Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer

Oncotarget

Volumn 3, Issue 11, 2012, Pages 1416-1427

  Venkannagari, Sreedhar ^a   Fiskus, Warren ^a   Peth, Karissa ^a   Atadja, Peter ^b   Hidalgo, Manuel ^c   Maitra, Anirban ^d   Bhalla, Kapil N ^a  

^a UNIVERSITY OF KANSAS CANCER CENTER   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c Centro Nacional de Investigaciones Oncológicas   (Spain)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

AKT; BEZ235; MTOR; Pan HDAC inhibitor; Pancreatic cancer

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; BIM PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; INITIATION FACTOR 4E BINDING PROTEIN 1; K RAS PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PANOBINOSTAT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN BAK; PROTEIN BCL X; PROTEIN KINASE B; PROTEIN TORC1; PROTEIN TORC2; S6 KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; ENZYME PHOSPHORYLATION; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MOLECULAR DYNAMICS; MONOTHERAPY; MOUSE; NONHUMAN; ONCOGENE K RAS; PANCREAS ADENOCARCINOMA; PROTEIN INDUCTION; TUMOR VOLUME; TUMOR XENOGRAFT;

EID: 84872807024     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.724     Document Type: Article

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