Inhibitors of vacuolar H+-ATPase impair the preferential accumulation of daunomycin in lysosomes and reverse the resistance to anthracyclines in drug-resistant renal epithelial cells

Biochemical Journal

Volumn 370, Issue 1, 2003, Pages 185-193

  Ouar, Zahia ^a   Bens, Marcelle ^a   Vignes, Caroline ^b   Paulais, Marc ^a   Pringel, Claudine ^c   Fleury, Jocelyne ^c   Cluzeaud, Françoise ^a   Lacave, Roger ^a   Vandewalle, Alain ^a  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔPITAL TENON   (France)

Author keywords

Anthracycline; Lysosome; Multidrug resistance; Proton pump; Renal cells

Indexed keywords

CELLS; DRUG THERAPY; ENZYMES;

INHIBITORS;

BIOCHEMISTRY;

ANTHRACYCLINE DERIVATIVE; ANTIINFECTIVE AGENT; BETA GLUCURONIDASE; BETA N ACETYLHEXOSAMINIDASE; CONCANAMYCIN A; DAUNORUBICIN; DOXORUBICIN; GLYCOPROTEIN P; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; VERAPAMIL;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL LEVEL; CELL LINE; CELL PH; CELL TRANSPORT; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG SENSITIVITY; DRUG TRANSPORT; ENZYME RELEASE; FLUORESCENCE ANALYSIS; KIDNEY EPITHELIUM; KIDNEY PROXIMAL TUBULE; LYSOSOME; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; DAUNORUBICIN; DRUG RESISTANCE; ENZYME INHIBITORS; EPITHELIAL CELLS; FLOW CYTOMETRY; HYDROGEN-ION CONCENTRATION; KIDNEY; LYSOSOMES; MICE; VACUOLAR PROTON-TRANSLOCATING ATPASES;

ANIMALIA;

EID: 0037442806     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021411     Document Type: Article

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