agents and as chemosensitizers in sporadic pancreatic cancer. J Clin Oncol. 29, 2011.
    • (2011) J Clin Oncol , vol.29
    • De Soto, J.M.R.1
  • 138
    • 84905163406 scopus 로고    scopus 로고
    • Phase IB trial of cisplatin (C), gemcitabine (G), and veliparib (V) in patients with known or potential BRCA or PALB2-mutated pancreas adenocarcinoma (PC)
    • O'Reilly E LM, Segal M, et al. Phase IB trial of cisplatin (C), gemcitabine (G), and veliparib (V) in patients with known or potential BRCA or PALB2-mutated pancreas adenocarcinoma (PC). J Clin Oncol. 32:5s, 2014.
    • (2014) J Clin Oncol , vol.32 , Issue.5
    • O'Reilly, E.L.M.1    Segal, M.2
  • 139
    • 0032704708 scopus 로고    scopus 로고
    • Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development
    • Rowinsky EK, Windle JJ, Von Hoff DD. Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development. J Clin Oncol. 1999; 17:3631-3652.
    • (1999) J Clin Oncol , vol.17 , pp. 3631-3652
    • Rowinsky, E.K.1    Windle, J.J.2    Von Hoff, D.D.3
  • 143
    • 84872807024 scopus 로고    scopus 로고
    • Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and panhistone deacetylase inhibitor against human pancreatic cancer
    • Venkannagari S, Fiskus W, Peth K, Atadja P, Hidalgo M, Maitra A, Bhalla KN. Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and panhistone deacetylase inhibitor against human pancreatic cancer. Oncotarget. 2012; 3:1416-1427.
    • (2012) Oncotarget , vol.3 , pp. 1416-1427
    • Venkannagari, S.1    Fiskus, W.2    Peth, K.3    Atadja, P.4    Hidalgo, M.5    Maitra, A.6    Bhalla, K.N.7
  • 144
    • 84950135539 scopus 로고    scopus 로고
    • Sirtainties in pancreatic cancer?
    • Rooman I. Sirtainties in pancreatic cancer? Oncoscience. 2014; 1:183-184.
    • (2014) Oncoscience , vol.1 , pp. 183-184
    • Rooman, I.1
  • 147
    • 84929318458 scopus 로고    scopus 로고
    • Novel approaches in the management of pancreatic ductal adenocarcinoma: potential promises for the future
    • Goel G, Sun W. Novel approaches in the management of pancreatic ductal adenocarcinoma: potential promises for the future. Journal of Hematology & Oncology. 2015; 8:44.
    • (2015) Journal of Hematology & Oncology , vol.8 , pp. 44
    • Goel, G.1    Sun, W.2


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