-
1
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
-
Burris III H.A., et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol 15 (1997) 2403-2413
-
(1997)
J Clin Oncol
, vol.15
, pp. 2403-2413
-
-
Burris III, H.A.1
-
2
-
-
0036682041
-
Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297
-
Berlin J.D., et al. Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol 20 (2002) 3270-3275
-
(2002)
J Clin Oncol
, vol.20
, pp. 3270-3275
-
-
Berlin, J.D.1
-
3
-
-
23644437797
-
Gemcitabine with or without continuous infusion 5-FU in advanced pancreatic cancer: A randomised phase II trial of the Italian oncology group for clinical research (GOIRC)
-
Di Costanzo F., et al. Gemcitabine with or without continuous infusion 5-FU in advanced pancreatic cancer: A randomised phase II trial of the Italian oncology group for clinical research (GOIRC). Br J Cancer 93 (2005) 185-189
-
(2005)
Br J Cancer
, vol.93
, pp. 185-189
-
-
Di Costanzo, F.1
-
4
-
-
20644464360
-
Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: Results of a GERCOR and GISCAD phase III trial
-
Louvet C., et al. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: Results of a GERCOR and GISCAD phase III trial. J Clin Oncol 23 (2005) 3509-3516
-
(2005)
J Clin Oncol
, vol.23
, pp. 3509-3516
-
-
Louvet, C.1
-
5
-
-
4644327989
-
Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate
-
Rocha Lima C.M., et al. Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J Clin Oncol 22 (2004) 3776-3783
-
(2004)
J Clin Oncol
, vol.22
, pp. 3776-3783
-
-
Rocha Lima, C.M.1
-
6
-
-
0035131918
-
Treatment of pancreatic cancer with a combination of docetaxel, gemcitabine and granulocyte colony-stimulating factor: A phase II study of the Greek Cooperative Group for Pancreatic Cancer
-
Stathopoulos G.P., et al. Treatment of pancreatic cancer with a combination of docetaxel, gemcitabine and granulocyte colony-stimulating factor: A phase II study of the Greek Cooperative Group for Pancreatic Cancer. Ann Oncol 12 (2001) 101-103
-
(2001)
Ann Oncol
, vol.12
, pp. 101-103
-
-
Stathopoulos, G.P.1
-
7
-
-
12244297140
-
Treatment of pancreatic cancer with a combination of irinotecan (CPT-11) and gemcitabine: A multicenter phase II study by the Greek Cooperative Group for Pancreatic Cancer
-
Stathopoulos G.P., et al. Treatment of pancreatic cancer with a combination of irinotecan (CPT-11) and gemcitabine: A multicenter phase II study by the Greek Cooperative Group for Pancreatic Cancer. Ann Oncol 14 (2003) 388-394
-
(2003)
Ann Oncol
, vol.14
, pp. 388-394
-
-
Stathopoulos, G.P.1
-
8
-
-
10744225818
-
Front-line treatment of inoperable or metastatic pancreatic cancer with gemcitabine and capecitabine: An intergroup, multicenter, phase II study
-
Stathopoulos G.P., et al. Front-line treatment of inoperable or metastatic pancreatic cancer with gemcitabine and capecitabine: An intergroup, multicenter, phase II study. Ann Oncol 15 (2004) 224-229
-
(2004)
Ann Oncol
, vol.15
, pp. 224-229
-
-
Stathopoulos, G.P.1
-
9
-
-
32944478346
-
Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer
-
Kindler H.L., et al. Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol 23 (2005) 8033-8040
-
(2005)
J Clin Oncol
, vol.23
, pp. 8033-8040
-
-
Kindler, H.L.1
-
10
-
-
33750977074
-
-
MJ Moore, D Goldstein, Hamm J, et al. Erlotinib improves survival when added to gemcitabine in patients with advanced pancreatic cancer. A phase III trial of the National Cancer Institute of Canada Clinical Trials Group. Proceedings of the 2005 Gastrointestinal Cancers Symposium. Miami: January 27-29, 2005. American Society of Clinical Oncology, Alexandria VA.
-
-
-
-
11
-
-
17544367410
-
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
-
Pitti R.M., et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 271 (1996) 12687-12690
-
(1996)
J Biol Chem
, vol.271
, pp. 12687-12690
-
-
Pitti, R.M.1
-
12
-
-
13344285339
-
Identification and characterization of a new member of the TNF family that induces apoptosis
-
Wiley S.R., et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3 (1995) 673-682
-
(1995)
Immunity
, vol.3
, pp. 673-682
-
-
Wiley, S.R.1
-
13
-
-
0038320035
-
Apo2L/TRAIL: Apoptosis signaling, biology, and potential for cancer therapy
-
Almasan A., and Ashkenazi A. Apo2L/TRAIL: Apoptosis signaling, biology, and potential for cancer therapy. Cytokine Growth Factor Rev 14 (2003) 337-348
-
(2003)
Cytokine Growth Factor Rev
, vol.14
, pp. 337-348
-
-
Almasan, A.1
Ashkenazi, A.2
-
14
-
-
0033210894
-
Selectivity of TRAIL-mediated apoptosis of cancer cells and synergy with drugs: The trail to non-toxic cancer therapeutics
-
[review]
-
Bonavida B., et al. Selectivity of TRAIL-mediated apoptosis of cancer cells and synergy with drugs: The trail to non-toxic cancer therapeutics. [review]. Int J Oncol 15 (1999) 793-802
-
(1999)
Int J Oncol
, vol.15
, pp. 793-802
-
-
Bonavida, B.1
-
15
-
-
29644444314
-
A novel anti-human DR5 monoclonal antibody with tumoricidal activity induces caspase-dependent and caspase-independent cell death
-
Guo Y., et al. A novel anti-human DR5 monoclonal antibody with tumoricidal activity induces caspase-dependent and caspase-independent cell death. J Biol Chem 280 (2005) 41940-41952
-
(2005)
J Biol Chem
, vol.280
, pp. 41940-41952
-
-
Guo, Y.1
-
16
-
-
0030770614
-
Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL
-
MacFarlane M., et al. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J Biol Chem 272 (1997) 25417-25420
-
(1997)
J Biol Chem
, vol.272
, pp. 25417-25420
-
-
MacFarlane, M.1
-
17
-
-
13144265771
-
A novel receptor for Apo2L/TRAIL contains a truncated death domain
-
Marsters S.A., et al. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr Biol 7 (1997) 1003-1006
-
(1997)
Curr Biol
, vol.7
, pp. 1003-1006
-
-
Marsters, S.A.1
-
18
-
-
0030762815
-
An antagonist decoy receptor and a death domain-containing receptor for TRAIL
-
Pan G., et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277 (1997) 815-818
-
(1997)
Science
, vol.277
, pp. 815-818
-
-
Pan, G.1
-
19
-
-
0030792712
-
Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
-
Sheridan J.P., et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277 (1997) 818-821
-
(1997)
Science
, vol.277
, pp. 818-821
-
-
Sheridan, J.P.1
-
20
-
-
0030996297
-
The receptor for the cytotoxic ligand TRAIL
-
Pan G., et al. The receptor for the cytotoxic ligand TRAIL. Science 276 (1997) 111-113
-
(1997)
Science
, vol.276
, pp. 111-113
-
-
Pan, G.1
-
21
-
-
12444288591
-
Type I and type II reactions in TRAIL-induced apoptosis-Results from dose-response studies
-
Rudner J., et al. Type I and type II reactions in TRAIL-induced apoptosis-Results from dose-response studies. Oncogene 24 (2005) 130-140
-
(2005)
Oncogene
, vol.24
, pp. 130-140
-
-
Rudner, J.1
-
22
-
-
7344233085
-
Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL
-
Emery J.G., et al. Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem 273 (1998) 14363-14367
-
(1998)
J Biol Chem
, vol.273
, pp. 14363-14367
-
-
Emery, J.G.1
-
23
-
-
0034022160
-
Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
-
Jo M., et al. Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat Med 6 (2000) 564-567
-
(2000)
Nat Med
, vol.6
, pp. 564-567
-
-
Jo, M.1
-
24
-
-
0035050960
-
Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions
-
Lawrence D., et al. Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions. Nat Med 7 (2001) 383-385
-
(2001)
Nat Med
, vol.7
, pp. 383-385
-
-
Lawrence, D.1
-
25
-
-
17944376030
-
Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity
-
Ichikawa K., et al. Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nat Med 7 (2001) 954-960
-
(2001)
Nat Med
, vol.7
, pp. 954-960
-
-
Ichikawa, K.1
-
26
-
-
21044441651
-
HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo
-
Pukac L., et al. HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo. Br J Cancer 92 (2005) 1430-1441
-
(2005)
Br J Cancer
, vol.92
, pp. 1430-1441
-
-
Pukac, L.1
-
27
-
-
0030827120
-
Oligosaccharides expressed on MUC1 produced by pancreatic and colon tumor cell lines
-
Burdick M.D., et al. Oligosaccharides expressed on MUC1 produced by pancreatic and colon tumor cell lines. J Biol Chem 272 (1997) 24198-24202
-
(1997)
J Biol Chem
, vol.272
, pp. 24198-24202
-
-
Burdick, M.D.1
-
28
-
-
0027499070
-
The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity
-
Crouch S.P., et al. The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity. J Immunol Methods 160 (1993) 81-88
-
(1993)
J Immunol Methods
, vol.160
, pp. 81-88
-
-
Crouch, S.P.1
-
29
-
-
0029107667
-
Comparison of MTT and ATP-based assays for the measurement of viable cell number
-
Petty R.D., et al. Comparison of MTT and ATP-based assays for the measurement of viable cell number. J Biolumin Chemilumin 10 (1995) 29-34
-
(1995)
J Biolumin Chemilumin
, vol.10
, pp. 29-34
-
-
Petty, R.D.1
-
30
-
-
0027374638
-
A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5, 5′, 6,6′-tetrachloro-1, 1′, 3,3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1)
-
Cossarizza A., et al. A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5, 5′, 6,6′-tetrachloro-1, 1′, 3,3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1). Biochem Biophys Res Commun 197 (1993) 40-45
-
(1993)
Biochem Biophys Res Commun
, vol.197
, pp. 40-45
-
-
Cossarizza, A.1
-
31
-
-
0025806764
-
Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1
-
Smiley S.T., et al. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci U S A 88 (1991) 3671-3675
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 3671-3675
-
-
Smiley, S.T.1
-
32
-
-
0034956807
-
Pancreatic adenocarcinoma cell lines show variable susceptibility to TRAIL-mediated cell death
-
Ibrahim S.M., et al. Pancreatic adenocarcinoma cell lines show variable susceptibility to TRAIL-mediated cell death. Pancreas 23 (2001) 72-79
-
(2001)
Pancreas
, vol.23
, pp. 72-79
-
-
Ibrahim, S.M.1
-
33
-
-
21644443678
-
Regulation of the resistance to TRAIL-induced apoptosis as a new strategy for pancreatic cancer
-
Mori T., et al. Regulation of the resistance to TRAIL-induced apoptosis as a new strategy for pancreatic cancer. Surgery 138 (2005) 71-77
-
(2005)
Surgery
, vol.138
, pp. 71-77
-
-
Mori, T.1
-
34
-
-
0035835494
-
Effects and expression of TRAIL and its apoptosis-promoting receptors in human pancreatic cancer
-
Ozawa F., et al. Effects and expression of TRAIL and its apoptosis-promoting receptors in human pancreatic cancer. Cancer Lett 163 (2001) 71-81
-
(2001)
Cancer Lett
, vol.163
, pp. 71-81
-
-
Ozawa, F.1
-
35
-
-
33644832724
-
Targeted induction of apoptosis in cancer management: The emerging role of tumor necrosis factor-related apoptosis-inducing ligand receptor activating agents
-
Rowinsky E.K. Targeted induction of apoptosis in cancer management: The emerging role of tumor necrosis factor-related apoptosis-inducing ligand receptor activating agents. J Clin Oncol 23 (2005) 9394-9407
-
(2005)
J Clin Oncol
, vol.23
, pp. 9394-9407
-
-
Rowinsky, E.K.1
-
36
-
-
33644515676
-
Anti-tumor activity of TRA-8 anti-death receptor 5 (DR5) monoclonal antibody in combination with chemotherapy and radiation therapy in a cervical cancer model
-
Straughn Jr. J.M., et al. Anti-tumor activity of TRA-8 anti-death receptor 5 (DR5) monoclonal antibody in combination with chemotherapy and radiation therapy in a cervical cancer model. Gynecol Oncol 101 (2006) 46-54
-
(2006)
Gynecol Oncol
, vol.101
, pp. 46-54
-
-
Straughn Jr., J.M.1
-
37
-
-
0345700303
-
Synergistic cytotoxic effect of TRAIL and gemcitabine in pancreatic cancer cells
-
Xu Z.W., et al. Synergistic cytotoxic effect of TRAIL and gemcitabine in pancreatic cancer cells. Anticancer Res 23 (2003) 251-258
-
(2003)
Anticancer Res
, vol.23
, pp. 251-258
-
-
Xu, Z.W.1
-
38
-
-
30944438876
-
Combination of cytosine deaminase suicide gene expression with DR5 antibody treatment increases cancer cell cytotoxicity
-
Kaliberov S.A., et al. Combination of cytosine deaminase suicide gene expression with DR5 antibody treatment increases cancer cell cytotoxicity. Cancer Gene Ther 13 (2006) 203-214
-
(2006)
Cancer Gene Ther
, vol.13
, pp. 203-214
-
-
Kaliberov, S.A.1
-
39
-
-
15144345497
-
Pro-caspase-3 is a major physiologic target of caspase-8
-
Stennicke H.R., et al. Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem 273 (1998) 27084-27090
-
(1998)
J Biol Chem
, vol.273
, pp. 27084-27090
-
-
Stennicke, H.R.1
-
40
-
-
27344456844
-
The anti-tumor effect of Apo2L/TRAIL on patient pancreatic adenocarcinomas grown as xenografts in SCID mice
-
Hylander B.L., et al. The anti-tumor effect of Apo2L/TRAIL on patient pancreatic adenocarcinomas grown as xenografts in SCID mice. J Transl Med 3 (2005) 22
-
(2005)
J Transl Med
, vol.3
, pp. 22
-
-
Hylander, B.L.1
-
41
-
-
13444291202
-
Suppression of pancreatic tumor growth in the liver by systemic administration of the TRAIL gene driven by the hTERT promoter
-
Jacob D., et al. Suppression of pancreatic tumor growth in the liver by systemic administration of the TRAIL gene driven by the hTERT promoter. Cancer Gene Ther 12 (2005) 109-115
-
(2005)
Cancer Gene Ther
, vol.12
, pp. 109-115
-
-
Jacob, D.1
|