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Volumn 79, Issue 1, 2011, Pages 157-166

Copper transporter 2 regulates endocytosis and controls tumor growth and sensitivity to cisplatin in vivo

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; CARRIER PROTEIN; CISPLATIN; COPPER TRANSPORTER 2; DEXTRAN; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN CDC42; RAC1 PROTEIN; UNCLASSIFIED DRUG; WORTMANNIN;

EID: 78650972288     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.068411     Document Type: Article
Times cited : (58)

References (54)
  • 1
    • 0025353691 scopus 로고
    • Cellular pharmacology of cisplatin: Perspectives on mechanisms of acquired resistance
    • Andrews PA and Howell SB (1990) Cellular pharmacology of cisplatin: perspectives on mechanisms of acquired resistance. Cancer Cells 2:35-43.
    • (1990) Cancer Cells , vol.2 , pp. 35-43
    • Andrews, P.A.1    Howell, S.B.2
  • 3
    • 38949145276 scopus 로고    scopus 로고
    • Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells
    • Bertinato J, Swist E, Plouffe LJ, Brooks SP, and L'abbé MR (2008) Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells. Biochem J 409:731-740.
    • (2008) Biochem J , vol.409 , pp. 731-740
    • Bertinato, J.1    Swist, E.2    Plouffe, L.J.3    Brooks, S.P.4    L'Abbé, M.R.5
  • 4
    • 77952416458 scopus 로고    scopus 로고
    • Regulation of copper transporter 2 expression by copper and cisplatin in human ovarian carcinoma cells
    • Blair BG, Larson CA, Adams PL, Abada PB, Safaei R, and Howell SB (2010) Regulation of copper transporter 2 expression by copper and cisplatin in human ovarian carcinoma cells. Mol Pharmacol 77:912-921.
    • (2010) Mol Pharmacol , vol.77 , pp. 912-921
    • Blair, B.G.1    Larson, C.A.2    Adams, P.L.3    Abada, P.B.4    Safaei, R.5    Howell, S.B.6
  • 5
    • 67650359894 scopus 로고    scopus 로고
    • Copper transporter 2 regulates the cellular accumulation and cytotoxicity of cisplatin and carboplatin
    • Blair BG, Larson CA, Safaei R, and Howell SB (2009) Copper transporter 2 regulates the cellular accumulation and cytotoxicity of cisplatin and carboplatin. Clin Cancer Res 15:4312-4321.
    • (2009) Clin Cancer Res , vol.15 , pp. 4312-4321
    • Blair, B.G.1    Larson, C.A.2    Safaei, R.3    Howell, S.B.4
  • 6
    • 58749104364 scopus 로고    scopus 로고
    • The promises and pitfalls of RNA-interference-based therapeutics
    • Castanotto D and Rossi JJ (2009) The promises and pitfalls of RNA-interference-based therapeutics. Nature 457:426-433.
    • (2009) Nature , vol.457 , pp. 426-433
    • Castanotto, D.1    Rossi, J.J.2
  • 8
    • 0028009789 scopus 로고
    • Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair
    • Chu G (1994) Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair. J Biol Chem 269:787-790.
    • (1994) J Biol Chem , vol.269 , pp. 787-790
    • Chu, G.1
  • 9
    • 0037422066 scopus 로고    scopus 로고
    • Regulated portals of entry into the cell
    • Conner SD and Schmid SL (2003) Regulated portals of entry into the cell. Nature 422:37-44.
    • (2003) Nature , vol.422 , pp. 37-44
    • Conner, S.D.1    Schmid, S.L.2
  • 12
    • 58549090357 scopus 로고    scopus 로고
    • Copper and angiogenesis: Unravelling a relationship key to cancer progression
    • Finney L, Vogt S, Fukai T, and Glesne D (2009) Copper and angiogenesis: unravelling a relationship key to cancer progression. Clin Exp Pharmacol Physiol 36:88-94.
    • (2009) Clin Exp Pharmacol Physiol , vol.36 , pp. 88-94
    • Finney, L.1    Vogt, S.2    Fukai, T.3    Glesne, D.4
  • 13
    • 0027233829 scopus 로고
    • Cellular accumulation of the anticancer agent cisplatin: A review
    • Gately DP and Howell SB (1993) Cellular accumulation of the anticancer agent cisplatin: a review. Br J Cancer 67:1171-1176.
    • (1993) Br J Cancer , vol.67 , pp. 1171-1176
    • Gately, D.P.1    Howell, S.B.2
  • 14
    • 58549089871 scopus 로고    scopus 로고
    • Elevated copper and oxidative stress in cancer cells as a target for cancer treatment
    • Gupte A and Mumper RJ (2009) Elevated copper and oxidative stress in cancer cells as a target for cancer treatment. Cancer Treat Rev 35:32-46.
    • (2009) Cancer Treat Rev , vol.35 , pp. 32-46
    • Gupte, A.1    Mumper, R.J.2
  • 15
    • 34547507297 scopus 로고    scopus 로고
    • Vertebrate Ctr1 coordinates morphogenesis and progenitor cell fate and regulates embryonic stem cell differentiation
    • Haremaki T, Fraser ST, Kuo YM, Baron MH, and Weinstein DC (2007) Vertebrate Ctr1 coordinates morphogenesis and progenitor cell fate and regulates embryonic stem cell differentiation. Proc Natl Acad Sci USA 104:12029-12034.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 12029-12034
    • Haremaki, T.1    Fraser, S.T.2    Kuo, Y.M.3    Baron, M.H.4    Weinstein, D.C.5
  • 16
    • 33845317647 scopus 로고    scopus 로고
    • The internalization and degradation of human copper transporter 1 following cisplatin exposure
    • Holzer AK and Howell SB (2006) The internalization and degradation of human copper transporter 1 following cisplatin exposure. Cancer Res 66:10944-10952.
    • (2006) Cancer Res , vol.66 , pp. 10944-10952
    • Holzer, A.K.1    Howell, S.B.2
  • 17
    • 33748922789 scopus 로고    scopus 로고
    • Contribution of the major copper influx transporter CTR1 to the cellular accumulation of cisplatin, carboplatin, and oxaliplatin
    • Holzer AK, Manorek GH, and Howell SB (2006) Contribution of the major copper influx transporter CTR1 to the cellular accumulation of cisplatin, carboplatin, and oxaliplatin. Mol Pharmacol 70:1390-1394.
    • (2006) Mol Pharmacol , vol.70 , pp. 1390-1394
    • Holzer, A.K.1    Manorek, G.H.2    Howell, S.B.3
  • 19
    • 84934436076 scopus 로고    scopus 로고
    • Pharmacological inhibition of endocytic pathways: Is it specific enough to be useful?
    • Ivanov AI (2008) Pharmacological inhibition of endocytic pathways: is it specific enough to be useful? Methods Mol Biol 440:15-33.
    • (2008) Methods Mol Biol , vol.440 , pp. 15-33
    • Ivanov, A.I.1
  • 20
    • 59449105383 scopus 로고    scopus 로고
    • Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1
    • Jandial DD, Farshchi-Heydari S, Larson CA, Elliott GI, Wrasidlo WJ, and Howell SB (2009) Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1. Clinical Cancer Research 15:553-560.
    • (2009) Clinical Cancer Research , vol.15 , pp. 553-560
    • Jandial, D.D.1    Farshchi-Heydari, S.2    Larson, C.A.3    Elliott, G.I.4    Wrasidlo, W.J.5    Howell, S.B.6
  • 21
    • 0031020450 scopus 로고    scopus 로고
    • Increased platinum-DNA damage tolerance is associated with cisplatin resistance and cross-resistance to various chemotherapeutic agents in unrelated human ovarian cancer cell lines
    • Johnson SW, Laub PB, Beesley JS, Ozols RF, and Hamilton TC (1997) Increased platinum-DNA damage tolerance is associated with cisplatin resistance and cross-resistance to various chemotherapeutic agents in unrelated human ovarian cancer cell lines. Cancer Res 57:850-856.
    • (1997) Cancer Res , vol.57 , pp. 850-856
    • Johnson, S.W.1    Laub, P.B.2    Beesley, J.S.3    Ozols, R.F.4    Hamilton, T.C.5
  • 23
    • 0026625502 scopus 로고
    • Establishment and characterization of an in vitro model of acquired resistance to cisplatin in a human testicular nonseminomatous germ cell line
    • Kelland LR, Mistry P, Abel G, Freidlos F, Loh SY, Roberts JJ, and Harrap KR (1992) Establishment and characterization of an in vitro model of acquired resistance to cisplatin in a human testicular nonseminomatous germ cell line. Cancer Res 52:1710-1716.
    • (1992) Cancer Res , vol.52 , pp. 1710-1716
    • Kelland, L.R.1    Mistry, P.2    Abel, G.3    Freidlos, F.4    Loh, S.Y.5    Roberts, J.J.6    Harrap, K.R.7
  • 25
    • 59449104509 scopus 로고    scopus 로고
    • The role of the mammalian copper transporter 1 in the cellular accumulation of platinum-based drugs
    • Larson CA, Blair BG, Safaei R, and Howell SB (2009) The role of the mammalian copper transporter 1 in the cellular accumulation of platinum-based drugs. Mol Pharmacol 75:324-330.
    • (2009) Mol Pharmacol , vol.75 , pp. 324-330
    • Larson, C.A.1    Blair, B.G.2    Safaei, R.3    Howell, S.B.4
  • 26
    • 70349679107 scopus 로고    scopus 로고
    • Aerosol delivery of liposomal formulated paclitaxel and vitamin E analog reduces murine mammary tumor burden and metastases
    • Latimer P, Menchaca M, Snyder RM, Yu W, Gilbert BE, Sanders BG, and Kline K (2009) Aerosol delivery of liposomal formulated paclitaxel and vitamin E analog reduces murine mammary tumor burden and metastases. Exp Biol Med (Maywood) 234:1244-1252.
    • (2009) Exp Biol Med (Maywood) , vol.234 , pp. 1244-1252
    • Latimer, P.1    Menchaca, M.2    Snyder, R.M.3    Yu, W.4    Gilbert, B.E.5    Sanders, B.G.6    Kline, K.7
  • 27
    • 0037174814 scopus 로고    scopus 로고
    • Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system
    • Lee J, Petris MJ, and Thiele DJ (2002) Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system. J Biol Chem 277:40253-40259.
    • (2002) J Biol Chem , vol.277 , pp. 40253-40259
    • Lee, J.1    Petris, M.J.2    Thiele, D.J.3
  • 28
    • 33644548947 scopus 로고    scopus 로고
    • Endocytic recycling compartments altered in cisplatin-resistant cancer cells
    • Liang XJ, Mukherjee S, Shen DW, Maxfield FR, and Gottesman MM (2006) Endocytic recycling compartments altered in cisplatin-resistant cancer cells. Cancer Res 66:2346-2353.
    • (2006) Cancer Res , vol.66 , pp. 2346-2353
    • Liang, X.J.1    Mukherjee, S.2    Shen, D.W.3    Maxfield, F.R.4    Gottesman, M.M.5
  • 29
    • 33744821896 scopus 로고    scopus 로고
    • Angiogenesis: Noninvasive quantitative assessment with contrast-enhanced functional US in murine model
    • Lucidarme O, Kono Y, Corbeil J, Choi SH, Golmard JL, Varner J, and Mattrey RF (2006) Angiogenesis: noninvasive quantitative assessment with contrast-enhanced functional US in murine model. Radiology 239:730-739.
    • (2006) Radiology , vol.239 , pp. 730-739
    • Lucidarme, O.1    Kono, Y.2    Corbeil, J.3    Choi, S.H.4    Golmard, J.L.5    Varner, J.6    Mattrey, R.F.7
  • 31
    • 0022519173 scopus 로고
    • Possible mechanism for differences in sensitivity to cis-platinum in human prostate tumor cell lines
    • Metcalfe SA, Cain K, and Hill BT (1986) Possible mechanism for differences in sensitivity to cis-platinum in human prostate tumor cell lines. Cancer Lett 31:163-169.
    • (1986) Cancer Lett , vol.31 , pp. 163-169
    • Metcalfe, S.A.1    Cain, K.2    Hill, B.T.3
  • 32
    • 0027197019 scopus 로고
    • Platinum resistance: Laboratory findings and clinical implications
    • Muggia FM and Los G (1993) Platinum resistance: laboratory findings and clinical implications. Stem Cells 11:182-193.
    • (1993) Stem Cells , vol.11 , pp. 182-193
    • Muggia, F.M.1    Los, G.2
  • 33
    • 0028158014 scopus 로고
    • Characterization of resistance mechanisms to cis- diamminedichloroplatinum(II) in three sublines of the CC531 colon adenocarcinoma cell line in vitro
    • Oldenburg J, Begg AC, van Vugt MJ, Ruevekamp M, Schornagel JH, Pinedo HM, and Los G (1994) Characterization of resistance mechanisms to cis-diamminedichloroplatinum(II) in three sublines of the CC531 colon adenocarcinoma cell line in vitro. Cancer Res 54:487-493.
    • (1994) Cancer Res , vol.54 , pp. 487-493
    • Oldenburg, J.1    Begg, A.C.2    Van Vugt, M.J.3    Ruevekamp, M.4    Schornagel, J.H.5    Pinedo, H.M.6    Los, G.7
  • 35
    • 0034893220 scopus 로고    scopus 로고
    • Metal transporters that contribute copper to metallochaperones in Saccharomyces cerevisiae
    • Portnoy ME, Schmidt PJ, Rogers RS, and Culotta VC (2001) Metal transporters that contribute copper to metallochaperones in Saccharomyces cerevisiae. Mol Genet Genomics 265:873-882.
    • (2001) Mol Genet Genomics , vol.265 , pp. 873-882
    • Portnoy, M.E.1    Schmidt, P.J.2    Rogers, R.S.3    Culotta, V.C.4
  • 36
    • 33846404174 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance and toxicity associated with platinating agents
    • Rabik CA and Dolan ME (2007) Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treat Rev 33:9-23.
    • (2007) Cancer Treat Rev , vol.33 , pp. 9-23
    • Rabik, C.A.1    Dolan, M.E.2
  • 37
    • 11144247945 scopus 로고    scopus 로고
    • Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter
    • Rees EM, Lee J, and Thiele DJ (2004) Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter. J Biol Chem 279:54221-54229.
    • (2004) J Biol Chem , vol.279 , pp. 54221-54229
    • Rees, E.M.1    Lee, J.2    Thiele, D.J.3
  • 38
    • 10644269449 scopus 로고    scopus 로고
    • Copper transporters regulate the cellular pharmacology and sensitivity to Pt drugs
    • Safaei R and Howell SB (2005) Copper transporters regulate the cellular pharmacology and sensitivity to Pt drugs. Crit Rev Oncol Hematol 53:13-23.
    • (2005) Crit Rev Oncol Hematol , vol.53 , pp. 13-23
    • Safaei, R.1    Howell, S.B.2
  • 39
    • 12244266858 scopus 로고    scopus 로고
    • Contribution of endocytic pathways to the uptake of cisplatin in sensitive and resistant ovarian cancer cells
    • Safaei R, Katano K, Samimi G, Holzer AK, Naerdemann W, and Howell SB (2004a) Contribution of endocytic pathways to the uptake of cisplatin in sensitive and resistant ovarian cancer cells. Proc Am Assoc Cancer Res 45:120.
    • (2004) Proc Am Assoc Cancer Res , vol.45 , pp. 120
    • Safaei, R.1    Katano, K.2    Samimi, G.3    Holzer, A.K.4    Naerdemann, W.5    Howell, S.B.6
  • 42
    • 18544370041 scopus 로고    scopus 로고
    • Cisplatin is a DNA-damaging antitumour compound triggering multifactorial biochemical responses in cancer cells: Importance of apoptotic pathways
    • Sedletska Y, Giraud-Panis MJ, and Malinge JM (2005) Cisplatin is a DNA-damaging antitumour compound triggering multifactorial biochemical responses in cancer cells: importance of apoptotic pathways. Curr Med Chem Anticancer Agents 5:251-265.
    • (2005) Curr Med Chem Anticancer Agents , vol.5 , pp. 251-265
    • Sedletska, Y.1    Giraud-Panis, M.J.2    Malinge, J.M.3
  • 43
    • 4844221319 scopus 로고    scopus 로고
    • Identification of cytoskeletal [14C]carboplatin-binding proteins reveals reduced expression and disorganization of actin and filamin in cisplatin-resistant cell lines
    • Shen DW, Liang XJ, Gawinowicz MA, and Gottesman MM (2004a) Identification of cytoskeletal [14C]carboplatin-binding proteins reveals reduced expression and disorganization of actin and filamin in cisplatin-resistant cell lines. Mol Pharmacol 66:789-793.
    • (2004) Mol Pharmacol , vol.66 , pp. 789-793
    • Shen, D.W.1    Liang, X.J.2    Gawinowicz, M.A.3    Gottesman, M.M.4
  • 44
    • 3843076458 scopus 로고    scopus 로고
    • Reduced expression of small GTPases and hypermethylation of the folate binding protein gene in cisplatin-resistant cells
    • Shen DW, Su A, Liang XJ, Pai-Panandiker A, and Gottesman MM (2004b) Reduced expression of small GTPases and hypermethylation of the folate binding protein gene in cisplatin-resistant cells. Br J Cancer 91:270-276.
    • (2004) Br J Cancer , vol.91 , pp. 270-276
    • Shen, D.W.1    Su, A.2    Liang, X.J.3    Pai-Panandiker, A.4    Gottesman, M.M.5
  • 45
    • 65749119430 scopus 로고    scopus 로고
    • Short interfering RNA-mediated gene silencing; towards successful application in human patients
    • Siomi MC (2009) Short interfering RNA-mediated gene silencing; towards successful application in human patients. Adv Drug Deliv Rev 61:668-671.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 668-671
    • Siomi, M.C.1
  • 46
    • 12344314253 scopus 로고    scopus 로고
    • Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells
    • Song IS, Savaraj N, Siddik ZH, Liu P, Wei Y, Wu CJ, and Kuo MT (2004) Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells. Mol Cancer Ther 3:1543-1549.
    • (2004) Mol Cancer Ther , vol.3 , pp. 1543-1549
    • Song, I.S.1    Savaraj, N.2    Siddik, Z.H.3    Liu, P.4    Wei, Y.5    Wu, C.J.6    Kuo, M.T.7
  • 49
    • 0026665349 scopus 로고
    • Sensitivity to novel platinum compounds of panels of human lung cancer cell lines with acquired and inherent resistance to cisplatin
    • Twentyman PR, Wright KA, Mistry P, Kelland LR, and Murrer BA (1992) Sensitivity to novel platinum compounds of panels of human lung cancer cell lines with acquired and inherent resistance to cisplatin. Cancer Res 52:5674-5680.
    • (1992) Cancer Res , vol.52 , pp. 5674-5680
    • Twentyman, P.R.1    Wright, K.A.2    Mistry, P.3    Kelland, L.R.4    Murrer, B.A.5
  • 51
    • 0023597598 scopus 로고
    • Differential uptake of cis-diamminedichloroplatinum (II) by sensitive and resistant murine L1210 leukemia cells
    • Waud WR (1987) Differential uptake of cis-diamminedichloroplatinum (II) by sensitive and resistant murine L1210 leukemia cells. Cancer Res 47:6549-6555.
    • (1987) Cancer Res , vol.47 , pp. 6549-6555
    • Waud, W.R.1
  • 54
    • 22144441320 scopus 로고    scopus 로고
    • Cisplatin damage: Are DNA repair proteins saviors or traitors to the cell?
    • Zorbas H and Keppler BK (2005) Cisplatin damage: are DNA repair proteins saviors or traitors to the cell? Chembiochem 6:1157-1166.
    • (2005) Chembiochem , vol.6 , pp. 1157-1166
    • Zorbas, H.1    Keppler, B.K.2


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