Translocation of platinum anticancer drugs by human copper ATPases ATP7A and ATP7B

Angewandte Chemie - International Edition

Volumn 53, Issue 5, 2014, Pages 1297-1301

  Tadini Buoninsegni, Francesco ^a,b   Bartolommei, Gianluca ^b   Rosa Moncelli, Maria ^b   Inesi, Giuseppe ^c   Galliani, Angela ^a   Sinisi, Marilu ^a   Losacco, Maurizio ^a   Natile, Giovanni ^a   Arnesano, Fabio ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

Author keywords

ATPases; Charge measurements; Copper; NMR spectroscopy; Platinum drugs

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; ATP7A PROTEIN, HUMAN; CATION TRANSPORT PROTEIN; CISPLATIN; COPPER; MKNK1 PROTEIN, HUMAN; OXALIPLATIN; PLATINUM COMPLEX; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN; SIGNAL PEPTIDE; SLC31A1 PROTEIN, HUMAN; WILSON DISEASE PROTEIN;

ANIMAL; ARTICLE; ATPASES; BIOSYNTHESIS; CHARGE MEASUREMENTS; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; DOWN REGULATION; DRUG EFFECT; DRUG RESISTANCE; ELECTROSPRAY MASS SPECTROMETRY; GENETICS; HUMAN; METABOLISM; MICROSOME; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLATINUM DRUGS; PROTEIN BINDING; PROTEIN MOTIF; SITE DIRECTED MUTAGENESIS; UPREGULATION;

ATPASES; CHARGE MEASUREMENTS; COPPER; NMR SPECTROSCOPY; PLATINUM DRUGS;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; ANIMALS; ANTINEOPLASTIC AGENTS; CATION TRANSPORT PROTEINS; CERCOPITHECUS AETHIOPS; CISPLATIN; COPPER; COS CELLS; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES; MUTAGENESIS, SITE-DIRECTED; ORGANOPLATINUM COMPOUNDS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; UP-REGULATION;

EID: 84893934538     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201307718     Document Type: Article

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