-
1
-
-
4644317795
-
Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells
-
Apte MV, Park S, Phillips PA, Santucci N, Goldstein D, Kumar RK, Ramm GA, Buchler M, Friess H, McCarroll JA, Keogh G, Merrett N, Pirola R, Wilson JS. Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells. Pancreas. 2004; 29:179-187.
-
(2004)
Pancreas
, vol.29
, pp. 179-187
-
-
Apte, M.V.1
Park, S.2
Phillips, P.A.3
Santucci, N.4
Goldstein, D.5
Kumar, R.K.6
Ramm, G.A.7
Buchler, M.8
Friess, H.9
McCarroll, J.A.10
Keogh, G.11
Merrett, N.12
Pirola, R.13
Wilson, J.S.14
-
2
-
-
84892805731
-
Cancer statistics, 2014
-
Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014; 64:9-29.
-
(2014)
CA Cancer J Clin
, vol.64
, pp. 9-29
-
-
Siegel, R.1
Ma, J.2
Zou, Z.3
Jemal, A.4
-
3
-
-
84869496369
-
Global burden of cancer: opportunities for prevention
-
Jemal A. Global burden of cancer: opportunities for prevention. Lancet. 2012; 380:1797-1799.
-
(2012)
Lancet
, vol.380
, pp. 1797-1799
-
-
Jemal, A.1
-
4
-
-
84885174025
-
Modest improvement in overall survival for patients with metastatic pancreatic cancer: a trend analysis using the surveillance, epidemiology, and end results registry from 1988 to 2008
-
Worni M, Guller U, White RR, Castleberry AW, Pietrobon R, Cerny T, Gloor B, Koeberle D. Modest improvement in overall survival for patients with metastatic pancreatic cancer: a trend analysis using the surveillance, epidemiology, and end results registry from 1988 to 2008. Pancreas. 2013; 42:1157-1163.
-
(2013)
Pancreas
, vol.42
, pp. 1157-1163
-
-
Worni, M.1
Guller, U.2
White, R.R.3
Castleberry, A.W.4
Pietrobon, R.5
Cerny, T.6
Gloor, B.7
Koeberle, D.8
-
5
-
-
79961021004
-
Pancreatic cancer surgery in the new millennium: better prediction of outcome
-
Hartwig W, Hackert T, Hinz U, Gluth A, Bergmann F, Strobel O, Buchler MW, Werner J. Pancreatic cancer surgery in the new millennium: better prediction of outcome. Ann Surg. 2011; 254:311-319.
-
(2011)
Ann Surg
, vol.254
, pp. 311-319
-
-
Hartwig, W.1
Hackert, T.2
Hinz, U.3
Gluth, A.4
Bergmann, F.5
Strobel, O.6
Buchler, M.W.7
Werner, J.8
-
6
-
-
12144287320
-
A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer
-
Neoptolemos JP, Stocken DD, Friess H, Bassi C, Dunn JA, Hickey H, Beger H, Fernandez-Cruz L, Dervenis C, Lacaine F, Falconi M, Pederzoli P, Pap A, Spooner D, Kerr DJ, Buchler MW. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med. 2004; 350:1200-1210.
-
(2004)
N Engl J Med
, vol.350
, pp. 1200-1210
-
-
Neoptolemos, J.P.1
Stocken, D.D.2
Friess, H.3
Bassi, C.4
Dunn, J.A.5
Hickey, H.6
Beger, H.7
Fernandez-Cruz, L.8
Dervenis, C.9
Lacaine, F.10
Falconi, M.11
Pederzoli, P.12
Pap, A.13
Spooner, D.14
Kerr, D.J.15
Buchler, M.W.16
-
7
-
-
33846405332
-
Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial
-
Oettle H, Post S, Neuhaus P, Gellert K, Langrehr J, Ridwelski K, Schramm H, Fahlke J, Zuelke C, Burkart C, Gutberlet K, Kettner E, Schmalenberg H, Weigang-Koehler K, Bechstein WO, Niedergethmann M, Schmidt-Wolf I, Roll L, Doerken B, Riess H. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA. 2007; 297:267-277.
-
(2007)
JAMA
, vol.297
, pp. 267-277
-
-
Oettle, H.1
Post, S.2
Neuhaus, P.3
Gellert, K.4
Langrehr, J.5
Ridwelski, K.6
Schramm, H.7
Fahlke, J.8
Zuelke, C.9
Burkart, C.10
Gutberlet, K.11
Kettner, E.12
Schmalenberg, H.13
Weigang-Koehler, K.14
Bechstein, W.O.15
Niedergethmann, M.16
Schmidt-Wolf, I.17
Roll, L.18
Doerken, B.19
Riess, H.20
more..
-
8
-
-
33845998896
-
The pancreatic stellate cell: a star on the rise in pancreatic diseases
-
Omary MB, Lugea A, Lowe AW, Pandol SJ. The pancreatic stellate cell: a star on the rise in pancreatic diseases. J Clin Invest. 2007; 117:50-59.
-
(2007)
J Clin Invest
, vol.117
, pp. 50-59
-
-
Omary, M.B.1
Lugea, A.2
Lowe, A.W.3
Pandol, S.J.4
-
9
-
-
71849112654
-
Desmoplasia of pancreatic ductal adenocarcinoma
-
Pandol S, Edderkaoui M, Gukovsky I, Lugea A, Gukovskaya A. Desmoplasia of pancreatic ductal adenocarcinoma. Clin Gastroenterol Hepatol. 2009; 7:S44-47.
-
(2009)
Clin Gastroenterol Hepatol
, vol.7
, pp. S44-S47
-
-
Pandol, S.1
Edderkaoui, M.2
Gukovsky, I.3
Lugea, A.4
Gukovskaya, A.5
-
10
-
-
2342629331
-
The pancreatic duct and its arteriovenous relationship: an underutilized aid in the diagnosis and distinction of pancreatic adenocarcinoma from pancreatic intraepithelial neoplasia. A study of 126 pancreatectomy specimens
-
Sharma S, Green KB. The pancreatic duct and its arteriovenous relationship: an underutilized aid in the diagnosis and distinction of pancreatic adenocarcinoma from pancreatic intraepithelial neoplasia. A study of 126 pancreatectomy specimens. Am J Surg Pathol. 2004; 28:613-620.
-
(2004)
Am J Surg Pathol
, vol.28
, pp. 613-620
-
-
Sharma, S.1
Green, K.B.2
-
11
-
-
77956416112
-
Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial
-
Neoptolemos JP, Stocken DD, Bassi C, Ghaneh P, Cunningham D, Goldstein D, Padbury R, Moore MJ, Gallinger S, Mariette C, Wente MN, Izbicki JR, Friess H, Lerch MM, Dervenis C, Olah A, Butturini G, Doi R, Lind PA, Smith D, Valle JW, Palmer DH, Buckels JA, Thompson J, McKay CJ, Rawcliffe CL, Buchler MW. Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA. 2010; 304:1073-1081.
-
(2010)
JAMA
, vol.304
, pp. 1073-1081
-
-
Neoptolemos, J.P.1
Stocken, D.D.2
Bassi, C.3
Ghaneh, P.4
Cunningham, D.5
Goldstein, D.6
Padbury, R.7
Moore, M.J.8
Gallinger, S.9
Mariette, C.10
Wente, M.N.11
Izbicki, J.R.12
Friess, H.13
Lerch, M.M.14
Dervenis, C.15
Olah, A.16
Butturini, G.17
Doi, R.18
Lind, P.A.19
Smith, D.20
Valle, J.W.21
Palmer, D.H.22
Buckels, J.A.23
Thompson, J.24
McKay, C.J.25
Rawcliffe, C.L.26
Buchler, M.W.27
more..
-
12
-
-
70249099504
-
A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer: Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer
-
Ueno H, Kosuge T, Matsuyama Y, Yamamoto J, Nakao A, Egawa S, Doi R, Monden M, Hatori T, Tanaka M, Shimada M, Kanemitsu K. A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer: Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer. Br J Cancer. 2009; 101:908-915.
-
(2009)
Br J Cancer
, vol.101
, pp. 908-915
-
-
Ueno, H.1
Kosuge, T.2
Matsuyama, Y.3
Yamamoto, J.4
Nakao, A.5
Egawa, S.6
Doi, R.7
Monden, M.8
Hatori, T.9
Tanaka, M.10
Shimada, M.11
Kanemitsu, K.12
-
13
-
-
77951755278
-
Pancreatic cancer
-
Hidalgo M. Pancreatic cancer. N Engl J Med. 2010; 362:1605-1617.
-
(2010)
N Engl J Med
, vol.362
, pp. 1605-1617
-
-
Hidalgo, M.1
-
14
-
-
79955921754
-
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
-
Conroy T, Desseigne F, Ychou M, Bouche O, Guimbaud R, Becouarn Y, Adenis A, Raoul JL, Gourgou-Bourgade S, de la Fouchardiere C, Bennouna J, Bachet JB, Khemissa-Akouz F, Pere-Verge D, Delbaldo C, Assenat E, Chauffert B, Michel P, Montoto-Grillot C, Ducreux M. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011; 364:1817-1825.
-
(2011)
N Engl J Med
, vol.364
, pp. 1817-1825
-
-
Conroy, T.1
Desseigne, F.2
Ychou, M.3
Bouche, O.4
Guimbaud, R.5
Becouarn, Y.6
Adenis, A.7
Raoul, J.L.8
Gourgou-Bourgade, S.9
de la Fouchardiere, C.10
Bennouna, J.11
Bachet, J.B.12
Khemissa-Akouz, F.13
Pere-Verge, D.14
Delbaldo, C.15
Assenat, E.16
Chauffert, B.17
Michel, P.18
Montoto-Grillot, C.19
Ducreux, M.20
more..
-
15
-
-
84886741654
-
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
-
Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, Seay T, Tjulandin SA, Ma WW, Saleh MN, Harris M, Reni M, Dowden S, Laheru D, Bahary N, Ramanathan RK, Tabernero J, Hidalgo M, Goldstein D, Van Cutsem E, Wei X, Iglesias J, Renschler MF. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 2013; 369:1691-1703.
-
(2013)
N Engl J Med
, vol.369
, pp. 1691-1703
-
-
Von Hoff, D.D.1
Ervin, T.2
Arena, F.P.3
Chiorean, E.G.4
Infante, J.5
Moore, M.6
Seay, T.7
Tjulandin, S.A.8
Ma, W.W.9
Saleh, M.N.10
Harris, M.11
Reni, M.12
Dowden, S.13
Laheru, D.14
Bahary, N.15
Ramanathan, R.K.16
Tabernero, J.17
Hidalgo, M.18
Goldstein, D.19
Van Cutsem, E.20
Wei, X.21
Iglesias, J.22
Renschler, M.F.23
more..
-
16
-
-
84898922484
-
Targeting hedgehog signaling in myelofibrosis and other hematologic malignancies
-
Tibes R, Mesa R. Targeting hedgehog signaling in myelofibrosis and other hematologic malignancies. Journal of Hematology & Oncology. 2014; 7:18.
-
(2014)
Journal of Hematology & Oncology
, vol.7
, pp. 18
-
-
Tibes, R.1
Mesa, R.2
-
17
-
-
84876249574
-
MEK and the inhibitors: from bench to bedside
-
Akinleye A, Furqan M, Mukhi N, Ravella P, Liu D. MEK and the inhibitors: from bench to bedside. J Hematol Oncol. 2013; 6:27.
-
(2013)
J Hematol Oncol
, vol.6
, pp. 27
-
-
Akinleye, A.1
Furqan, M.2
Mukhi, N.3
Ravella, P.4
Liu, D.5
-
18
-
-
65649120430
-
In vitro and in vivo radiosensitization with AZD6244 (ARRY-142886), an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase
-
Chung EJ, Brown AP, Asano H, Mandler M, Burgan WE, Carter D, Camphausen K, Citrin D. In vitro and in vivo radiosensitization with AZD6244 (ARRY-142886), an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase. Clin Cancer Res. 2009; 15:3050-3057.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3050-3057
-
-
Chung, E.J.1
Brown, A.P.2
Asano, H.3
Mandler, M.4
Burgan, W.E.5
Carter, D.6
Camphausen, K.7
Citrin, D.8
-
19
-
-
67449156112
-
Antitumor effects and biomarkers of activity of AZD0530, a Src inhibitor, in pancreatic cancer
-
Rajeshkumar NV, Tan AC, De Oliveira E, Womack C, Wombwell H, Morgan S, Warren MV, Walker J, Green TP, Jimeno A, Messersmith WA, Hidalgo M. Antitumor effects and biomarkers of activity of AZD0530, a Src inhibitor, in pancreatic cancer. Clin Cancer Res. 2009; 15:4138-4146.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4138-4146
-
-
Rajeshkumar, N.V.1
Tan, A.C.2
De Oliveira, E.3
Womack, C.4
Wombwell, H.5
Morgan, S.6
Warren, M.V.7
Walker, J.8
Green, T.P.9
Jimeno, A.10
Messersmith, W.A.11
Hidalgo, M.12
-
20
-
-
84864346162
-
A phase II open-label randomized study to assess the efficacy and safety of selumetinib (AZD6244 [ARRY-142886]) versus capecitabine in patients with advanced or metastatic pancreatic cancer who have failed first-line gemcitabine therapy
-
Bodoky G, Timcheva C, Spigel DR, La Stella PJ, Ciuleanu TE, Pover G, Tebbutt NC. A phase II open-label randomized study to assess the efficacy and safety of selumetinib (AZD6244 [ARRY-142886]) versus capecitabine in patients with advanced or metastatic pancreatic cancer who have failed first-line gemcitabine therapy. Invest New Drugs. 2012; 30:1216-1223.
-
(2012)
Invest New Drugs
, vol.30
, pp. 1216-1223
-
-
Bodoky, G.1
Timcheva, C.2
Spigel, D.R.3
La Stella, P.J.4
Ciuleanu, T.E.5
Pover, G.6
Tebbutt, N.C.7
-
21
-
-
84893468215
-
Kras as a key oncogene and therapeutic target in pancreatic cancer
-
Collins MA, Pasca di Magliano M. Kras as a key oncogene and therapeutic target in pancreatic cancer. Front Physiol. 2013; 4:407.
-
(2013)
Front Physiol
, vol.4
, pp. 407
-
-
Collins, M.A.1
Pasca di Magliano, M.2
-
22
-
-
84898961547
-
CHIP is a novel tumor suppressor in pancreatic cancer through targeting EGFR
-
Wang T, Yang J, Xu J, Li J, Cao Z, Zhou L, You L, Shu H, Lu Z, Li H, Li M, Zhang T, Zhao Y. CHIP is a novel tumor suppressor in pancreatic cancer through targeting EGFR. Oncotarget. 2014; 5:1969-1986.
-
(2014)
Oncotarget
, vol.5
, pp. 1969-1986
-
-
Wang, T.1
Yang, J.2
Xu, J.3
Li, J.4
Cao, Z.5
Zhou, L.6
You, L.7
Shu, H.8
Lu, Z.9
Li, H.10
Li, M.11
Zhang, T.12
Zhao, Y.13
-
23
-
-
77950498286
-
Randomized phase III trial of gemcitabine plus cisplatin compared with single-agent gemcitabine as first-line treatment of patients with advanced pancreatic cancer: the GIP-1 study
-
Colucci G, Labianca R, Di Costanzo F, Gebbia V, Carteni G, Massidda B, Dapretto E, Manzione L, Piazza E, Sannicolo M, Ciaparrone M, Cavanna L, Giuliani F, Maiello E, Testa A, Pederzoli P, Falconi M, Gallo C, Di Maio M, Perrone F. Randomized phase III trial of gemcitabine plus cisplatin compared with single-agent gemcitabine as first-line treatment of patients with advanced pancreatic cancer: the GIP-1 study. J Clin Oncol. 2010; 28:1645-1651.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1645-1651
-
-
Colucci, G.1
Labianca, R.2
Di Costanzo, F.3
Gebbia, V.4
Carteni, G.5
Massidda, B.6
Dapretto, E.7
Manzione, L.8
Piazza, E.9
Sannicolo, M.10
Ciaparrone, M.11
Cavanna, L.12
Giuliani, F.13
Maiello, E.14
Testa, A.15
Pederzoli, P.16
Falconi, M.17
Gallo, C.18
Di Maio, M.19
Perrone, F.20
more..
-
24
-
-
73949135518
-
Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer
-
Cunningham D, Chau I, Stocken DD, Valle JW, Smith D, Steward W, Harper PG, Dunn J, Tudur-Smith C, West J, Falk S, Crellin A, Adab F, Thompson J, Leonard P, Ostrowski J, Eatock M, Scheithauer W, Herrmann R, Neoptolemos JP. Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer. J Clin Oncol. 2009; 27:5513-5518.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5513-5518
-
-
Cunningham, D.1
Chau, I.2
Stocken, D.D.3
Valle, J.W.4
Smith, D.5
Steward, W.6
Harper, P.G.7
Dunn, J.8
Tudur-Smith, C.9
West, J.10
Falk, S.11
Crellin, A.12
Adab, F.13
Thompson, J.14
Leonard, P.15
Ostrowski, J.16
Eatock, M.17
Scheithauer, W.18
Herrmann, R.19
Neoptolemos, J.P.20
more..
-
25
-
-
68949114505
-
Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group
-
Poplin E, Feng Y, Berlin J, Rothenberg ML, Hochster H, Mitchell E, Alberts S, O'Dwyer P, Haller D, Catalano P, Cella D, Benson AB 3rd. Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group. J Clin Oncol. 2009; 27:3778-3785.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3778-3785
-
-
Poplin, E.1
Feng, Y.2
Berlin, J.3
Rothenberg, M.L.4
Hochster, H.5
Mitchell, E.6
Alberts, S.7
O'Dwyer, P.8
Haller, D.9
Catalano, P.10
Cella, D.11
Benson, A.B.12
-
26
-
-
33749071359
-
Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancer
-
Abou-Alfa GK, Letourneau R, Harker G, Modiano M, Hurwitz H, Tchekmedyian NS, Feit K, Ackerman J, De Jager RL, Eckhardt SG, O'Reilly EM. Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancer. J Clin Oncol. 2006; 24:4441-4447.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4441-4447
-
-
Abou-Alfa, G.K.1
Letourneau, R.2
Harker, G.3
Modiano, M.4
Hurwitz, H.5
Tchekmedyian, N.S.6
Feit, K.7
Ackerman, J.8
De Jager, R.L.9
Eckhardt, S.G.10
O'Reilly, E.M.11
-
27
-
-
33748297529
-
A multicenter phase III trial comparing irinotecan-gemcitabine (IG) with gemcitabine (G) monotherapy as first-line treatment in patients with locally advanced or metastatic pancreatic cancer
-
Stathopoulos GP, Syrigos K, Aravantinos G, Polyzos A, Papakotoulas P, Fountzilas G, Potamianou A, Ziras N, Boukovinas J, Varthalitis J, Androulakis N, Kotsakis A, Samonis G, Georgoulias V. A multicenter phase III trial comparing irinotecan-gemcitabine (IG) with gemcitabine (G) monotherapy as first-line treatment in patients with locally advanced or metastatic pancreatic cancer. Br J Cancer. 2006; 95:587-592.
-
(2006)
Br J Cancer
, vol.95
, pp. 587-592
-
-
Stathopoulos, G.P.1
Syrigos, K.2
Aravantinos, G.3
Polyzos, A.4
Papakotoulas, P.5
Fountzilas, G.6
Potamianou, A.7
Ziras, N.8
Boukovinas, J.9
Varthalitis, J.10
Androulakis, N.11
Kotsakis, A.12
Samonis, G.13
Georgoulias, V.14
-
28
-
-
27144530079
-
A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer
-
Oettle H, Richards D, Ramanathan RK, van Laethem JL, Peeters M, Fuchs M, Zimmermann A, John W, Von Hoff D, Arning M, Kindler HL. A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer. Ann Oncol. 2005; 16:1639-1645.
-
(2005)
Ann Oncol
, vol.16
, pp. 1639-1645
-
-
Oettle, H.1
Richards, D.2
Ramanathan, R.K.3
van Laethem, J.L.4
Peeters, M.5
Fuchs, M.6
Zimmermann, A.7
John, W.8
Von Hoff, D.9
Arning, M.10
Kindler, H.L.11
-
29
-
-
0036682041
-
Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297
-
Berlin JD, Catalano P, Thomas JP, Kugler JW, Haller DG, Benson AB 3rd. Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol. 2002; 20:3270-3275.
-
(2002)
J Clin Oncol
, vol.20
, pp. 3270-3275
-
-
Berlin, J.D.1
Catalano, P.2
Thomas, J.P.3
Kugler, J.W.4
Haller, D.G.5
Benson, A.B.6
-
30
-
-
77955914277
-
Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205
-
Philip PA, Benedetti J, Corless CL, Wong R, O'Reilly EM, Flynn PJ, Rowland KM, Atkins JN, Mirtsching BC, Rivkin SE, Khorana AA, Goldman B, Fenoglio-Preiser CM, Abbruzzese JL, Blanke CD. Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205. J Clin Oncol. 2010; 28:3605-3610.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3605-3610
-
-
Philip, P.A.1
Benedetti, J.2
Corless, C.L.3
Wong, R.4
O'Reilly, E.M.5
Flynn, P.J.6
Rowland, K.M.7
Atkins, J.N.8
Mirtsching, B.C.9
Rivkin, S.E.10
Khorana, A.A.11
Goldman, B.12
Fenoglio-Preiser, C.M.13
Abbruzzese, J.L.14
Blanke, C.D.15
-
31
-
-
77955887676
-
Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303)
-
Kindler HL, Niedzwiecki D, Hollis D, Sutherland S, Schrag D, Hurwitz H, Innocenti F, Mulcahy MF, O'Reilly E, Wozniak TF, Picus J, Bhargava P, Mayer RJ, Schilsky RL, Goldberg RM. Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J Clin Oncol. 2010; 28:3617-3622.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3617-3622
-
-
Kindler, H.L.1
Niedzwiecki, D.2
Hollis, D.3
Sutherland, S.4
Schrag, D.5
Hurwitz, H.6
Innocenti, F.7
Mulcahy, M.F.8
O'Reilly, E.9
Wozniak, T.F.10
Picus, J.11
Bhargava, P.12
Mayer, R.J.13
Schilsky, R.L.14
Goldberg, R.M.15
-
32
-
-
84929083437
-
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial of Ganitumab or Placebo in Combination With Gemcitabine as First-Line Therapy for Metastatic Adenocarcinoma of the Pancreas: the GAMMA Trial
-
Fuchs CS, Azevedo S, Okusaka T, Van Laethem JL, Lipton LR, Riess H, Szczylik C, Moore MJ, Peeters M, Bodoky G, Ikeda M, Melichar B, Nemecek R, Ohkawa S, Swieboda-Sadlej A, Tjulandin SA, Van Cutsem E, Loberg R, Haddad V, Gansert JL, Bach BA, Carrato A. A Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial of Ganitumab or Placebo in Combination With Gemcitabine as First-Line Therapy for Metastatic Adenocarcinoma of the Pancreas: the GAMMA Trial. Annals of Oncology. 2015; 26doi:10.1093/annonc/mdv1027.
-
(2015)
Annals of Oncology
, vol.26
-
-
Fuchs, C.S.1
Azevedo, S.2
Okusaka, T.3
Van Laethem, J.L.4
Lipton, L.R.5
Riess, H.6
Szczylik, C.7
Moore, M.J.8
Peeters, M.9
Bodoky, G.10
Ikeda, M.11
Melichar, B.12
Nemecek, R.13
Ohkawa, S.14
Swieboda-Sadlej, A.15
Tjulandin, S.A.16
Van Cutsem, E.17
Loberg, R.18
Haddad, V.19
Gansert, J.L.20
Bach, B.A.21
Carrato, A.22
more..
-
33
-
-
84868107516
-
BAYPAN study: a double-blind phase III randomized trial comparing gemcitabine plus sorafenib and gemcitabine plus placebo in patients with advanced pancreatic cancer
-
Goncalves A, Gilabert M, Francois E, Dahan L, Perrier H, Lamy R, Re D, Largillier R, Gasmi M, Tchiknavorian X, Esterni B, Genre D, Moureau-Zabotto L, Giovannini M, Seitz JF, Delpero JR, Turrini O, Viens P, Raoul JL. BAYPAN study: a double-blind phase III randomized trial comparing gemcitabine plus sorafenib and gemcitabine plus placebo in patients with advanced pancreatic cancer. Ann Oncol. 2012; 23:2799-2805.
-
(2012)
Ann Oncol
, vol.23
, pp. 2799-2805
-
-
Goncalves, A.1
Gilabert, M.2
Francois, E.3
Dahan, L.4
Perrier, H.5
Lamy, R.6
Re, D.7
Largillier, R.8
Gasmi, M.9
Tchiknavorian, X.10
Esterni, B.11
Genre, D.12
Moureau-Zabotto, L.13
Giovannini, M.14
Seitz, J.F.15
Delpero, J.R.16
Turrini, O.17
Viens, P.18
Raoul, J.L.19
-
34
-
-
79952036599
-
Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study
-
Kindler HL, Ioka T, Richel DJ, Bennouna J, Letourneau R, Okusaka T, Funakoshi A, Furuse J, Park YS, Ohkawa S, Springett GM, Wasan HS, Trask PC, Bycott P, Ricart AD, Kim S, Van Cutsem E. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study. Lancet Oncol. 2011; 12:256-262.
-
(2011)
Lancet Oncol
, vol.12
, pp. 256-262
-
-
Kindler, H.L.1
Ioka, T.2
Richel, D.J.3
Bennouna, J.4
Letourneau, R.5
Okusaka, T.6
Funakoshi, A.7
Furuse, J.8
Park, Y.S.9
Ohkawa, S.10
Springett, G.M.11
Wasan, H.S.12
Trask, P.C.13
Bycott, P.14
Ricart, A.D.15
Kim, S.16
Van Cutsem, E.17
-
35
-
-
84880051791
-
Prospective randomized phase II trial with gemcitabine versus gemcitabine plus sunitinib in advanced pancreatic cancer: A study of the CESAR Central European Society for Anticancer Drug Research-EWIV
-
Richly H, Maute L, Heil G, Russel J, Jager E, Koeberle D, Fuxius S, Weigang-Koehler K, Aulitzky W, Woehrmann B, Hartung GG, Moritz B, Burkholder I, Scheulen ME, Bergmann L. Prospective randomized phase II trial with gemcitabine versus gemcitabine plus sunitinib in advanced pancreatic cancer: A study of the CESAR Central European Society for Anticancer Drug Research-EWIV. ASCO Meeting Abstracts. 2013; 31:4035.
-
(2013)
ASCO Meeting Abstracts
, vol.31
, pp. 4035
-
-
Richly, H.1
Maute, L.2
Heil, G.3
Russel, J.4
Jager, E.5
Koeberle, D.6
Fuxius, S.7
Weigang-Koehler, K.8
Aulitzky, W.9
Woehrmann, B.10
Hartung, G.G.11
Moritz, B.12
Burkholder, I.13
Scheulen, M.E.14
Bergmann, L.15
-
36
-
-
84879952361
-
Randomised, placebo-controlled, double-blind, parallelgroup phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer
-
Rougier P, Riess H, Manges R, Karasek P, Humblet Y, Barone C, Santoro A, Assadourian S, Hatteville L, Philip PA. Randomised, placebo-controlled, double-blind, parallelgroup phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer. Eur J Cancer. 2013; 49:2633-2642.
-
(2013)
Eur J Cancer
, vol.49
, pp. 2633-2642
-
-
Rougier, P.1
Riess, H.2
Manges, R.3
Karasek, P.4
Humblet, Y.5
Barone, C.6
Santoro, A.7
Assadourian, S.8
Hatteville, L.9
Philip, P.A.10
-
37
-
-
2342645506
-
Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer
-
Van Cutsem E, van de Velde H, Karasek P, Oettle H, Vervenne WL, Szawlowski A, Schoffski P, Post S, Verslype C, Neumann H, Safran H, Humblet Y, Perez Ruixo J, Ma Y, Von Hoff D. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J Clin Oncol. 2004; 22:1430-1438.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1430-1438
-
-
Van Cutsem, E.1
van de Velde, H.2
Karasek, P.3
Oettle, H.4
Vervenne, W.L.5
Szawlowski, A.6
Schoffski, P.7
Post, S.8
Verslype, C.9
Neumann, H.10
Safran, H.11
Humblet, Y.12
Perez Ruixo, J.13
Ma, Y.14
Von Hoff, D.15
-
38
-
-
58249085318
-
Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer
-
Wolpin BM, Hezel AF, Abrams T, Blaszkowsky LS, Meyerhardt JA, Chan JA, Enzinger PC, Allen B, Clark JW, Ryan DP, Fuchs CS. Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer. J Clin Oncol. 2009; 27:193-198.
-
(2009)
J Clin Oncol
, vol.27
, pp. 193-198
-
-
Wolpin, B.M.1
Hezel, A.F.2
Abrams, T.3
Blaszkowsky, L.S.4
Meyerhardt, J.A.5
Chan, J.A.6
Enzinger, P.C.7
Allen, B.8
Clark, J.W.9
Ryan, D.P.10
Fuchs, C.S.11
-
39
-
-
84904063663
-
A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas
-
Infante JR, Somer BG, Park JO, Li CP, Scheulen ME, Kasubhai SM, Oh DY, Liu Y, Redhu S, Steplewski K, Le N. A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas. Eur J Cancer. 2014; 50:2072-2081.
-
(2014)
Eur J Cancer
, vol.50
, pp. 2072-2081
-
-
Infante, J.R.1
Somer, B.G.2
Park, J.O.3
Li, C.P.4
Scheulen, M.E.5
Kasubhai, S.M.6
Oh, D.Y.7
Liu, Y.8
Redhu, S.9
Steplewski, K.10
Le, N.11
-
40
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore MJ, Goldstein D, Hamm J, Figer A, Hecht JR, Gallinger S, Au HJ, Murawa P, Walde D, Wolff RA, Campos D, Lim R, Ding K, Clark G, Voskoglou-Nomikos T, Ptasynski M, Parulekar W. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2007; 25:1960-1966.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
Figer, A.4
Hecht, J.R.5
Gallinger, S.6
Au, H.J.7
Murawa, P.8
Walde, D.9
Wolff, R.A.10
Campos, D.11
Lim, R.12
Ding, K.13
Clark, G.14
Voskoglou-Nomikos, T.15
Ptasynski, M.16
Parulekar, W.17
-
41
-
-
44849120686
-
A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes
-
Yada A, Yazawa M, Ishida S, Yoshida H, Ichikawa K, Kurakata S, Fujiwara K. A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes. Ann Oncol. 2008; 19:1060-1067.
-
(2008)
Ann Oncol
, vol.19
, pp. 1060-1067
-
-
Yada, A.1
Yazawa, M.2
Ishida, S.3
Yoshida, H.4
Ichikawa, K.5
Kurakata, S.6
Fujiwara, K.7
-
42
-
-
17944376030
-
Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity
-
Ichikawa K, Liu W, Zhao L, Wang Z, Liu D, Ohtsuka T, Zhang H, Mountz JD, Koopman WJ, Kimberly RP, Zhou T. Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nat Med. 2001; 7:954-960.
-
(2001)
Nat Med
, vol.7
, pp. 954-960
-
-
Ichikawa, K.1
Liu, W.2
Zhao, L.3
Wang, Z.4
Liu, D.5
Ohtsuka, T.6
Zhang, H.7
Mountz, J.D.8
Koopman, W.J.9
Kimberly, R.P.10
Zhou, T.11
-
43
-
-
0033667778
-
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
-
Sprick MR, Weigand MA, Rieser E, Rauch CT, Juo P, Blenis J, Krammer PH, Walczak H. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity. 2000; 12:599-609.
-
(2000)
Immunity
, vol.12
, pp. 599-609
-
-
Sprick, M.R.1
Weigand, M.A.2
Rieser, E.3
Rauch, C.T.4
Juo, P.5
Blenis, J.6
Krammer, P.H.7
Walczak, H.8
-
44
-
-
0032555697
-
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
-
Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 1998; 94:491-501.
-
(1998)
Cell
, vol.94
, pp. 491-501
-
-
Li, H.1
Zhu, H.2
Xu, C.J.3
Yuan, J.4
-
45
-
-
33751012407
-
Treatment with gemcitabine and TRA-8 antideath receptor-5 mAb reduces pancreatic adenocarcinoma cell viability in vitro and growth in vivo
-
discussion 1300
-
DeRosier LC, Huang ZQ, Sellers JC, Buchsbaum DJ, Vickers SM. Treatment with gemcitabine and TRA-8 antideath receptor-5 mAb reduces pancreatic adenocarcinoma cell viability in vitro and growth in vivo. J Gastrointest Surg. 2006; 10:1291-1300. discussion 1300.
-
(2006)
J Gastrointest Surg
, vol.10
, pp. 1291-1300
-
-
DeRosier, L.C.1
Huang, Z.Q.2
Sellers, J.C.3
Buchsbaum, D.J.4
Vickers, S.M.5
-
46
-
-
37549019355
-
TRA-8 anti-DR5 monoclonal antibody and gemcitabine induce apoptosis and inhibit radiologically validated orthotopic pancreatic tumor growth
-
Derosier LC, Vickers SM, Zinn KR, Huang Z, Wang W, Grizzle WE, Sellers J, Stockard CR Jr, Zhou T, Oliver PG, Arnoletti P, Lobuglio AF, Buchsbaum DJ. TRA-8 anti-DR5 monoclonal antibody and gemcitabine induce apoptosis and inhibit radiologically validated orthotopic pancreatic tumor growth. Mol Cancer Ther. 2007; 6:3198-3207.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 3198-3207
-
-
Derosier, L.C.1
Vickers, S.M.2
Zinn, K.R.3
Huang, Z.4
Wang, W.5
Grizzle, W.E.6
Sellers, J.7
Stockard, C.R.8
Zhou, T.9
Oliver, P.G.10
Arnoletti, P.11
Lobuglio, A.F.12
Buchsbaum, D.J.13
-
47
-
-
77649301860
-
Phase I trial of weekly tigatuzumab, an agonistic humanized monoclonal antibody targeting death receptor 5 (DR5)
-
Forero-Torres A, Shah J, Wood T, Posey J, Carlisle R, Copigneaux C, Luo FR, Wojtowicz-Praga S, Percent I, Saleh M. Phase I trial of weekly tigatuzumab, an agonistic humanized monoclonal antibody targeting death receptor 5 (DR5). Cancer Biother Radiopharm. 2010; 25:13-19.
-
(2010)
Cancer Biother Radiopharm
, vol.25
, pp. 13-19
-
-
Forero-Torres, A.1
Shah, J.2
Wood, T.3
Posey, J.4
Carlisle, R.5
Copigneaux, C.6
Luo, F.R.7
Wojtowicz-Praga, S.8
Percent, I.9
Saleh, M.10
-
48
-
-
84903549192
-
Phase 2, multicenter, open-label study of tigatuzumab (CS-1008), a humanized monoclonal antibody targeting death receptor 5, in combination with gemcitabine in chemotherapy-naive patients with unresectable or metastatic pancreatic cancer
-
Forero-Torres A, Infante JR, Waterhouse D, Wong L, Vickers S, Arrowsmith E, He AR, Hart L, Trent D, Wade J, Jin X, Wang Q, Austin T, Rosen M, Beckman R, von Roemeling R, Greenberg J, Saleh M. Phase 2, multicenter, open-label study of tigatuzumab (CS-1008), a humanized monoclonal antibody targeting death receptor 5, in combination with gemcitabine in chemotherapy-naive patients with unresectable or metastatic pancreatic cancer. Cancer Med. 2013; 2:925-932.
-
(2013)
Cancer Med
, vol.2
, pp. 925-932
-
-
Forero-Torres, A.1
Infante, J.R.2
Waterhouse, D.3
Wong, L.4
Vickers, S.5
Arrowsmith, E.6
He, A.R.7
Hart, L.8
Trent, D.9
Wade, J.10
Jin, X.11
Wang, Q.12
Austin, T.13
Rosen, M.14
Beckman, R.15
von Roemeling, R.16
Greenberg, J.17
Saleh, M.18
-
49
-
-
0026528966
-
Enhancement of transforming potential of human insulinlike growth factor 1 receptor by N-terminal truncation and fusion to avian sarcoma virus UR2 gag sequence
-
Liu D, Rutter WJ, Wang LH. Enhancement of transforming potential of human insulinlike growth factor 1 receptor by N-terminal truncation and fusion to avian sarcoma virus UR2 gag sequence. Journal of virology. 1992; 66:374-385.
-
(1992)
Journal of virology
, vol.66
, pp. 374-385
-
-
Liu, D.1
Rutter, W.J.2
Wang, L.H.3
-
50
-
-
0027453779
-
Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions
-
Liu D, Zong CS, Wang LH. Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions. Journal of virology. 1993; 67:6835-6840.
-
(1993)
Journal of virology
, vol.67
, pp. 6835-6840
-
-
Liu, D.1
Zong, C.S.2
Wang, L.H.3
-
51
-
-
0027402605
-
Modulating effects of the extracellular sequence of the human insulinlike growth factor I receptor on its transforming and tumorigenic potential
-
Liu D, Rutter WJ, Wang LH. Modulating effects of the extracellular sequence of the human insulinlike growth factor I receptor on its transforming and tumorigenic potential. Journal of virology. 1993; 67:9-18.
-
(1993)
Journal of virology
, vol.67
, pp. 9-18
-
-
Liu, D.1
Rutter, W.J.2
Wang, L.H.3
-
52
-
-
0002607682
-
Oncogenes, Protein Tyrosine Kinases, and Signal Transduction
-
Liu D, Wang LH. Oncogenes, Protein Tyrosine Kinases, and Signal Transduction. Journal of biomedical science. 1994; 1:65-82.
-
(1994)
Journal of biomedical science
, vol.1
, pp. 65-82
-
-
Liu, D.1
Wang, L.H.2
-
53
-
-
46949105858
-
FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells
-
Liu W, Bloom DA, Cance WG, Kurenova EV, Golubovskaya VM, Hochwald SN. FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis. 2008; 29:1096-1107.
-
(2008)
Carcinogenesis
, vol.29
, pp. 1096-1107
-
-
Liu, W.1
Bloom, D.A.2
Cance, W.G.3
Kurenova, E.V.4
Golubovskaya, V.M.5
Hochwald, S.N.6
-
54
-
-
0028997487
-
Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles
-
Bergmann U, Funatomi H, Yokoyama M, Beger HG, Korc M. Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles. Cancer Res. 1995; 55:2007-2011.
-
(1995)
Cancer Res
, vol.55
, pp. 2007-2011
-
-
Bergmann, U.1
Funatomi, H.2
Yokoyama, M.3
Beger, H.G.4
Korc, M.5
-
55
-
-
64249110119
-
Molecular mechanisms involved in activity of h7C10, a humanized monoclonal antibody, to IGF-1 receptor
-
Broussas M, Dupont J, Gonzalez A, Blaecke A, Fournier M, Corvaia N, Goetsch L. Molecular mechanisms involved in activity of h7C10, a humanized monoclonal antibody, to IGF-1 receptor. Int J Cancer. 2009; 124:2281-2293.
-
(2009)
Int J Cancer
, vol.124
, pp. 2281-2293
-
-
Broussas, M.1
Dupont, J.2
Gonzalez, A.3
Blaecke, A.4
Fournier, M.5
Corvaia, N.6
Goetsch, L.7
-
56
-
-
34248170187
-
Functional responses and in vivo anti-tumour activity of h7C10: a humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors
-
Pandini G, Wurch T, Akla B, Corvaia N, Belfiore A, Goetsch L. Functional responses and in vivo anti-tumour activity of h7C10: a humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors. Eur J Cancer. 2007; 43:1318-1327.
-
(2007)
Eur J Cancer
, vol.43
, pp. 1318-1327
-
-
Pandini, G.1
Wurch, T.2
Akla, B.3
Corvaia, N.4
Belfiore, A.5
Goetsch, L.6
-
57
-
-
77953193972
-
Dalotuzumab, a recombinant humanized mAb targeted against IGFR1 for the treatment of cancer
-
Scartozzi M, Bianconi M, Maccaroni E, Giampieri R, Berardi R, Cascinu S. Dalotuzumab, a recombinant humanized mAb targeted against IGFR1 for the treatment of cancer. Curr Opin Mol Ther. 2010; 12:361-371.
-
(2010)
Curr Opin Mol Ther
, vol.12
, pp. 361-371
-
-
Scartozzi, M.1
Bianconi, M.2
Maccaroni, E.3
Giampieri, R.4
Berardi, R.5
Cascinu, S.6
-
58
-
-
10344247119
-
A recombinant humanized antiinsulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and antiepidermal growth factor receptor therapy against human cancer xenografts
-
Goetsch L, Gonzalez A, Leger O, Beck A, Pauwels PJ, Haeuw JF, Corvaia N. A recombinant humanized antiinsulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and antiepidermal growth factor receptor therapy against human cancer xenografts. Int J Cancer. 2005; 113:316-328.
-
(2005)
Int J Cancer
, vol.113
, pp. 316-328
-
-
Goetsch, L.1
Gonzalez, A.2
Leger, O.3
Beck, A.4
Pauwels, P.J.5
Haeuw, J.F.6
Corvaia, N.7
-
59
-
-
80053525113
-
A phase I pharmacokinetic and pharmacodynamic study of dalotuzumab (MK-0646), an anti-insulin-like growth factor-1 receptor monoclonal antibody, in patients with advanced solid tumors
-
Atzori F, Tabernero J, Cervantes A, Prudkin L, Andreu J, Rodriguez-Braun E, Domingo A, Guijarro J, Gamez C, Rodon J, Di Cosimo S, Brown H, Clark J, Hardwick JS, Beckman RA, Hanley WD, Hsu K, Calvo E, Rosello S, Langdon RB, Baselga J. A phase I pharmacokinetic and pharmacodynamic study of dalotuzumab (MK-0646), an anti-insulin-like growth factor-1 receptor monoclonal antibody, in patients with advanced solid tumors. Clin Cancer Res. 2011; 17:6304-6312.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6304-6312
-
-
Atzori, F.1
Tabernero, J.2
Cervantes, A.3
Prudkin, L.4
Andreu, J.5
Rodriguez-Braun, E.6
Domingo, A.7
Guijarro, J.8
Gamez, C.9
Rodon, J.10
Di Cosimo, S.11
Brown, H.12
Clark, J.13
Hardwick, J.S.14
Beckman, R.A.15
Hanley, W.D.16
Hsu, K.17
Calvo, E.18
Rosello, S.19
Langdon, R.B.20
Baselga, J.21
more..
-
60
-
-
79960219919
-
Randomized phase II study of gemcitabine (G) plus anti-IGF-1R antibody MK-0646, G plus erlotinib (E) plus MK-0646 and G plus E for advanced pancreatic cancer
-
Javle M VG, et al. Randomized phase II study of gemcitabine (G) plus anti-IGF-1R antibody MK-0646, G plus erlotinib (E) plus MK-0646 and G plus E for advanced pancreatic cancer. J Clin Oncol. 29:2011.
-
J Clin Oncol
, vol.29
, pp. 2011
-
-
Javle, M.1
Bathini, V.G.2
-
61
-
-
77952912435
-
Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types
-
Kaplan-Lefko PJ, Graves JD, Zoog SJ, Pan Y, Wall J, Branstetter DG, Moriguchi J, Coxon A, Huard JN, Xu R, Peach ML, Juan G, Kaufman S, Chen Q, Bianchi A, Kordich JJ, Ma M, Foltz IN, Gliniak BC. Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types. Cancer Biol Ther. 2010; 9:618-631.
-
(2010)
Cancer Biol Ther
, vol.9
, pp. 618-631
-
-
Kaplan-Lefko, P.J.1
Graves, J.D.2
Zoog, S.J.3
Pan, Y.4
Wall, J.5
Branstetter, D.G.6
Moriguchi, J.7
Coxon, A.8
Huard, J.N.9
Xu, R.10
Peach, M.L.11
Juan, G.12
Kaufman, S.13
Chen, Q.14
Bianchi, A.15
Kordich, J.J.16
Ma, M.17
Foltz, I.N.18
Gliniak, B.C.19
-
62
-
-
0035835494
-
Effects and expression of TRAIL and its apoptosis-promoting receptors in human pancreatic cancer
-
Ozawa F, Friess H, Kleeff J, Xu ZW, Zimmermann A, Sheikh MS, Buchler MW. Effects and expression of TRAIL and its apoptosis-promoting receptors in human pancreatic cancer. Cancer Lett. 2001; 163:71-81.
-
(2001)
Cancer Lett
, vol.163
, pp. 71-81
-
-
Ozawa, F.1
Friess, H.2
Kleeff, J.3
Xu, Z.W.4
Zimmermann, A.5
Sheikh, M.S.6
Buchler, M.W.7
-
63
-
-
68649085369
-
A phase Ib study to evaluate the safety and efficacy of AMG 655 in combination with gemcitabine (G) in patients (pts) with metastatic pancreatic cancer (PC)
-
Kindler HL GL, Stephenson J, et al. A phase Ib study to evaluate the safety and efficacy of AMG 655 in combination with gemcitabine (G) in patients (pts) with metastatic pancreatic cancer (PC). J Clin Oncol. 2009; 27.
-
(2009)
J Clin Oncol
, pp. 27
-
-
Kindler, H.L.1
Garbo, L.2
Stephenson, J.3
-
64
-
-
84862531853
-
A randomized, placebo-controlled phase 2 study of ganitumab (AMG 479) or conatumumab (AMG 655) in combination with gemcitabine in patients with metastatic pancreatic cancer
-
Kindler HL, Richards DA, Garbo LE, Garon EB, Stephenson JJ Jr., Rocha-Lima CM, Safran H, Chan D, Kocs DM, Galimi F, McGreivy J, Bray SL, Hei Y, Feigal EG, Loh E, Fuchs CS. A randomized, placebo-controlled phase 2 study of ganitumab (AMG 479) or conatumumab (AMG 655) in combination with gemcitabine in patients with metastatic pancreatic cancer. Ann Oncol. 2012; 23:2834-2842.
-
(2012)
Ann Oncol
, vol.23
, pp. 2834-2842
-
-
Kindler, H.L.1
Richards, D.A.2
Garbo, L.E.3
Garon, E.B.4
Stephenson, J.J.5
Rocha-Lima, C.M.6
Safran, H.7
Chan, D.8
Kocs, D.M.9
Galimi, F.10
McGreivy, J.11
Bray, S.L.12
Hei, Y.13
Feigal, E.G.14
Loh, E.15
Fuchs, C.S.16
-
65
-
-
34848903049
-
IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor
-
Rowinsky EK, Youssoufian H, Tonra JR, Solomon P, Burtrum D, Ludwig DL. IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor. Clin Cancer Res. 2007; 13:5549s-5555s.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5549s-5555s
-
-
Rowinsky, E.K.1
Youssoufian, H.2
Tonra, J.R.3
Solomon, P.4
Burtrum, D.5
Ludwig, D.L.6
-
66
-
-
9144234724
-
A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo
-
Burtrum D, Zhu Z, Lu D, Anderson DM, Prewett M, Pereira DS, Bassi R, Abdullah R, Hooper AT, Koo H, Jimenez X, Johnson D, Apblett R, Kussie P, Bohlen P, Witte L, Hicklin DJ, Ludwig DL. A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res. 2003; 63:8912-8921.
-
(2003)
Cancer Res
, vol.63
, pp. 8912-8921
-
-
Burtrum, D.1
Zhu, Z.2
Lu, D.3
Anderson, D.M.4
Prewett, M.5
Pereira, D.S.6
Bassi, R.7
Abdullah, R.8
Hooper, A.T.9
Koo, H.10
Jimenez, X.11
Johnson, D.12
Apblett, R.13
Kussie, P.14
Bohlen, P.15
Witte, L.16
Hicklin, D.J.17
Ludwig, D.L.18
-
67
-
-
35148889523
-
A phase I, first in man study of weekly IMC-A12, a fully human insulin-like growth factor receptor IgG1 monoclonal antibody in patients with advanced solid tumors
-
Higano CS YE, Whiting SH, et al. A phase I, first in man study of weekly IMC-A12, a fully human insulin-like growth factor receptor IgG1 monoclonal antibody in patients with advanced solid tumors. ASCO. 2007; A269 2009.
-
(2009)
ASCO. 2007
, pp. A269
-
-
Higano, C.S.1
Yu, Y.E.2
Whiting, S.H.3
-
68
-
-
84908500883
-
Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWOG S0727)
-
Philip PA, Goldman B, Ramanathan RK, Lenz HJ, Lowy AM, Whitehead RP, Wakatsuki T, Iqbal S, Gaur R, Benedetti JK, Blanke CD. Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWOG S0727). Cancer. 2014; 120:2980-2985.
-
(2014)
Cancer
, vol.120
, pp. 2980-2985
-
-
Philip, P.A.1
Goldman, B.2
Ramanathan, R.K.3
Lenz, H.J.4
Lowy, A.M.5
Whitehead, R.P.6
Wakatsuki, T.7
Iqbal, S.8
Gaur, R.9
Benedetti, J.K.10
Blanke, C.D.11
-
71
-
-
84856287736
-
A humanized anti-IGF-1R monoclonal antibody (R1507) and/or metformin enhance gemcitabine-induced apoptosis in pancreatic cancer cells
-
Kawanami T, Takiguchi S, Ikeda N, Funakoshi A. A humanized anti-IGF-1R monoclonal antibody (R1507) and/or metformin enhance gemcitabine-induced apoptosis in pancreatic cancer cells. Oncol Rep. 2012; 27:867-872.
-
(2012)
Oncol Rep
, vol.27
, pp. 867-872
-
-
Kawanami, T.1
Takiguchi, S.2
Ikeda, N.3
Funakoshi, A.4
-
72
-
-
84950113573
-
Effect of R1507, an anti-IGF-1R monocolonal antibody, on sensitization of pancreatic cancer cell lines to mTOR inhibition
-
Dragovich T BA, Pineda C, et al. Effect of R1507, an anti-IGF-1R monocolonal antibody, on sensitization of pancreatic cancer cell lines to mTOR inhibition. 2010 Gastrointestinal Cancers Symposium Abstract 177.
-
2010 Gastrointestinal Cancers Symposium Abstract
-
-
Dragovich, T.1
Miller, B.A.2
Pineda, C.3
-
73
-
-
77950974697
-
A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors
-
Kurzrock R, Patnaik A, Aisner J, Warren T, Leong S, Benjamin R, Eckhardt SG, Eid JE, Greig G, Habben K, McCarthy CD, Gore L. A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors. Clin Cancer Res. 2010; 16:2458-2465.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2458-2465
-
-
Kurzrock, R.1
Patnaik, A.2
Aisner, J.3
Warren, T.4
Leong, S.5
Benjamin, R.6
Eckhardt, S.G.7
Eid, J.E.8
Greig, G.9
Habben, K.10
McCarthy, C.D.11
Gore, L.12
-
74
-
-
84859475889
-
Phase I rapid dose-escalation study of AGS-1C4D4, a human anti-PSCA (prostate stem cell antigen) monoclonal antibody, in patients with castrationresistant prostate cancer: a PCCTC trial
-
Antonarakis ES, Carducci MA, Eisenberger MA, Denmeade SR, Slovin SF, Jelaca-Maxwell K, Vincent ME, Scher HI, Morris MJ. Phase I rapid dose-escalation study of AGS-1C4D4, a human anti-PSCA (prostate stem cell antigen) monoclonal antibody, in patients with castrationresistant prostate cancer: a PCCTC trial. Cancer Chemother Pharmacol. 2012; 69:763-771.
-
(2012)
Cancer Chemother Pharmacol
, vol.69
, pp. 763-771
-
-
Antonarakis, E.S.1
Carducci, M.A.2
Eisenberger, M.A.3
Denmeade, S.R.4
Slovin, S.F.5
Jelaca-Maxwell, K.6
Vincent, M.E.7
Scher, H.I.8
Morris, M.J.9
-
75
-
-
0035360275
-
Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma
-
Argani P, Rosty C, Reiter RE, Wilentz RE, Murugesan SR, Leach SD, Ryu B, Skinner HG, Goggins M, Jaffee EM, Yeo CJ, Cameron JL, Kern SE, Hruban RH. Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma. Cancer Res. 2001; 61:4320-4324.
-
(2001)
Cancer Res
, vol.61
, pp. 4320-4324
-
-
Argani, P.1
Rosty, C.2
Reiter, R.E.3
Wilentz, R.E.4
Murugesan, S.R.5
Leach, S.D.6
Ryu, B.7
Skinner, H.G.8
Goggins, M.9
Jaffee, E.M.10
Yeo, C.J.11
Cameron, J.L.12
Kern, S.E.13
Hruban, R.H.14
-
76
-
-
62749184977
-
Prostate stem cell antigen: a prospective therapeutic and diagnostic target
-
Raff AB, Gray A, Kast WM. Prostate stem cell antigen: a prospective therapeutic and diagnostic target. Cancer Lett. 2009; 277:126-132.
-
(2009)
Cancer Lett
, vol.277
, pp. 126-132
-
-
Raff, A.B.1
Gray, A.2
Kast, W.M.3
-
77
-
-
0035956985
-
Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts
-
Saffran DC, Raitano AB, Hubert RS, Witte ON, Reiter RE, Jakobovits A. Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts. Proc Natl Acad Sci U S A. 2001; 98:2658-2663.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 2658-2663
-
-
Saffran, D.C.1
Raitano, A.B.2
Hubert, R.S.3
Witte, O.N.4
Reiter, R.E.5
Jakobovits, A.6
-
78
-
-
27144471037
-
Anti-prostate stem cell antigen monoclonal antibody 1G8 induces cell death in vitro and inhibits tumor growth in vivo via a Fc-independent mechanism
-
Gu Z, Yamashiro J, Kono E, Reiter RE. Anti-prostate stem cell antigen monoclonal antibody 1G8 induces cell death in vitro and inhibits tumor growth in vivo via a Fc-independent mechanism. Cancer Res. 2005; 65:9495-9500.
-
(2005)
Cancer Res
, vol.65
, pp. 9495-9500
-
-
Gu, Z.1
Yamashiro, J.2
Kono, E.3
Reiter, R.E.4
-
79
-
-
84867126282
-
A phase I/IIA study of AGS-PSCA for castration-resistant prostate cancer
-
Morris MJ, Eisenberger MA, Pili R, Denmeade SR, Rathkopf D, Slovin SF, Farrelly J, Chudow JJ, Vincent M, Scher HI, Carducci MA. A phase I/IIA study of AGS-PSCA for castration-resistant prostate cancer. Ann Oncol. 2012; 23:2714-2719.
-
(2012)
Ann Oncol
, vol.23
, pp. 2714-2719
-
-
Morris, M.J.1
Eisenberger, M.A.2
Pili, R.3
Denmeade, S.R.4
Rathkopf, D.5
Slovin, S.F.6
Farrelly, J.7
Chudow, J.J.8
Vincent, M.9
Scher, H.I.10
Carducci, M.A.11
-
80
-
-
84883811812
-
Global, multicenter, randomized, phase II trial of gemcitabine and gemcitabine plus AGS-1C4D4 in patients with previously untreated, metastatic pancreatic cancer
-
Wolpin BM, O'Reilly EM, Ko YJ, Blaszkowsky LS, Rarick M, Rocha-Lima CM, Ritch P, Chan E, Spratlin J, Macarulla T, McWhirter E, Pezet D, Lichinitser M, Roman L, Hartford A, Morrison K, Jackson L, Vincent M, Reyno L, Hidalgo M. Global, multicenter, randomized, phase II trial of gemcitabine and gemcitabine plus AGS-1C4D4 in patients with previously untreated, metastatic pancreatic cancer. Ann Oncol. 2013; 24:1792-1801.
-
(2013)
Ann Oncol
, vol.24
, pp. 1792-1801
-
-
Wolpin, B.M.1
O'Reilly, E.M.2
Ko, Y.J.3
Blaszkowsky, L.S.4
Rarick, M.5
Rocha-Lima, C.M.6
Ritch, P.7
Chan, E.8
Spratlin, J.9
Macarulla, T.10
McWhirter, E.11
Pezet, D.12
Lichinitser, M.13
Roman, L.14
Hartford, A.15
Morrison, K.16
Jackson, L.17
Vincent, M.18
Reyno, L.19
Hidalgo, M.20
more..
-
81
-
-
84938081971
-
Phase Ib of anticancer stem cell antibody OMP-59R5 (anti-Notch2/3) in combination with nab-paclitaxel and gemcitabine (Nab-P+Gem) in patients (pts) with untreated metastatic pancreatic cancer (mPC)
-
O'Reilly E SL, Bendell J, et al. Phase Ib of anticancer stem cell antibody OMP-59R5 (anti-Notch2/3) in combination with nab-paclitaxel and gemcitabine (Nab-P+Gem) in patients (pts) with untreated metastatic pancreatic cancer (mPC). J Clin Oncol. 32, 2014.
-
(2014)
J Clin Oncol
, vol.32
-
-
O'Reilly, E.1
Smith, L.2
Bendell, J.3
-
82
-
-
84904550068
-
A phase II study of the gamma secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma
-
De Jesus-Acosta A, Laheru D, Maitra A, Arcaroli J, Rudek MA, Dasari A, Blatchford PJ, Quackenbush K, Messersmith W. A phase II study of the gamma secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma. Invest New Drugs. 2014; 32:739-745.
-
(2014)
Invest New Drugs
, vol.32
, pp. 739-745
-
-
De Jesus-Acosta, A.1
Laheru, D.2
Maitra, A.3
Arcaroli, J.4
Rudek, M.A.5
Dasari, A.6
Blatchford, P.J.7
Quackenbush, K.8
Messersmith, W.9
-
83
-
-
84950120183
-
Final results of a phase 1b of OMP-59R5 (anti-notch2/3/stem cell antibody) in combination with nab-paclitaxel and gemcitabine (Nab-P + Gem) in patients with untreated metastatic pancreatic cancer
-
Bendell J CA, Smith L, et al. Final results of a phase 1b of OMP-59R5 (anti-notch2/3/stem cell antibody) in combination with nab-paclitaxel and gemcitabine (Nab-P + Gem) in patients with untreated metastatic pancreatic cancer. Annals of Oncology. 2014; 25. iv210-iv253 10.1093/annonc/mdu334.2014.
-
(2014)
Annals of Oncology
, vol.25
, pp. iv210-iv225
-
-
Bendell, J.1
Cohn, A.2
Smith, L.3
-
84
-
-
84868191187
-
Fractionated radioimmunotherapy with (90) Y-clivatuzumab tetraxetan and low-dose gemcitabine is active in advanced pancreatic cancer: A phase 1 trial
-
Ocean AJ, Pennington KL, Guarino MJ, Sheikh A, Bekaii-Saab T, Serafini AN, Lee D, Sung MW, Gulec SA, Goldsmith SJ, Manzone T, Holt M, O'Neil BH, Hall N, Montero AJ, Kauh J, Gold DV, Horne H, Wegener WA, Goldenberg DM. Fractionated radioimmunotherapy with (90) Y-clivatuzumab tetraxetan and low-dose gemcitabine is active in advanced pancreatic cancer: A phase 1 trial. Cancer. 2012; 118:5497-5506.
-
(2012)
Cancer
, vol.118
, pp. 5497-5506
-
-
Ocean, A.J.1
Pennington, K.L.2
Guarino, M.J.3
Sheikh, A.4
Bekaii-Saab, T.5
Serafini, A.N.6
Lee, D.7
Sung, M.W.8
Gulec, S.A.9
Goldsmith, S.J.10
Manzone, T.11
Holt, M.12
O'Neil, B.H.13
Hall, N.14
Montero, A.J.15
Kauh, J.16
Gold, D.V.17
Horne, H.18
Wegener, W.A.19
Goldenberg, D.M.20
more..
-
85
-
-
0347123435
-
Mucins in cancer: protection and control of the cell surface
-
Hollingsworth MA, Swanson BJ. Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer. 2004; 4:45-60.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 45-60
-
-
Hollingsworth, M.A.1
Swanson, B.J.2
-
86
-
-
37549037486
-
PAM4-reactive MUC1 is a biomarker for early pancreatic adenocarcinoma
-
Gold DV, Karanjawala Z, Modrak DE, Goldenberg DM, Hruban RH. PAM4-reactive MUC1 is a biomarker for early pancreatic adenocarcinoma. Clin Cancer Res. 2007; 13:7380-7387.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 7380-7387
-
-
Gold, D.V.1
Karanjawala, Z.2
Modrak, D.E.3
Goldenberg, D.M.4
Hruban, R.H.5
-
87
-
-
78549263079
-
Detection of earlystage pancreatic adenocarcinoma
-
Gold DV, Goggins M, Modrak DE, Newsome G, Liu M, Shi C, Hruban RH, Goldenberg DM. Detection of earlystage pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2010; 19:2786-2794.
-
(2010)
Cancer Epidemiol Biomarkers Prev
, vol.19
, pp. 2786-2794
-
-
Gold, D.V.1
Goggins, M.2
Modrak, D.E.3
Newsome, G.4
Liu, M.5
Shi, C.6
Hruban, R.H.7
Goldenberg, D.M.8
-
88
-
-
84867801436
-
Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy
-
Rachagani S, Torres M, Kumar S, Haridas D, Baine M, Macha M, Kaur S, Ponnusamy M, Dey P, Seshacharyulu P, Johansson S, Jain M, Wagner K-U, Batra S. Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy. Journal of Hematology & Oncology. 2012; 5:68.
-
(2012)
Journal of Hematology & Oncology
, vol.5
, pp. 68
-
-
Rachagani, S.1
Torres, M.2
Kumar, S.3
Haridas, D.4
Baine, M.5
Macha, M.6
Kaur, S.7
Ponnusamy, M.8
Dey, P.9
Seshacharyulu, P.10
Johansson, S.11
Jain, M.12
Wagner, K.-U.13
Batra, S.14
-
89
-
-
0037422201
-
MUC1 alters beta-catenindependent tumor formation and promotes cellular invasion
-
Schroeder JA, Adriance MC, Thompson MC, Camenisch TD, Gendler SJ. MUC1 alters beta-catenindependent tumor formation and promotes cellular invasion. Oncogene. 2003; 22:1324-1332.
-
(2003)
Oncogene
, vol.22
, pp. 1324-1332
-
-
Schroeder, J.A.1
Adriance, M.C.2
Thompson, M.C.3
Camenisch, T.D.4
Gendler, S.J.5
-
90
-
-
2442693937
-
The MUC1 oncoprotein activates the anti-apoptotic phosphoinositide 3-kinase/Akt and Bcl-xL pathways in rat 3Y1 fibroblasts
-
Raina D, Kharbanda S, Kufe D. The MUC1 oncoprotein activates the anti-apoptotic phosphoinositide 3-kinase/Akt and Bcl-xL pathways in rat 3Y1 fibroblasts. J Biol Chem. 2004; 279:20607-20612.
-
(2004)
J Biol Chem
, vol.279
, pp. 20607-20612
-
-
Raina, D.1
Kharbanda, S.2
Kufe, D.3
-
91
-
-
13844262819
-
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
-
Wei X, Xu H, Kufe D. Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Cancer Cell. 2005; 7:167-178.
-
(2005)
Cancer Cell
, vol.7
, pp. 167-178
-
-
Wei, X.1
Xu, H.2
Kufe, D.3
-
92
-
-
0028281327
-
Characterization of monoclonal antibody PAM4 reactive with a pancreatic cancer mucin
-
Gold DV, Lew K, Maliniak R, Hernandez M, Cardillo T. Characterization of monoclonal antibody PAM4 reactive with a pancreatic cancer mucin. Int J Cancer. 1994; 57:204-210.
-
(1994)
Int J Cancer
, vol.57
, pp. 204-210
-
-
Gold, D.V.1
Lew, K.2
Maliniak, R.3
Hernandez, M.4
Cardillo, T.5
-
93
-
-
0031010328
-
Radioimmunotherapy of experimental pancreatic cancer with 131I-labeled monoclonal antibody PAM4
-
Gold DV, Cardillo T, Vardi Y, Blumenthal R. Radioimmunotherapy of experimental pancreatic cancer with 131I-labeled monoclonal antibody PAM4. Int J Cancer. 1997; 71:660-667.
-
(1997)
Int J Cancer
, vol.71
, pp. 660-667
-
-
Gold, D.V.1
Cardillo, T.2
Vardi, Y.3
Blumenthal, R.4
-
94
-
-
0034800607
-
Therapeutic advantage of (90)yttrium-versus (131)iodine-labeled PAM4 antibody in experimental pancreatic cancer
-
Cardillo TM, Ying Z, Gold DV. Therapeutic advantage of (90)yttrium-versus (131)iodine-labeled PAM4 antibody in experimental pancreatic cancer. Clin Cancer Res. 2001; 7:3186-3192.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3186-3192
-
-
Cardillo, T.M.1
Ying, Z.2
Gold, D.V.3
-
95
-
-
0037137849
-
Combined gemcitabine and radioimmunotherapy for the treatment of pancreatic cancer
-
Cardillo TM, Blumenthal R, Ying Z, Gold DV. Combined gemcitabine and radioimmunotherapy for the treatment of pancreatic cancer. Int J Cancer. 2002; 97:386-392.
-
(2002)
Int J Cancer
, vol.97
, pp. 386-392
-
-
Cardillo, T.M.1
Blumenthal, R.2
Ying, Z.3
Gold, D.V.4
-
96
-
-
1542405316
-
Combined 90Yttrium-DOTA-labeled PAM4 antibody radioimmunotherapy and gemcitabine radiosensitization for the treatment of a human pancreatic cancer xenograft
-
Gold DV, Modrak DE, Schutsky K, Cardillo TM. Combined 90Yttrium-DOTA-labeled PAM4 antibody radioimmunotherapy and gemcitabine radiosensitization for the treatment of a human pancreatic cancer xenograft. Int J Cancer. 2004; 109:618-626.
-
(2004)
Int J Cancer
, vol.109
, pp. 618-626
-
-
Gold, D.V.1
Modrak, D.E.2
Schutsky, K.3
Cardillo, T.M.4
-
97
-
-
0141679534
-
Lowdose radioimmunotherapy ((90)Y-PAM4) combined with gemcitabine for the treatment of experimental pancreatic cancer
-
Gold DV, Schutsky K, Modrak D, Cardillo TM. Lowdose radioimmunotherapy ((90)Y-PAM4) combined with gemcitabine for the treatment of experimental pancreatic cancer. Clin Cancer Res. 2003; 9:3929S-3937S.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3929S-3937S
-
-
Gold, D.V.1
Schutsky, K.2
Modrak, D.3
Cardillo, T.M.4
-
98
-
-
79959273645
-
Treatment of advanced pancreatic carcinoma with 90Y-Clivatuzumab Tetraxetan: a phase I single-dose escalation trial
-
Gulec SA, Cohen SJ, Pennington KL, Zuckier LS, Hauke RJ, Horne H, Wegener WA, Teoh N, Gold DV, Sharkey RM, Goldenberg DM. Treatment of advanced pancreatic carcinoma with 90Y-Clivatuzumab Tetraxetan: a phase I single-dose escalation trial. Clin Cancer Res. 2011; 17:4091-4100.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4091-4100
-
-
Gulec, S.A.1
Cohen, S.J.2
Pennington, K.L.3
Zuckier, L.S.4
Hauke, R.J.5
Horne, H.6
Wegener, W.A.7
Teoh, N.8
Gold, D.V.9
Sharkey, R.M.10
Goldenberg, D.M.11
-
99
-
-
84924256234
-
Feasibility and results of a randomized phase lb study of fractionated 90Y-clivatuzumab tetraxetan in patients with metastatic pancreatic cancer having two or more prior therapies
-
Picozzi V RR, Lowery M, et al. Feasibility and results of a randomized phase lb study of fractionated 90Y-clivatuzumab tetraxetan in patients with metastatic pancreatic cancer having two or more prior therapies. J Clin Oncol. 32:5s2014.
-
(2014)
J Clin Oncol
, vol.32
, Issue.5
-
-
Picozzi, V.R.R.1
Lowery, M.2
-
100
-
-
84861856844
-
Efficacy and safety of vismodegib in advanced basal-cell carcinoma
-
Sekulic A, Migden MR, Oro AE, Dirix L, Lewis KD, Hainsworth JD, Solomon JA, Yoo S, Arron ST, Friedlander PA, Marmur E, Rudin CM, Chang AL, Low JA, Mackey HM, Yauch RL, Graham RA, Reddy JC, Hauschild A. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med. 2012; 366:2171-2179.
-
(2012)
N Engl J Med
, vol.366
, pp. 2171-2179
-
-
Sekulic, A.1
Migden, M.R.2
Oro, A.E.3
Dirix, L.4
Lewis, K.D.5
Hainsworth, J.D.6
Solomon, J.A.7
Yoo, S.8
Arron, S.T.9
Friedlander, P.A.10
Marmur, E.11
Rudin, C.M.12
Chang, A.L.13
Low, J.A.14
Mackey, H.M.15
Yauch, R.L.16
Graham, R.A.17
Reddy, J.C.18
Hauschild, A.19
-
101
-
-
69949084378
-
GDC-0449-a potent inhibitor of the hedgehog pathway
-
Robarge KD, Brunton SA, Castanedo GM, Cui Y, Dina MS, Goldsmith R, Gould SE, Guichert O, Gunzner JL, Halladay J, Jia W, Khojasteh C, Koehler MF, Kotkow K, La H, Lalonde RL, Lau K, Lee L, Marshall D, Marsters JC Jr., Murray LJ, Qian C, Rubin LL, Salphati L, Stanley MS, Stibbard JH, Sutherlin DP, Ubhayaker S, Wang S, Wong S, et al. GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg Med Chem Lett. 2009; 19:5576-5581.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 5576-5581
-
-
Robarge, K.D.1
Brunton, S.A.2
Castanedo, G.M.3
Cui, Y.4
Dina, M.S.5
Goldsmith, R.6
Gould, S.E.7
Guichert, O.8
Gunzner, J.L.9
Halladay, J.10
Jia, W.11
Khojasteh, C.12
Koehler, M.F.13
Kotkow, K.14
La, H.15
Lalonde, R.L.16
Lau, K.17
Lee, L.18
Marshall, D.19
Marsters, J.C.20
Murray, L.J.21
Qian, C.22
Rubin, L.L.23
Salphati, L.24
Stanley, M.S.25
Stibbard, J.H.26
Sutherlin, D.P.27
Ubhayaker, S.28
Wang, S.29
Wong, S.30
more..
-
103
-
-
84860709668
-
Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway
-
Lu JT, Zhao WD, He W, Wei W. Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway. Acta Pharmacol Sin. 2012; 33:691-700.
-
(2012)
Acta Pharmacol Sin
, vol.33
, pp. 691-700
-
-
Lu, J.T.1
Zhao, W.D.2
He, W.3
Wei, W.4
-
104
-
-
84868616969
-
Regulation of DNA damage following termination of Hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancer
-
Agyeman A, Mazumdar T, Houghton JA. Regulation of DNA damage following termination of Hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancer. Oncotarget. 2012; 3:854-868.
-
(2012)
Oncotarget
, vol.3
, pp. 854-868
-
-
Agyeman, A.1
Mazumdar, T.2
Houghton, J.A.3
-
105
-
-
84873099101
-
Progress from clinical trials and emerging non-conventional therapies for the treatment of Medulloblastomas
-
Ajeawung NF, Wang HY, Kamnasaran D. Progress from clinical trials and emerging non-conventional therapies for the treatment of Medulloblastomas. Cancer Lett. 2013; 330:130-140.
-
(2013)
Cancer Lett
, vol.330
, pp. 130-140
-
-
Ajeawung, N.F.1
Wang, H.Y.2
Kamnasaran, D.3
-
106
-
-
84867116494
-
Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway
-
Ramaswamy B, Lu Y, Teng KY, Nuovo G, Li X, Shapiro CL, Majumder S. Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway. Cancer Res. 2012; 72:5048-5059.
-
(2012)
Cancer Res
, vol.72
, pp. 5048-5059
-
-
Ramaswamy, B.1
Lu, Y.2
Teng, K.Y.3
Nuovo, G.4
Li, X.5
Shapiro, C.L.6
Majumder, S.7
-
107
-
-
84863230921
-
Activation of Hedgehog pathway in gastrointestinal cancers
-
Yang L, Su X, Xie J. Activation of Hedgehog pathway in gastrointestinal cancers. Vitam Horm. 2012; 88:461-472.
-
(2012)
Vitam Horm
, vol.88
, pp. 461-472
-
-
Yang, L.1
Su, X.2
Xie, J.3
-
108
-
-
84870940346
-
Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch
-
Bertrand FE, Angus CW, Partis WJ, Sigounas G. Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch. Cell Cycle. 2012; 11:4344-4351.
-
(2012)
Cell Cycle
, vol.11
, pp. 4344-4351
-
-
Bertrand, F.E.1
Angus, C.W.2
Partis, W.J.3
Sigounas, G.4
-
109
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S, Fernandezdel Castillo C, Yajnik V, Antoniu B, McMahon M, Warshaw AL, Hebrok M. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 2003; 425:851-856.
-
(2003)
Nature
, vol.425
, pp. 851-856
-
-
Thayer, S.P.1
di Magliano, M.P.2
Heiser, P.W.3
Nielsen, C.M.4
Roberts, D.J.5
Lauwers, G.Y.6
Qi, Y.P.7
Gysin, S.8
Fernandezdel Castillo, C.9
Yajnik, V.10
Antoniu, B.11
McMahon, M.12
Warshaw, A.L.13
Hebrok, M.14
-
111
-
-
70949096151
-
The hedgehog pathway and pancreatic cancer
-
Hidalgo M, Maitra A. The hedgehog pathway and pancreatic cancer. N Engl J Med. 2009; 361:2094-2096.
-
(2009)
N Engl J Med
, vol.361
, pp. 2094-2096
-
-
Hidalgo, M.1
Maitra, A.2
-
112
-
-
80555145216
-
Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms
-
Singh BN, Fu J, Srivastava RK, Shankar S. Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PLoS One. 2011; 6:e27306.
-
(2011)
PLoS One
, vol.6
-
-
Singh, B.N.1
Fu, J.2
Srivastava, R.K.3
Shankar, S.4
-
113
-
-
67650289584
-
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
-
Scales SJ, de Sauvage FJ. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci. 2009; 30:303-312.
-
(2009)
Trends Pharmacol Sci
, vol.30
, pp. 303-312
-
-
Scales, S.J.1
de Sauvage, F.J.2
-
114
-
-
84880071454
-
Final analysis of a phase IB/randomized phase II study of gemcitabine (G) plus placebo (P) or vismodegib (V), a hedgehog (Hh) pathway inhibitor, in patients (pts) with metastatic pancreatic cancer (PC): A University of Chicago phase II consortium study
-
Catenacci D BN, Nattam S, et al. Final analysis of a phase IB/randomized phase II study of gemcitabine (G) plus placebo (P) or vismodegib (V), a hedgehog (Hh) pathway inhibitor, in patients (pts) with metastatic pancreatic cancer (PC): A University of Chicago phase II consortium study. J Clin Oncol. 31, 2013.
-
(2013)
J Clin Oncol
, vol.31
-
-
Catenacci, D.B.N.1
Nattam, S.2
-
115
-
-
84903143748
-
A phase II study of vismodegib, a hedgehog (Hh) pathway inhibitor, combined with gemcitabine and nab-paclitaxel (nab-P) in patients (pts) with untreated metastatic pancreatic ductal adenocarcinoma (PDA)
-
De Jesus-Acosta A ODP, Ramanathan R, et al. A phase II study of vismodegib, a hedgehog (Hh) pathway inhibitor, combined with gemcitabine and nab-paclitaxel (nab-P) in patients (pts) with untreated metastatic pancreatic ductal adenocarcinoma (PDA). J Clin Oncol. 32, 2014.
-
(2014)
J Clin Oncol
, vol.32
-
-
De Jesus-Acosta, A.1
O'Dwyer, P.2
Ramanathan, R.3
-
116
-
-
70349658639
-
Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT
-
Dubreuil P, Letard S, Ciufolini M, Gros L, Humbert M, Casteran N, Borge L, Hajem B, Lermet A, Sippl W, Voisset E, Arock M, Auclair C, Leventhal PS, Mansfield CD, Moussy A, Hermine O. Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT. PLoS One. 2009; 4:e7258.
-
(2009)
PLoS One
, vol.4
-
-
Dubreuil, P.1
Letard, S.2
Ciufolini, M.3
Gros, L.4
Humbert, M.5
Casteran, N.6
Borge, L.7
Hajem, B.8
Lermet, A.9
Sippl, W.10
Voisset, E.11
Arock, M.12
Auclair, C.13
Leventhal, P.S.14
Mansfield, C.D.15
Moussy, A.16
Hermine, O.17
-
117
-
-
77950128955
-
Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model
-
Humbert M, Casteran N, Letard S, Hanssens K, Iovanna J, Finetti P, Bertucci F, Bader T, Mansfield CD, Moussy A, Hermine O, Dubreuil P. Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model. PLoS One. 2010; 5:e9430.
-
(2010)
PLoS One
, vol.5
-
-
Humbert, M.1
Casteran, N.2
Letard, S.3
Hanssens, K.4
Iovanna, J.5
Finetti, P.6
Bertucci, F.7
Bader, T.8
Mansfield, C.D.9
Moussy, A.10
Hermine, O.11
Dubreuil, P.12
-
118
-
-
68949166379
-
Phase 1 dose-escalation study of oral tyrosine kinase inhibitor masitinib in advanced and/or metastatic solid cancers
-
Soria JC, Massard C, Magne N, Bader T, Mansfield CD, Blay JY, Bui BN, Moussy A, Hermine O, Armand JP. Phase 1 dose-escalation study of oral tyrosine kinase inhibitor masitinib in advanced and/or metastatic solid cancers. Eur J Cancer. 2009; 45:2333-2341.
-
(2009)
Eur J Cancer
, vol.45
, pp. 2333-2341
-
-
Soria, J.C.1
Massard, C.2
Magne, N.3
Bader, T.4
Mansfield, C.D.5
Blay, J.Y.6
Bui, B.N.7
Moussy, A.8
Hermine, O.9
Armand, J.P.10
-
119
-
-
68649120877
-
Oral tyrosine kinase inhibitor masitinib in combination with gemcitabine in patients with advanced pancreatic cancer: A multicenter phase II study
-
Hammel F MF, Deplanque G, et al. Oral tyrosine kinase inhibitor masitinib in combination with gemcitabine in patients with advanced pancreatic cancer: A multicenter phase II study. J Clin Oncol. 27:15s, 2009.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15
-
-
Hammel, F.1
Mornex, F.2
Deplanque, G.3
-
120
-
-
84929321103
-
Masitinib in nonresectable pancreatic cancer: Results of a phase III randomized placebo-controlled trial
-
Deplanque G DM, Hebbar M, et al. Masitinib in nonresectable pancreatic cancer: Results of a phase III randomized placebo-controlled trial. J Clin Oncol. 31, 2013.
-
(2013)
J Clin Oncol
, vol.31
-
-
Deplanque, G.1
Demarchi, M.2
Hebbar, M.3
-
121
-
-
33947401129
-
Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogenactivated protein kinase kinase 1/2 inhibitor
-
Yeh TC, Marsh V, Bernat BA, Ballard J, Colwell H, Evans RJ, Parry J, Smith D, Brandhuber BJ, Gross S, Marlow A, Hurley B, Lyssikatos J, Lee PA, Winkler JD, Koch K, Wallace E. Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogenactivated protein kinase kinase 1/2 inhibitor. Clin Cancer Res. 2007; 13:1576-1583.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1576-1583
-
-
Yeh, T.C.1
Marsh, V.2
Bernat, B.A.3
Ballard, J.4
Colwell, H.5
Evans, R.J.6
Parry, J.7
Smith, D.8
Brandhuber, B.J.9
Gross, S.10
Marlow, A.11
Hurley, B.12
Lyssikatos, J.13
Lee, P.A.14
Winkler, J.D.15
Koch, K.16
Wallace, E.17
-
122
-
-
43749103335
-
mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers
-
Adjei AA, Cohen RB, Franklin W, Morris C, Wilson D, Molina JR, Hanson LJ, Gore L, Chow L, Leong S, Maloney L, Gordon G, Simmons H, Marlow A, Litwiler K, mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J Clin Oncol. 2008; 26:2139-2146.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2139-2146
-
-
Adjei, A.A.1
Cohen, R.B.2
Franklin, W.3
Morris, C.4
Wilson, D.5
Molina, J.R.6
Hanson, L.J.7
Gore, L.8
Chow, L.9
Leong, S.10
Maloney, L.11
Gordon, G.12
Simmons, H.13
Marlow, A.14
Litwiler, K.15
-
123
-
-
84880053768
-
Dual MEK/EGFR inhibition for advanced, chemotherapy-refractory pancreatic cancer: A multicenter phase II trial of selumetinib (AZD6244; ARRY-142886) plus erlotinib
-
Ko A TM, Bekaii-Saab T, et al. Dual MEK/EGFR inhibition for advanced, chemotherapy-refractory pancreatic cancer: A multicenter phase II trial of selumetinib (AZD6244; ARRY-142886) plus erlotinib. J Clin Oncol. 31, 2013.
-
(2013)
J Clin Oncol
, vol.31
-
-
Ko, A.1
Tempero, M.2
Bekaii-Saab, T.3
-
124
-
-
54549086723
-
Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530
-
Chang YM, Bai L, Liu S, Yang JC, Kung HJ, Evans CP. Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530. Oncogene. 2008; 27:6365-6375.
-
(2008)
Oncogene
, vol.27
, pp. 6365-6375
-
-
Chang, Y.M.1
Bai, L.2
Liu, S.3
Yang, J.C.4
Kung, H.J.5
Evans, C.P.6
-
125
-
-
84862018553
-
A phase I/II study of the Src inhibitor saracatinib (AZD0530) in combination with gemcitabine in advanced pancreatic cancer
-
Renouf DJ, Moore MJ, Hedley D, Gill S, Jonker D, Chen E, Walde D, Goel R, Southwood B, Gauthier I, Walsh W, McIntosh L, Seymour L. A phase I/II study of the Src inhibitor saracatinib (AZD0530) in combination with gemcitabine in advanced pancreatic cancer. Invest New Drugs. 2012; 30:779-786.
-
(2012)
Invest New Drugs
, vol.30
, pp. 779-786
-
-
Renouf, D.J.1
Moore, M.J.2
Hedley, D.3
Gill, S.4
Jonker, D.5
Chen, E.6
Walde, D.7
Goel, R.8
Southwood, B.9
Gauthier, I.10
Walsh, W.11
McIntosh, L.12
Seymour, L.13
-
126
-
-
77951678924
-
Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo
-
Kim K, Kong SY, Fulciniti M, Li X, Song W, Nahar S, Burger P, Rumizen MJ, Podar K, Chauhan D, Hideshima T, Munshi NC, Richardson P, Clark A, Ogden J, Goutopoulos A, Rastelli L, Anderson KC, Tai YT. Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo. Br J Haematol. 2010; 149:537-549.
-
(2010)
Br J Haematol
, vol.149
, pp. 537-549
-
-
Kim, K.1
Kong, S.Y.2
Fulciniti, M.3
Li, X.4
Song, W.5
Nahar, S.6
Burger, P.7
Rumizen, M.J.8
Podar, K.9
Chauhan, D.10
Hideshima, T.11
Munshi, N.C.12
Richardson, P.13
Clark, A.14
Ogden, J.15
Goutopoulos, A.16
Rastelli, L.17
Anderson, K.C.18
Tai, Y.T.19
-
127
-
-
78751480476
-
MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy
-
Yoon J, Koo KH, Choi KY. MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy. Cancer Res. 2011; 71:445-453.
-
(2011)
Cancer Res
, vol.71
, pp. 445-453
-
-
Yoon, J.1
Koo, K.H.2
Choi, K.Y.3
-
128
-
-
84880059449
-
Pimasertib plus gemcitabine in metastatic pancreatic adenocarcinoma: Results of a safety run-in part of a phase II trial
-
Verslype C HP, Hidalgo M, et al. Pimasertib plus gemcitabine in metastatic pancreatic adenocarcinoma: Results of a safety run-in part of a phase II trial. J Clin Oncol. 31, 2013.
-
(2013)
J Clin Oncol
, vol.31
-
-
Verslype, C.1
Gerber, H.P.2
Hidalgo, M.3
-
129
-
-
70149119899
-
RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer
-
Iverson C, Larson G, Lai C, Yeh LT, Dadson C, Weingarten P, Appleby T, Vo T, Maderna A, Vernier JM, Hamatake R, Miner JN, Quart B. RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer. Cancer Res. 2009; 69:6839-6847.
-
(2009)
Cancer Res
, vol.69
, pp. 6839-6847
-
-
Iverson, C.1
Larson, G.2
Lai, C.3
Yeh, L.T.4
Dadson, C.5
Weingarten, P.6
Appleby, T.7
Vo, T.8
Maderna, A.9
Vernier, J.M.10
Hamatake, R.11
Miner, J.N.12
Quart, B.13
-
130
-
-
77957164869
-
Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts
-
Chang Q, Chapman MS, Miner JN, Hedley DW. Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts. BMC Cancer. 2010; 10:515.
-
(2010)
BMC Cancer
, vol.10
, pp. 515
-
-
Chang, Q.1
Chapman, M.S.2
Miner, J.N.3
Hedley, D.W.4
-
131
-
-
84905169057
-
Phase II study of refametinib (BAY 86-9766), an allosteric dual MEK 1/2 inhibitor, and gemcitabine in patients with unresectable, locally advanced, or metastatic pancreatic cancer
-
Van Laethem J JJ, Heinemann V, et al. Phase II study of refametinib (BAY 86-9766), an allosteric dual MEK 1/2 inhibitor, and gemcitabine in patients with unresectable, locally advanced, or metastatic pancreatic cancer. J Clin Oncol. 32:5s, 2014.
-
(2014)
J Clin Oncol
, vol.32
, Issue.5
-
-
Van Laethem, J.1
Rinehart, J.J.2
Heinemann, V.3
-
132
-
-
79551518231
-
Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase
-
Zhou L, McMahon C, Bhagat T, Alencar C, Yu Y, Fazzari M, Sohal D, Heuck C, Gundabolu K, Ng C, Mo Y, Shen W, Wickrema A, Kong G, Friedman E, Sokol L, Mantzaris I, Pellagatti A, Boultwood J, Platanias LC, Steidl U, Yan L, Yingling JM, Lahn MM, List A, Bitzer M, Verma A. Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase. Cancer Res. 2011; 71:955-963.
-
(2011)
Cancer Res
, vol.71
, pp. 955-963
-
-
Zhou, L.1
McMahon, C.2
Bhagat, T.3
Alencar, C.4
Yu, Y.5
Fazzari, M.6
Sohal, D.7
Heuck, C.8
Gundabolu, K.9
Ng, C.10
Mo, Y.11
Shen, W.12
Wickrema, A.13
Kong, G.14
Friedman, E.15
Sokol, L.16
Mantzaris, I.17
Pellagatti, A.18
Boultwood, J.19
Platanias, L.C.20
Steidl, U.21
Yan, L.22
Yingling, J.M.23
Lahn, M.M.24
List, A.25
Bitzer, M.26
Verma, A.27
more..
-
133
-
-
84947566680
-
Phase Ib study evaluating safety and pharmacokinetics (PK) of the oral transforming growth factor-beta (TGF-ß) receptor I kinase inhibitor LY2157299 monohydrate (LY) when combined with gemcitabine in patients with advanced cancer
-
Kozloff M CR, Nadal T, et al. Phase Ib study evaluating safety and pharmacokinetics (PK) of the oral transforming growth factor-beta (TGF-ß) receptor I kinase inhibitor LY2157299 monohydrate (LY) when combined with gemcitabine in patients with advanced cancer. J Clin Oncol. 31, 2013.
-
(2013)
J Clin Oncol
, vol.31
-
-
Kozloff, M.1
Carbonero, R.2
Nadal, T.3
-
134
-
-
79959277790
-
Novel PARP inhibitors with potent antitumor activity as single-agent and combination therapies
-
A121. 2009
-
Wang B CD, Feng Y, et al. Novel PARP inhibitors with potent antitumor activity as single-agent and combination therapies. Mol Cancer Ther. 2009; 8:A121. 2009.
-
(2009)
Mol Cancer Ther
, vol.8
-
-
Wang, B.1
Davis, C.D.2
Feng, Y.3
-
135
-
-
84880316545
-
First-in-human trial of novel oral PARP inhibitor BMN 673 in patients with solid tumors
-
De Bono J ML, Gonzalez M, et al. First-in-human trial of novel oral PARP inhibitor BMN 673 in patients with solid tumors. J Clin Oncol. 31, 2013.
-
(2013)
J Clin Oncol
, vol.31
-
-
De Bono, J.M.L.1
Gonzalez, M.2
-
136
-
-
34249006299
-
ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models
-
Donawho CK, Luo Y, Penning TD, Bauch JL, Bouska JJ, Bontcheva-Diaz VD, Cox BF, DeWeese TL, Dillehay LE, Ferguson DC, Ghoreishi-Haack NS, Grimm DR, Guan R, Han EK, Holley-Shanks RR, Hristov B, Idler KB, Jarvis K, Johnson EF, Kleinberg LR, Klinghofer V, Lasko LM, Liu X, Marsh KC, McGonigal TP, Meulbroek JA, Olson AM, Palma JP, Rodriguez LE, Shi Y, et al. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res. 2007; 13:2728-2737.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2728-2737
-
-
Donawho, C.K.1
Luo, Y.2
Penning, T.D.3
Bauch, J.L.4
Bouska, J.J.5
Bontcheva-Diaz, V.D.6
Cox, B.F.7
DeWeese, T.L.8
Dillehay, L.E.9
Ferguson, D.C.10
Ghoreishi-Haack, N.S.11
Grimm, D.R.12
Guan, R.13
Han, E.K.14
Holley-Shanks, R.R.15
Hristov, B.16
Idler, K.B.17
Jarvis, K.18
Johnson, E.F.19
Kleinberg, L.R.20
Klinghofer, V.21
Lasko, L.M.22
Liu, X.23
Marsh, K.C.24
McGonigal, T.P.25
Meulbroek, J.A.26
Olson, A.M.27
Palma, J.P.28
Rodriguez, L.E.29
Shi, Y.30
more..
-
137
-
-
84907955592
-
The use of PARP inhibitors as single agents and as chemosensitizers in sporadic pancreatic cancer
-
De Soto J MR. The use of PARP inhibitors as single agents and as chemosensitizers in sporadic pancreatic cancer. J Clin Oncol. 29, 2011.
-
(2011)
J Clin Oncol
, vol.29
-
-
De Soto, J.M.R.1
-
138
-
-
84905163406
-
Phase IB trial of cisplatin (C), gemcitabine (G), and veliparib (V) in patients with known or potential BRCA or PALB2-mutated pancreas adenocarcinoma (PC)
-
O'Reilly E LM, Segal M, et al. Phase IB trial of cisplatin (C), gemcitabine (G), and veliparib (V) in patients with known or potential BRCA or PALB2-mutated pancreas adenocarcinoma (PC). J Clin Oncol. 32:5s, 2014.
-
(2014)
J Clin Oncol
, vol.32
, Issue.5
-
-
O'Reilly, E.L.M.1
Segal, M.2
-
139
-
-
0032704708
-
Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development
-
Rowinsky EK, Windle JJ, Von Hoff DD. Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development. J Clin Oncol. 1999; 17:3631-3652.
-
(1999)
J Clin Oncol
, vol.17
, pp. 3631-3652
-
-
Rowinsky, E.K.1
Windle, J.J.2
Von Hoff, D.D.3
-
140
-
-
0013227128
-
A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice
-
Weisz B, Giehl K, Gana-Weisz M, Egozi Y, Ben-Baruch G, Marciano D, Gierschik P, Kloog Y. A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice. Oncogene. 1999; 18:2579-2588.
-
(1999)
Oncogene
, vol.18
, pp. 2579-2588
-
-
Weisz, B.1
Giehl, K.2
Gana-Weisz, M.3
Egozi, Y.4
Ben-Baruch, G.5
Marciano, D.6
Gierschik, P.7
Kloog, Y.8
-
141
-
-
84875534210
-
Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer
-
Laheru D, Shah P, Rajeshkumar NV, McAllister F, Taylor G, Goldsweig H, Le DT, Donehower R, Jimeno A, Linden S, Zhao M, Song D, Rudek MA, Hidalgo M. Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer. Invest New Drugs. 2012; 30:2391-2399.
-
(2012)
Invest New Drugs
, vol.30
, pp. 2391-2399
-
-
Laheru, D.1
Shah, P.2
Rajeshkumar, N.V.3
McAllister, F.4
Taylor, G.5
Goldsweig, H.6
Le, D.T.7
Donehower, R.8
Jimeno, A.9
Linden, S.10
Zhao, M.11
Song, D.12
Rudek, M.A.13
Hidalgo, M.14
-
143
-
-
84872807024
-
Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and panhistone deacetylase inhibitor against human pancreatic cancer
-
Venkannagari S, Fiskus W, Peth K, Atadja P, Hidalgo M, Maitra A, Bhalla KN. Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and panhistone deacetylase inhibitor against human pancreatic cancer. Oncotarget. 2012; 3:1416-1427.
-
(2012)
Oncotarget
, vol.3
, pp. 1416-1427
-
-
Venkannagari, S.1
Fiskus, W.2
Peth, K.3
Atadja, P.4
Hidalgo, M.5
Maitra, A.6
Bhalla, K.N.7
-
144
-
-
84950135539
-
Sirtainties in pancreatic cancer?
-
Rooman I. Sirtainties in pancreatic cancer? Oncoscience. 2014; 1:183-184.
-
(2014)
Oncoscience
, vol.1
, pp. 183-184
-
-
Rooman, I.1
-
145
-
-
84910071856
-
Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic cancer
-
Yan HH, Jung KH, Son MK, Fang Z, Kim SJ, Ryu YL, Kim J, Kim MH, Hong SS. Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic cancer. Oncotarget. 2014; 5:9150-9168.
-
(2014)
Oncotarget
, vol.5
, pp. 9150-9168
-
-
Yan, H.H.1
Jung, K.H.2
Son, M.K.3
Fang, Z.4
Kim, S.J.5
Ryu, Y.L.6
Kim, J.7
Kim, M.H.8
Hong, S.S.9
-
146
-
-
85016649923
-
Novel ALK inhibitors in clinical use and development
-
Iragavarapu C, Mustafa M, Akinleye A, Furqan M, Mittal V, Cang S, Liu D. Novel ALK inhibitors in clinical use and development. Journal of Hematology & Oncology. 2015; 8:17.
-
(2015)
Journal of Hematology & Oncology
, vol.8
, pp. 17
-
-
Iragavarapu, C.1
Mustafa, M.2
Akinleye, A.3
Furqan, M.4
Mittal, V.5
Cang, S.6
Liu, D.7
-
147
-
-
84929318458
-
Novel approaches in the management of pancreatic ductal adenocarcinoma: potential promises for the future
-
Goel G, Sun W. Novel approaches in the management of pancreatic ductal adenocarcinoma: potential promises for the future. Journal of Hematology & Oncology. 2015; 8:44.
-
(2015)
Journal of Hematology & Oncology
, vol.8
, pp. 44
-
-
Goel, G.1
Sun, W.2
|